Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity [0.03%]
肿瘤产生的氨被调节性T细胞代谢以进一步阻碍抗肿瘤免疫反应
Jian Gu,Yu Li,Qiuyang Chen et al.
Jian Gu et al.
Mechanisms of adaptation of regulatory T cells (Tregs) to harsh tumor metabolic microenvironments for suppression of anti-tumor immunity remain largely unclear. Here, using spatial metabolomics and transcriptomics, we show that human hepato...
Benjamin P Kay,Muriah D Wheelock,Joshua S Siegel et al.
Benjamin P Kay et al.
Prescription stimulants (e.g., methylphenidate) are thought to improve attention, but evidence from prior fMRI studies is conflicted. We utilized resting-state fMRI data from the Adolescent Brain Cognitive Development Study (n = 11,875; 8-1...
The evolving landscape of Alzheimer's disease therapy: From Aβ to tau [0.03%]
阿尔茨海默病治疗领域的发展：从淀粉样蛋白到tau蛋白质
Jean-Philippe Courade,Henrik Zetterberg,Günter U Höglinger et al.
Jean-Philippe Courade et al.
A marked evolution in Alzheimer's disease (AD) therapy research is ongoing. In this perspective, we highlight emerging outcomes of tau-targeting approaches with disease-modifying potential evidenced by PET-based slowing of tau accumulation ...
Elizabeth V Goldfarb
Elizabeth V Goldfarb
In this issue of Cell, Kay and colleagues show robust and reproducible differences in human brain networks associated with stimulants. Individuals taking stimulants had distinct functional connectivity of a set of brain networks linked to b...
Marito Hayashi
Marito Hayashi
In this issue of Cell, Jaschke and Luchsinger et al. uncover a gut-to-brain signaling mechanism that dynamically shapes protein intake. During recovery from extreme fasting, ammonia derived from the metabolism of specific dietary amino acid...
A 3D in vitro model for studying human implantation and implantation failure [0.03%]
一种研究人类着床和着床失败的三维体外模型
Qian Li,Yang Yuan,Wentao Zhao et al.
Qian Li et al.
A better understanding of human implantation is essential for improving assisted reproduction outcomes and addressing recurrent implantation failure (RIF). However, ethical constraints and limited access to human embryos make direct studies...
Matteo A Molè,Sarah Elderkin,Irene Zorzan et al.
Matteo A Molè et al.
Implantation of a human embryo into the endometrium is a crucial event in gestation, as it marks the initiation of a pregnancy and is prone to high failure rates. We have limited understanding of these stages because of the inaccessibility ...
Mapping cellular targets of covalent cancer drugs in the entire mammalian body [0.03%]
绘制整个哺乳动物机体中癌细胞靶向共价药物的作用图谱
Zhengyuan Pang,Verina H Leung,Cailynn C Wang et al.
Zhengyuan Pang et al.
As our understanding of biological systems reaches single-cell and high spatial resolutions, it becomes imperative that pharmacological approaches match this precision to understand drug actions. This need is particularly urgent for the tar...
Constantine N Tzouanas,Jessica E S Shay,Marc S Sherman et al.
Constantine N Tzouanas et al.
During chronic stress, cells must support both tissue function and their own survival. Hepatocytes perform metabolic, synthetic, and detoxification roles, but chronic nutrient imbalances can induce hepatocyte death and precipitate metabolic...
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases [0.03%]
核点蛋白形成内在的和MALAT1依赖性的微相分离现象
Min Kyung Shinn,Dylan T Tomares,Vicky Liu et al.
Min Kyung Shinn et al.
Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific sequence grammars. Such proteins include serine/arginine-rich splicing factors (SRSFs) and tr...