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期刊名:Cell

缩写:CELL

ISSN:0092-8674

e-ISSN:1097-4172

IF/分区:42.5/Q1

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共收录本刊相关文章索引9614
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Jakob Trendel,Simon Trendel,Shuyao Sha et al. Jakob Trendel et al.
In a human cell, DNA is packed with histones, RNA, and chromatin-associated proteins, forming a cohesive gel. At any given moment, only a subset of the proteome has physical access to the DNA and organizes its structure, transcription, repl...
Xianwei Song,Shanjie Tang,Hui Liu et al. Xianwei Song et al.
Epigenetic pathways could provide a mechanistic explanation for the inheritance of acquired characteristics, as proposed by Lamarck in 1802, but epigenetic alterations that endow adaptive hereditary traits have rarely been observed. Here, i...
Yoav Ben-Simon,Marcus Hooper,Sujatha Narayan et al. Yoav Ben-Simon et al.
The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential for understanding its function in health and dis...
Bo Li,James Elsten-Brown,Miao Li et al. Bo Li et al.
Identifying additional immune checkpoints hindering antitumor T cell responses is key to the development of next-generation cancer immunotherapies. Here, we report the induction of serotonin transporter (SERT), a regulator of serotonin leve...
Yuping Wang,Xinli Song,Xiangmao Chen et al. Yuping Wang et al.
Female sociosexual behaviors, essential for survival and reproduction, are modulated by ovarian hormones and triggered in the context of appropriate social cues. Here, we identify primary estrous-sensitive Cacna1h-expressing medial prefront...
Asael Roichman,Qianying Zuo,Sunghoon Hwang et al. Asael Roichman et al.
Phosphatidylinositol 3-kinase (PI3K) signaling is both the effector pathway of insulin and among the most frequently activated pathways in human cancer. In murine cancer models, the efficacy of PI3K inhibitors is dramatically enhanced by a ...
Ran Guo,Ouyang Chen,Yang Zhou et al. Ran Guo et al.
G-protein-biased agonists have been shown to enhance opioid analgesia by circumventing β-arrestin-2 (βarr2) signaling. We previously reported that SBI-553, a neurotensin receptor 1 (NTSR1)-positive allosteric modulator biased toward βarr...
Eitan Erez Zahavi,Indrek Koppel,Riki Kawaguchi et al. Eitan Erez Zahavi et al.
Neuronal growth and regeneration are regulated by local translation of mRNAs in axons. We examined RNA polyadenylation changes upon sensory neuron injury and found upregulation of a subset of polyadenylated B2-SINE repeat elements, hereby t...
Zhisen Yang,Hong Wei,Yulin Gan et al. Zhisen Yang et al.
Auxin is crucial in orchestrating diverse aspects of plant growth and development and modulating responses to environmental signals. The asymmetric spatiotemporal distribution of auxin generates local gradient patterns, which are regulated ...
Tom S Weber,Christine Biben,Denise C Miles et al. Tom S Weber et al.
Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding for in vivo clonal lineage tracing for bulk tissue and single-cell readout. Embryonic day...