Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases [0.03%]
核点蛋白形成内在的和MALAT1依赖性的微相分离现象
Min Kyung Shinn,Dylan T Tomares,Vicky Liu et al.
Min Kyung Shinn et al.
Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific sequence grammars. Such proteins include serine/arginine-rich splicing factors (SRSFs) and tr...
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense [0.03%]
dendritic细胞调节淋巴结中的固有适应性平衡以实现最佳宿主防御
Jessica Y Huang,Michael Y Gerner
Jessica Y Huang
Lymph nodes (LNs) enable innate defense to limit pathogen dissemination while also driving adaptive immunity. Yet, certain innate responses can restrict adaptive processes, suggesting that these must be tightly regulated. Here, we report th...
Gut microbiota promotes immune tolerance at the maternal-fetal interface [0.03%]
肠道微生物群促进母胎界面上的免疫耐受性
Julia A Brown,Mohammed Amir,Shui Yu et al.
Julia A Brown et al.
Immune tolerance at the maternal-fetal interface (MFI) is required for fetal development. Excessive maternal interferon-gamma (IFN-γ) and interleukin-17 (IL-17) are linked to pregnancy complications, but the regulation of maternal IFN-γ a...
Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma [0.03%]
靶向TFAP2β凝聚可抑制食管鳞癌发展
Zhaomin Deng,Lu Pu,Kai Deng et al.
Zhaomin Deng et al.
Exploring targeted therapies for esophageal squamous cell carcinoma (ESCC) remains challenging. Although investigating the roles and therapeutic applications of liquid-liquid phase separation (LLPS) is increasingly of interest, its relation...
Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain [0.03%]
发育哺乳动物大脑中神经元和免疫细胞动态的在体观察
Zhen Long,Yongzhen Yu,Chenyi He et al.
Zhen Long et al.
The mammalian brain contains diverse neuronal and immune cell types that exhibit dynamic motions in response to distinct extracellular environments. However, technical limitations make it difficult to investigate complex cellular motions in...
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons [0.03%]
肠神经元的体内转录组、功能、回路和转化分析
Claire J Millett,James J Shaver,Bernadette Bracken et al.
Claire J Millett et al.
Enteric neurons (ENs) are interwoven into the gastrointestinal (GI) tract, where they integrate local and external information to coordinate gut function across diverse cell types. Since EN dysfunction underlies the pathophysiology of multi...
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses [0.03%]
mRNA疫苗的不同成分协同指导有效的生发中心反应
Diana Castaño,Emily Bettini,Binod Kumar et al.
Diana Castaño et al.
Nucleoside-modified messenger RNA (mRNA) vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cell differentiation. The lipid nanoparticles (LNPs) of mRNA vaccines possess inherent adjuvant activi...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion [0.03%]
黑色素瘤细胞通过输出人类白细胞抗原来诱骗细胞毒性T细胞以促进免疫逃逸
Yoav Chemla,Orit Itzhaki,Stav Melamed et al.
Yoav Chemla et al.
While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by mela...
The neutrophil collective [0.03%]
中性粒细胞集体行为
Iván Ballesteros,Andrés Hidalgo
Iván Ballesteros
More than a century after their discovery, neutrophils continue to puzzle immunologists. Their remarkable migratory, cytotoxic, phagocytic, and degranulating capacities gave rise to the traditional perception that they are dedicated microbe...
Are ultrasensitive ctDNA assays ready for clinical use in early-stage NSCLC? [0.03%]
超灵敏ctDNA检测在早期NSCLC中临床应用的准备就绪了吗？
Sam Khan,Janice J N Li,Natasha B Leighl
Sam Khan
Disease recurrence in early-stage non-small cell lung cancer (NSCLC) remains a persistent clinical challenge, underscoring the need for better prognostic biomarkers. In this preview, we highlight the clinical implications of ultrasensitive ...