Nicholas A Prescott,Tracy Biaco,Andrés Mansisidor et al.
Nicholas A Prescott et al.
Chronic hepatitis B virus (HBV) infection is an incurable pathogen responsible for causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral co...
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants [0.03%]
胞间连丝作为非常规的膜接触位点调控着植物细胞间的分子交换
Jessica Pérez-Sancho,Marija Smokvarska,Gwennogan Dubois et al.
Jessica Pérez-Sancho et al.
Membrane contact sites (MCSs) are fundamental for intracellular communication, but their role in intercellular communication remains unexplored. We show that in plants, plasmodesmata communication bridges function as atypical endoplasmic re...
Victoria N Parikh,Sharlene M Day,Neal K Lakdawala et al.
Victoria N Parikh et al.
Cardiomyopathies are primary disorders of the heart muscle. Three key phenotypes have been defined, based on morphology and arrhythmia burden: hypertrophic cardiomyopathy (HCM), with thickened heart muscle and diastolic dysfunction; dilated...
Jacqueline Cordes,Shubo Zhao,Carla M Engel et al.
Jacqueline Cordes et al.
RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage from endogenous and environmental sourc...
Artem Khan,Yuyang Liu,Mark Gad et al.
Artem Khan et al.
Solute carrier (SLC) proteins play critical roles in maintaining cellular and organismal homeostasis by transporting small molecules and ions. Despite a growing body of research over the past decade, physiological substrates and functions o...
SecY translocon chaperones protein folding during membrane protein insertion [0.03%]
SecY转运蛋白在膜蛋白插入过程中伴娘蛋白质折叠过程
Xiaomin Ou,Chengying Ma,Dongjie Sun et al.
Xiaomin Ou et al.
The Sec translocon is vital for guiding membrane protein insertion into lipid bilayers. The insertion and folding processes of membrane proteins are poorly understood. Here, we report cryo-electron microscopy structures of multi-spanning me...
Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion [0.03%]
视觉皮层中的运动和前庭信号可以实现自我产生的视觉运动与外部产生的视觉运动的分离
Mateo Vélez-Fort,Lee Cossell,Laura Porta et al.
Mateo Vélez-Fort et al.
Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation pr...
Jacob Parres-Gold,Matthew Levine,Benjamin Emert et al.
Jacob Parres-Gold et al.
Many biological signaling pathways employ proteins that competitively dimerize in diverse combinations. These dimerization networks can perform biochemical computations in which the concentrations of monomer inputs determine the concentrati...
Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor [0.03%]
感染蝙蝠的Merbecovirus HKU5-CoV 血液线2能利用人类ACE2作为细胞受体
Jing Chen,Wei Zhang,Yang Li et al.
Jing Chen et al.
Merbecoviruses comprise four viral species with remarkable genetic diversity: MERS-related coronavirus, Tylonycterisbat coronavirus HKU4, Pipistrellusbat coronavirus HKU5, and Hedgehog coronavirus 1. However, the potential human spillover r...
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins [0.03%]
从RNA毒素-抗毒素系统进化而来的可重新编程的RNA导向CRISPR系统
Shai Zilberzwige-Tal,Han Altae-Tran,Soumya Kannan et al.
Shai Zilberzwige-Tal et al.
Despite ongoing efforts to study CRISPR systems, the evolutionary origins giving rise to reprogrammable RNA-guided mechanisms remain poorly understood. Here, we describe an integrated sequence/structure evolutionary tracing approach to iden...