Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder [0.03%]
脑溶酶体细胞类型蛋白质图谱鉴定出SLC45A1相关疾病是一种溶酶体疾病
Ali Ghoochani,Julia C Heiby,Eshaan S Rawat et al.
Ali Ghoochani et al.
Mutations in lysosomal genes cause neurodegeneration and neuronopathic lysosomal storage disorders (LSDs). Despite their essential role in brain homeostasis, the cell-type-specific composition and function of lysosomes remain poorly underst...
Fibroblasts of disparate developmental origins harbor anatomically variant scarring potential [0.03%]
不同发育起源的成纤维细胞具有不同的解剖学特异性瘢痕形成潜能
Michelle F Griffin,Dayan J Li,Kellen Chen et al.
Michelle F Griffin et al.
Progress toward anti-scarring therapies has been hampered by our limited understanding of fibroblast populations underlying fibrotic vs. regenerative healing. The site-dependent fibroblast heterogeneity acquired during development points to...
Establishing the relationship between brain cellular senescence and brain structure [0.03%]
建立大脑细胞衰老与大脑结构之间的关系
Anina N Lund,Brian H Kopell,Negar Golestani et al.
Anina N Lund et al.
Cellular senescence and brain atrophy are both associated with brain aging, suggesting these processes may share underlying biological mechanisms. This study investigated these mechanisms by integrating structural neuroimaging with gene and...
Mammalian genome writing: Unlocking new length scales for genome engineering [0.03%]
哺乳动物基因组写入：解锁新的尺度以进行基因组工程
Sudarshan Pinglay,John T Atwater,Ran Brosh et al.
Sudarshan Pinglay et al.
The ability to design and engineer mammalian genomes across arbitrary length scales would transform biology and medicine. Such capabilities would enable the systematic dissection of mechanisms governing gene regulation and the influence of ...
Alejandro De Los Angeles,Tim Bayne,Nissim Benvenisty et al.
Alejandro De Los Angeles et al.
Human stem-cell-based embryo models (SCBEMs) imperfectly mimic some-but not all-features of early human development. Yet as these models become increasingly sophisticated, they raise important ethical and regulatory questions. Despite their...
Discoveries beyond molecular mimicry describe how EBV drives multiple sclerosis [0.03%]
超出分子模拟的发现揭示了EB病毒如何驱动多发性硬化症的发展
Lawrence Steinman,Scott S Zamvil
Lawrence Steinman
In the current issue of Cell, three papers describe new mechanistic information about how EBV transforms B cells to become antigen-presenting cells in the brain that drive demyelinating disease.1,2,3. ...
Aaron Kilgallon,Rafael Tubelleza,Arutha Kulasinghe
Aaron Kilgallon
Multiplex immunofluorescence proteomics is a powerful method in spatial biology to decipher cell types, states, and architecture in tissues. In this issue of Cell, Valanarasu et al. develop GigaTIME, an expansive population-scale analysis o...
Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2 [0.03%]
人嗅觉受体OR6A2中气味分子的可逆共价连接的结构解码
Tian Wang,Yiran Wu,Ling Wang et al.
Tian Wang et al.
Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II OR, selectively senses medium-chain aldeh...
Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors [0.03%]
关于游离脂肪酸嗅觉受体的II类嗅觉受体介导的游离脂肪酸气味检测机制的新见解
Xiang Han,Ming-Hui Zhang,Nai-Kang Rong et al.
Xiang Han et al.
Smell is one of the fundamental senses mediated by thousands of odorant receptors (ORs). How hydrophobic and volatile odor molecules are recognized by class II ORs remains elusive. Here, we present cryo-electron microscopy (cryo-EM) structu...
Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target [0.03%]
识别出Or5v1/Olfr110为氧化脂素受体和抗肥胖靶点
Xiao-Yan Ge,Jie Cheng,Li-Jun Zhang et al.
Xiao-Yan Ge et al.
Oxylipins are important metabolic messengers for normal life activities, and olfactory receptors (ORs) are known for their low affinity for odor and are not considered oxylipin receptors. By developing the "anonymous receptor identification...