Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain [0.03%]
用于在活体大脑中可视化α-突触核蛋白病理的基因编码荧光报告系统
Li Zhang,Minhui Yu,Guoqing Chen et al.
Li Zhang et al.
Lewy bodies, a pathological hallmark of Parkinson's disease, are α-synuclein-enriched cytoplasmic inclusions that drive progressive neurodegeneration. A long-standing yet unmet goal has been the visualization of α-synuclein (α-Syn) inclu...
Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice [0.03%]
通过恢复下丘脑视前核的昼夜节律反转小鼠衰老标志并延长其寿命
Haijiao Zhao,Meimei Liao,Ran Huo et al.
Haijiao Zhao et al.
Age-related circadian disruptions accelerate physiological decline and shorten lifespan. Enhancing circadian amplitude has emerged as a promising strategy for ameliorating age-associated disorders. Here, we show that the circadian-phase-opt...
Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs [0.03%]
用于阿尔茨海默病的SPYTACs高效降解淀粉样蛋白-β
Fei Teng,Jing Liu,Tongtong Cui et al.
Fei Teng et al.
Clearance of aberrant cerebral amyloid-β (Aβ) deposits represents a promising therapeutic strategy for Alzheimer's disease (AD), yet current anti-Aβ immunotherapy raises safety concerns due to frequent adverse effects. Extracellular targ...
Luqiang Guo,Elizabeth McFadden,Megan M Slough et al.
Luqiang Guo et al.
New World hantaviruses cause severe infections in humans. Previous structural studies have advanced our understanding of hantavirus glycoprotein architecture; however, the lack of high-resolution structures of the glycoprotein tetramer and ...
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle [0.03%]
柠檬酸盐清除是经典TCA循环中aconitase 2的主要功能
Abigail Xie,Julia S Brunner,Sangita Chakraborty et al.
Abigail Xie et al.
The tricarboxylic acid (TCA) cycle couples nutrient oxidation with the generation of reducing equivalents that power oxidative phosphorylation. Nevertheless, the requirement for components of the TCA cycle is context-specific, raising the q...
Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation [0.03%]
丙酮酸通过诱导STAT1蛋白丙酮酰化自然抑制干扰素信号传导
Yibo Zuo,Qin Wang,Wanying Tian et al.
Yibo Zuo et al.
Glycolysis is a central metabolic pathway that converts glucose into pyruvate. Although pyruvate has been well documented to be a key and terminal metabolite of glycolysis with both energetic and biosynthetic roles, its non-metabolic functi...
The MicrobeAtlas database: Global trends and insights into Earth's microbial ecosystems [0.03%]
MicrobeAtlas数据库：全球趋势及地球微生物生态系统的见解
João Frederico Matias Rodrigues,Janko Tackmann,Lukas Malfertheiner et al.
João Frederico Matias Rodrigues et al.
Environmental DNA sequencing has revolutionized our understanding of microbial diversity and ecology. Microbiomes have now been sequenced across the entire planet-from the deep subsurface to the mountaintops-covering a myriad of hosts, biom...
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease [0.03%]
维生素B2和B3的营养基因组学揭示了NAXD疾病的疗法
Ankur Garg,Skyler Y Blume,Helen Huynh et al.
Ankur Garg et al.
Vitamins are essential metabolites that must be obtained from external sources. In modern times, they have become widely available, leading to their ad hoc consumption. We developed a nutritional genomics framework to systematically identif...
Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis [0.03%]
大规模神经疾病蛋白质组学研究揭示了多发性硬化症的生物标志物组合和靶点
Jakob Maximilian Bader,Christine Makarov,Sabrina Richter et al.
Jakob Maximilian Bader et al.
Cerebrospinal fluid (CSF) is central to neurological diagnostics, yet biomarkers are lacking for many clinical needs. To enable its large-scale proteomic characterization, we developed a high-throughput mass spectrometry workflow quantifyin...
Michał Małszycki,Lisa Martina,İbrahim Avşar Ilık et al.
Michał Małszycki et al.
Nuclear speckles are conserved, membrane-less organelles linked to various post-transcriptional processes. Here, we examined their roles in human cells by engineered, acute removal of SON and SRRM2, two conserved speckle core components cha...