Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models [0.03%]
封装线粒体的移植可缓解线粒体和帕金森氏病模型的小肠缺血再灌注损伤及功能障碍
Shiwei Du,Qi Long,Yanshuang Zhou et al.
Shiwei Du et al.
Mitochondrial transplantation holds significant potential for the treatment of mitochondrial diseases. However, how to efficiently deliver exogenous mitochondria to somatic cells or tissues remains unresolved. We present a mitochondrial tra...
Four centuries of commercial whaling eroded 11,000 years of population stability in bowhead whales [0.03%]
四百年商业捕鲸活动破坏了波弗特鲸鱼一万一千年的种群稳定性
Michael V Westbury,Stuart C Brown,Andrea A Cabrera et al.
Michael V Westbury et al.
Bowhead whales were heavily exploited during commercial whaling between the 16th and 20th centuries. Current and near-future climate warming poses a new threat. Assessing bowhead vulnerability to climatic change remains challenging due to i...
Tadashi Yamamuro,Daisuke Katoh,Guilherme Martins Silva et al.
Tadashi Yamamuro et al.
Mitochondria provide a variety of metabolites, in addition to ATP, to meet cell-specific needs. One such metabolite is phosphoenolpyruvate (PEP), which contains a higher-energy phosphate bond than ATP and has diverse biological functions. H...
Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes [0.03%]
基于深度学习的从头发现和设计疗法以逆转与疾病相关的转录表型
Jing Xing,Mingdian Tan,Dmitry Leshchiner et al.
Jing Xing et al.
Identifying drugs that reverse disease-associated transcriptomic features has been widely explored for drug repurposing, but its potential for de novo drug discovery remains underexplored. Here, we present gene expression profile predictor ...
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons [0.03%]
功能RNA切割驱动了V型CRISPR- Cas系统从转座子中进化产生
Shuai Jin,Zixu Zhu,Yunjia Li et al.
Shuai Jin et al.
Published Erratum
Cell. 2026 Mar 17:S0092-8674(26)00281-3. DOI:10.1016/j.cell.2026.03.014 2026
Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy [0.03%]
基于多能干细胞的筛选发现西地那非可治疗线粒体疾病
Annika Zink,Dao-Fu Dai,Annika Wittich et al.
Annika Zink et al.
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS), causing psychomotor regression and metabolic crises. To accelerate drug d...
Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain [0.03%]
衰老小鼠大脑中细胞类型特异性转座子去甲基化和TAD重塑
Qiurui Zeng,Wenliang Wang,Wei Tian et al.
Qiurui Zeng et al.
Aging is a major risk factor for neurodegenerative diseases, yet the underlying epigenetic mechanisms remain unclear. Here, we generated a comprehensive single-nucleus cell atlas of brain aging across multiple brain regions, comprising 132,...
Human-specific features of the cerebellum and ZP2-regulated synapse development [0.03%]
ZP2调控的突触发育及小脑的特有人类特征
Suel-Kee Kim,Adriana Cherskov,Aastha Sindhwani et al.
Suel-Kee Kim et al.
Understanding the unique features of the human brain compared with non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the evolutionary development of human ada...
Wei Qian,Xiaoqin Wei,Andrew J Barros et al.
Wei Qian et al.
The COVID-19 pandemic has highlighted the long-term consequences of viral pneumonia, yet its impact on cancer development remains unclear. Here, we show that patients previously hospitalized with severe COVID-19 have an increased risk of su...
Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility [0.03%]
肠道微生物产生的烟酸控制结肠区域特征和损伤易感性
Jérémie Rispal,Jasmine R Garcia,Brisa Palikuqi et al.
Jérémie Rispal et al.
The regionalized structure of the intestinal epithelium is critical for its function, and the risk for certain diseases has a regional bias. However, how regionalization is established and how it influences disease susceptibility remain poo...