Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation [0.03%]
加速间歇θ爆发刺激的 frontal-insular 回路机制
Shane B Johnson,Devin Rocks,Laura Chalençon et al.
Shane B Johnson et al.
Published Erratum
Cell. 2026 May 29:S0092-8674(26)00580-5. DOI:10.1016/j.cell.2026.05.021 2026
A causal link between autoantibodies and neurological symptoms in long COVID [0.03%]
长新冠患者自身抗体与神经症状之间存在因果关系
Keyla Santos Guedes de Sá,Julio Silva,Rafael Bayarri-Olmos et al.
Keyla Santos Guedes de Sá et al.
Acute SARS-CoV-2 infection triggers the de novo production of diverse, functional autoantibodies (AABs) that remain elevated in long COVID (LC), but their pathogenic role remains unclear. Using tissue-based immunofluorescence, ELISA, human ...
Jinlong Y Lu,William B Tu,Shuai Ma et al.
Jinlong Y Lu et al.
Aging is characterized by the loss of tissue homeostasis, traditionally captured by the hallmarks of aging, yet how these hallmarks integrate to drive organismal decline remains unresolved. We propose mesenchymal drift, a process in which c...
B cells just got a workout [0.03%]
B细胞锻炼一下
Maria E Moreno-Fernandez,Senad Divanovic
Maria E Moreno-Fernandez
In this issue of Cell, Mao et al. reveal that B cells play an unexpected, immune-independent role in exercise physiology by facilitating multi-organ communication. Secreting TGF-β1, they transcriptionally reprogram hepatic glutamine metabo...
Autoantibodies in long COVID: A mechanistic foothold in a heterogeneous disease [0.03%]
长期新冠中的自身抗体：在异质性疾病中寻找机制切入点
Emma C Wall,Alex G Richter
Emma C Wall
Long COVID is a heterogeneous, multi-system disease that poses challenges for patients, health systems, and economies. Two papers in Cell and Cell Reports Medicine from independent groups suggest that autoantibodies in a subset of long COVI...
Per Uhlén
Per Uhlén
Two studies in this issue of Cell, by Bintu et al. and Brann et al., overturn the long-standing zonal model of olfactory receptor organization. Using image-based spatial transcriptomics, they reveal that receptors occupy reproducible positi...
Farnesylation-driven KRAS phase separation promotes colon tumor growth [0.03%]
牻牛儿酰化驱动的KRAS相分离可促进结肠肿瘤生长
Xingwen Wang,Yi Zhang,Minqiao Lu et al.
Xingwen Wang et al.
Kirsten Rat Sarcoma viral oncogene homolog (KRAS) is one of the most frequently activated driver genes across human cancers. We identified a regulatory mechanism where KRAS forms condensates in the cytoplasm through liquid-liquid phase sepa...
Dan Yue,Gangyu Sun,Yunlong Cao et al.
Dan Yue et al.
Recognition of Wnt proteins by Frizzled (Fzd) receptors and the low-density lipoprotein receptor-related protein 5/6 (LRP5/6) co-receptor is essential for canonical Wnt signaling. It remains enigmatic how Wnt simultaneously interacts with F...
Uncovering spatially resolved functional genomics with CRISPR screen sequencing [0.03%]
具有CRISPR筛选测序的时空分辨功能基因组学研究
Haorui Zhang,Zongxu Zhang,Peiyu Wang et al.
Haorui Zhang et al.
Spatial omics has advanced our understanding of tissue-level biology, yet tools to systematically link gene functional perturbations to spatial phenotypes and signaling pathways remain limited. To address this, we developed spatial CRISPR s...
TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy [0.03%]
TPPP/p25淀粉样蛋白作为多系统萎缩的特异性生物标志物的作用
Shuyi Zeng,Shenqing Zhang,Shengnan Zhang et al.
Shuyi Zeng et al.
Detection of α-synuclein (α-syn) amyloid seeds in human biofluids has attracted great interest for clinical diagnosis of synucleinopathies. However, as a common biomarker, α-syn lacks specificity in reliably differentiating distinct diso...