LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery [0.03%]
LUMI-实验室：一种自主平台，利用基础模型发现用于mRNA递送的离子化脂质设计
Yue Xu,Haotian Cui,Kuan Pang et al.
Yue Xu et al.
Integrating AI with robotics offers a promising approach to molecular discovery and optimization, enabling efficient exploration of vast chemical spaces. However, its application in emerging fields is often constrained by sparse historical ...
A regulatory network promotes apoplastic alkalinization to prime plant immunity in tissues distal to site of infection [0.03%]
一个调控网络促进植物远距离组织中的细胞间隙碱化以启动免疫反应
Hongze Wang,Xiuming Li,Keran Zhai et al.
Hongze Wang et al.
Immune activation in plants triggers extracellular alkalinization, presumably by inhibiting plasma membrane H+-ATPases. The precise role and underlying mechanisms of this process remain poorly understood. Here, we show that Pseudomonas syri...
Editing strigolactone hormone receptor for robust antiviral silencing in rice [0.03%]
编辑独脚金内酯激素受体以增强水稻的抗病毒基因沉默效应
Guoyi Yang,Ming Wu,Shuai Zhang et al.
Guoyi Yang et al.
The small interfering RNA (siRNA) pathway directs broad-spectrum antiviral defense through RNA silencing so that virulent infection requires efficient suppression of the defense mechanism. Here, we show that strigolactone (SL) hormone signa...
Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition [0.03%]
真菌来源的纤维二糖代谢途径供能T细胞以避开瘤内葡萄糖竞争
Matthew L Miller,Timothy J Thauland,Smriti Sameer Nagarajan et al.
Matthew L Miller et al.
Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucose. We sought to restore TIL function by providing them with an exclusive fuel source. The ...
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression [0.03%]
GPX1-OSBPL8轴介导非经典体内铁死亡及癌症生长抑制
Zhangchuan Xia,Xin Yang,Sviatlana N Samovich et al.
Zhangchuan Xia et al.
Ferroptosis is a tumor-suppressive mechanism with therapeutic potential. While canonical ferroptosis is usually triggered by inducers, such as erastin and RSL-3, or by glutathione peroxidase (GPX)4 loss, how ferroptosis occurs naturally in ...
Fluid flow and environmental geometry guide the journey of swimming bacteria [0.03%]
流体流动和环境几何结构引导游泳细菌的旅程
Eleonora Secchi
Eleonora Secchi
In natural and artificial settings, fluid flow and hydrodynamic interactions shape how bacteria attach to surfaces and form biofilms. Tao et al. show that motile E. coli can swim upstream through microstructured environments, revealing how ...
Listening to the bladder field: Urine liquid biopsies reveal differential treatment responses in NMIBC [0.03%]
听从膀胱的指示：尿液液体活检揭示NMIBC的不同治疗反应
Katharina Jonas,Tina Moser,Ellen Heitzer
Katharina Jonas
In this issue of Cell, Shi and colleagues introduce a urine-based liquid biopsy approach that reshapes how treatment response in NMIBC is assessed. They use urine tumor DNA to detect minimal residual disease and disentangle the contribution...
Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC [0.03%]
触动神经：感觉神经元在三阴性乳腺癌中的作用机制研究
Debra Barki,Neta Eilat,Ruth Scherz-Shouval
Debra Barki
The tumor microenvironment drives cancer progression, yet neural contributions remain underexplored. Zhang et al. unravel a signaling circuit involving cancer cells, sensory neurons, and cancer-associated fibroblasts that promotes desmoplas...
Sheng Luan
Sheng Luan
Rooted in place, plants must continuously respond and adapt to their ever-changing environment to survive, especially as climate change intensifies. Calcium ions (Ca²⁺) play a central role in plant responses to both biotic and abiotic cha...
Tuning the sensitivity of mechanosensory receptors through histidine scanning [0.03%]
通过组氨酸扫描调节机械感受器的敏感度
Yuanhao Wang,Yuhan Wang,Wenjie Yuan et al.
Yuanhao Wang et al.
T cell receptor (TCR)-T cell therapy is effective for solid tumors, yet identifying potent, specific TCRs for tumor antigens is challenging. Conventional affinity maturation may cause fatal off-target toxicity. Catch bonds play a crucial ro...