Wenxiang Huang,Ruijun Wang,Xinquan Yang et al.
Wenxiang Huang et al.
Ferroptosis is an iron-dependent form of regulated cell death. However, the critical regulators that restrain iron overload to suppress ferroptosis remain undefined. Utilizing multi-omics, we identify the E3 ubiquitin ligase membrane-associ...
Engineered commensals for metabolic modulation of the gut-liver-brain axis [0.03%]
用于调节肠-肝-脑轴代谢的共生菌工程改造
Nikhil Aggarwal,Haosheng Shen,Li Ting Lee et al.
Nikhil Aggarwal et al.
The gut-liver-brain axis is central to metabolic and neurological homeostasis and is mediated by host- and microbiota-derived metabolites. Disruptions in this axis contribute to complex disorders, underscoring the need for targeted, multi-m...
Nuclear envelope budding enables export of large transcripts in muscle cells [0.03%]
核膜出芽作用使肌肉细胞的大转录本得以输出
Sofia Zaganelli,Janet B Meehl,Robert G Abrisch et al.
Sofia Zaganelli et al.
Nuclear envelope (NE) budding (NEB) has emerged as an alternative route for nuclear export of viral particles that are too large to pass through the nuclear pore complex. Yet the significance of this unconventional export pathway for large ...
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets [0.03%]
基于机制的抑郁症G蛋白偶联受体药物靶点识别
Hermany Munguba,Anisul Arefin,Ryota Hasegawa et al.
Hermany Munguba et al.
Depression is driven by dysfunction in discrete neural circuits, but a deeper understanding of the underlying molecular and synaptic mechanisms is needed to guide the development of therapeutics. Here, we decipher the mechanisms of action o...
Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation [0.03%]
丙酮酸通过诱导STAT1蛋白丙酮酰化自然抑制干扰素信号传导
Yibo Zuo,Qin Wang,Wanying Tian et al.
Yibo Zuo et al.
Published Erratum
Cell. 2026 Apr 22:S0092-8674(26)00453-8. DOI:10.1016/j.cell.2026.04.018 2026
The evolution of high-order genome architecture revealed from 1,000 species [0.03%]
来自1,000个物种的高等级基因组架构进化历程
Yizhuo Che,Stephen J Bush,Hui Lin et al.
Yizhuo Che et al.
Spatial genome organization plays a crucial regulatory role, but its evolutionary development remains unclear. Leveraging Hi-C data from 1,025 species, we trace the evolutionary trajectories of genome organization through 2 higher-order arc...
Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states [0.03%]
来自阿尔茨海默病小胶质细胞样的体细癌变异驱动炎性和增殖状态
August Yue Huang,Zinan Zhou,Maya Talukdar et al.
August Yue Huang et al.
Alzheimer's disease (AD) is a neurodegenerative condition characterized by microglia-mediated neuroinflammation. Deep (>1,000×) panel sequencing of 311 brain samples revealed enrichment of somatic single-nucleotide variants (sSNVs) in canc...
Hai-Yan Zhou,Xu Feng,Jie Wen et al.
Hai-Yan Zhou et al.
With the ongoing rise in global temperatures, the prevalence of heat-stress-related chronic health disorders has increased. However, whether heat stress has an enduring impact on metabolic health remains unclear. Here, we report that mice e...
Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells [0.03%]
在人主要CD4⁺T细胞中系统发现抗HIV和促HIV宿主因子
Ujjwal Rathore,Eli Dugan,Hunter Thornton et al.
Ujjwal Rathore et al.
Host factors that promote or restrict human immunodeficiency virus (HIV) infection in human CD4+ T cells have not been comprehensively identified. We employed orthogonal genome-wide CRISPR activation (CRISPRa) and CRISPR knockout screens in...
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency [0.03%]
p53通过调节化学重编程过程中细胞周期阻滞来保护体细胞向多能性转变
Lin Cheng,Yanglu Wang,Zhihan Yang et al.
Lin Cheng et al.
Cell fate manipulation is powerful for generating desired cell types through reprogramming. However, reprogramming induces dramatic changes in cell states and identities, which can be risky, necessitating strict regulation to ensure safety ...