The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM [0.03%]
CAR-T细胞治疗后复发的胶质母细胞瘤中内源性免疫区室的关键作用
Nelson F Freeburg,Daniel Chafamo,Gayathri Konanur Gopikrishna et al.
Nelson F Freeburg et al.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median survival of under 15 months and no effective treatment after recurrence. A recent phase 1 trial of intracerebroventricular bivalent chimeric antige...
Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK [0.03%]
桥状蛋白VPS13A介导的脂质转运机制及其与翻转酶XK的合作关系
Bodan Hu,Daniel Álvarez,Cristian Rocha-Roa et al.
Bodan Hu et al.
In eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer between organelles. BLTPs span the cytosolic space between organelles at contact sites, featuring hydrophobic channels fo...
Two distinct causes contribute to the low efficiency of human pre-implantation development [0.03%]
两种不同的原因导致人类植入前胚胎发育效率低下
Zixuan Li,Lizhi Leng,Jinglei Zhai et al.
Zixuan Li et al.
∼50% of fertilized eggs arrest during human pre-implantation development, representing a major bottleneck for assisted reproductive technology. The underlying causes remain controversial. By imaging ∼150 live human and monkey fertilized e...
Nuclear proteome reveals microtubule-associated protein regulating fate and disease [0.03%]
核蛋白组学揭示了调节命运和疾病的微管相关蛋白
Florencia Merino,Lucas Miranda,Aparajita Kumar et al.
Florencia Merino et al.
Cellular differentiation and morphogenesis require the coordination between cytoskeletal remodeling and transcriptional programs, raising the question of how cytoskeletal information is conveyed to the nucleus. Here, we profile the nuclear ...
Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine [0.03%]
抗癌剂cephalotaxinone和homoerythratine的全合成
Runze Tian,Feifan Lin,Nianxin Guo et al.
Runze Tian et al.
Cephalotaxine-type and homoerythrina-type alkaloids are structurally unique and biologically important natural products isolated from endangered species that belong to the genus Cephalotaxus. Among them, homoharringtonine (HHT [1]) is a mar...
Transposable element DNA and RNA: Drivers of gene expression, evolution, and disease [0.03%]
可移动元件的DNA和RNA：基因表达、进化及疾病驱动因素
Jessica Sook Yuin Ho,Christopher H Douse,Ivan Marazzi
Jessica Sook Yuin Ho
Transposable elements (TEs) comprise nearly half of mammalian genomes and have shaped genome architecture, chromatin organization, and transcriptional landscapes. Thanks to recent advances in long-read sequencing and functional (epi)genomic...
Lu Tian,Yinqing Li
Lu Tian
RNA velocity can predict the direction of cell-state change, but the regulatory programs shaping these changes remain difficult to identify. In this issue of Cell, Wang et al. introduce RegVelo, a framework that integrates gene regulatory n...
Catching waves of polyploids [0.03%]
捕捉多倍体的浪潮
Jeff J Doyle
Jeff J Doyle
In this issue of Cell, Chen et al. analyze angiosperm genomes to map whole-genome duplication events, revealing non-random waves of polyploidy linked to climatic shifts and periods of low diversity. They suggest polyploids may have preferen...
Melanie Grusdat,Dirk Brenner
Melanie Grusdat
T cells live or die by their metabolism, yet one nutrient can serve very different ends. In this issue of Cell, Kelly et al. show that cysteine's sulfur is partitioned between glutathione and iron-sulfur cluster synthesis. This routing driv...
Vidyani Suryadevara,Negin Farzad,Mingyu Yang et al.
Vidyani Suryadevara et al.
Cellular senescence comprises diverse cell states emerging across human tissues during aging and disease. Integrating single-cell and spatial multi-omics with AI-driven analyses enables systematic mapping of senescent cell heterogeneity ("s...