Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns [0.03%]
新生儿肠道微生物群衍生的次黄嘌呤编程抗流感保护性CD8⁺T细胞反应
Joseph Stevens,Erica Culberson,Jeremy Kinder et al.
Joseph Stevens et al.
Early-life susceptibility to respiratory viral infections remains a major public health concern, yet the underlying mechanisms are poorly understood. We demonstrate that antibiotic-induced dysbiosis impairs influenza-specific CD8+ T cell im...
Sensory Neurons that Detect Stretch and Nutrients in the Digestive System [0.03%]
检测消化道伸展和营养物质的感觉神经元
Erika K Williams,Rui B Chang,David E Strochlic et al.
Erika K Williams et al.
Published Erratum
Cell. 2025 Jun 7:S0092-8674(25)00631-2. DOI:10.1016/j.cell.2025.05.043 2025
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects [0.03%]
微生物移植导致的微生物组不匹配引发持久的代谢和免疫调节的脱靶效应
Orlando DeLeon,Mora Mocanu,Alan Tan et al.
Orlando DeLeon et al.
Fecal microbiota transplant (FMT) is an increasingly used intervention, but its suitability to restore regional gut microbiota, particularly in the small bowel (SB), must be questioned because of its predominant anaerobic composition. In hu...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS [0.03%]
病毒蛋白触发的着丝粒DNA扩增激活核内cGAS传感器
Xavier Lahaye,Patrick Tran Van,Camellia Chakraborty et al.
Xavier Lahaye et al.
The cGAS-cGAMP-STING pathway is crucial for antiviral immunity. While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activation. How viruses may activate nuclear...
Infrequent strong connections constrain connectomic predictions of neuronal function [0.03%]
罕见的强大连接限制了联结组预测神经元功能的能力
Timothy A Currier,Thomas R Clandinin
Timothy A Currier
How does circuit wiring constrain neural computation? Recent work has leveraged connectomic datasets to predict the functions of cells and circuits in the brains of multiple species. However, many of these hypotheses have not been compared ...
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE [0.03%]
微生物色氨酸-胆酸共轭代谢物通过孤儿受体MRGPRD改善糖稳态
Jun Lin,Qixing Nie,Jie Cheng et al.
Jun Lin et al.
Recently, microbial amino-acid-conjugated bile acids (MABAs) have been found to be prevalent in human samples. However, their physiological significance is still unclear. Here, we identify tryptophan-conjugated cholic acid (Trp-CA) as the m...
Serena Porcari,Siew C Ng,Laurence Zitvogel et al.
Serena Porcari et al.
Despite promising evidence in diagnostics and therapeutics, microbiome research is not yet implemented into clinical medicine. Several initiatives, including the standardization of microbiome research, the refinement of microbiome clinical ...
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs [0.03%]
意料之外：RBCs 中的 NLRP3-caspase-8 依赖性细胞死亡
Rebecca E Tweedell,Thirumala-Devi Kanneganti
Rebecca E Tweedell
Red blood cell (RBC) lysis can cause morbidity and mortality. However, the molecular mechanisms underlying RBC lysis are not fully characterized, limiting therapeutic options. In this issue of Cell, Chen et al. identify a crucial role for t...
Alexandre P Magalhaes,Denes Hnisz
Alexandre P Magalhaes
Transcription factors can form nuclear condensates at genomic sites, and condensates are thought to enhance transcriptional activity. In this issue of Cell, Saad et al. suggest that DNA binding prevents rather than facilitates condensate fo...
Advancing proteomic analysis for understanding disease biology and biomarker discovery [0.03%]
促进蛋白质组分析以了解疾病生物学和生物标志物发现
Carlos Cruchaga
Carlos Cruchaga
Advances in proteomics research have enhanced our understanding of disease biology. In a recent issue of Cell, Malmström et al. constructed a comprehensive proteome atlas linking proteins to specific tissues and blood cells to enable track...