Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain [0.03%]
偏向 Arrestin 结合的神经紧张素受体 1 阿花托剂可缓解急性疼痛和慢性疼痛
Ran Guo,Ouyang Chen,Yang Zhou et al.
Ran Guo et al.
G-protein-biased agonists have been shown to enhance opioid analgesia by circumventing β-arrestin-2 (βarr2) signaling. We previously reported that SBI-553, a neurotensin receptor 1 (NTSR1)-positive allosteric modulator biased toward βarr...
Eitan Erez Zahavi,Indrek Koppel,Riki Kawaguchi et al.
Eitan Erez Zahavi et al.
Neuronal growth and regeneration are regulated by local translation of mRNAs in axons. We examined RNA polyadenylation changes upon sensory neuron injury and found upregulation of a subset of polyadenylated B2-SINE repeat elements, hereby t...
Zhisen Yang,Hong Wei,Yulin Gan et al.
Zhisen Yang et al.
Auxin is crucial in orchestrating diverse aspects of plant growth and development and modulating responses to environmental signals. The asymmetric spatiotemporal distribution of auxin generates local gradient patterns, which are regulated ...
LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs [0.03%]
LoxCode 体内条形码揭示胚胎干细胞向胎儿器官的命运偏向
Tom S Weber,Christine Biben,Denise C Miles et al.
Tom S Weber et al.
Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding for in vivo clonal lineage tracing for bulk tissue and single-cell readout. Embryonic day...
Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development [0.03%]
gastrulation后卵黄囊样胚胎干细胞模型可作为人类胚外组织发育研究的体外模型
Borzo Gharibi,Oliver C K Inge,Irene Rodriguez-Hernandez et al.
Borzo Gharibi et al.
The amnion, an extra-embryonic tissue in mammalian embryos, is thought to provide crucial signaling, structural, and nutritional support during pregnancy. Despite its pivotal importance, studying human amnion formation and function has been...
Maria H Festing,Kubra B Akkaya-Colak,Maria M Mihaylova
Maria H Festing
Several organs undergo changes during pregnancy to accommodate fetal growth, including the small intestine. However, the signals that trigger this intestinal remodeling are not well understood. In a recent study, Ameku et al. describe an an...
Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? [0.03%]
公共宏基因组中的线粒体DNA：机遇还是隐私威胁？
Mohamed S Sarhan,Giacomo Antonello,Hansi Weissensteiner et al.
Mohamed S Sarhan et al.
Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been overlooked and frequently persists. We disc...
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice [0.03%]
嵌合抗原受体T细胞治疗后的免疫疗法相关的认知障碍小鼠模型
Anna C Geraghty,Lehi Acosta-Alvarez,Maria C Rotiroti et al.
Anna C Geraghty et al.
Immunotherapies have revolutionized cancer care for many tumor types, but their potential long-term cognitive impacts are incompletely understood. Here, we demonstrated in mouse models that chimeric antigen receptor (CAR) T cell therapy for...
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity [0.03%]
环二核苷酸诱导的磷脂酶丝状聚合调控广泛的CBASS免疫反应
Jingge Wang,Zhao Li,Hao Lang et al.
Jingge Wang et al.
Cyclic-oligonucleotide-based antiphage signaling systems (CBASS), a widespread antiviral bacterial immune system homologous to the mammalian cGAS-STING pathway, synthesizes cyclic nucleotide signals and triggers effector proteins to induce ...
Robert Frömel,Julia Rühle,Aina Bernal Martinez et al.
Robert Frömel et al.
During cellular differentiation, enhancers transform overlapping gradients of transcription factors (TFs) to highly specific gene expression patterns. However, the vast complexity of regulatory DNA impedes the identification of the underlyi...