A natural gene on-off system confers field thermotolerance for grain quality and yield in rice [0.03%]
水稻田间高温抗性自然基因开关型调控系统可保护籽粒品质和产量
Wei Li,Ke Yang,Chaofan Hu et al.
Wei Li et al.
Published Erratum
Cell. 2025 Jul 3:S0092-8674(25)00744-5. DOI:10.1016/j.cell.2025.06.041 2025
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation [0.03%]
同义突变通过表转录调控制约黄瓜驯化
Tongxu Xin,Zhen Zhang,Yueying Zhang et al.
Tongxu Xin et al.
Synonymous mutations, once known as "silent" mutations, are increasingly attracting the interest of biologists. Although they may affect transcriptional or post-transcriptional processes, their impact on biological traits remains under-inve...
Development of clinically viable non-muscle myosin II small molecule inhibitors [0.03%]
临床可行的非肌肉肌球蛋白II小分子抑制剂的研发
Laszlo Radnai,Erica J Young,Carlos Kikuti et al.
Laszlo Radnai et al.
Non-muscle myosin II (NMII), a molecular motor that regulates critical processes such as cytokinesis and neuronal plasticity, has substantial therapeutic potential. However, translating this potential to in vivo use has been hampered by a l...
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity [0.03%]
LAG-3与T细胞受体的距离指导T细胞激活和自身免疫的抑制作用
Jasper Du,Hui Chen,Jia You et al.
Jasper Du et al.
Therapeutically targeting pathogenic T cells in autoimmune diseases has been challenging. Although LAG-3, an inhibitory checkpoint receptor specifically expressed on activated T cells, is known to bind to major histocompatibility complex cl...
Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids [0.03%]
中胚层和内胚叶的共开发使得能够在肺和肠道类器官中实现组织特异性血管化
Yifei Miao,Nicole M Pek,Cheng Tan et al.
Yifei Miao et al.
The vasculature and mesenchyme exhibit distinct organ-specific characteristics adapted to local physiological needs, shaped by microenvironmental and cell-cell interactions from early development. To recapitulate this entire process, we co-...
Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications [0.03%]
血管性痴呆伴局灶性缺血的细胞间相互作用网络的解析及其治疗应用
Min Tian,Riki Kawaguchi,Yang Shen et al.
Min Tian et al.
Vascular dementia (VaD), the second-leading cause of dementia, is primarily a white matter ischemic disease with no direct therapies. Cell-cell interactions within lesion sites dictate disease progression or repair. To elucidate key interce...
Functional assessment of all ATM SNVs using prime editing and deep learning [0.03%]
利用先导编辑和深度学习对所有ATM剪切位变异进行功能评估
Kwang Seob Lee,Joon-Goo Min,Yumin Cheong et al.
Kwang Seob Lee et al.
Ataxia telangiectasia mutated (ATM), a large gene with 63 exons, plays a critical role in the DNA damage response, and its loss of function increases cancer risk and affects the prognosis of cancer patients. However, interpreting the functi...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement [0.03%]
假尿苷RNA通过损伤内溶酶体加工和TLR结合而避免免疫检测
Marleen Bérouti,Mirko Wagner,Wilhelm Greulich et al.
Marleen Bérouti et al.
Recognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize RNA degradation products generated by endolysosomal nucleases. RNA modifications present ...
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation [0.03%]
果蝇单细胞3D时空多组学图谱揭示全景关键细胞类型分化调控因子
Mingyue Wang,Qinan Hu,Zhencheng Tu et al.
Mingyue Wang et al.
The development of a multicellular organism is a highly intricate process tightly regulated by numerous genes and pathways in both spatial and temporal manners. Here, we present Flysta3D-v2, a comprehensive multi-omics atlas of the model or...
50,000 years of evolutionary history of India: Impact on health and disease variation [0.03%]
印度5万年的进化历史：对健康和疾病变异的影响
Elise Kerdoncuff,Laurits Skov,Nick Patterson et al.
Elise Kerdoncuff et al.
India has been underrepresented in genomic surveys. We generated whole-genome sequences from 2,762 individuals in India, capturing the genetic diversity across most geographic regions, linguistic groups, and historically underrepresented co...