Transplanting light-dependent reactions for mammalian eye photosynthesis [0.03%]
移植光依赖反应以用于哺乳动物眼睛的光合作用
Kuoran Xing,Yan Yan,Ziyu Zhu et al.
Kuoran Xing et al.
Mammalian eyes are exposed to visible light but cannot perform photosynthesis. Here, we show that introducing a nanoscale, structurally and functionally preserved thylakoid system, LEAF (light-reaction enriched thylakoid NADPH-foundry), int...
Cell-autonomous control of CAR signaling and receptor shedding via ADAM17-mediated proteolysis [0.03%]
ADAM17介导的蛋白水解对CAR信号转导和受体脱落的自主控制
Jeremy R Bjelajac,Adrià Cañellas-Socias,Preeti Nehra et al.
Jeremy R Bjelajac et al.
We sought to endow T cell autonomous regulation of cell surface protein expression by exploiting the conditional proteolytic activity of ADAM17 following T cell activation. Screening of canonical ADAM17 substrates yielded a minimal 15-aa CD...
Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models [0.03%]
封装线粒体的移植可缓解线粒体疾病和帕金森病模型小鼠的功能障碍
Shiwei Du,Qi Long,Yanshuang Zhou et al.
Shiwei Du et al.
Published Erratum
Cell. 2026 May 14:S0092-8674(26)00521-0. DOI:10.1016/j.cell.2026.05.004 2026
A comparison of deep multiomics profiles across ethnicity, geography, and age [0.03%]
跨种族、地理位置和年龄段的深度多组学谱系比较
Nasim Barapour,John Z Cao,Yue Wu et al.
Nasim Barapour et al.
Despite extensive research, molecular differences in human populations and the influence of ancestry, age, geography, and diet are poorly understood. We performed comprehensive multiomics profiling (including genomics, transcriptomics, prot...
Comparative Study
Cell. 2026 May 14;189(10):3004-3024.e35. DOI:10.1016/j.cell.2026.04.032 2026
Navigating the clinical progress of antibody-drug conjugates: Emerging opportunities and remaining challenges [0.03%]
抗体偶联药物的临床进展及其面临的机遇与挑战
Louise Conilh,Virginia Metrangolo,Silvia Crescioli et al.
Louise Conilh et al.
Antibody-drug conjugates are among the fastest-growing anticancer therapies, delivering potent payloads directly to tumor cells with improved safety across hematologic and solid tumors. This review focuses on their biology and where the fie...
Alexandra E Jerrett,Nicolai R Hathiramani,Jessica B Spinelli
Alexandra E Jerrett
Mitochondria generate phosphoenolpyruvate (PEP), although its export mechanism and physiological roles were unknown. In this issue of Cell, Kajimura and colleagues identify SLC25A35 as the mitochondrial PEP exporter and uncover a previously...
Ayesha Umair,Alexander P Hynes
Ayesha Umair
Bacterial viruses can send and receive signals to inform critical decisions. In this issue of Cell, Manley et al. and Gallego-del-Sol et al. independently identify crosstalk between bacterial viruses, leading us to wonder what the informati...
This is IT: How accelerated intermittent theta burst stimulation relieves depression symptoms [0.03%]
这才是IT：加速间歇θ爆发刺激如何缓解抑郁症状
Morteza Salimi,Dhakshin S Ramanathan
Morteza Salimi
In this issue of Cell, Gongwer et al.1 and Johnson et al.2 identify the plasticity of intratelencephalic (IT) neuronal projections to anterior insula as a central substrate mediating the antidepressant effects of accelerated intermittent th...
Discovery and heterologous reconstitution of a plant noncanonical quasi-circadian gene regulatory network [0.03%]
植物非经典准昼夜基因调控网络的发现与异源重构
Shuyu Wang,Yanning Su,Yufeng Xu et al.
Shuyu Wang et al.
Circadian rhythms are mainly generated by a gene regulatory network (GRN) constituted by transcription factors (TFs). Comparisons between plant and mammalian circadian clock GRNs suggest conservation of the network architecture rather than ...
Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects [0.03%]
基于图像的汇集表型分析揭示了多维度的疾病特异性变异效应
Sriram Pendyala,Katie Partington,Nicholas Bradley et al.
Sriram Pendyala et al.
Genetic variants produce complex phenotypic effects that confound current assays and predictive models. We developed variant in situ sequencing (VIS-seq), a pooled, image-based method measuring variant effects on molecular and cellular phen...