Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits [0.03%]
肠道微生物产生具有心血管代谢益处的二硝基亚铁复合物
Andrei L Kleschyov,Miho Shimari,Ariela Maína Boeder et al.
Andrei L Kleschyov et al.
Gut bacteria affect host physiology, but the underlying mechanisms are not completely understood. We identify a pathway whereby gut microbes convert inorganic nitrate and non-heme iron into mobile bioactive dinitrosyl iron complexes (DNICs)...
Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function [0.03%]
由结构域重组设计的合成转录因子可增强CAR-T细胞的抗肿瘤功能
Oliver Takacsi-Nagy,Sivakanthan Kasinathan,Austin Hartman et al.
Oliver Takacsi-Nagy et al.
Human protein-coding genes evolved via rearrangement of domains from ancestral genes. We develop a scalable, evolutionarily guided method to assemble novel genes from constituent domains within a protein family, termed DESynR (domain engine...
RNA structures regulate norovirus life cycle and enable rational attenuation in vivo [0.03%]
RNA结构调控诺如病毒的生活周期并在活体内实现理性的减毒设计
Tanja Hann,Arya B Ökten,Renata B Filler et al.
Tanja Hann et al.
Viral genomes encode regulatory RNA structures that orchestrate key steps of viral replication and gene expression. Although these structures are increasingly recognized as critical regulators of viral function, their systematic characteriz...
Mutually beneficial interactions between bacteria and Arabidopsis promote phosphorus nutrition and growth [0.03%]
细菌和拟南芥之间的互惠作用促进磷营养和生长
Yongjin Wang,Chulei Gao,Fang Liu et al.
Yongjin Wang et al.
It remains unknown whether plants establish mutualistic relationships with any bacteria to cope with phosphorus (P) limitation. We characterized root-bacterial microbiome members to show that many of them may cooperate with Arabidopsis to p...
Xiao Zhang,Guangyao Lai,Xiangyu Guo et al.
Xiao Zhang et al.
High-throughput single-cell omics of non-human primate brain tissue provides a powerful platform to investigate the molecular basis of brain aging. Here, we present a comprehensive transcriptomic and chromatin accessibility atlas of 2,955,8...
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution [0.03%]
无需测序的单分子分辨率全基因组空间转录组学
Yubao Cheng,Shengyuan Dang,Yuan Zhang et al.
Yubao Cheng et al.
Published Erratum
Cell. 2026 Sep 17;189(19):6208. DOI:10.1016/j.cell.2026.08.021 2026
Leo Dupire,Aly A Khan,Theofanis Karaletsos et al.
Leo Dupire et al.
Generative AI (Gen-AI) has shown a remarkable impact in several biological research areas, from protein folding and de novo design to pathogenic mutation prediction. However, it remains unclear whether these molecular-level successes can tr...
Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human [0.03%]
小鼠和人类脑血管周巨噬细胞通过cMAF依赖性转录程序调节内皮细胞功能
Simone Brioschi,Julia A Belk,Steffen E Storck et al.
Simone Brioschi et al.
Brain perivascular macrophages maintain brain physiology, yet their transcriptional regulators and functions in health and disease remain unclear. Using single-cell multi-omics and functional experiments, we identify cellular musculoaponeur...
Pushkal Sharma,Heather R Keys,Ryan P Mansell et al.
Pushkal Sharma et al.
Polyamines are essential and evolutionarily conserved metabolites present at millimolar concentrations in mammalian cells. Cells tightly regulate polyamine homeostasis through complex feedback mechanisms, yet the precise role necessitating ...
Ancient genomes reveal distinct human dispersals and social stratification in the settlement history of western Remote Oceania [0.03%]
古代基因组揭示了大洋洲西部远程岛屿人类迁徙和社会分层的定居历史
Michal Feldman,Lara R Arauna,Selina Carlhoff et al.
Michal Feldman et al.
The settlement of western Remote Oceania involved interactions among deeply divergent populations. Initial settlement ∼3,000 years ago by Lapita-associated, Southeast Asian-related groups was followed by Papuan-related expansions and later...