Weixu Wang,Zhiyuan Hu,Philipp Weiler et al.
Weixu Wang et al.
Cell fate transitions are driven by regulatory circuitry, yet RNA velocity models cellular dynamics without explicitly accounting for gene regulatory interactions, limiting mechanistic insight. Conversely, gene regulatory network (GRN) infe...
AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology [0.03%]
基于病理学的乳腺癌生物标志物的空间转录组学解锁人工智能预测
Eldad D Shulman,Emma M Campagnolo,Roshan Lodha et al.
Eldad D Shulman et al.
Spatial transcriptomics (ST) assays are transforming our understanding of tumor heterogeneity, but their high cost limits their application in large-scale biomarker discovery. Here, we present "Path2Space," a deep-learning model that predic...
Geraldine Veeckmans,Lene Devos,Nicholas Gilbo et al.
Geraldine Veeckmans et al.
Ischemia-reperfusion injury (IRI) is a major clinical challenge in transplantation, vascular surgeries, myocardial infarction, and stroke. Disruption of energy and redox homeostasis triggers ferroptosis, a regulated, iron-dependent form of ...
Zhanli Wang,Lu Han,Lei Gao et al.
Zhanli Wang et al.
Phytoalexins are core components of plant chemical defense against pathogens. However, the genetic basis and regulatory mechanisms governing their biosynthesis remain preliminary. Debneyol is a well-defined, broad-spectrum fungicidal phytoa...
Streptomyces enrichment in roots during drought is uncoupled from plant benefit and is driven by host suppression of iron uptake and immunity [0.03%]
植株在干旱期间轮枝菌根部富集与其植物益处脱钩，并且由宿主抑制铁吸收和免疫驱动
Connor R Fitzpatrick,Ryker Allen Smith,Junko Hige et al.
Connor R Fitzpatrick et al.
Drought reshapes the plant root microbiota, yet the mechanistic drivers and consequences of this observation remain unclear. We discovered that suppression of host immunity and iron homeostasis is required for Streptomyces enrichment in roo...
Hengchi Chen,Fabricio Almeida-Silva,Garben Logghe et al.
Hengchi Chen et al.
Polyploidy, or whole-genome duplication (WGD), serves as both a significant evolutionary force and a potential evolutionary dead end, particularly among angiosperms. Despite the prevalence of polyploid organisms, instances of ancient polypl...
Jiaming Li,Beier Jiang,Wei Zhang et al.
Jiaming Li et al.
Human aging is characterized by complex structural and functional decline, but quantifying its heterogeneity and assessing biological age remain challenges. We present the mCAS (multicentric Chinese aging standardized cohort) developed from...
Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation [0.03%]
间歇式加速θ爆发刺激的 frontal-insular 回路机制
Shane B Johnson,Devin Rocks,Laura Chalençon et al.
Shane B Johnson et al.
Transcranial magnetic stimulation (TMS) is a widely used neuromodulation treatment for depression, but its mechanisms are poorly understood. Indirect clinical evidence suggests that TMS enhances plasticity within the prefrontal cortical tar...
A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers [0.03%]
血脑屏障样血管阀限制神经内分泌癌的免疫治疗效果
Yiyun Wang,Ailing Zhong,Bo Wang et al.
Yiyun Wang et al.
Small cell lung cancer (SCLC), a highly aggressive neuroendocrine malignancy, exhibits poor response to immunotherapy, and the underlying mechanisms remain unclear. Here, we identify a blood-brain barrier-like vascular gate (BVG) in SCLC, d...
A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation [0.03%]
一种细胞特异性机制驱动经颅磁刺激的快速抗抑郁作用
Michael W Gongwer,Alex Qi,Alexander S Enos et al.
Michael W Gongwer et al.
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for brain disorders, but its therapeutic mechanism is poorly understood. We developed a mouse model of rTMS with superior clinical face validity and investigated t...