Alexander Hooftman,Alexander Keller,Andrea Ablasser
Alexander Hooftman
The cGAS-STING pathway is a central mechanism of innate immunity that detects double-stranded DNA and translates it into transcriptional and other cellular effector responses. Beyond its canonical role in antiviral defense, the pathway sens...
Corina Amor
Corina Amor
Identifying safe and effective targets remains a major bottleneck for CAR T cell therapies. In this issue of Cell, Baker and colleagues developed a large language model (LLM)-assisted scoring framework to streamline this process and as a re...
Michael Riedl,Michael Sixt
Michael Riedl
Most cells polarize and migrate in response to electrical fields. In this issue of Cell, Belliveau et al. identify TMEM154/Galvanin, a receptor that serves as a cellular antenna to sense electrical gradients and guide migration toward the c...
Rosa Trotta,Linsha Ma,Massimiliano Mazzone
Rosa Trotta
Vessel normalization aims to correct the abnormal vasculature in the tumor to improve drug delivery and immune control. In this issue of Cell, Wang et al. identify an immune-excluding vasculature in small-cell lung cancer, where excessive v...
Shared neural geometries for bilingual semantic representations in human hippocampal neurons [0.03%]
人类海马神经元的双语语义表示共享神经几何形状
Xinyuan Yan,Ana G Chavez,Melissa Franch et al.
Xinyuan Yan et al.
The human brain has the remarkable ability to comprehend and express similar concepts in multiple languages. To understand how it does so, we examined responses of hippocampal neurons during passive listening, directed speaking, and spontan...
Reconstituting human primitive streak formation through extra-embryonic cell coordination [0.03%]
通过额外胚胎细胞的协调重组人类原始条纹的形成
Qiaoyan Shen,Xin Zhang,Naixin Chen et al.
Qiaoyan Shen et al.
Gastrulation is the fundamental stage of human development, governed by the faithful interaction between embryonic and extra-embryonic tissues. Despite its significance, the role of extra-embryonic lineages in directing embryonic diversific...
Proteomic analysis of dental enamel from 20 Homo naledi individuals shows no male markers [0.03%]
对20个纳勒迪人牙齿 enamel的蛋白质组分析未发现男性标志物
Palesa P Madupe,Alberto J Taurozzi,Claire Koenig et al.
Palesa P Madupe et al.
The Rising Star cave system excavations resulted in a high number of well-preserved skeletal specimens from multiple individuals of Homo naledi, showing a high degree of morphological homogeneity, including dental variation possibly consist...
An emergent disease-associated motor neuron state precedes cell death in ALS [0.03%]
ALS中一种与疾病相关的感觉神经元状态先于细胞死亡出现
Olivia Gautier,Jacob A Blum,Thao P Nguyen et al.
Olivia Gautier et al.
To define molecular determinants of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), we generated longitudinal single-nucleus transcriptomes and chromatin accessibility profiles of spinal motor neurons together with spatial...
Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance [0.03%]
铜死亡-免疫交互作用为克服免疫治疗耐药性提供策略
Guang Lei,Zhengze Lu,Zhihao Xu et al.
Guang Lei et al.
Cuproptosis is a recently identified form of copper-dependent cell death that depends on ferredoxin 1 (FDX1)-mediated protein lipoylation. Here, we reveal that CD8+ T cell-mediated antitumor immunity enhances tumor cell susceptibility to cu...
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy [0.03%]
粒细胞-单核细胞祖细胞的扩增和CAR工程化用于细胞免疫治疗
Shi Yue,Zheng Guo,Crystal Pan et al.
Shi Yue et al.
Engineered macrophages are promising for tumor immunotherapy but are limited by poor ex vivo expansion, genetic tractability, and biodistribution after transfer. Here, we develop defined culture conditions that enable long-term expansion of...