Sulfur partitioning from cysteine controls T cell proliferation and effector function [0.03%]
半胱氨酸的硫分配控制T细胞增殖和效应功能
Beth Kelly,Minsun Cha,Tatjana Gremelspacher et al.
Beth Kelly et al.
Delineating how acquired nutrients are partitioned into different intracellular pathways and how these various fates support distinct functions in T cells is limited. We show that CD8+ T cells acquire cysteine to serve both as a substrate f...
A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy [0.03%]
阳性的uPAR肿瘤生态系统容易被CAR-T细胞疗法攻击
Zeda Zhang,Yu-Jui Ho,Xin Fang et al.
Zeda Zhang et al.
Chimeric antigen receptor (CAR) T cells have transformed hematologic cancer therapy but remain limited in solid tumors by antigen heterogeneity and a suppressive, pro-fibrotic microenvironment. We previously identified the urokinase plasmin...
Margarette H Clevenger,Denis Cipurko,Ashwini Patil et al.
Margarette H Clevenger et al.
The laboratory mouse is a key model system for biomedical research, yet body-wide measurement tools are lacking. Here, we generate spatiotranscriptomics profiles of whole-mouse sections that accurately capture histological regions. We spati...
Advancing precision health discovery in a genetically diverse health system [0.03%]
遗传多样化的医疗系统中的精准医学发现研究取得进展
Roni Haas,Michael P Margolis,Angela Wei et al.
Roni Haas et al.
Linking genetic data with electronic health records in hospital biobanks promises to advance precision medicine, but limited ancestral diversity constrains discovery and generalizability. We analyzed 93,936 participants from the UCLA ATLAS ...
Heng Lyu,Cong Xing,Wanwan Huai et al.
Heng Lyu et al.
Stimulator of interferon genes (STING) activation requires coat protein complex II (COPII)-mediated endoplasmic reticulum (ER) exit, but the mechanism remains elusive. Here, we identify EEΦxΦ (339EEVTV343 in human STING) as the ER-exit mo...
Development of non-spatial grid-like neural codes tracks inference and intelligence [0.03%]
非空间网格样神经编码的发展跟踪推理和智力
Yukun Qu,Jianxin Ou,Luoyao Pang et al.
Yukun Qu et al.
Piaget's theory posits that children develop structured knowledge schemas for inferring and assimilating new information, yet the underlying neural mechanisms remain unclear. In 203 participants aged 8-25 years, we investigated how maturati...
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures [0.03%]
全神经变性蛋白质组学揭示了疾病亚型和分子特征
Him K Shrestha,Huan Sun,Jay M Yarbro et al.
Him K Shrestha et al.
Neurodegenerative diseases (NDs) pose clinical challenges due to their complexity and molecular heterogeneity. Here, we present a pan-neurodegeneration atlas (PanNDA) from multilayer, deep proteomic analysis of 2,279 human brain samples spa...
The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites [0.03%]
coco这种bmp抑制剂可重新激活乳腺癌的肺转移病灶中的癌细胞
Hua Gao,Goutam Chakraborty,Ai Ping Lee-Lim et al.
Hua Gao et al.
Published Erratum
Cell. 2026 Mar 21:S0092-8674(26)00327-2. DOI:10.1016/j.cell.2026.03.026 2026
Hannah T Tam,Jingyu Peng,Rebecca Freeman et al.
Hannah T Tam et al.
Some mammalian tissues can replace lost cells within one lineage, but organ-level regeneration-restoring diverse cell types across lineages-remains rare. Here, we show that late embryonic full-thickness skin injuries heal by regenerating ep...
The E3-ome gene-centric compendium reveals the human E3 ligase landscape [0.03%]
E3-ome基因中心汇编揭示了人类E3连接酶的全景图谱
Ngee Kiat Chua,Tania J González-Robles,Cameron J Reddington et al.
Ngee Kiat Chua et al.
To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the human genome. The E3-ome integrates experimental data, bioinformatics, and published researc...