Cellular architecture and neighborhood-informed virtual spatial tumor profiling from histopathology [0.03%]
基于细胞架构和邻域信息的虚拟空间肿瘤图谱病理学分析方法
Yuchen Li,Zhe Li,Ryan Quinton et al.
Yuchen Li et al.
The tumor microenvironment (TME) critically shapes disease progression and therapeutic resistance. However, a comprehensive understanding of its spatial architecture remains elusive, and clinical translation is challenging. Here, we present...
A CRISPR knockout mouse library for functional genomics in influenza research [0.03%]
用于流感研究的功能基因组学的CRISPR敲除小鼠库
Hiroshi Ueki,Yuriko Tomita,Calvin Duong et al.
Hiroshi Ueki et al.
Functional validation of host factors in whole-animal models is a major bottleneck in virology; it hinders the translation of data from in vitro studies into a deeper understanding of the viral life cycle and pathogenesis. To address this c...
The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM [0.03%]
CAR-T细胞治疗后复发的胶质母细胞瘤中内源性免疫区室的关键作用
Nelson F Freeburg,Daniel Chafamo,Gayathri Konanur Gopikrishna et al.
Nelson F Freeburg et al.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median survival of under 15 months and no effective treatment after recurrence. A recent phase 1 trial of intracerebroventricular bivalent chimeric antige...
Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK [0.03%]
桥状蛋白VPS13A介导的脂质转运机制及其与翻转酶XK的合作关系
Bodan Hu,Daniel Álvarez,Cristian Rocha-Roa et al.
Bodan Hu et al.
In eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer between organelles. BLTPs span the cytosolic space between organelles at contact sites, featuring hydrophobic channels fo...
Two distinct causes contribute to the low efficiency of human pre-implantation development [0.03%]
两种不同的原因导致人类植入前胚胎发育效率低下
Zixuan Li,Lizhi Leng,Jinglei Zhai et al.
Zixuan Li et al.
∼50% of fertilized eggs arrest during human pre-implantation development, representing a major bottleneck for assisted reproductive technology. The underlying causes remain controversial. By imaging ∼150 live human and monkey fertilized e...
Nuclear proteome reveals microtubule-associated protein regulating fate and disease [0.03%]
核蛋白组学揭示了调节命运和疾病的微管相关蛋白
Florencia Merino,Lucas Miranda,Aparajita Kumar et al.
Florencia Merino et al.
Cellular differentiation and morphogenesis require the coordination between cytoskeletal remodeling and transcriptional programs, raising the question of how cytoskeletal information is conveyed to the nucleus. Here, we profile the nuclear ...
Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine [0.03%]
抗癌剂cephalotaxinone和homoerythratine的全合成
Runze Tian,Feifan Lin,Nianxin Guo et al.
Runze Tian et al.
Cephalotaxine-type and homoerythrina-type alkaloids are structurally unique and biologically important natural products isolated from endangered species that belong to the genus Cephalotaxus. Among them, homoharringtonine (HHT [1]) is a mar...
Transposable element DNA and RNA: Drivers of gene expression, evolution, and disease [0.03%]
可移动元件的DNA和RNA：基因表达、进化及疾病驱动因素
Jessica Sook Yuin Ho,Christopher H Douse,Ivan Marazzi
Jessica Sook Yuin Ho
Transposable elements (TEs) comprise nearly half of mammalian genomes and have shaped genome architecture, chromatin organization, and transcriptional landscapes. Thanks to recent advances in long-read sequencing and functional (epi)genomic...
Lu Tian,Yinqing Li
Lu Tian
RNA velocity can predict the direction of cell-state change, but the regulatory programs shaping these changes remain difficult to identify. In this issue of Cell, Wang et al. introduce RegVelo, a framework that integrates gene regulatory n...
Catching waves of polyploids [0.03%]
捕捉多倍体的浪潮
Jeff J Doyle
Jeff J Doyle
In this issue of Cell, Chen et al. analyze angiosperm genomes to map whole-genome duplication events, revealing non-random waves of polyploidy linked to climatic shifts and periods of low diversity. They suggest polyploids may have preferen...