Paloma Gonzalez-Perez,Craig Blackstone
Paloma Gonzalez-Perez
In this issue of Cell, Guo et al. report the development of a new exon-skipping, RNA-editing-based therapy for Duchenne muscular dystrophy. The dual mechanism of action through both ADAR-dependent and -independent pathways has the potential...
Photosynthetic medicine: Engineering a plant-derived nanofoundry to power mammalian cells [0.03%]
光合医学：工程化植物衍生纳米工厂以驱动哺乳动物细胞
Qimanguli Saiding,Tian Xie,Wei Tao
Qimanguli Saiding
Mammalian eyes receive constant visible light yet lack photosynthesis. Xing et al. engineer an intact thylakoid grana nanoparticle enabling light-driven NADPH production within corneal cells, restoring antioxidant defenses and interrupting ...
Map of spiking activity underlying change detection in the mouse visual system [0.03%]
小鼠视觉系统中变化检测的神经元放电活动图谱
Corbett Bennett,Samuel D Gale,Greggory Heller et al.
Corbett Bennett et al.
Visual behavior requires coordinated activity across hierarchically organized brain circuits. Understanding this complexity demands datasets that are both large-scale (sampling many areas) and dense (recording many neurons in each area). He...
A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions [0.03%]
一套病毒型ORFeome库可对病原体-宿主相互作用进行系统水平的遗传解析
Eric Fujimura,Colin N O&#x;Leary,Mamie Z Li et al.
Eric Fujimura et al.
Virological research has traditionally focused on individual viruses or viral families. Advances in DNA synthesis now allow large-scale construction of individual gene products, enabling systematic exploration of the virome. Here, we develo...
Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs [0.03%]
溶酶体机器的征用塑造了支持珊瑚礁的细胞内光合共生的进化路径
Shumpei Maruyama,Catherine F Henderson,Natalie Swinhoe et al.
Shumpei Maruyama et al.
Endosymbiosis has spurred the evolution of new organelles across life. Corals and other cnidarians have repeatedly evolved an organelle, called the symbiosome, which houses intracellular algal symbionts. However, the molecular mechanisms en...
LEF1 and niche factors determine T cell stemness across chronic diseases [0.03%]
LEF1和生态位因素决定慢性疾病中T细胞的干细胞特性
Svetlana Miakicheva,Katrina M Hawley,Paul Zumbo et al.
Svetlana Miakicheva et al.
In settings of persistent (self or foreign) antigen, such as autoimmunity and chronic infection, immune responses are sustained by stem-like T cells. Although TCF1 has emerged as a key transcription factor (TF) associated with stemness, the...
Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders [0.03%]
主要神经退行性疾病中TOP1介导的神经元基因组损伤的共同规律
Zinan Zhou,Lovelace J Luquette,Guanlan Dong et al.
Zinan Zhou et al.
Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD) represent two major categories of neurodegenerative disorders-TAR DNA-binding protein 43 (TDP-43) and tau proteinopathies-for which the mechani...
Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis [0.03%]
来自空间快照的四维分子图谱描绘了毛囊发生动力学过程
Soichiro Asami,Chenshuo Yin,Jean Fan et al.
Soichiro Asami et al.
Understanding organ formation requires capturing molecular information simultaneously in three-dimensional (3D) space and across developmental time. To this end, we developed 3D DNase-Enhanced Expression Profiling (3DEEP), a tissue-clearing...
Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data [0.03%]
基于4D晶格光片显微镜数据的全细胞颗粒数字孪生仿真模拟
Eric Arkfeld,Zichen Wang,Hiroyuki Hakozaki et al.
Eric Arkfeld et al.
We introduce a whole-cell digital twin framework that integrates four-dimensional (4D) (x, y, z, and t) lattice light-sheet microscopy with particle-based reaction-diffusion simulations in ReaDDy to model mesoscale intracellular organelle d...
Systematic discovery of pathogen effector functions across human pathogens and pathways [0.03%]
在病原体和途径中系统发现效应物功能
Tomas Pachano,He Leng,Guillaume Dugied et al.
Tomas Pachano et al.
Pathogens deploy effector proteins to exploit host cell biology, and most effector open reading frames (ORFs) are rapidly evolving and lack functional annotation. We developed the effector ORFeome (eORFeome), a scalable functional genomics ...