Functional assessment of all ATM SNVs using prime editing and deep learning [0.03%]
利用先导编辑和深度学习对所有ATM剪切位变异进行功能评估
Kwang Seob Lee,Joon-Goo Min,Yumin Cheong et al.
Kwang Seob Lee et al.
Ataxia telangiectasia mutated (ATM), a large gene with 63 exons, plays a critical role in the DNA damage response, and its loss of function increases cancer risk and affects the prognosis of cancer patients. However, interpreting the functi...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement [0.03%]
假尿苷RNA通过损伤内溶酶体加工和TLR结合而避免免疫检测
Marleen Bérouti,Mirko Wagner,Wilhelm Greulich et al.
Marleen Bérouti et al.
Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize RNA degradation products generated by endolysosomal nucleases. RNA modifications present ...
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation [0.03%]
果蝇单细胞3D时空多组学图谱揭示全景关键细胞类型分化调控因子
Mingyue Wang,Qinan Hu,Zhencheng Tu et al.
Mingyue Wang et al.
The development of a multicellular organism is a highly intricate process tightly regulated by numerous genes and pathways in both spatial and temporal manners. Here, we present Flysta3D-v2, a comprehensive multi-omics atlas of the model or...
50,000 years of evolutionary history of India: Impact on health and disease variation [0.03%]
印度5万年的进化历史：对健康和疾病变异的影响
Elise Kerdoncuff,Laurits Skov,Nick Patterson et al.
Elise Kerdoncuff et al.
India has been underrepresented in genomic surveys. We generated whole-genome sequences from 2,762 individuals in India, capturing the genetic diversity across most geographic regions, linguistic groups, and historically underrepresented co...
Yusuf H Roohani,Tony J Hua,Po-Yuan Tung et al.
Yusuf H Roohani et al.
Virtual cells are an emerging frontier at the intersection of artificial intelligence and biology. A key goal of these cell state models is predicting cellular responses to perturbations. The Virtual Cell Challenge is being established to c...
Zheyi Ni,Hailan Hu
Zheyi Ni
The reproductive cycle in females influences their social and sexual behaviors. In this issue of Cell, Wang et al. find that the calcium channel Cav3.2 in the brain's prefrontal cortex functions as a hormone-regulated electrophysiological s...
Response to: The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved [0.03%]
关于SARS-CoV-2 NiRAN结构域介导的GTP依赖性RNA加帽反应机制的文章的回答
Yucen Huang,Liping Tan,Yixiao Liu et al.
Yucen Huang et al.
The SARS-CoV-2 polymerase NiRAN domain initiates RNA capping. Previous results showed that both GTP and GDP can be utilized by NiRAN to yield GpppA together with RNAylated nsp9 (RNA-nsp9); however, the G-pocket substrate selection and the w...
Systematic profiling reveals betaine as an exercise mimetic for geroprotection [0.03%]
系统性分析发现甜菜碱可作为防衰运动模拟剂
Lingling Geng,Jiale Ping,Ruochen Wu et al.
Lingling Geng et al.
Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males. Acute ex...
A host organelle integrates stolen chloroplasts for animal photosynthesis [0.03%]
一个宿主细胞器整合了被盗的叶绿体进行动物光合作用
Corey A H Allard,Angus B Thies,Rishav Mitra et al.
Corey A H Allard et al.
Eukaryotic life evolved over a billion years ago when ancient cells engulfed and integrated prokaryotes to become modern mitochondria and chloroplasts. Sacoglossan "solar-powered" sea slugs possess the ability to acquire organelles within a...
The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved [0.03%]
SARS-CoV-2 NiRAN结构域介导的GTP依赖的RNA加帽机制尚未解析
Gabriel I Small,Seth A Darst,Elizabeth A Campbell
Gabriel I Small
The Nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain initiates mRNA capping in coronaviruses through a GDP-polyribonucleotidyltransferase reaction, with RNA covalently linked to nsp9. GDP is the preferred substrate for this r...