An iPSC-derived CD19/BCMA CAR-NK therapy in a patient with systemic sclerosis [0.03%]
一名系统性硬化症患者的iPSC衍生CD19 / BCMA CAR-NK疗法
Xiaobing Wang,Yi Zhang,Yi Jin et al.
Xiaobing Wang et al.
This study reports the first-in-human application of iPSC-derived CD19/BCMA dual-targeting chimeric antigen receptor-natural killer (CAR-NK) cells (QN-139b) in a patient with severe, diffuse cutaneous systemic sclerosis. The allogeneic prod...
Xinlu Ding,Fuu-Jiun Hwang,Daniel Silverman et al.
Xinlu Ding et al.
Sleep is known to promote tissue growth and regulate metabolism, partly by enhancing growth hormone (GH) release, but the underlying circuit mechanism is unknown. We demonstrate how GH release, which is enhanced during both rapid eye moveme...
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity [0.03%]
用于治疗二型糖尿病和肥胖的偏向于GRK的肾上腺素受体激动剂
Aikaterini Motso,Benjamin Pelcman,Anastasia Kalinovich et al.
Aikaterini Motso et al.
Biased agonism of G protein-coupled receptors (GPCRs) offers potential for safer medications. Current efforts have explored the balance between G proteins and β-arrestin; however, other transducers like GPCR kinases (GRKs) remain understud...
Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment [0.03%]
解析人类加速区域在人和黑猩猩神经发育过程中的三维互作组
Atreyo Pal,Mark A Noble,Matheo Morales et al.
Atreyo Pal et al.
Published Erratum
Cell. 2025 Jun 21:S0092-8674(25)00688-9. DOI:10.1016/j.cell.2025.06.022 2025
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment [0.03%]
可扩展生成和遗传变异的功能分类以加速先天性免疫缺陷的临床诊断和治疗
Zachary H Walsh,Chris J Frangieh,Neeharika Kothapalli et al.
Zachary H Walsh et al.
Next-generation sequencing is pivotal for diagnosing inborn errors of immunity (IEI) but predominantly yields variants of uncertain significance (VUS), creating clinical ambiguity. Activated PI3Kδ syndrome (APDS) is caused by gain-of-funct...
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling [0.03%]
胆碱能神经元活性通过毒蕈碱信号促进弥漫性中线胶质瘤生长
Richard Drexler,Antonia Drinnenberg,Avishai Gavish et al.
Richard Drexler et al.
Glutamatergic neuronal activity promotes proliferation of both oligodendrocyte precursor cells (OPCs) and gliomas, including diffuse midline glioma (DMG). However, the role of neuromodulatory brainstem neurons projecting to midline structur...
Bivalent chromatin instructs lineage specification during hematopoiesis [0.03%]
双价染色体在造血过程中的谱系分化中起指导作用
Masaki Yagi,Gracia Bonilla,Michael S Hoetker et al.
Masaki Yagi et al.
Developmental gene expression is regulated by the dynamic interplay of histone H3 lysine 4 (H3K4) and histone H3 lysine 27 (H3K27) methylation, yet the physiological roles of these epigenetic modifications remain incompletely understood. He...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [0.03%]
免疫蛋白酶体扰乱神经元代谢并驱动多发性硬化症的神经退行性病变
Marcel S Woo,Johannes Brand,Lukas C Bal et al.
Marcel S Woo et al.
Inflammation, aberrant proteostasis, and energy depletion are hallmarks of neurodegenerative diseases such as multiple sclerosis (MS). However, the interplay between inflammation, proteasomal dysfunction in neurons, and its consequences for...
Interfamily co-transfer of sensor and helper NLRs extends immune receptor functionality between angiosperms [0.03%]
高等植物中传感器和辅助NLR受体的组间转移扩展了免疫受体的功能性
Xiaofei Du,Maheen Alam,Kamil Witek et al.
Xiaofei Du et al.
Plant nucleotide-binding, leucine-rich repeat (NLR) immune receptors recognize pathogen effectors and activate defense. NLR genes can be non-functional in distantly related plants (restricted taxonomic functionality, RTF). Here, we enable S...
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging [0.03%]
通过成像进行单细胞转录组分析和多模态谱型(STAMP)
Emanuele Pitino,Anna Pascual-Reguant,Felipe Segato-Dezem et al.
Emanuele Pitino et al.
Single-cell RNA sequencing has revolutionized our understanding of cellular diversity but remains constrained by scalability, high costs, and the destruction of cells during analysis. To overcome these challenges, we developed STAMP (single...