Lu Tian,Yinqing Li
Lu Tian
RNA velocity can predict the direction of cell-state change, but the regulatory programs shaping these changes remain difficult to identify. In this issue of Cell, Wang et al. introduce RegVelo, a framework that integrates gene regulatory n...
Catching waves of polyploids [0.03%]
捕捉多倍体的浪潮
Jeff J Doyle
Jeff J Doyle
In this issue of Cell, Chen et al. analyze angiosperm genomes to map whole-genome duplication events, revealing non-random waves of polyploidy linked to climatic shifts and periods of low diversity. They suggest polyploids may have preferen...
Melanie Grusdat,Dirk Brenner
Melanie Grusdat
T cells live or die by their metabolism, yet one nutrient can serve very different ends. In this issue of Cell, Kelly et al. show that cysteine's sulfur is partitioned between glutathione and iron-sulfur cluster synthesis. This routing driv...
Vidyani Suryadevara,Negin Farzad,Mingyu Yang et al.
Vidyani Suryadevara et al.
Cellular senescence comprises diverse cell states emerging across human tissues during aging and disease. Integrating single-cell and spatial multi-omics with AI-driven analyses enables systematic mapping of senescent cell heterogeneity ("s...
RNA structure programs endogenous ADAR for precise and efficient editing [0.03%]
RNA结构决定内源性ADAR精准而高效的编辑作用
Deli Song,Gexing Liu,Wei Zhang et al.
Deli Song et al.
Leveraging endogenous adenosine deaminase (ADAR) enzymes through engineered ADAR-recruiting RNAs (arRNAs) offers a safe, programmable strategy for RNA editing without exogenous enzyme delivery. Yet an incomplete understanding of ADAR's mech...
William J Nathan,Chuanyuan Chen,Rosy Sakr et al.
William J Nathan et al.
Platinum agents are cornerstone therapies for many cancers but often cause neurotoxicity in post-mitotic tissues, for which effective interventions are lacking. This limitation reflects an incomplete understanding of neuronal responses to D...
Continuous modeling of primate embryogenesis from totipotency to early organogenesis [0.03%]
从全能到早期器官发生连续建模灵长类动物胚胎发育
Wei Zheng,Bing Peng,Zilin Chen et al.
Wei Zheng et al.
Embryo-like structures, or embryoids, are powerful models to investigate early embryonic development. Yet, previous models cover only partial developmental stages, restricting their applications. Here, we successfully generate primate organ...
Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans [0.03%]
通过圆形单链arRNA引导的外显子跳跃逆转猴子和人类杜氏肌营养不良症
Wenting Guo,Huixian Tang,Zongyi Yi et al.
Wenting Guo et al.
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder caused by mutations in the DMD gene, leading to progressive muscle degeneration, loss of mobility, and premature death. Here, we applied leverage endogenous adenosine deami...
Persistent and transient senescent cells contribute to brain-barrier development [0.03%]
持久性和瞬时性衰老细胞有助于脑屏障发育
L Ashley Watson,Zoe Adelsheim,Mackenzie J Carter et al.
L Ashley Watson et al.
Establishment of the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier requires precise coordination between diverse cell types to protect and nourish the brain. Here, we identify developmentally programmed p21+ senescen...
Prion-based protein self-assembly tunes mutagenesis to enable rapid adaptation [0.03%]
基于朊病毒的蛋白质自组装调节突变以实现快速适应
Alexandria Van Elgort,Christopher M Jakobson,Yiwen R Chen et al.
Alexandria Van Elgort et al.
Mutations supply the raw material for evolution, yet because most are neutral or deleterious, elevated mutation rates are typically transient. Nonetheless, modeling predicts that a mechanism for heritable but reversible "mutagenesis switche...