Auxin signaling [0.03%]
生长素信号转导
Jiashu Chu,Aaron Chun Hou Ang,Martijn de Roij et al.
Jiashu Chu et al.
Following its discovery nearly a century ago, the signaling molecule auxin has captured the interest of plant scientists. Mostly through genetics, key components of the auxin response were identified, and these were rapidly connected in a t...
Paul Bastard,Tyler Hulett,Karl Smith-Byrne et al.
Paul Bastard et al.
Why cancer arises, progresses, or proves fatal in some people but not others remains largely unresolved. Antibody repertoires, including autoantibodies targeting immune pathways, may shape cancer immunosurveillance. Mapping antibody landsca...
Matthew E Hudson,Gopal Battu
Matthew E Hudson
Smartphone-wielding citizen scientists and an AI called FLORIST are transforming ecology at the continental scale. In this issue of Cell, when Tibbs-Cortes et al. pair the crowdsourced data with controlled genetics, they discover how switch...
UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins [0.03%]
出乎意料的调控：RNA分子伴侣驯服内在无序蛋白
Miriam Linsenmeier,James Shorter
Miriam Linsenmeier
How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3' UTR of an mRNA co-translationally chaperones the protein it encodes, preventing intrinsically disordered regions from...
The intrinsic cardiac nervous system is essential for cardiac function and survival [0.03%]
固有心脏神经系统对心脏功能和生存至关重要
Qian J Xu,Marissa C Applegate,I-Uen Yvonne Hsu et al.
Qian J Xu et al.
The intrinsic cardiac nervous system (ICNS) is a key node in heart-brain communication and an emerging target for cardiac therapy, yet its physiological importance and functional organization remain poorly understood. Here, we show that the...
Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development [0.03%]
染色质调节因子ANKRD11凝聚物限制过度转录的基因以保障发育顺利进行
Tao Zhang,Xiufeng Li,Wei Zhou et al.
Tao Zhang et al.
Genes that define cell identity are often highly transcribed, but how their activity is regulated to prevent pathological dysregulation remains elusive. Using a two-tiered genetic screen, we identify a network of genes regulating hypertrans...
Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer [0.03%]
基于MSA的Pairformer模型在蛋白质相互作用预测中的应用拓展研究
Yo Akiyama,Zhidian Zhang,Olivia Tang et al.
Yo Akiyama et al.
Protein-protein interactions underlie biological complexity, and modeling their coevolution is essential for characterizing and engineering molecular assemblies. While protein and genomic language models have excelled at modeling individual...
Rotem Shalita,Maya Ben Yehuda,Chamutal Gur et al.
Rotem Shalita et al.
B cell-depleting therapies are effective in multiple sclerosis (MS), yet some patients relapse, underscoring the need for more precise interventions. To identify new therapeutic targets, we generated a single-cell RNA sequencing (scRNA-seq)...
CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics [0.03%]
脑蛛网膜开启结构调节嗅束脑脊液清除功能的研究
Seon Pyo Hong,Cheolhwa Jin,Myung Jin Yang et al.
Seon Pyo Hong et al.
Meningeal (dural) lymphatics are essential for cerebrospinal fluid (CSF) clearance to cervical lymph nodes, yet the precise pathway is incompletely understood. Using a multifaceted approach in mice, we examined tracer dynamics and the CSF o...
A domestication-selected enhancer coordinates source-sink balance to improve harvest index and yield in maize [0.03%]
一个被驯化的增强子协调源-库平衡以提高玉米的收获指数和产量
Li Guo,Jinliang Xia,Junxiang Tang et al.
Li Guo et al.
Crop yield is fundamentally determined by the harvest index, the proportion of photosynthates allocated to grain. However, its genetic and evolutionary basis remains elusive. Here, we show that the maize harvest index increased by 81% durin...