Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex [0.03%]
溶酶体KICSTOR-GATOR1-SAMTOR营养感受超级复合物的结构
Christopher J Lupton,Charles Bayly-Jones,Shuqi Dong et al.
Christopher J Lupton et al.
The guanosine triphosphate (GTP)-bound state of the heterodimeric Rag GTPases functions as a molecular switch regulating mechanistic target of rapamycin complex 1 (mTORC1) activation at the lysosome downstream of amino acid fluctuations. Un...
Chengyu Zou,Peiying Li,Bin Li et al.
Chengyu Zou et al.
Recent advances in regulatory T cell (Treg) biology and clinical application of Treg-based treatments show promise as a new generation of transforming therapeutics for immune-related disorders, positioning Tregs as a "living drug" to rebuil...
Andreas Linkermann
Andreas Linkermann
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respiratory chain to release copper and kill acu...
A trunkload of ancient RNA [0.03%]
一车满满的古rna
Sébastien Calvignac-Spencer,Carles Lalueza-Fox
Sébastien Calvignac-Spencer
Ancient DNA has become a workhorse for evolutionary biologists. In contrast, ancient RNA studies have been rare and often methodologically controversial. Mármol-Sánchez et al. provide compelling evidence that aRNA survived up to ca. 50,00...
EcDNA-borne structural variants drive oncogenic fusion transcript amplification [0.03%]
染色体外 DNA 诱导结构变异并驱动致癌融合转录本扩增
Hyerim Yi,Shu Zhang,Jason Swinderman et al.
Hyerim Yi et al.
Extrachromosomal DNA (ecDNA) amplifications are key drivers of human cancers. Here, we show that ecDNAs are major platforms for generating and amplifying oncogene fusion transcripts across diverse cancer types. By integrating analysis of wh...
Guangqing Lu,Shanshan Zhang,Mengyang Feng et al.
Guangqing Lu et al.
While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacterized. To address this knowledge gap, we developed "cytokine cellular locating platforms" (...
Evolutionary transcriptomics unveils rapid changes of gene expression patterns in flowering plants [0.03%]
进化转录组学揭示了开花植物基因表达模式的快速变化
Christoph Schuster,Alexander Gabel,Hajk-Georg Drost et al.
Christoph Schuster et al.
The evolutionary history of angiosperms (flowering plants) is characterized by a highly accelerated rate of diversification. Although a number of hypotheses have been proposed to explain the ecological success and rapid rise of angiosperms,...
Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors [0.03%]
细胞外GPX4通过树突状ZP3受体损害抗肿瘤免疫反应
Jiao Liu,Xiutao Cai,Junhao Lin et al.
Jiao Liu et al.
Understanding the immunogenic properties of different forms of cell death is critical for rationalized antineoplastic therapeutic development. Here, we identify a regulatory axis that suppresses the immunogenicity of ferroptosis. During fer...
A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration [0.03%]
糖酵解通路通过磷酸戊糖途径成为感觉稳态和轴突再生的代谢检查点
Yayue Song,Lucia Luengo-Gutierrez,Virag Sagi-Kiss et al.
Yayue Song et al.
Homeostasis and repair in the nervous system are thought to rely on distinct molecular programs. Here, we uncover an unexpected role for the pentose phosphate pathway (PPP) in peripheral sensory axons, where it supports both homeostatic mec...
Structure of pancreatic hIAPP fibrils derived from patients with type 2 diabetes [0.03%]
2型糖尿病患者胰岛素淀粉样多肽纤维的结构
Wenjing Liu,Jianting Han,Wei Gong et al.
Wenjing Liu et al.
Type 2 diabetes (T2D) impacts the quality of life and lifespan of nearly 10% of the global population. Human islet amyloid polypeptide (hIAPP) constitutes a major component of islet amyloid deposition in patients with T2D, with hIAPP fibril...