Phase separation to buffer growth-mediated dilution in synthetic circuits [0.03%]
相分离缓释生长介导的稀释以稳定合成线路中的分子浓度
Rong Zhang,Wangfei Yang,Rixin Zhang et al.
Rong Zhang et al.
Fluctuations in host cell growth pose a critical challenge for maintaining reliable function in synthetic gene circuits. Growth-mediated dilution causes a global reduction in circuit component concentrations, which can significantly destabi...
StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models [0.03%]
隐秘的调节因子：一种免疫原性免费的CRISPR平台在免疫健全模型中揭示隐藏的转移调控因素
Massimo Saini,Francesc Castro-Giner,Adriana Hotz et al.
Massimo Saini et al.
CRISPR screens have become standard gene discovery platforms in various contexts, including cancer. Yet commonly available CRISPR-Cas9 tools are increasingly recognized as unfit for in vivo investigations in immunocompetent contexts, due to...
Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status [0.03%]
现存和灭绝的大猩猩基因组序列揭示了其系统发育、人口历史及保护现状
Sheng Wang,Zehui Chen,Ayun Luo et al.
Sheng Wang et al.
Gibbons (family Hylobatidae), small apes closely related to humans and great apes, remain understudied despite their threatened status. Here, we present extensive genomic resources, including chromosome-level reference genomes, whole-genome...
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction [0.03%]
纵向超高灵敏度ctDNA检测技术在肺癌高分辨率风险预测中的应用
James R M Black,Takahiro Karasaki,Charles W Abbott et al.
James R M Black et al.
Biomarkers accurately informing prognostic assessment and therapeutic strategy are critical for improving patient outcome in oncology. Here, we apply a whole-genome, tumor-informed circulating tumor DNA (ctDNA) detection approach to address...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions [0.03%]
染色质结构单碱基解析绘制染色质交互作用的统合理论模型
Hangpeng Li,James L T Dalgleish,George Lister et al.
Hangpeng Li et al.
Chromatin structure is a key determinant of gene expression in eukaryotes, but it has not been possible to define the structure of cis-regulatory elements at the scale of the proteins that bind them. Here, we generate multidimensional chrom...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration [0.03%]
植物再生过程中单个体细胞编程为全能状态的时间分辨重编程
Li Ping Tang,Li Ming Zhai,Jiming Li et al.
Li Ping Tang et al.
Published Erratum
Cell. 2025 Nov 5:S0092-8674(25)01240-1. DOI:10.1016/j.cell.2025.10.035 2025
Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states [0.03%]
肠-脑信号在机体从消耗状态下恢复期间限制饮食蛋白摄入量的作用机制研究
Nikolai P Jaschke,Joseph R Luchsinger,Zuojia Chen et al.
Nikolai P Jaschke et al.
Dietary needs are dynamic, with optimal ranges for nutrients varying over time and across physiological states. How optimal nutrient set points are established and why they are adjusted remains largely unknown. In our efforts to understand ...
Disparate leukemia mutations converge on nuclear phase-separated condensates [0.03%]
不同的白血病突变汇聚到细胞核相分离凝聚物中
Gandhar K Datar,Elmira Khabusheva,Archish Anand et al.
Gandhar K Datar et al.
During cancer development, mutations promote changes in gene expression that cause transformation. Leukemia associated with aberrant HOXA expression is driven by translocations of nucleoporin genes or KMT2A as well as mutations in NPM1. The...
Generation of antigen-specific paired-chain antibodies using large language models [0.03%]
使用大型语言模型生成抗原特异性配对链抗体
Perry T Wasdin,Nicole V Johnson,Alexis K Janke et al.
Perry T Wasdin et al.
The traditional process of antibody discovery is limited by inefficiency, high costs, and low success rates. Recent approaches employing artificial intelligence (AI) have been developed to optimize existing antibodies and generate antibody ...
Chiara Fornetto,Thomas Euler,Tom Baden
Chiara Fornetto
Vision first evolved in the water, where the spectral content of light informs about viewing distance. However, whether and how aquatic visual systems exploit this "fact of physics" remains unknown. Here, we show that zebrafish use "color" ...