Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy [0.03%]
能量平衡的脑控制：减肥药物治疗的启示
Valdemar Brimnes Ingemann Johansen,Jonas Petersen,Jens Lund et al.
Valdemar Brimnes Ingemann Johansen et al.
Despite the evolution of hardwired homeostatic mechanisms to balance food intake with energy needs, the obesity epidemic continues to escalate globally. However, recent breakthroughs in delineating the molecular signaling pathways by which ...
Olena Didenko,John N Wood
Olena Didenko
In this issue of Cell, Ji and colleagues describe the development of SBI-810, a β-arrestin-biased modulator of neurotensin receptor 1 (NTSR1). This compound provides potent analgesia in rodent models of acute and chronic pain without side ...
iPSC-derived CAR-NK cells: Off-the-shelf cellular therapy for systemic sclerosis [0.03%]
基于iPSC的CAR-NK细胞：系统性硬化症的现货型细胞疗法
May Daher,Katayoun Rezvani
May Daher
Chimeric antigen receptor (CAR) T cell therapy has opened new possibilities for patients with refractory autoimmune diseases such as systemic sclerosis, but personalized manufacturing and treatment-related toxicities limit its broader use. ...
Highly conserved Betacoronavirus sequences are broadly recognized by human T cells [0.03%]
高度保守的贝塔冠状病毒序列被人类T细胞广泛识别
Tertuliano Alves Pereira Neto,Christian Zmasek,Liliana Avalos et al.
Tertuliano Alves Pereira Neto et al.
The COVID-19 pandemic highlighted the critical need for vaccine strategies capable of addressing emerging viral threats. Betacoronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome...
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation [0.03%]
复合组蛋白修饰的转座子通过RNA依赖的方式发挥作用并调节细胞命运
Ziqiang Zhou,Shicong Zhu,Yaqiang Hong et al.
Ziqiang Zhou et al.
Discrete genomic units can recombine into composite transposons that transcribe and transpose as single units, but their regulation and function are not fully understood. We report that composite transposons harbor bivalent histone marks, w...
Ju-Chan Park,Heesoo Uhm,Yong-Woo Kim et al.
Ju-Chan Park et al.
The prime editing (PE) system consists of a Cas9 nickase fused to a reverse transcriptase, which introduces precise edits into the target genomic region guided by a PE guide RNA. However, PE efficiency is limited by mismatch repair. To over...
Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales [0.03%]
迭代重组酶技术实现从千碱基到百万碱基数尺度的高效精准基因组编辑
Chao Sun,Hongchao Li,Yijing Liu et al.
Chao Sun et al.
Genome editing technologies face challenges in achieving precise, large-scale DNA manipulations in higher organisms, including inefficiency, limited editing scales and types, and the retention of undesired sequences such as recombination si...
Ruonan Di,Qianqian Du,Yuhua Xie et al.
Ruonan Di et al.
The transition from water to land required animals to evolve specialized paw skin to support body weight and enable locomotion. We identify an evolutionarily emerged mechanism in skin epithelial cells that adapts to this mechanical demand. ...
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience [0.03%]
阿尔茨海默病进展和认知韧性的单细胞多区域表观基因组重构
Zunpeng Liu,Shanshan Zhang,Benjamin T James et al.
Zunpeng Liu et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, yet its epigenetic underpinnings remain elusive. Here, we generate and integrate single-cell epigenomic and transcriptomic profiles of ...
Design of soluble Notch agonists that drive T cell development and boost immunity [0.03%]
可溶性Notch激动剂的设计用于驱动T细胞发育和增强免疫反应
Rubul Mout,Ran Jing,Mayuri Tanaka-Yano et al.
Rubul Mout et al.
The rational design of receptor agonists to control cell signaling is an emerging strategy for developing disease therapeutics. Creating a soluble cytokine-like agonist for the Notch receptor, which regulates cell fate in embryonic and adul...