HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity [0.03%]
HypoxyStat，一种提高氧血红蛋白亲和力的低氧治疗小分子形式
Skyler Y Blume,Ankur Garg,Yolanda Martí-Mateos et al.
Skyler Y Blume et al.
We have previously demonstrated that chronic inhaled hypoxia is remarkably therapeutic in the premier animal model of mitochondrial Leigh syndrome, the Ndufs4 knockout (KO) mouse. Subsequent work has extended this finding to additional mito...
Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness [0.03%]
乳腺上皮内淋巴细胞促进泌乳及后代健康
Dan Corral,Eduard Ansaldo,Jérémie Delaleu et al.
Dan Corral et al.
Breastfeeding is an obligatory requirement of mammalian survival. This fundamental process is associated with the adaptation of maternal physiology, including the transformation of the mammary gland into a milk-secreting organ. How maternal...
Tom Hindmarsh Sten,Rufei Li,Florian Hollunder et al.
Tom Hindmarsh Sten et al.
Males of many species have evolved behavioral traits to both attract females and repel rivals. Here, we explore mate selection in Drosophila from both the male and female perspective to shed light on how these key components of sexual selec...
Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism [0.03%]
同义突变通过干扰m6A依赖的信使RNA代谢促进肿瘤发生
Yiheng Lan,Zhen Xia,Qizhe Shao et al.
Yiheng Lan et al.
Cancer cells acquire numerous mutations during tumorigenesis, including synonymous mutations that do not change the amino acid sequence of a protein. RNA N6-methyladenosine (m6A) is a post-transcriptional modification that plays critical ro...
Jing-Jing Xu,Yuan Lei,Xiao-Fan Zhang et al.
Jing-Jing Xu et al.
Coenzyme Q (CoQ) is essential for energy production by mitochondrial respiration, and it is a supplement most often used to promote cardiovascular health. Humans make CoQ10, but cereals and some vegetable/fruit crops synthesize CoQ9 with a ...
Resistance to Striga parasitism through reduction of strigolactone exudation [0.03%]
通过减少赤霉素外渗来抵抗Striga寄生
Jiayang Shi,Cuo Mei,Fengyong Ge et al.
Jiayang Shi et al.
Parasitism with Striga poses a major threat to global food production. Striga germination and growth rely on strigolactones (SLs) exuded by crop roots under phosphate (Pi)-deficient conditions, although the mechanism of this host-parasite i...
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation [0.03%]
ArfGAP2促进STING质子通道活性、细胞因子转运和自身炎症
Subhajit Poddar,Samuel D Chauvin,Christopher H Archer et al.
Subhajit Poddar et al.
Stimulator of interferon genes (STING) transmits signals downstream of the cytosolic DNA sensor cyclic guanosine monophosphate-AMP synthase (cGAS), leading to transcriptional upregulation of cytokines. However, components of the STING signa...
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice [0.03%]
不同错配修复复合体基因决定了亨廷顿小鼠神经元CAG重复序列的扩增速率及其特异性病理变化
Nan Wang,Shasha Zhang,Peter Langfelder et al.
Nan Wang et al.
Huntington's disease (HD) modifiers include mismatch-repair (MMR) genes, but their connections to neuronal pathogenesis remain unclear. Here, we genetically tested 9 HD genome-wide association study (GWAS)/MMR genes in mutant Huntingtin (mH...
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 [0.03%]
肺源性促血栓微环境通过整合素β2驱动癌症相关血栓和转移的形成及应用抗氧化剂治疗的可能性研究外泌体机制研究
Serena Lucotti,Yusuke Ogitani,Candia M Kenific et al.
Serena Lucotti et al.
Cancer is a systemic disease with complications beyond the primary tumor site. Among them, thrombosis is the second leading cause of death in patients with certain cancers (e.g., pancreatic ductal adenocarcinoma [PDAC]) and advanced-stage d...
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution [0.03%]
中性粒细胞源性胞外囊泡通过调控补体活化促进炎症消退
Alan Y Hsu,Qingxiang Huang,Xiong Pi et al.
Alan Y Hsu et al.
Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation ...