Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy [0.03%]
病毒蛋白酶触发的裂解性细胞死亡作为通用抗病毒mRNA疗法
Lin Li,Xiu-Li Yan,Hao-Yang Wang et al.
Lin Li et al.
While gasdermin (GSDM)-mediated pyroptosis is a potent immune effector, its antiviral potential remains largely untapped. Here, we introduce viral protease-initiated lytic cell death (VID), a universal mRNA therapeutic platform inspired by ...
A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death [0.03%]
一种连接乙酰转移酶和促癌细胞死亡的双价分子胶粘剂
Meredith N Nix,Sai Gourisankar,Kevin J Bowman et al.
Meredith N Nix et al.
Developing cancer therapies that induce specific death of malignant cells is critical for preventing relapse. Highly effective strategies, such as immunotherapy, exemplify this principle. Here, we provide the mechanistic basis for a small-m...
Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context [0.03%]
染色质原生环境下的增强子、促进子和启动子的稳健调控互作关系
Zhou Zhou,Yang Cheng,Jaret Lieberth et al.
Zhou Zhou et al.
Enhancers are abundant and critical gene-distal cis-regulatory elements with distinct architectural features; however, a mechanistic understanding of their interactions within endogenous chromatin contexts remains challenging. Here, we deve...
Zhikai Wang,Xinping Jin,Yue Wu et al.
Zhikai Wang et al.
Peripheral nerves regulate skin homeostasis by secreting neurotransmitters, but their role during skin aging remains incompletely understood. Here, we report that cutaneous denervation accelerates skin aging, as evidenced by collagen reduct...
Boron-bridged GIPCs stabilize cell wall anchoring and PIN polar domains [0.03%]
硼桥GIPC稳定细胞壁锚定位和PIN极性区域
Mingliang He,Cheng Zhang,Zihan Li et al.
Mingliang He et al.
Boron (B) is an essential plant micronutrient whose deficiency impairs global crop yields. Glycosylinositol phosphorylceramides (GIPCs) are major lipids in the plasma membrane (PM), and PIN-FORMED (PIN) proteins mediate polar auxin transpor...
Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues [0.03%]
组织中单细胞的全长转录组剪接本分辨率空间成像技术
Limor Cohen,Aaron R Halpern,Timothy R Blosser et al.
Limor Cohen et al.
Cell and tissue functions arise from complex interactions among numerous genes, and a systematic understanding of these functions requires isoform-resolved transcriptomic analysis of single cells with high spatial resolution. Here, we intro...
Spatial proximity sequencing maps developmental dynamics in the germinal center [0.03%]
空间接近性测序描绘生发中心的发育动力学
Huili Wang,Junjie Xia,Peer Mohamed Suhail Mujibur Rahman et al.
Huili Wang et al.
Spatial profiling of proteins and protein interactions facilitates understanding of cell functions within tissues and is essential for studies in signaling, immunity, and cancer. We present spatial proximity sequencing (Sprox-seq) for simul...
Xin Man,Wen-Ting Zhang,Yu-Di Zhang et al.
Xin Man et al.
Spliceosomal introns impose a universal processing burden on eukaryotes and obstruct genome minimization because their essentiality remains unresolved. By exploiting Spo11-independent meiosis in synthetic single-chromosome Saccharomyces cer...
Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies [0.03%]
阿尔茨海默病的研究进展：从分子机制到治疗策略
Michelle D Rudman,Jason D Ulrich,David M Holtzman
Michelle D Rudman
Alzheimer's disease (AD) remains the leading cause of dementia worldwide and an escalating global health crisis. The hallmark amyloid plaques and neurofibrillary tangles (NFT) are now known to be accompanied by a complex array of pathologie...
Bridging omics and physiology to build multimodal clocks of human aging [0.03%]
整合组学和生理学构建人类衰老的多模态时钟
Seda Koyuncu,Dunja Petrovic,David Vilchez
Seda Koyuncu
Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associated signatures to construct a multi-layer ...