Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells [0.03%]
偶然性癌症免疫治疗源于稀有但功能关键的火花T细胞
Emanuel Salazar-Cavazos,Dongya Jia,Yoann Missolo-Koussou et al.
Emanuel Salazar-Cavazos et al.
Cancer immunotherapies trigger highly variable responses in patients and in genetically identical mouse models. To assess the intrinsic stochasticity of these therapies, we performed thousands of well-controlled ex vivo immunoassays. We sho...
Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment [0.03%]
感觉神经元通过刺激乳腺癌肿瘤微环境中的致密细胞外基质促进免疫排斥反应
Si-Wei Zhang,Han Wang,Yi Xiao et al.
Si-Wei Zhang et al.
Innervation is critical in tumor progression. However, the involvement of sensory neurons in the ecosystem of triple-negative breast cancer (TNBC) remains poorly elucidated. Here, we decipher that sensory neurons, the dominant neuron type i...
Thomas H Naragon,Joani W Viliunas,Mina Yousefelahiyeh et al.
Thomas H Naragon et al.
Why symbiotic organisms evolve irreversible dependencies on hosts is an outstanding question. We report a biological stealth device in a beetle that permits infiltration of ant societies. Via transcriptional silencing, the beetle switches o...
Shifting paradigms in tissue stem cell biology: Insights from the intestine [0.03%]
组织干细胞生物学的范式转换：来自肠的研究启示
Hans Clevers
Hans Clevers
The small intestinal epithelium represents the most rapidly self-renewing adult mammalian tissue, with a turnover time of 1-2 weeks. It contains ∼12 easily recognizable cell types with a wide diversity of functions, including nutrient abso...
Jonathan T Ting
Jonathan T Ting
In this issue of Cell, Lin et al. present a new adeno-associated virus (AAV)-based toolbox that enables efficient expression of full-length proteins exceeding the conventional single-vector packaging limit. This technology overcomes key lim...
Yixin Gao,Yushan Peng,Jiying Cheng et al.
Yixin Gao et al.
The dura mater, the outermost meningeal layer that samples and presents central nervous system (CNS)-derived antigens, is a pivotal interface for CNS immunosurveillance. Here, we show that meningeal blood vessel blockage effectively suppres...
Jannis Körner,Derek Howard,Hans Jürgen Solinski et al.
Jannis Körner et al.
Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains elusive, pr...
Divergent tumor immunity determined by bacteria-cancer cell engagement [0.03%]
由细菌与癌细胞相互作用决定的不同的肿瘤免疫应答
Bingqing Yao,Xiaoqin Liu,Kanghui Ruan et al.
Bingqing Yao et al.
Intratumor bacteria represent an understudied yet influential component of the cancer ecosystem, critically impinging cancer progression. In PyMT breast tumors, we find intracellular bacteria, when residing in cancer cell cytosol, promote m...
Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics [0.03%]
人类眶额皮层神经活动与强迫症行为动力学相关联
Young-Hoon Nho,Liming Qiu,Robert L Seilheimer et al.
Young-Hoon Nho et al.
Biomarkers of obsessive-compulsive disorder (OCD) symptom dynamics and related behavior could advance personalized interventions. Aberrant activity in the orbitofrontal cortex (OFC) has been implicated in symptom exacerbation in OCD. We con...
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin [0.03%]
交感上皮交叉对话控制皮肤中驻留记忆T细胞的免疫监视作用
Peng Zhang,Juju Miao,Haoyue Yu et al.
Peng Zhang et al.
Effective host defense and immunosurveillance at barrier tissues require coordinated functions of multiple cell types. Here, we show that in the skin, sympathetic nerves engage with epidermal keratinocytes to regulate the local density of t...