Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors [0.03%]
肿瘤中的细胞外染色体DNA复制和维持与DNA损伤通路偶联
Xing Kang,Xinran Li,Jiaqi Zhou et al.
Xing Kang et al.
Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells. However, the functional significance of ecDNA and the molecular components involved in its replication and maintenance remain largely unknown. Here, using CRISPR-C technolog...
Tomotsune Ameku,Anna Laddach,Hannah Beckwith et al.
Tomotsune Ameku et al.
Published Erratum
Cell. 2025 Apr 26:S0092-8674(25)00459-3. DOI:10.1016/j.cell.2025.04.023 2025
Menghan Liu,Sydney B Blattman,Mai Takahashi et al.
Menghan Liu et al.
Published Erratum
Cell. 2025 Apr 25:S0092-8674(25)00453-2. DOI:10.1016/j.cell.2025.04.018 2025
RNA polymerase II partitioning is a shared feature of diverse oncofusion condensates [0.03%]
RNA聚合酶II分区是多种致癌融合凝聚体的共同特征
Heankel Lyons,Prashant Pradhan,Gopinath Prakasam et al.
Heankel Lyons et al.
Condensates regulate transcription by selectively compartmentalizing biomolecules, yet the rules of specificity and their relationship to function remain enigmatic. To identify rules linked to function, we leverage the genetic selection bia...
Nan Zhou,Jingzhi Chen,Meiqin Hu et al.
Nan Zhou et al.
Lysosomes maintain an acidic pH of 4.5-5.0, optimal for macromolecular degradation. Whereas proton influx is produced by a V-type H+ ATPase, proton efflux is mediated by a fast H+ leak through TMEM175 channels, as well as an unidentified sl...
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors [0.03%]
外侧缰核神经元-星形胶质细胞偶联介导类似抑郁的行为反应
Qianqian Xin,Junying Wang,Jinkun Zheng et al.
Qianqian Xin et al.
The lateral habenula (LHb) neurons and astrocytes have been strongly implicated in depression etiology, but it was not clear how the two dynamically interact during depression onset. Here, using multi-brain-region calcium photometry recordi...
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network [0.03%]
人类趋化因子-G蛋白偶联受体相互作用网络中选择性和泛选择性编码和解码
Andrew B Kleist,Martyna Szpakowska,Lindsay J Talbot et al.
Andrew B Kleist et al.
In humans, selective and promiscuous interactions between 46 secreted chemokine ligands and 23 cell surface chemokine receptors of the G-protein-coupled receptor (GPCR) family form a complex network to coordinate cell migration. While chemo...
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias [0.03%]
融合突变剪接因子的白血病中的错拼变异新抗原及同源T细胞受体
Won Jun Kim,Edie I Crosse,Emma De Neef et al.
Won Jun Kim et al.
Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bona fide neoantigens translated from highly stereotyped splicing alterations promoted by neo...
Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis [0.03%]
下丘脑PNOC/NPY神经元构成能量稳态中瘦素控制的介导因素
Marie H Solheim,Sima Stroganov,Weiyi Chen et al.
Marie H Solheim et al.
Leptin acts in the brain to suppress appetite, yet the responsible neurocircuitries underlying leptin's anorectic effect are incompletely defined. Prepronociceptin (PNOC)-expressing neurons mediate diet-induced hyperphagia and weight gain i...
Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer's disease [0.03%]
PHGDH的转录调控驱动阿尔茨海默病淀粉样蛋白病理学发展
Junchen Chen,Fatemeh Hadi,Xingzhao Wen et al.
Junchen Chen et al.
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about...