Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells [0.03%]
遗传变异揭示了一个可调控造血干细胞的同源异型长非编码RNA
Peng Lyu,Gaurav Agarwal,Chun-Jie Guo et al.
Peng Lyu et al.
The HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the HOXA locus, we identified a genetic variant, rs17437411, associated with globally reduced bl...
An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut [0.03%]
肠道厌氧病原体重构宿主代谢以驱动炎症肠道内的需氧生长
Luisella Spiga,Ryan T Fansler,Yifan Wu et al.
Luisella Spiga et al.
To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How anaerobic pathogens construct nutrient niches in the densely populated large intestine remains poorly...
Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse [0.03%]
异基因造血干细胞移植后复发的体内供体来源的记忆CAR-T细胞的独特动态变化
Luca Gattinoni,Gabriele Inchingolo,Dennis C Harrer et al.
Luca Gattinoni et al.
Donor-derived CD19-CAR T cells offer a therapeutic option for B cell malignancies relapsing after allogeneic hematopoietic stem cell transplantation but are often constrained by poor engraftment, expansion, and persistence. In a first-in-hu...
PLANeT: Understanding and leveraging the genome of land plants for a sustainable future [0.03%]
PLANET：了解和利用陆地植物基因组以实现可持续未来
Li Wang,Mohamed Amar,Carlos I Arbizu et al.
Li Wang et al.
Land plants underpin civilization and planetary health, yet their genomic diversity remains largely uncharted. Current resources are unstandardized and scarce, lacking reference genomes for 95% of genera, 70% of families, and 51% of orders,...
Angiocrine signaling drives liver fibrosis: From mechanism to early clinical translation [0.03%]
肝纤维化中的血管内分泌信号作用：从机制到早期临床转化研究
Sheng Cao,Vijay H Shah
Sheng Cao
Hu et al identify ROCK2 in liver sinusoidal endothelial cells as a key factor in liver fibrosis. Through single-cell analysis, knockout models, protein studies, and early clinical research, the authors show that ROCK2-driven endothelial cyt...
Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function [0.03%]
蛋白质稳态维持T细胞分化潜能和肿瘤浸润淋巴细胞的功能
Nicole E Scharping,Xuezhen Ge,Maria Inês Matias et al.
Nicole E Scharping et al.
Tumor-infiltrating lymphocytes (TIL) often fail to restrain tumor growth due to progressive differentiation into an "exhausted" state. Tissue-resident memory T cells (TRM) maintain protection from infection for years in healthy tissues, and...
Differential inhibition of Morbillivirus and Henipavirus polymerases by ERDRP-0519 and structure-guided inhibitor optimization [0.03%]
ERDRP-0519选择性抑制莫勒病毒和亨尼帕病毒聚合酶及基于结构的抑制剂优化
Lu Xue,Jiacheng Gui,Shenghua Gao et al.
Lu Xue et al.
ERDRP-0519 is a non-nucleoside polymerase inhibitor developed against measles virus (MeV) of the Morbillivirus genus. Here, we show that ERDRP-0519 also cross-inhibits Nipah virus (NiV) of the Henipavirus genus with reduced potency. ERDRP-0...
Spatial organization and detection of social odors in mouse primary olfactory system [0.03%]
小鼠初级嗅觉系统中的社交气味的空间组织和检测机制研究
Bogdan Bintu,Yoh Isogai,Ignatius Jenie et al.
Bogdan Bintu et al.
The detection of olfactory cues is essential to signal food, predators, and social encounters. To determine how the sensory detection of physiologically relevant odors is systematically mapped into the mouse primary olfactory system, we use...
Unbiased niche labeling maps immune-excluded niche in bone metastasis [0.03%]
无偏倚小生境标记揭示骨转移灶中的免疫排除型小生境
Zhan Xu,Fengshuo Liu,Yunfeng Ding et al.
Zhan Xu et al.
Metastatic cancer cell fate is shaped by the local microenvironment niches. To unbiasedly define the cellular and molecular features of metastatic niches, we developed sortase A-based microenvironment niche tagging (SAMENT), which selective...
Dongdong Hao,Zhina Xiao,Wei Yan et al.
Dongdong Hao et al.
Endoplasmic reticulum (ER) redox homeostasis is critical for ER functionality and is implicated in various human diseases, yet its physiological significance in plants remains largely elusive. Ethylene, a key phytohormone, is perceived and ...