EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation [0.03%]
EB病毒与HLA-DR15通过髓鞘肽呈递联合驱动多发性硬化症
Jian Wang,Yuhan Qiu,Zoe Marti et al.
Jian Wang et al.
Epstein-Barr virus (EBV) is involved in causing and probably also in perpetuating multiple sclerosis (MS). Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and prefere...
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis [0.03%]
EB病毒通过ANK2特异性T细胞与多发性硬化相联系
Olivia G Thomas,Urszula Rykaczewska,Marina Galešić et al.
Olivia G Thomas et al.
Epstein-Barr virus (EBV) infection constitutes a prerequisite for multiple sclerosis (MS) development, and cross-reactivity between EBV nuclear antigen 1 (EBNA1) and anoctamin-2 (ANO2) antibodies was previously demonstrated in persons with ...
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex [0.03%]
溶酶体KICSTOR-GATOR1-SAMTOR营养感受超级复合物的结构
Christopher J Lupton,Charles Bayly-Jones,Shuqi Dong et al.
Christopher J Lupton et al.
The guanosine triphosphate (GTP)-bound state of the heterodimeric Rag GTPases functions as a molecular switch regulating mechanistic target of rapamycin complex 1 (mTORC1) activation at the lysosome downstream of amino acid fluctuations. Un...
Chengyu Zou,Peiying Li,Bin Li et al.
Chengyu Zou et al.
Recent advances in regulatory T cell (Treg) biology and clinical application of Treg-based treatments show promise as a new generation of transforming therapeutics for immune-related disorders, positioning Tregs as a "living drug" to rebuil...
Andreas Linkermann
Andreas Linkermann
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respiratory chain to release copper and kill acu...
A trunkload of ancient RNA [0.03%]
一车满满的古rna
Sébastien Calvignac-Spencer,Carles Lalueza-Fox
Sébastien Calvignac-Spencer
Ancient DNA has become a workhorse for evolutionary biologists. In contrast, ancient RNA studies have been rare and often methodologically controversial. Mármol-Sánchez et al. provide compelling evidence that aRNA survived up to ca. 50,00...
EcDNA-borne structural variants drive oncogenic fusion transcript amplification [0.03%]
染色体外 DNA 诱导结构变异并驱动致癌融合转录本扩增
Hyerim Yi,Shu Zhang,Jason Swinderman et al.
Hyerim Yi et al.
Extrachromosomal DNA (ecDNA) amplifications are key drivers of human cancers. Here, we show that ecDNAs are major platforms for generating and amplifying oncogene fusion transcripts across diverse cancer types. By integrating analysis of wh...
Guangqing Lu,Shanshan Zhang,Mengyang Feng et al.
Guangqing Lu et al.
While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacterized. To address this knowledge gap, we developed "cytokine cellular locating platforms" (...
Evolutionary transcriptomics unveils rapid changes of gene expression patterns in flowering plants [0.03%]
进化转录组学揭示了开花植物基因表达模式的快速变化
Christoph Schuster,Alexander Gabel,Hajk-Georg Drost et al.
Christoph Schuster et al.
The evolutionary history of angiosperms (flowering plants) is characterized by a highly accelerated rate of diversification. Although a number of hypotheses have been proposed to explain the ecological success and rapid rise of angiosperms,...
Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors [0.03%]
细胞外GPX4通过树突状ZP3受体损害抗肿瘤免疫反应
Jiao Liu,Xiutao Cai,Junhao Lin et al.
Jiao Liu et al.
Understanding the immunogenic properties of different forms of cell death is critical for rationalized antineoplastic therapeutic development. Here, we identify a regulatory axis that suppresses the immunogenicity of ferroptosis. During fer...