Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy [0.03%]
用于靶向药物输送和增强癌症免疫治疗的敏化肥大细胞
Yan Xu,Xiaoge Zhang,Xiao Han et al.
Yan Xu et al.
Cell-mediated drug-delivery systems have garnered significant attention for their potential to boost therapeutic efficacy in cancer treatment. Here, we engineered immunoglobulin E (IgE)-sensitized mast cells (IgE-MCs) to achieve antigen-gui...
Multimodal AI generates virtual population for tumor microenvironment modeling [0.03%]
多模态AI生成肿瘤微环境建模的虚拟人群
Jeya Maria Jose Valanarasu,Hanwen Xu,Naoto Usuyama et al.
Jeya Maria Jose Valanarasu et al.
The tumor immune microenvironment (TIME) critically impacts cancer progression and immunotherapy response. Multiplex immunofluorescence (mIF) is a powerful imaging modality for deciphering TIME, but its applicability is limited by high cost...
Sung Ryul Choi,Thorsten B Blum,Matteo Giono et al.
Sung Ryul Choi et al.
Microtubules have long been recognized as upstream mediators of intracellular signaling, but the mechanisms underlying this fundamental function remain elusive. Here, we identify the structural basis by which microtubules regulate the guani...
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues [0.03%]
用于密集细胞组织光激活生物打印的生物材料极简主义方法
Mian Wang,Wanlu Li,Jin Hao et al.
Mian Wang et al.
Conventional hydrogel-based bioprinting methods often suffer from insufficient cell densities, which may limit crucial cell-cell interactions and impair overall tissue functions. Here, we present an approach that modifies cell membranes wit...
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks [0.03%]
裸盖菇素诱发皮层网络的活动依赖性重塑
Quan Jiang,Ling-Xiao Shao,Shenqin Yao et al.
Quan Jiang et al.
Psilocybin holds promise as a treatment for mental illnesses. One dose of psilocybin induces structural remodeling of dendritic spines in the medial frontal cortex in mice. The dendritic spines would be innervated by presynaptic neurons, bu...
Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease [0.03%]
自身抗体诱发的足细胞膜芽突起驱动自身免疫性肾脏病
Karen Lahme,Wiebke Sachs,Sarah Froembling et al.
Karen Lahme et al.
Chronic kidney disease affects 1 in 10 people worldwide, with damage to specialized blood filter cells of the kidney, called podocytes, playing a critical role. In membranous nephropathy (MN), a major cause of nephrotic syndrome, circulatin...
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis [0.03%]
GPX4中的一个类似fin-loop的结构可介导铁死亡下的神经保护作用
Svenja M Lorenz,Adam Wahida,Mark J Bostock et al.
Svenja M Lorenz et al.
Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous antioxidant defenses. Glutathione peroxidase 4 (G...
Rose Z Hill,Jonathan W Nelson,Georgina Gyarmati et al.
Rose Z Hill et al.
Renin synthesis and release is the rate-limiting step of the renin-angiotensin-aldosterone system (RAAS) that controls fluid homeostasis. A major activator of the RAAS is a decrease in perfusion pressure within the kidneys, suggesting a lin...
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells [0.03%]
撤稿通知：基于CRISPR的转录组RNA靶向筛选发现人类细胞中的功能必需型长链非编码RNA
Wen-Wei Liang,Simon Müller,Sydney K Hart et al.
Wen-Wei Liang et al.
Published Erratum
Cell. 2025 Dec 3:S0092-8674(25)01367-4. DOI:10.1016/j.cell.2025.11.032 2025
Fertilization triggers early proteomic symmetry breaking in mammalian embryos [0.03%]
受精触发哺乳动物胚胎早期蛋白组对称性破缺
Lisa K Iwamoto-Stohl,Aleksandra A Petelski,Baiyi Quan et al.
Lisa K Iwamoto-Stohl et al.
While non-mammalian embryos often rely on spatial pre-patterning, mammalian development has long been thought to begin with equivalent blastomeres. However, emerging evidence challenges this. Here, using multiplexed and label-free single-ce...