Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer [0.03%]
空间生物学揭示免疫抑制非黑色素瘤皮肤癌中的巨噬细胞状态改变
Shorook Naara,Veena Kochat,Xiayu Rao et al.
Shorook Naara et al.
Immunosuppressed patients with non-melanoma skin cancer experience worse clinical outcomes, yet the tumor immune microenvironment associated with systemic immunosuppression remains incompletely defined. Using integrated single-cell, spatial...
Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis [0.03%]
渐冻症患者语言功能和执行功能下降的不同细胞表型
Joana Petrescu,Cláudio Gouveia Roque,Christopher A Jackson et al.
Joana Petrescu et al.
Cognitive manifestations, including impairments in language and executive functions, are seen in amyotrophic lateral sclerosis (ALS), but the underlying mechanisms remain unclear. We mapped prefrontal cortex regions from ALS patients by int...
Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer [0.03%]
靶向周围5-HT2A受体可增强结直肠癌的抗肿瘤免疫反应
YaTing Wen,LingJie Tang,WenWen Duan et al.
YaTing Wen et al.
Cancer remains a leading cause of morbidity and mortality worldwide. While classical psychedelics have been used clinically to treat cancer-associated psychiatric disorders, their impact on tumor progression is unclear. Here, we show that b...
Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions [0.03%]
早期人脑皮层代谢图谱揭示了糖酵解重塑和戊糖磷酸途径控制细胞命运转变
Jessenya Mil,Jose A Soto,Abigail S Krall et al.
Jessenya Mil et al.
Cortical development involves rapid progenitor expansion and cell diversification supported by tightly regulated metabolic programs, yet these programs remain largely uncharacterized in human development. Here, we generated a metabolic atla...
Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration [0.03%]
超快深度3D组织学使胶质瘤浸润术中定位成为可能
Zhijie Liu,Yingying Li,Lingchao Chen et al.
Zhijie Liu et al.
Three-dimensional (3D) histology provides volumetric insights into tissue microarchitectures across entire specimens, holding great promise for more accurate prognostication. However, existing methods are too slow for intraoperative consult...
Max C Lauring,Ming Yang,Aditya Sarode et al.
Max C Lauring et al.
Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of VH(D)JH genes in germinal center B cells for antibody diversification and affinity maturation. How AID specifically targets VH(D)JH remains unclear. We ...
Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance [0.03%]
乳酸溶菌酶通过改变婴儿的微生物群来驱动DC造血并提高耐病性
Daniel R Howard,Ridwan B Rashid,Tufael Ahmed et al.
Daniel R Howard et al.
Breastfeeding reduces the risk of severe lower respiratory infections (sLRIs), a leading cause of infant mortality; however, the protective mechanisms remain elusive. Here, we demonstrated that the absence of milk-derived osteopontin (OPN),...
Spatial atlas of the human brain vasculature reveals specialized cell ensembles [0.03%]
人脑血管空间图谱揭示了专门的细胞组合
Jerry C Wang,Damian Sanchez,Santhosh Arul et al.
Jerry C Wang et al.
The brain vasculature comprises diverse specialized cells that are essential for brain function, yet their spatial organization remains poorly understood. Here, we construct a comprehensive cerebrovascular cell atlas encompassing 314,535 tr...
Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection [0.03%]
精氨酸摄取驱动密码子依赖的MHC I类分子翻译从而改善结肠肿瘤发生和呼吸道病毒感染时的免疫反应
Qiushuang Wu,Lara M Seydlitz,Vladislav Iakimov et al.
Qiushuang Wu et al.
Amino acid levels fluctuate across diverse pathological conditions. Whether such amino acid modulations directly shape pathophysiology by regulating host gene expression remains unknown. We found that extracellular arginine restriction, obs...
Ricardo Barrientos,Billie Meadowcroft,Besaiz J Sánchez-Sánchez et al.
Ricardo Barrientos et al.
The regulation of 3D cell shape is a fundamental problem of life. In multicellular tissues, cell shape emerges through the balance of forces inside and outside the cell. In epithelia, the basement membrane (BM) is the first extracellular ba...