The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved
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The Nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain initiates mRNA capping in coronaviruses through a GDP-polyribonucleotidyltransferase reaction, with RNA covalently linked to nsp9. GDP is the preferred substrate for this reaction, but the NiR... ...
