Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation [0.03%]
Gasdermin E 将病毒介导的焦亡与致死性肝脂质累积偶联在一起
Chaojie Wang,Xiaojie Zheng,Yunfa Zhang et al.
Chaojie Wang et al.
Tick-borne orthonairoviruses, including the emerging wetland virus (WELV), pose a growing public health concern as cases increase, yet their pathogenesis remains unclear. Here, we show that WELV infection causes fatal liver dysfunction in p...
CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer [0.03%]
利用CRISPR筛选技术识别恢复癌症中年龄相关T细胞功能障碍的靶点
Alex C Y Chen,Keely Y Ji,Cansu Yerinde et al.
Alex C Y Chen et al.
Immune aging impairs T cell-mediated tumor control as well as cancer immunotherapy outcomes. The most important drivers of T cell dysfunction in aged tumors remain unknown. We performed single-cell CRISPR screens to identify Dusp5 and Zfp21...
Why machines don't speak biology: Toward native biological language models [0.03%]
为什么机器不懂生物学：迈向原生的生物语言模型
Yonatan Stelzer,Amos Tanay
Yonatan Stelzer
Recent advances in AI inspire visions of universal models of biology. Yet living systems are evolved, emergent processes whose behaviors cannot be inferred from their parts alone. We propose grounding AI in canonical biological processes, c...
Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system [0.03%]
协同的RNA和蛋白质模板的双链DNA合成由双重逆转录酶免疫系统完成
Megan Wang,Kanta Yoneyama,Rimantė Žedaveinytė et al.
Megan Wang et al.
Defense-associated reverse transcriptase (DRT) systems mediate antiviral immunity through distinct modes of cDNA synthesis: class 1 DRTs catalyze untemplated synthesis, whereas class 2 DRTs polymerize non-coding RNA-templated products. Howe...
Advancing cancer detection and treatment using longitudinal routine clinical data [0.03%]
利用纵向常规临床数据推动癌症的检测与治疗
Fei Liu,Kai Wang,Hui Xu et al.
Fei Liu et al.
Cancer management remains fragmented across its continuum, from late-stage diagnosis and salvage therapies to non-personalized surveillance. Here, we present Oncoformer, a unified multimodal transformer model trained on the China Oncology M...
UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling [0.03%]
基于分子表征到表型建模的药物基因组学跨领域泛化研究
Yiming Li,Min Zeng,Jun Zhu et al.
Yiming Li et al.
Systematically simulating and predicting phenotypic effects of diverse interventions across heterogeneous cellular environments is central to the vision of artificial intelligence virtual cell (AIVC). However, disparities in perturbagen mod...
Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4 [0.03%]
动态二聚体-of-二聚体结构定义了人类CNNM4中的Mg2+转运过程
Zhiyong Bai,X Edward Zhou,Wei Lü et al.
Zhiyong Bai et al.
Mg2+ is essential for all living organisms, yet its transport across mammalian membranes remains poorly understood. Here, we present cryoelectron microscopy (cryo-EM) structures of a full-length mammalian Mg2+ transporter on the plasma memb...
Haifu Tu,Qian Liu,Tiantian Ye et al.
Haifu Tu et al.
Drought threatens crop productivity, yet enhancing tolerance often compromises yield. Abscisic acid (ABA) signaling is central to drought response, but its deep conservation can constrain adaptive flexibility. Here, we identify ROAD1 (rice ...
Trichoderma swollenin activates AtABCB5-dependent auxin efflux to promote plant development [0.03%]
芽枝霉菌Swollenin通过激活AtABCB5依赖的生长素外排促进植物生长发育
Jiaxin Lu,Jing Liu,Siqi Jiang et al.
Jiaxin Lu et al.
The beneficial fungus Trichoderma enhances plant growth and stress tolerance through poorly understood mechanisms. Here, we show that Trichoderma harzianum swollenin ThSWO contributes to efficient root colonization and plant growth promotio...
Alex Chan,Wearn-Xin Yee,Deepto Mozumdar et al.
Alex Chan et al.
Bacteriophage genomes are densely packed with coding sequences and frequently encode genes of unknown function. Unbiased phage functional genomics approaches are therefore needed, particularly for large lytic phages. Here, we harness the ma...