Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states [0.03%]
来自阿尔茨海默病小胶质细胞样的体细癌变异驱动炎性和增殖状态
August Yue Huang,Zinan Zhou,Maya Talukdar et al.
August Yue Huang et al.
Alzheimer's disease (AD) is a neurodegenerative condition characterized by microglia-mediated neuroinflammation. Deep (>1,000×) panel sequencing of 311 brain samples revealed enrichment of somatic single-nucleotide variants (sSNVs) in canc...
Hai-Yan Zhou,Xu Feng,Jie Wen et al.
Hai-Yan Zhou et al.
With the ongoing rise in global temperatures, the prevalence of heat-stress-related chronic health disorders has increased. However, whether heat stress has an enduring impact on metabolic health remains unclear. Here, we report that mice e...
Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells [0.03%]
在人主要CD4⁺T细胞中系统发现抗HIV和促HIV宿主因子
Ujjwal Rathore,Eli Dugan,Hunter Thornton et al.
Ujjwal Rathore et al.
Host factors that promote or restrict human immunodeficiency virus (HIV) infection in human CD4+ T cells have not been comprehensively identified. We employed orthogonal genome-wide CRISPR activation (CRISPRa) and CRISPR knockout screens in...
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency [0.03%]
p53通过调节化学重编程过程中细胞周期阻滞来保护体细胞向多能性转变
Lin Cheng,Yanglu Wang,Zhihan Yang et al.
Lin Cheng et al.
Cell fate manipulation is powerful for generating desired cell types through reprogramming. However, reprogramming induces dramatic changes in cell states and identities, which can be risky, necessitating strict regulation to ensure safety ...
A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes [0.03%]
一种植物筛选方法鉴定出大蒜中的一种化合物能阻止果蝇和蚊子的交配和产卵
Shimaa A M Ebrahim,Gaëlle J S Talross,Hany K M Dweck et al.
Shimaa A M Ebrahim et al.
One means of controlling insect disease vectors and pests is with compounds that manipulate their behavior. An extraordinary variety of phytochemicals, i.e., compounds produced by plants, activate insect chemosensory systems. Fruits and veg...
Gut microbiome is associated with recurrence-free survival in patients with resected high-risk melanoma receiving adjuvant immune checkpoint blockade [0.03%]
胃肠道微生态与接受辅助免疫检查点抑制的高危黑色素瘤术后患者无病生存相关性研究
Mykhaylo Usyk,Richard B Hayes,Rob Knight et al.
Mykhaylo Usyk et al.
Patients with resected, high-risk melanoma receive adjuvant immune checkpoint blockade (ICB), yet clinical benefit remains unpredictable, with 25%-40% of patients experiencing recurrence. To evaluate whether pre-treatment gut microbiome (GM...
B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism [0.03%]
B细胞缺乏通过重塑肝脏谷氨酸代谢限制运动能力
Youxiang Mao,Ziyan Xia,Xu Pan et al.
Youxiang Mao et al.
B cells are an essential component of humoral immunity, and B cell depletion therapies have clinically succeeded in eliminating cancerous B cells and treating autoimmune diseases. Here, we report an immune-independent function of B cells th...
Predicting competition and substrate preferences for targeted microbiome alteration [0.03%]
预测竞争和底物偏好以进行靶向改变微生物组
Oriane Moyne,Grant J Norton,Mahmoud Al-Bassam et al.
Oriane Moyne et al.
Microbiome science has greatly expanded our understanding of microbial life and its roles in the environment and human health. Yet microbiome science often relies on descriptive, correlation-based approaches that limit causal insight and in...
2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity [0.03%]
2’3’-cGAMP诱导的膜剪切促进广谱抗噬菌体免疫反应
Yina Gao,Zhaolong Li,Yufei Zhou et al.
Yina Gao et al.
Cyclic-oligonucleotide-based anti-phage signaling system (CBASS), a central prokaryotic antiviral strategy and evolutionary ancestor of the mammalian cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, relies on c...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [0.03%]
免疫蛋白酶体扰乱神经元代谢并驱动多发性硬化症的神经退行性疾病发展
Marcel S Woo,Johannes Brand,Lukas C Bal et al.
Marcel S Woo et al.
Published Erratum
Cell. 2026 Apr 16:S0092-8674(26)00396-X. DOI:10.1016/j.cell.2026.04.007 2026