The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites [0.03%]
coco这种bmp抑制剂可重新激活乳腺癌的肺转移病灶中的癌细胞
Hua Gao,Goutam Chakraborty,Ai Ping Lee-Lim et al.
Hua Gao et al.
Published Erratum
Cell. 2026 Mar 21:S0092-8674(26)00327-2. DOI:10.1016/j.cell.2026.03.026 2026
Hannah T Tam,Jingyu Peng,Rebecca Freeman et al.
Hannah T Tam et al.
Some mammalian tissues can replace lost cells within one lineage, but organ-level regeneration-restoring diverse cell types across lineages-remains rare. Here, we show that late embryonic full-thickness skin injuries heal by regenerating ep...
The E3-ome gene-centric compendium reveals the human E3 ligase landscape [0.03%]
E3-ome基因中心汇编揭示了人类E3连接酶的全景图谱
Ngee Kiat Chua,Tania J González-Robles,Cameron J Reddington et al.
Ngee Kiat Chua et al.
To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the human genome. The E3-ome integrates experimental data, bioinformatics, and published researc...
An activated wheat CCG10-NLR immune receptor forms an octameric resistosome [0.03%]
活化的 wheat CCG10-NLR 免疫受体形成八聚体抗病小体
Guanghao Guo,He Zhao,Kaihong Bai et al.
Guanghao Guo et al.
Nucleotide-binding, leucine-rich repeat (NLR) receptors are widespread intracellular immune sensors across kingdoms. Plant G10-type coiled-coil (CCG10)-NLRs constitute a distinct phylogenetic clade that remains poorly characterized. Here, w...
Richard Bailleul,Nicolas Cuny,Diana Khoromskaia et al.
Richard Bailleul et al.
How morphological diversity arises from variations in biomechanical processes remains an open question. Although forces shape tissues, how force-generating systems differ across species to create diverse forms is unclear. Here, we combine c...
Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air [0.03%]
可控的人类流感感染揭示了空气中的感染性病毒异质排出现象
Nahara Vargas-Maldonado,Nishit Shetty,Lucas M Ferreri et al.
Nahara Vargas-Maldonado et al.
Influenza virus is transmitted via respiratory expulsions, but detecting infectious virus in expulsions is challenging. Here, we describe quantification and genotyping of infectious virus in respiratory particles using a modular influenza s...
Haikun Song,Wei Wang,Tingfang Mei et al.
Haikun Song et al.
Targeted protein degradation (TPD) technologies provide huge opportunities for drug discovery, but degrading transmembrane (TM) targets remains challenging. Since TM proteins are canonically folded on the endoplasmic reticulum (ER) membrane...
Jiangbo Wei,Chuan He
Jiangbo Wei
RNA is frequently chemically modified, with over 170 types of chemical modifications identified to date in cellular RNAs. These modifications, along with their effector proteins, constitute new layers of gene expression regulation by contro...
Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles [0.03%]
基于构象集合从序列预测RNA的细胞活性熵理论上限
Ainan Geng,Rohit Roy,Megan Ken et al.
Ainan Geng et al.
Despite advances in structure prediction from sequence, predicting cellular activity requires conformational ensembles that capture propensities to form functionally active states. Such ensembles remain difficult to measure and even harder ...
Jacob Parres-Gold,Matthew Levine,Benjamin Emert et al.
Jacob Parres-Gold et al.
Published Erratum
Cell. 2026 Mar 18:S0092-8674(26)00282-5. DOI:10.1016/j.cell.2026.03.015 2026