Shuai He,Chun-Ling Luo,Tao Luo et al.
Shuai He et al.
The second trimester of pregnancy is a pivotal stage in human immune system development. Utilizing single-cell RNA sequencing and T cell receptor sequencing, we profiled 2,868,420 immune cells from 321 samples across 23 organs, including ad...
Unveiling conformation-selective regulation of the norepinephrine transporter [0.03%]
解开去甲肾上腺素转运蛋白的构象选择性调节机制
Heng Zhang,Tianwei Zhang,Dingyan Wang et al.
Heng Zhang et al.
The norepinephrine transporter (NET) plays a crucial role in synaptic neurotransmission and is implicated in major depression and attention-deficit/hyperactivity disorders, yet our understanding of its allosteric, conformation-selective reg...
Protein restriction reprograms the multi-organ proteomic landscape of mouse aging [0.03%]
蛋白质限制重塑了小鼠衰老过程中的多器官蛋白质组景观
Tian Lu,Yuting Xie,Yingrui Wang et al.
Tian Lu et al.
Population aging is accelerating, yet the multi-organ aging process and the geroprotective effects of dietary protein restriction (PR) remain poorly understood. Here, we conducted comprehensive proteomic analyses on 41 mouse tissues during ...
Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance [0.03%]
癌细胞劫持器官间神经免疫回路以逃避免疫监控
Yu Zhang,Yibo Guo,Zheqi Liu et al.
Yu Zhang et al.
Whether and how cancer exploits distant organs to escape immune surveillance remains largely unknown. Using clinical data from head and neck squamous cell carcinoma (HNSCC) patients and three murine oral cancer models, we find that cancer c...
Adrenergic signaling coordinates distant and local responses to amputation in axolotl [0.03%]
肾上腺素信号整合了墨西哥钝头螈肢体再生的远端和近端反应
Duygu Payzin-Dogru,Tim Froitzheim,Steven J Blair et al.
Duygu Payzin-Dogru et al.
Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. He...
Lina Wang,Qiaoling Liu,Siru Li et al.
Lina Wang et al.
Detection of DNA is a fundamental strategy for life to recognize non-self or abnormal-self to subsequently trigger the downstream responses. However, the mechanism underlying DNA sensing is incompletely understood. Here, we show that a key ...
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2 [0.03%]
SARS-CoV-2同时存在模板循环和RNA加帽的结构基础
Liming Yan,Yucen Huang,Yixiao Liu et al.
Liming Yan et al.
In the SARS-CoV-2 replication-transcription complex (RTC), the nascent template-product duplex is unwound into a template strand for recycling and a product strand that needs to be capped. Here, we determined structures of the SARS-CoV-2 RT...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome [0.03%]
泛修饰谱分析促进热调节的核糖体表转录组的跨进化解析
Miguel A Garcia-Campos,Joe Georgeson,Ronit Nir et al.
Miguel A Garcia-Campos et al.
Ribosomal RNA (rRNA) constitutes the core of ribosomes and is extensively chemically modified. Technical challenges have precluded systematically dissecting rRNA modifications and their dynamics. We develop Pan-Mod-seq, permitting inference...
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success [0.03%]
肿瘤微环境的腔隙结构促进CD8+T细胞浸润并预测免疫治疗效果
Aya Ludin,Georgia L Stirtz,Asaf Tal et al.
Aya Ludin et al.
T cell-mediated tumor killing underlies immunotherapy success. Here, we used long-term in vivo imaging and high-resolution spatial transcriptomics of zebrafish endogenous melanoma, as well as multiplex imaging of human melanoma, to identify...
Chen Zhou,Huican Li,Jiaxing Wang et al.
Chen Zhou et al.
Design of ion channels responsive to environmental cues has significant implications in modulating cellular activities and sensor development, but it remains a significant challenge due to the complexities involved in designing stimuli-indu...