The MicrobeAtlas database: Global trends and insights into Earth's microbial ecosystems [0.03%]
MicrobeAtlas数据库：全球趋势及地球微生物生态系统的见解
João Frederico Matias Rodrigues,Janko Tackmann,Lukas Malfertheiner et al.
João Frederico Matias Rodrigues et al.
Environmental DNA sequencing has revolutionized our understanding of microbial diversity and ecology. Microbiomes have now been sequenced across the entire planet-from the deep subsurface to the mountaintops-covering a myriad of hosts, biom...
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease [0.03%]
维生素B2和B3的营养基因组学揭示了NAXD疾病的疗法
Ankur Garg,Skyler Y Blume,Helen Huynh et al.
Ankur Garg et al.
Vitamins are essential metabolites that must be obtained from external sources. In modern times, they have become widely available, leading to their ad hoc consumption. We developed a nutritional genomics framework to systematically identif...
Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis [0.03%]
大规模神经疾病蛋白质组学研究揭示了多发性硬化症的生物标志物组合和靶点
Jakob Maximilian Bader,Christine Makarov,Sabrina Richter et al.
Jakob Maximilian Bader et al.
Cerebrospinal fluid (CSF) is central to neurological diagnostics, yet biomarkers are lacking for many clinical needs. To enable its large-scale proteomic characterization, we developed a high-throughput mass spectrometry workflow quantifyin...
Michał Małszycki,Lisa Martina,İbrahim Avşar Ilık et al.
Michał Małszycki et al.
Nuclear speckles are conserved, membrane-less organelles linked to various post-transcriptional processes. Here, we examined their roles in human cells by engineered, acute removal of SON and SRRM2, two conserved speckle core components cha...
Whole-organ and whole-body 3D atlases enable cellome-wide profiling [0.03%]
整体和全身三维图谱可实现细胞组学范围内的特征分析
Shota Y Yoshida,Katsuhiko Matsumoto,Satoshi Takagi et al.
Shota Y Yoshida et al.
Recent advancements in tissue clearing and light-sheet fluorescence microscopy have enabled whole-organ/body-scale analysis at single-cell resolution. However, comprehensive bioinformatics resources like digitized whole-cellome maps, analog...
LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery [0.03%]
LUMI-实验室：一种自主平台，利用基础模型发现用于mRNA递送的离子化脂质设计
Yue Xu,Haotian Cui,Kuan Pang et al.
Yue Xu et al.
Integrating AI with robotics offers a promising approach to molecular discovery and optimization, enabling efficient exploration of vast chemical spaces. However, its application in emerging fields is often constrained by sparse historical ...
A regulatory network promotes apoplastic alkalinization to prime plant immunity in tissues distal to site of infection [0.03%]
一个调控网络促进植物远距离组织中的细胞间隙碱化以启动免疫反应
Hongze Wang,Xiuming Li,Keran Zhai et al.
Hongze Wang et al.
Immune activation in plants triggers extracellular alkalinization, presumably by inhibiting plasma membrane H+-ATPases. The precise role and underlying mechanisms of this process remain poorly understood. Here, we show that Pseudomonas syri...
Editing strigolactone hormone receptor for robust antiviral silencing in rice [0.03%]
编辑独脚金内酯激素受体以增强水稻的抗病毒基因沉默效应
Guoyi Yang,Ming Wu,Shuai Zhang et al.
Guoyi Yang et al.
The small interfering RNA (siRNA) pathway directs broad-spectrum antiviral defense through RNA silencing so that virulent infection requires efficient suppression of the defense mechanism. Here, we show that strigolactone (SL) hormone signa...
Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition [0.03%]
真菌来源的纤维二糖代谢途径供能T细胞以避开瘤内葡萄糖竞争
Matthew L Miller,Timothy J Thauland,Smriti Sameer Nagarajan et al.
Matthew L Miller et al.
Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucose. We sought to restore TIL function by providing them with an exclusive fuel source. The ...
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression [0.03%]
GPX1-OSBPL8轴介导非经典体内铁死亡及癌症生长抑制
Zhangchuan Xia,Xin Yang,Sviatlana N Samovich et al.
Zhangchuan Xia et al.
Ferroptosis is a tumor-suppressive mechanism with therapeutic potential. While canonical ferroptosis is usually triggered by inducers, such as erastin and RSL-3, or by glutathione peroxidase (GPX)4 loss, how ferroptosis occurs naturally in ...