Per Uhlén
Per Uhlén
Two studies in this issue of Cell, by Bintu et al. and Brann et al., overturn the long-standing zonal model of olfactory receptor organization. Using image-based spatial transcriptomics, they reveal that receptors occupy reproducible positi...
Farnesylation-driven KRAS phase separation promotes colon tumor growth [0.03%]
牻牛儿酰化驱动的KRAS相分离可促进结肠肿瘤生长
Xingwen Wang,Yi Zhang,Minqiao Lu et al.
Xingwen Wang et al.
Kirsten Rat Sarcoma viral oncogene homolog (KRAS) is one of the most frequently activated driver genes across human cancers. We identified a regulatory mechanism where KRAS forms condensates in the cytoplasm through liquid-liquid phase sepa...
Dan Yue,Gangyu Sun,Yunlong Cao et al.
Dan Yue et al.
Recognition of Wnt proteins by Frizzled (Fzd) receptors and the low-density lipoprotein receptor-related protein 5/6 (LRP5/6) co-receptor is essential for canonical Wnt signaling. It remains enigmatic how Wnt simultaneously interacts with F...
Uncovering spatially resolved functional genomics with CRISPR screen sequencing [0.03%]
具有CRISPR筛选测序的时空分辨功能基因组学研究
Haorui Zhang,Zongxu Zhang,Peiyu Wang et al.
Haorui Zhang et al.
Spatial omics has advanced our understanding of tissue-level biology, yet tools to systematically link gene functional perturbations to spatial phenotypes and signaling pathways remain limited. To address this, we developed spatial CRISPR s...
TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy [0.03%]
TPPP/p25淀粉样蛋白作为多系统萎缩的特异性生物标志物的作用
Shuyi Zeng,Shenqing Zhang,Shengnan Zhang et al.
Shuyi Zeng et al.
Detection of α-synuclein (α-syn) amyloid seeds in human biofluids has attracted great interest for clinical diagnosis of synucleinopathies. However, as a common biomarker, α-syn lacks specificity in reliably differentiating distinct diso...
Harnessing citizen science to contextualize adaptation mechanism discovery [0.03%]
利用公民科学发掘并诠释适应机制的调控模式
Laura E Tibbs-Cortes,Linqian Han,Jeremy B Jewell et al.
Laura E Tibbs-Cortes et al.
Species occupying broad geographic regions have evolved multiple mechanisms to regulate phenological characteristics, enabling adaptations to diverse native habitats. By developing computer vision AI to process citizen science observations ...
Scavenger receptor class F member 2 is an intracellular receptor for hepatitis B virus [0.03%]
肝炎B病毒的胞内受体FHRL2的鉴定
Cong Li,Yixue Wang,Rui Xiong et al.
Cong Li et al.
Hepatitis B virus (HBV) infects hepatocytes by specific binding to the cell-surface receptor-sodium taurocholate cotransporting polypeptide (NTCP)-through the preS1 region of its large envelope protein, followed by a less well-understood tr...
Genome instability triggers intercellular DNA transfer between human cells [0.03%]
基因不稳定触发人细胞间的细胞间DNA转移
Elizabeth G Maurais,Alice Mazzagatti,Yu-Fen Lin et al.
Elizabeth G Maurais et al.
The mammalian genome is safeguarded within the confines of the interphase nucleus. However, genomic instability can trigger the mislocalization of nuclear DNA to the cytoplasm within micronuclei or as fragmented chromosomes. Beyond activati...
Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer [0.03%]
伤害性感觉神经限制三级淋巴组织以促进肺癌发展
Ya-Hsuan Ho,Giacomo Bregni,Marco Stazi et al.
Ya-Hsuan Ho et al.
Sensory innervation regulates lung physiology and pathology, but its role in lung cancer is poorly understood. We show that lung adenocarcinoma (LUAD) progression locally amplifies nociceptive sensory innervation and activation, which drive...
The temporal architecture of the seminiferous epithelial cycle revealed by spatial transcriptomics [0.03%]
空间转录组学揭示了生精上皮周期的时空架构
Arun Chakravorty,Jina Yun,Henry Amrhein et al.
Arun Chakravorty et al.
Spermatogenesis features the seminiferous epithelial cycle, a periodic progression of germ-cell differentiation along the seminiferous tubules. Using seqFISH+ spatial transcriptomics, we profiled 2,653 genes in 867,062 mouse testis cells, r...