Harnessing citizen science to contextualize adaptation mechanism discovery [0.03%]
利用公民科学发掘并诠释适应机制的调控模式
Laura E Tibbs-Cortes,Linqian Han,Jeremy B Jewell et al.
Laura E Tibbs-Cortes et al.
Species occupying broad geographic regions have evolved multiple mechanisms to regulate phenological characteristics, enabling adaptations to diverse native habitats. By developing computer vision AI to process citizen science observations ...
Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus [0.03%]
肝炎B病毒的胞内受体FHRL2的鉴定
Cong Li,Yixue Wang,Rui Xiong et al.
Cong Li et al.
Hepatitis B virus (HBV) infects hepatocytes by specific binding to the cell-surface receptor-sodium taurocholate cotransporting polypeptide (NTCP)-through the preS1 region of its large envelope protein, followed by a less well-understood tr...
Genome instability triggers intercellular DNA transfer between human cells [0.03%]
基因不稳定触发人细胞间的细胞间DNA转移
Elizabeth G Maurais,Alice Mazzagatti,Yu-Fen Lin et al.
Elizabeth G Maurais et al.
The mammalian genome is safeguarded within the confines of the interphase nucleus. However, genomic instability can trigger the mislocalization of nuclear DNA to the cytoplasm within micronuclei or as fragmented chromosomes. Beyond activati...
Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer [0.03%]
伤害性感觉神经限制三级淋巴组织以促进肺癌发展
Ya-Hsuan Ho,Giacomo Bregni,Marco Stazi et al.
Ya-Hsuan Ho et al.
Sensory innervation regulates lung physiology and pathology, but its role in lung cancer is poorly understood. We show that lung adenocarcinoma (LUAD) progression locally amplifies nociceptive sensory innervation and activation, which drive...
The temporal architecture of the seminiferous epithelial cycle revealed by spatial transcriptomics [0.03%]
空间转录组学揭示了生精上皮周期的时空架构
Arun Chakravorty,Jina Yun,Henry Amrhein et al.
Arun Chakravorty et al.
Spermatogenesis features the seminiferous epithelial cycle, a periodic progression of germ-cell differentiation along the seminiferous tubules. Using seqFISH+ spatial transcriptomics, we profiled 2,653 genes in 867,062 mouse testis cells, r...
Transplanting light-dependent reactions for mammalian eye photosynthesis [0.03%]
移植光依赖反应以用于哺乳动物眼睛的光合作用
Kuoran Xing,Yan Yan,Ziyu Zhu et al.
Kuoran Xing et al.
Mammalian eyes are exposed to visible light but cannot perform photosynthesis. Here, we show that introducing a nanoscale, structurally and functionally preserved thylakoid system, LEAF (light-reaction enriched thylakoid NADPH-foundry), int...
Cell-autonomous control of CAR signaling and receptor shedding via ADAM17-mediated proteolysis [0.03%]
ADAM17介导的蛋白水解对CAR信号转导和受体脱落的自主控制
Jeremy R Bjelajac,Adrià Cañellas-Socias,Preeti Nehra et al.
Jeremy R Bjelajac et al.
We sought to endow T cell autonomous regulation of cell surface protein expression by exploiting the conditional proteolytic activity of ADAM17 following T cell activation. Screening of canonical ADAM17 substrates yielded a minimal 15-aa CD...
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models [0.03%]
封装线粒体的移植可缓解线粒体疾病和帕金森病模型小鼠的功能障碍
Shiwei Du,Qi Long,Yanshuang Zhou et al.
Shiwei Du et al.
Published Erratum
Cell. 2026 May 14:S0092-8674(26)00521-0. DOI:10.1016/j.cell.2026.05.004 2026
A comparison of deep multiomics profiles across ethnicity, geography, and age [0.03%]
跨种族、地理位置和年龄段的深度多组学谱系比较
Nasim Barapour,John Z Cao,Yue Wu et al.
Nasim Barapour et al.
Despite extensive research, molecular differences in human populations and the influence of ancestry, age, geography, and diet are poorly understood. We performed comprehensive multiomics profiling (including genomics, transcriptomics, prot...
Comparative Study
Cell. 2026 May 14;189(10):3004-3024.e35. DOI:10.1016/j.cell.2026.04.032 2026
Navigating the clinical progress of antibody-drug conjugates: Emerging opportunities and remaining challenges [0.03%]
抗体偶联药物的临床进展及其面临的机遇与挑战
Louise Conilh,Virginia Metrangolo,Silvia Crescioli et al.
Louise Conilh et al.
Antibody-drug conjugates are among the fastest-growing anticancer therapies, delivering potent payloads directly to tumor cells with improved safety across hematologic and solid tumors. This review focuses on their biology and where the fie...