Dynamics of natural selection preceding human viral epidemics and pandemics [0.03%]
先于人类病毒大流行发生的自然选择动态机制
Jennifer L Havens,Sergei L Kosakovsky Pond,Jordan D Zehr et al.
Jennifer L Havens et al.
Using a phylogenetic framework to characterize natural selection, we investigate the hypothesis that zoonotic viruses require adaptation prior to zoonosis to sustain human-to-human transmission. Examining the zoonotic emergence of Ebola vir...
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis [0.03%]
选择性靶向内皮和血管周细胞的血管生成因子ROCK2治疗肝纤维化
Yan Hu,Biao Yang,Chengju Xiao et al.
Yan Hu et al.
Liver fibrosis is a prominent pathological process contributing to death from hepatic diseases, including metabolic dysfunction-associated steatohepatitis (MASH). There is limited treatment for liver fibrosis. Here, we find that upregulatio...
β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer [0.03%]
β-羟丁酸改善癌症CAR-T细胞的代谢适应性
Shan Liu,Puneeth Guruprasad,Ranjani Ramasubramanian et al.
Shan Liu et al.
The influence of lifestyle factors, such as diet, on the effectiveness of T cell-mediated cancer immunotherapies remains unclear. Here, we demonstrate that the ketogenic diet (KD)-induced ketone metabolite β-hydroxybutyrate (BHB) augments ...
Light-directed evolution of dynamic, multi-state, and computational protein functionalities [0.03%]
光驱动的蛋白质功能的动态、多状态和计算性进化
Vojislav Gligorovski,Marco Labagnara,Lorenzo Scutteri et al.
Vojislav Gligorovski et al.
Evolving dynamic, multi-state, and computational protein functionalities is challenging because it requires selection pressure on all the states of a protein of interest (POI) and the transitions between them. To create a continuous directe...
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema [0.03%]
代谢物门控血管收缩转换开关：OXGR1激活机制可使抗炎剂用于治疗酒渣鼻红斑
Wenqin Xiao,Yan Zhu,Xinjie Tang et al.
Wenqin Xiao et al.
Rosacea, an inflammatory skin disorder, poses a dilemma owing to limited effectiveness of treatments for pathological vasodilation-mediated erythema. Here, we identify oxoglutaric acid (α-KG) as a rosacea-associated metabolite elevated in ...
Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain [0.03%]
用于在活体大脑中可视化α-突触核蛋白病理的基因编码荧光报告系统
Li Zhang,Minhui Yu,Guoqing Chen et al.
Li Zhang et al.
Lewy bodies, a pathological hallmark of Parkinson's disease, are α-synuclein-enriched cytoplasmic inclusions that drive progressive neurodegeneration. A long-standing yet unmet goal has been the visualization of α-synuclein (α-Syn) inclu...
Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice [0.03%]
通过恢复下丘脑视前核的昼夜节律反转小鼠衰老标志并延长其寿命
Haijiao Zhao,Meimei Liao,Ran Huo et al.
Haijiao Zhao et al.
Age-related circadian disruptions accelerate physiological decline and shorten lifespan. Enhancing circadian amplitude has emerged as a promising strategy for ameliorating age-associated disorders. Here, we show that the circadian-phase-opt...
Efficient amyloid-β degradation in Alzheimer's disease using SPYTACs [0.03%]
用于阿尔茨海默病的SPYTACs高效降解淀粉样蛋白-β
Fei Teng,Jing Liu,Tongtong Cui et al.
Fei Teng et al.
Clearance of aberrant cerebral amyloid-β (Aβ) deposits represents a promising therapeutic strategy for Alzheimer's disease (AD), yet current anti-Aβ immunotherapy raises safety concerns due to frequent adverse effects. Extracellular targ...
Luqiang Guo,Elizabeth McFadden,Megan M Slough et al.
Luqiang Guo et al.
New World hantaviruses cause severe infections in humans. Previous structural studies have advanced our understanding of hantavirus glycoprotein architecture; however, the lack of high-resolution structures of the glycoprotein tetramer and ...
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle [0.03%]
柠檬酸盐清除是经典TCA循环中aconitase 2的主要功能
Abigail Xie,Julia S Brunner,Sangita Chakraborty et al.
Abigail Xie et al.
The tricarboxylic acid (TCA) cycle couples nutrient oxidation with the generation of reducing equivalents that power oxidative phosphorylation. Nevertheless, the requirement for components of the TCA cycle is context-specific, raising the q...