Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease [0.03%]
优化干细胞输注时间以预防急性的移植物抗宿主病
Yiwen Hou,Yue Wu,Yang Cao et al.
Yiwen Hou et al.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for a broad spectrum of malignant and nonmalignant hematological disorders. However, the success of allo-HSCT is often overshadowed by acute graft-ver...
Pierre Sabatier,Maico Lechner,Ulises H Guzmán et al.
Pierre Sabatier et al.
Single-cell proteomics (SCPs) has advanced significantly, yet it remains largely unidimensional, focusing primarily on protein abundances. In this study, we employed a pulsed stable isotope labeling by amino acids in cell culture (pSILAC) a...
Mechanism of DNA capture by the MukBEF SMC complex and its inhibition by a viral DNA mimic [0.03%]
黏性末端捕获机制促进MukBEF-SMC复合体高效环化DNA并与其噬菌体分子模彷者相互作用
Frank Bürmann,Bryony Clifton,Sophie Koekemoer et al.
Frank Bürmann et al.
Ring-like structural maintenance of chromosome (SMC) complexes are crucial for genome organization and operate through mechanisms of DNA entrapment and loop extrusion. Here, we explore the DNA loading process of the bacterial SMC complex Mu...
A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer [0.03%]
单细胞全景图揭示了抗PD-1治疗的非小细胞肺癌中的免疫异质性
Zedao Liu,Zhenlin Yang,Junqi Wu et al.
Zedao Liu et al.
Anti-PD-(L)1 treatment is standard for non-small cell lung cancer (NSCLC), but patients show variable responses to the same regimen. The tumor immune microenvironment (TIME) is associated with immunotherapy response, yet the heterogeneous u...
Large language models deconstruct the clinical intuition behind diagnosing autism [0.03%]
大型语言模型解构自闭症诊断的临床直觉背后的原理
Jack Stanley,Emmett Rabot,Siva Reddy et al.
Jack Stanley et al.
Efforts to use genome-wide assays or brain scans to diagnose autism have seen diminishing returns. Yet the clinical intuition of healthcare professionals, based on longstanding first-hand experience, remains the gold standard for diagnosis ...
Functional and antigenic landscape of the Nipah virus receptor-binding protein [0.03%]
尼帕病毒受体结合蛋白的功能和抗原景观
Brendan B Larsen,Teagan McMahon,Jack T Brown et al.
Brendan B Larsen et al.
Nipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies. Here, we use deep mutational scanning to mea...
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force [0.03%]
肠神经元Piezo1通过感知力量维持机械和免疫稳态
Zili Xie,Lillian Rose,Jing Feng et al.
Zili Xie et al.
The gastrointestinal (GI) tract experiences a myriad of mechanical forces while orchestrating digestion and barrier immunity. A central conductor of these processes, the enteric nervous system (ENS), detects luminal pressure to regulate per...
Nanoscale DNA tracing reveals the self-organization mechanism of mitotic chromosomes [0.03%]
纳米级DNA追踪揭示有丝分裂染色体自组织机制
Kai Sandvold Beckwith,Andreas Brunner,Natalia Rosalia Morero et al.
Kai Sandvold Beckwith et al.
How genomic DNA is folded during cell division to form the characteristic rod-shaped mitotic chromosomes essential for faithful genome inheritance is a long-standing open question in biology. Here, we use nanoscale DNA tracing in single div...
Kyungdeok Kim,Daviti Abramishvili,Siling Du et al.
Kyungdeok Kim et al.
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral chan...
Florian Wollweber,Jingwei Xu,Rafael I Ponce-Toledo et al.
Florian Wollweber et al.
Microtubules are a hallmark of eukaryotes. Archaeal and bacterial homologs of tubulins typically form homopolymers and non-tubular superstructures. The origin of heterodimeric tubulins assembling into microtubules remains unclear. Here, we ...