A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression [0.03%]
GPX1-OSBPL8轴介导非经典体内铁死亡及癌症生长抑制
Zhangchuan Xia,Xin Yang,Sviatlana N Samovich et al.
Zhangchuan Xia et al.
Ferroptosis is a tumor-suppressive mechanism with therapeutic potential. While canonical ferroptosis is usually triggered by inducers, such as erastin and RSL-3, or by glutathione peroxidase (GPX)4 loss, how ferroptosis occurs naturally in ...
Fluid flow and environmental geometry guide the journey of swimming bacteria [0.03%]
流体流动和环境几何结构引导游泳细菌的旅程
Eleonora Secchi
Eleonora Secchi
In natural and artificial settings, fluid flow and hydrodynamic interactions shape how bacteria attach to surfaces and form biofilms. Tao et al. show that motile E. coli can swim upstream through microstructured environments, revealing how ...
Listening to the bladder field: Urine liquid biopsies reveal differential treatment responses in NMIBC [0.03%]
听从膀胱的指示：尿液液体活检揭示NMIBC的不同治疗反应
Katharina Jonas,Tina Moser,Ellen Heitzer
Katharina Jonas
In this issue of Cell, Shi and colleagues introduce a urine-based liquid biopsy approach that reshapes how treatment response in NMIBC is assessed. They use urine tumor DNA to detect minimal residual disease and disentangle the contribution...
Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC [0.03%]
触动神经：感觉神经元在三阴性乳腺癌中的作用机制研究
Debra Barki,Neta Eilat,Ruth Scherz-Shouval
Debra Barki
The tumor microenvironment drives cancer progression, yet neural contributions remain underexplored. Zhang et al. unravel a signaling circuit involving cancer cells, sensory neurons, and cancer-associated fibroblasts that promotes desmoplas...
Sheng Luan
Sheng Luan
Rooted in place, plants must continuously respond and adapt to their ever-changing environment to survive, especially as climate change intensifies. Calcium ions (Ca²⁺) play a central role in plant responses to both biotic and abiotic cha...
Tuning the sensitivity of mechanosensory receptors through histidine scanning [0.03%]
通过组氨酸扫描调节机械感受器的敏感度
Yuanhao Wang,Yuhan Wang,Wenjie Yuan et al.
Yuanhao Wang et al.
T cell receptor (TCR)-T cell therapy is effective for solid tumors, yet identifying potent, specific TCRs for tumor antigens is challenging. Conventional affinity maturation may cause fatal off-target toxicity. Catch bonds play a crucial ro...
A circadian rheostat drives proton electrochemical gradients to optimize cell-type-specific growth in Arabidopsis [0.03%]
拟南芥中的一个昼夜调节器驱动质子电化学梯度以优化细胞类型的特定生长
Lu Xiong,Motohide Seki,Akiko Satake et al.
Lu Xiong et al.
Plant growth relies on the activity of key transcription factors. Here, we uncover a mechanism for organ-specific growth driven by opposing electrochemical signals that propagate in a cell-type-specific manner. Using a genetically encoded p...
Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design [0.03%]
婴儿双歧杆菌和长双歧杆菌基因组图谱为婴幼儿益生菌设计提供信息
Yan Shao,Shuyi Wang,Bonface M Gichuki et al.
Yan Shao et al.
Bifidobacterium longum and B. infantis are pioneer colonizers of the neonatal gut and are widely used as probiotics to support infant growth, development, and disease resistance. However, commercial strains derived largely from high-income ...
Unified modeling of 3D molecular generation via atomic interactions with PocketXMol [0.03%]
基于原子相互作用的三维分子生成统一建模（通过PocketXMol）
Xingang Peng,Ruihan Guo,Fenglin Guo et al.
Xingang Peng et al.
We present PocketXMol, an atom-level model that unifies generative tasks related to protein pocket interactions. Using atomic prompts as task specifications, PocketXMol supports various molecular tasks, including structure prediction and de...
Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury [0.03%]
全脑神经胶质细胞分布、少突胶质细胞发生和髓鞘损伤图谱测绘
Yu Kang T Xu,Abigail Bush,Ephraim Musheyev et al.
Yu Kang T Xu et al.
Insulating sheaths of myelin accelerate neuronal communication in the mammalian brain. Oligodendrocytes that produce myelin are generated throughout life to gradually increase myelin coverage, but these dynamics have not been defined brain-...