The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [0.03%]
免疫蛋白酶体扰乱神经元代谢并驱动多发性硬化症的神经退行性疾病发展
Marcel S Woo,Johannes Brand,Lukas C Bal et al.
Marcel S Woo et al.
Published Erratum
Cell. 2026 Apr 16:S0092-8674(26)00396-X. DOI:10.1016/j.cell.2026.04.007 2026
Pietro Paolo Vitiello,Vito Amodio,Alberto Bardelli
Pietro Paolo Vitiello
Cancer therapy evolved from cytotoxic chemotherapy to targeted and immune treatments guided by molecular profiling. Early cytotoxic drugs, rooted in mustard-gas observations, remain effective but toxic. Targeted agents exploit oncogenic vul...
Josep M Llovet,Roser Pinyol,Silvia Affo et al.
Josep M Llovet et al.
The hallmarks of cancer, first proposed in 2000, have since provided a unified framework for understanding the complexity of carcinogenesis. This conceptual model has profoundly influenced the treatment landscape of primary liver cancer, wh...
Frank Winkler,Sophie Heuer,Ferdinand Althammer et al.
Frank Winkler et al.
Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, while cancer can likewise influence the nervous system, promoting neural reprogramming and...
Daniela F Quail,Johanna A Joyce
Daniela F Quail
Tumors evolve within complex, adaptive ecosystems that operate across spatial, temporal, and systemic scales. Within each tumor microenvironment, numerous diverse cell populations assemble into specialized niches that are continually shaped...
Mapping intratumor heterogeneity across layers for advancing immunotherapy [0.03%]
跨层次绘制肿瘤内异质性以推进免疫治疗
Jean-Christophe Marine,Osnat Bartok,Shira Sagie et al.
Jean-Christophe Marine et al.
Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate dyn...
Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature [0.03%]
靶向新生血管：来自25年正常化肿瘤血管的启示
Sonu Subudhi,Somin Lee,Rakesh K Jain
Sonu Subudhi
Tumors acquire blood vessels primarily via sprouting angiogenesis and co-option of pre-existing host vasculature, but also via intussusception, vasculogenesis from bone-marrow-derived progenitors, vascular mimicry, and endothelial transdiff...
Cell death in cancer [0.03%]
癌症中的细胞死亡
Marcus Conrad,Andreas Strasser,Philipp J Jost et al.
Marcus Conrad et al.
"Evasion of cell death" is a hallmark of cancer, enabling transformed cells to withstand oncogenic and therapeutic stress. Restoring cancer cell death is an appealing strategy but requires a deep understanding of cell death programs. Over t...
Ivy Tsz-Lo Wong,Chris Bailey,Sihan Wu et al.
Ivy Tsz-Lo Wong et al.
Some aggressive cancers exhibit a level of rapid genome change and therapy resistance that is difficult to explain. Research over the past decade has shown that extrachromosomal DNA (ecDNA) can be the cause. When oncogenic genetic elements ...
Timothy A Yap,H Charles Manning,Puja Sapra et al.
Timothy A Yap et al.
Genomic instability is a defining feature of cancer, which arises when the cellular systems that maintain DNA integrity falter, enabling the accumulation of genetic and epigenetic alterations that drive malignant transformation. It is both ...