Coalescing single-cell genomes and transcriptomes to decode breast cancer progression [0.03%]
融合单细胞基因组和转录组以破译乳腺癌的进展
Kaile Wang,Rui Ye,Shanshan Bai et al.
Kaile Wang et al.
Understanding epithelial lineages of breast cancer and genotype-phenotype relationships requires direct measurements of the genome and transcriptome of the same single cells at scale. To achieve this, we developed wellDR-seq, a high-genomic...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views [0.03%]
重新思考RNA结合蛋白：核糖调节改变了以往的观点
Matthias W Hentze,Pia Sommerkamp,Venkatraman Ravi et al.
Matthias W Hentze et al.
RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as the ribosome and the spliceosome. Around 1,000 RBPs account for these functions in mammalia...
Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction [0.03%]
通过BBM-BAR1重编程小孢子命运实现高效的体内单倍体诱导
Ce Shi,Zifu Zhao,Yicheng Zhong et al.
Ce Shi et al.
Haploid induction (HI) through stress-treated microspore culture has gained significant attention for over half a century, yet the molecular mechanism underlying microspore fate transition for androgenesis remains poorly understood. Here, w...
Tumors hijack macrophages for iron supply to promote bone metastasis and anemia [0.03%]
肿瘤劫持巨噬细胞铁供应以促进骨转移和贫血发生
Yujiao Han,Hirak Sarkar,Zhan Xu et al.
Yujiao Han et al.
Bone marrow is both a primary site for hematopoiesis and a fertile niche for metastasis. The mechanism of the common occurrence of anemia among patients with bone metastasis remains poorly understood. Here, we show that a specialized popula...
Yajun Li,Runhui Li,Junzhong Shang et al.
Yajun Li et al.
How evolution builds genes, how these genes attain enhanced expression, and how they integrate into existing regulatory networks to drive phenotypic diversification are all fascinating questions. Here, we generated chromosome-level genome a...
Benjamin Guinet,Nikolay Oskolkov,Kelsey Moreland et al.
Benjamin Guinet et al.
Ancient genomic studies have extensively explored human-microbial interactions, yet research on non-human animals remains limited. In this study, we analyzed ancient microbial DNA from 483 mammoth remains spanning over 1 million years, incl...
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution [0.03%]
Stereo-seq V2：以高分辨率在FFPE切片上进行总RNA的空间绘制
Yu Zhao,Young Li,Ying He et al.
Yu Zhao et al.
Performing total RNA profiling on formalin-fixed, paraffin-embedded (FFPE) samples, the predominant sample conservation method in clinical practice, remains challenging for current spatial transcriptomics techniques. Here, we introduce Ster...
Li Yang,Yu Zhang,Xin-Xin Yu et al.
Li Yang et al.
The liver undergoes metabolic adaptations during gestation and lactation to meet evolving physiological demands, yet the precise processes, regulatory mechanisms, and functions remain unclear. Using high-resolution single-cell RNA sequencin...
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity [0.03%]
用于治疗二型糖尿病和肥胖的偏向性肾上腺素受体激动剂
Aikaterini Motso,Benjamin Pelcman,Anastasia Kalinovich et al.
Aikaterini Motso et al.
Published Erratum
Cell. 2025 Aug 28:S0092-8674(25)00977-8. DOI:10.1016/j.cell.2025.08.022 2025
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles [0.03%]
分裂位点E3连接酶机制使ZNFX1能够泛素化并聚集单链RNA形成被泛素包被的核糖蛋白颗粒
Daniel B Grabarczyk,Eric J Aird,Vanessa Reznikow et al.
Daniel B Grabarczyk et al.
Eukaryotic cells use a multi-layered immune response to combat intracellular pathogens. The ubiquitin ligase ZNFX1 has emerged as a crucial yet little understood player that regulates the immune response while protecting against RNA viruses...