Single-cell susceptibility to viral infection is driven by variable cell states [0.03%]
细胞对病毒感染的敏感性由不同的细胞状态驱动
Sam Reffsin,Jesse Miller,Kasirajan Ayyanathan et al.
Sam Reffsin et al.
The ability of a virus to infect a cell is partly determined by host factors required for the viral life cycle. However, not every cell of a given type is equally susceptible to infection. Profiling susceptible subsets of cells could reveal...
Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function [0.03%]
从单细胞到器官的桥梁：介尺度模块作为组织功能的基本单元
Yun Chen,Ronald N Germain,Ginger L Hunter et al.
Yun Chen et al.
Recent studies at molecular and genomic scales have enriched our understanding of life's most fundamental building block: the cell. However, bridging the gap between single-cell phenotypes and the emergent functions of tissues and organs re...
Vera Gorbunova,Andrei Seluanov
Vera Gorbunova
Age-dependent exhaustion of endogenous stem cell pools-and the resulting decline in tissue regeneration and homeostatic maintenance-is a hallmark of organismal aging and age-related pathology. In a study published in Cell, Liu and collabora...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome [0.03%]
贯穿人类蛋白质组的预测内在无序区域的分子语法
Kiersten M Ruff,Matthew R King,Alexander W Ying et al.
Kiersten M Ruff et al.
Intrinsically disordered regions (IDRs) of proteins are defined by molecular grammars. This refers to IDR-specific non-random amino acid compositions and non-random patterning of distinct pairs of amino acid types. Here, we introduce gramma...
Chunyu Wang,Nan Zhang,Yujie Shao et al.
Chunyu Wang et al.
Presynaptic 5-HT1AR autoreceptors predominantly signal through Gi3 protein, mediating feedback inhibition that hampers the therapeutic efficacy of conventional antidepressants. By contrast, postsynaptic heteroreceptors mainly couple to Go, ...
Phase separation to buffer growth-mediated dilution in synthetic circuits [0.03%]
相分离缓释生长介导的稀释以稳定合成线路中的分子浓度
Rong Zhang,Wangfei Yang,Rixin Zhang et al.
Rong Zhang et al.
Fluctuations in host cell growth pose a critical challenge for maintaining reliable function in synthetic gene circuits. Growth-mediated dilution causes a global reduction in circuit component concentrations, which can significantly destabi...
StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models [0.03%]
隐秘的调节因子：一种免疫原性免费的CRISPR平台在免疫健全模型中揭示隐藏的转移调控因素
Massimo Saini,Francesc Castro-Giner,Adriana Hotz et al.
Massimo Saini et al.
CRISPR screens have become standard gene discovery platforms in various contexts, including cancer. Yet commonly available CRISPR-Cas9 tools are increasingly recognized as unfit for in vivo investigations in immunocompetent contexts, due to...
Genome sequences of extant and extinct gibbons reveal their phylogeny, demographic history, and conservation status [0.03%]
现存和灭绝的大猩猩基因组序列揭示了其系统发育、人口历史及保护现状
Sheng Wang,Zehui Chen,Ayun Luo et al.
Sheng Wang et al.
Gibbons (family Hylobatidae), small apes closely related to humans and great apes, remain understudied despite their threatened status. Here, we present extensive genomic resources, including chromosome-level reference genomes, whole-genome...
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction [0.03%]
纵向超高灵敏度ctDNA检测技术在肺癌高分辨率风险预测中的应用
James R M Black,Takahiro Karasaki,Charles W Abbott et al.
James R M Black et al.
Biomarkers accurately informing prognostic assessment and therapeutic strategy are critical for improving patient outcome in oncology. Here, we apply a whole-genome, tumor-informed circulating tumor DNA (ctDNA) detection approach to address...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions [0.03%]
染色质结构单碱基解析绘制染色质交互作用的统合理论模型
Hangpeng Li,James L T Dalgleish,George Lister et al.
Hangpeng Li et al.
Chromatin structure is a key determinant of gene expression in eukaryotes, but it has not been possible to define the structure of cis-regulatory elements at the scale of the proteins that bind them. Here, we generate multidimensional chrom...