Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2 [0.03%]
人嗅觉受体OR6A2中气味分子的可逆共价连接的结构解码
Tian Wang,Yiran Wu,Ling Wang et al.
Tian Wang et al.
Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II OR, selectively senses medium-chain aldeh...
Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors [0.03%]
关于游离脂肪酸嗅觉受体的II类嗅觉受体介导的游离脂肪酸气味检测机制的新见解
Xiang Han,Ming-Hui Zhang,Nai-Kang Rong et al.
Xiang Han et al.
Smell is one of the fundamental senses mediated by thousands of odorant receptors (ORs). How hydrophobic and volatile odor molecules are recognized by class II ORs remains elusive. Here, we present cryo-electron microscopy (cryo-EM) structu...
Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target [0.03%]
识别出Or5v1/Olfr110为氧化脂素受体和抗肥胖靶点
Xiao-Yan Ge,Jie Cheng,Li-Jun Zhang et al.
Xiao-Yan Ge et al.
Oxylipins are important metabolic messengers for normal life activities, and olfactory receptors (ORs) are known for their low affinity for odor and are not considered oxylipin receptors. By developing the "anonymous receptor identification...
Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity [0.03%]
人类遗传学指导发现具有抗炎作用的CARD9抑制剂
Jason S Rush,Joshua D Wertheimer,Steven D Goldberg et al.
Jason S Rush et al.
Human genetic association studies highlight key genes involved in disease pathology, yet targets identified by these analyses often fall outside the traditional definitions of druggability. A rare truncated variant of the scaffold protein C...
Marta Puig-Tintó,Sebastian Ortiz,Sasha Meek et al.
Marta Puig-Tintó et al.
Essential for eukaryotes, multiple copies of the exocyst complex tether each secretory vesicle to the plasma membrane (PM) in constitutive exocytosis. The exocyst higher-order structure (ExHOS) that coordinates the action of these multiple ...
Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy [0.03%]
纳米颗粒劫持颅骨免疫细胞用于中枢神经系统药物输送和中风治疗
Xize Gao,Xiangrong Liu,Nanxing Wang et al.
Xize Gao et al.
The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells u...
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo [0.03%]
多模态超分子靶向嵌合体能够在活体内时空解析蛋白质降解
Ji Liu,Tianyu Ma,Rui Yao et al.
Ji Liu et al.
Targeted protein degradation (TPD) has transformed strategies for modulating protein function in both basic biology and therapeutic development. However, current strategies often lack the spatial and temporal precision required for in vivo ...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation [0.03%]
EB病毒潜伏膜蛋白1表达的B细胞在中枢神经系统中捕获髓鞘抗原导致脱髓鞘病灶形成
Hyein Kim,Mika Schneider,Yakine Raach et al.
Hyein Kim et al.
The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In mice, we observed that viral infections induce infiltration of B cells int...
EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation [0.03%]
EB病毒与HLA-DR15通过髓鞘肽呈递联合驱动多发性硬化症
Jian Wang,Yuhan Qiu,Zoe Marti et al.
Jian Wang et al.
Epstein-Barr virus (EBV) is involved in causing and probably also in perpetuating multiple sclerosis (MS). Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and prefere...
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis [0.03%]
EB病毒通过ANK2特异性T细胞与多发性硬化相联系
Olivia G Thomas,Urszula Rykaczewska,Marina Galešić et al.
Olivia G Thomas et al.
Epstein-Barr virus (EBV) infection constitutes a prerequisite for multiple sclerosis (MS) development, and cross-reactivity between EBV nuclear antigen 1 (EBNA1) and anoctamin-2 (ANO2) antibodies was previously demonstrated in persons with ...