Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration [0.03%]
植物再生过程中单个体细胞向全能状态时间分辨率重编程
Li Ping Tang,Li Ming Zhai,Jiming Li et al.
Li Ping Tang et al.
Totipotency enables single cells to regenerate an organism, yet how differentiated somatic cells reacquire this potential remains unclear. Here, we show that LEAFY COTYLEDON2 (LEC2) reprograms SPEECHLESS (SPCH)-expressing meristemoid mother...
Samson Glaser,Maxim I Molodtsov,John F X Diffley et al.
Samson Glaser et al.
Following eukaryotic genome replication, the ring-shaped cohesin complex embraces the two newly synthesized sister chromatids, enabling their faithful segregation during cell divisions. Replisome passage through cohesin rings has been envis...
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines [0.03%]
挖掘CD4抗原谱库用于下一代结核病疫苗的研发
Samuel J Vidal,Ninaad Lasrado,Lisa H Tostanoski et al.
Samuel J Vidal et al.
Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, and Bacillus Calmette-Guérin (BCG) remains the only clinically approved vaccine. An enduring challenge in TB vaccine development is systematic antigen selec...
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV [0.03%]
HIV患者CD8+T细胞免疫代谢缺陷破坏肠道屏障功能
Upasana Das Adhikari,Leah M Froehle,Alexandra N Pipkin et al.
Upasana Das Adhikari et al.
A hallmark of HIV infection is disruption of intestinal barrier integrity that persists in people with HIV (PWH) despite treatment with antiretroviral therapy (ART). This disruption is central to HIV disease progression, yet the causes rema...
Jose A Canovas,Li Wang,Ahmed A M Mohamed et al.
Jose A Canovas et al.
The innate attraction to sweet mediates appetitive and consummatory responses. Here, we dissected the circuit driving responses to sweet and showed that amygdala neurons tuned to sweet connect to the bed nucleus of the stria-terminalis (BNS...
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling [0.03%]
小胶质细胞-星形胶质细胞通过Wnt信号相互作用调节突触重塑
Travis E Faust,Yi-Han Lee,Ciara D O&#x;Connor et al.
Travis E Faust et al.
Astrocytes and microglia are emerging key regulators of activity-dependent synapse remodeling that engulf and remove synapses in response to changes in neural activity. Yet, the degree to which these cells communicate to coordinate this pro...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization [0.03%]
类壳感染颗粒可扩大噬菌体诱导的染色体岛转导的宿主范围
Lingchen He,Jonasz B Patkowski,Jinlong Wang et al.
Lingchen He et al.
Some mobile genetic elements spread among unrelated bacterial species through unknown mechanisms. Recently, we discovered that identical capsid-forming phage-inducible chromosomal islands (cf-PICIs), a new family of phage satellites, are pr...
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution [0.03%]
人工智能镜像实验科学揭示基因转移机制对细菌进化至关重要
José R Penadés,Juraj Gottweis,Lingchen He et al.
José R Penadés et al.
Artificial intelligence (AI) models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging since an AI-generated hypothesis can take decades to validate. Here, we challenge the a...
Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition [0.03%]
基于长读取元基因组的无文化依赖性元泛基因组学揭示了与儿童营养不良的关系
Jeremiah J Minich,Nicholas Allsing,M Omar Din et al.
Jeremiah J Minich et al.
The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enab...
Peng Xie,Juan Shen,Yi Yang et al.
Peng Xie et al.
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial section...