Him K Shrestha,Huan Sun,Jay M Yarbro et al.
Him K Shrestha et al.
Neurodegenerative diseases (NDs) pose clinical challenges due to their complexity and molecular heterogeneity. Here, we present a pan-neurodegeneration atlas (PanNDA) from multilayer, deep proteomic analysis of 2,279 human brain samples spa...
Hua Gao,Goutam Chakraborty,Ai Ping Lee-Lim et al.
Hua Gao et al.
Published Erratum
Cell. 2026 Mar 21:S0092-8674(26)00327-2. DOI:10.1016/j.cell.2026.03.026 2026
Hannah T Tam,Jingyu Peng,Rebecca Freeman et al.
Hannah T Tam et al.
Some mammalian tissues can replace lost cells within one lineage, but organ-level regeneration-restoring diverse cell types across lineages-remains rare. Here, we show that late embryonic full-thickness skin injuries heal by regenerating ep...
Ngee Kiat Chua,Tania J González-Robles,Cameron J Reddington et al.
Ngee Kiat Chua et al.
To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the human genome. The E3-ome integrates experimental data, bioinformatics, and published researc...
Guanghao Guo,He Zhao,Kaihong Bai et al.
Guanghao Guo et al.
Nucleotide-binding, leucine-rich repeat (NLR) receptors are widespread intracellular immune sensors across kingdoms. Plant G10-type coiled-coil (CCG10)-NLRs constitute a distinct phylogenetic clade that remains poorly characterized. Here, w...
Richard Bailleul,Nicolas Cuny,Diana Khoromskaia et al.
Richard Bailleul et al.
How morphological diversity arises from variations in biomechanical processes remains an open question. Although forces shape tissues, how force-generating systems differ across species to create diverse forms is unclear. Here, we combine c...
Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air [0.03%]
Nahara Vargas-Maldonado,Nishit Shetty,Lucas M Ferreri et al.
Nahara Vargas-Maldonado et al.
Influenza virus is transmitted via respiratory expulsions, but detecting infectious virus in expulsions is challenging. Here, we describe quantification and genotyping of infectious virus in respiratory particles using a modular influenza s...
Haikun Song,Wei Wang,Tingfang Mei et al.
Haikun Song et al.
Targeted protein degradation (TPD) technologies provide huge opportunities for drug discovery, but degrading transmembrane (TM) targets remains challenging. Since TM proteins are canonically folded on the endoplasmic reticulum (ER) membrane...
Jiangbo Wei,Chuan He
Jiangbo Wei
RNA is frequently chemically modified, with over 170 types of chemical modifications identified to date in cellular RNAs. These modifications, along with their effector proteins, constitute new layers of gene expression regulation by contro...
Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles [0.03%]
Ainan Geng,Rohit Roy,Megan Ken et al.
Ainan Geng et al.
Despite advances in structure prediction from sequence, predicting cellular activity requires conformational ensembles that capture propensities to form functionally active states. Such ensembles remain difficult to measure and even harder ...