Cell. 2025 Jun 9:S0092-8674(25)00565-3. doi: 10.1016/j.cell.2025.05.015 Q142.52025
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
微生物组可使长链和短链脂肪酸来源的N-酰基甘油衍生脂质发生多样化 翻译改进
Helena Mannochio-Russo 1, Vincent Charron-Lamoureux 1, Martijn van Faassen 2, Santosh Lamichhane 3, Wilhan D Gonçalves Nunes 1, Victoria Deleray 1, Adriana V Ayala 4, Yuichiro Tanaka 4, Abubaker Patan 1, Kyle Vittali 1, Prajit Rajkumar 1, Yasin El Abiead 1, Haoqi Nina Zhao 1, Paulo Wender Portal Gomes 1, Ipsita Mohanty 1, Carlynda Lee 1, Aidan Sund 1, Meera Sharma 1, Yuanhao Liu 1, David Pattynama 1, Gregory T Walker 5, Grant J Norton 5, Lora Khatib 6, Mohammadsobhan S Andalibi 7, Crystal X Wang 8, Ronald J Ellis 9, David J Moore 8, Jennifer E Iudicello 8, Donald Franklin Jr 8, Scott Letendre 10, Loryn Chin 11, Corinn Walker 12, Simone Renwick 13, Jasmine Zemlin 14, Michael J Meehan 1, Xinyang Song 15, Dennis Kasper 16, Zachary Burcham 17, Jane J Kim 18, Sejal Kadakia 19, Manuela Raffatellu 20, Lars Bode 13, Hiutung Chu 21, Karsten Zengler 11, Mingxun Wang 22, Dionicio Siegel 1, Rob Knight 23, Pieter C Dorrestein 24
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作者单位
1 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.2 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.3 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Institute of Biomedicine, Faculty of Medicine, University of Turku & Turku Bioscience Center, University of Turku and Åbo Akademi University, 20520 Turku, Finland.4 Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.5 Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.6 Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.7 Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.8 Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.9 Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.10 HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.11 Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.12 Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.13 Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE) and the Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA 92093, USA.14 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.15 Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.16 Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.17 Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.18 Department of Pediatrics, Division of Pediatric Endocrinology, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital San Diego, San Diego, CA 92123, USA.19 Division of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, CA 92868, USA.20 Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Chiba University - UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines, La Jolla, CA 92093, USA.21 Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Chiba University - UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines, La Jolla, CA 92093, USA.22 Department of Computer Science and Engineering, University of California, Riverside, Riverside, CA 92521, USA.23 Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA 92093, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.24 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: pdorrestein@health.ucsd.edu.
DOI: 10.1016/j.cell.2025.05.015 PMID: 40499541
摘要 中英对照阅读
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spectral library retrieving N-acyl lipid patterns from 2,700 public datasets, identifying 851 N-acyl lipids that were detected 356,542 times. 777 are not documented in lipid structural databases, with 18% of these derived fr... ...点击完成人机验证后继续浏览
N-酰基脂质是多种生物学过程的重要介质，包括免疫功能和应激反应。为了通过非靶向基于质谱的代谢组学增强对N-酰基脂质的检测，我们创建了一个参考光谱库，从2,700个公共数据集中检索N-酰基脂质模式，并识别出851种被检测到356,542次的N-酰基脂质。其中777种未在脂质结构数据库中记录，这其中有18%来源于短链脂肪酸，并存在于消化系统和其他器官中。它们的水平因饮食和微生物定植而变化，在糖尿病患者中的水平也有所不同。我们使用该库将包括组胺和多胺结合物在内的微生物N-酰基脂质与HIV状态及认知障碍联系起来。这一资源将在未来研究中增强对这些化合物的注释，以进一步理解它们在健康和疾病中的作用，并强调大规模非靶向代谢组学数据在代谢物发现方面的价值。
关键词：HIV；MASST；MassQL；N-酰基脂质；SCFA；代谢组学数据分析；微生物；神经认知障碍；库规模分析；短链脂肪酸。
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