The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids [0.03%]
微生物组可使长链和短链脂肪酸来源的N-酰基甘油衍生脂质发生多样化
Helena Mannochio-Russo,Vincent Charron-Lamoureux,Martijn van Faassen et al.
Helena Mannochio-Russo et al.
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spec...
Unveiling the origins and genetic makeup of the "forgotten people": A study of the Sarmatian-period population in the Carpathian Basin [0.03%]
揭开“被遗忘的人”的起源和遗传构成：喀尔巴阡盆地萨马提亚时期人群研究
Oszkár Schütz,Zoltán Maróti,Balázs Tihanyi et al.
Oszkár Schütz et al.
The nomadic Sarmatians dominated the Pontic Steppe from the 3rd century BCE and the Great Hungarian Plain from 50 CE until the Huns' 4th-century expansion. In this study, we present a large-scale genetic analysis of 156 genomes from 1st- to...
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling [0.03%]
神经内分泌细胞通过沙漠型 Hedgehog 信号协调再生过程
William Kong,Wan-Jin Lu,Megha Dubey et al.
William Kong et al.
Understanding the mechanisms underlying mammalian regeneration may enable development of novel regenerative therapies. We present a mechanism wherein Desert hedgehog (Dhh), secreted from epithelial neuroendocrine cells, elicits a regenerati...
Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns [0.03%]
新生儿肠道微生物群衍生的次黄嘌呤编程抗流感保护性CD8⁺T细胞反应
Joseph Stevens,Erica Culberson,Jeremy Kinder et al.
Joseph Stevens et al.
Early-life susceptibility to respiratory viral infections remains a major public health concern, yet the underlying mechanisms are poorly understood. We demonstrate that antibiotic-induced dysbiosis impairs influenza-specific CD8+ T cell im...
Sensory Neurons that Detect Stretch and Nutrients in the Digestive System [0.03%]
检测消化道伸展和营养物质的感觉神经元
Erika K Williams,Rui B Chang,David E Strochlic et al.
Erika K Williams et al.
Published Erratum
Cell. 2025 Jun 7:S0092-8674(25)00631-2. DOI:10.1016/j.cell.2025.05.043 2025
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects [0.03%]
微生物移植导致的微生物组不匹配引发持久的代谢和免疫调节的脱靶效应
Orlando DeLeon,Mora Mocanu,Alan Tan et al.
Orlando DeLeon et al.
Fecal microbiota transplant (FMT) is an increasingly used intervention, but its suitability to restore regional gut microbiota, particularly in the small bowel (SB), must be questioned because of its predominant anaerobic composition. In hu...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS [0.03%]
病毒蛋白触发的着丝粒DNA扩增激活核内cGAS传感器
Xavier Lahaye,Patrick Tran Van,Camellia Chakraborty et al.
Xavier Lahaye et al.
The cGAS-cGAMP-STING pathway is crucial for antiviral immunity. While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activation. How viruses may activate nuclear...
Infrequent strong connections constrain connectomic predictions of neuronal function [0.03%]
罕见的强大连接限制了联结组预测神经元功能的能力
Timothy A Currier,Thomas R Clandinin
Timothy A Currier
How does circuit wiring constrain neural computation? Recent work has leveraged connectomic datasets to predict the functions of cells and circuits in the brains of multiple species. However, many of these hypotheses have not been compared ...
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE [0.03%]
微生物色氨酸-胆酸共轭代谢物通过孤儿受体MRGPRD改善糖稳态
Jun Lin,Qixing Nie,Jie Cheng et al.
Jun Lin et al.
Recently, microbial amino-acid-conjugated bile acids (MABAs) have been found to be prevalent in human samples. However, their physiological significance is still unclear. Here, we identify tryptophan-conjugated cholic acid (Trp-CA) as the m...
Serena Porcari,Siew C Ng,Laurence Zitvogel et al.
Serena Porcari et al.
Despite promising evidence in diagnostics and therapeutics, microbiome research is not yet implemented into clinical medicine. Several initiatives, including the standardization of microbiome research, the refinement of microbiome clinical ...