Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 [0.03%]
冠状蛋白、肌动蛋白丝互作的分子机制研究
Wout Oosterheert,Micaela Boiero Sanders,Oliver Hofnagel et al.
Wout Oosterheert et al.
Rapid remodeling of actin filament (F-actin) networks is essential for the movement and morphogenesis of eukaryotic cells. The conserved actin-binding proteins coronin, cofilin, and actin-interacting protein 1 (AIP1) act in synergy to promo...
Genetic modifiers and ascertainment drive variable expressivity of complex disorders [0.03%]
遗传修饰物的鉴定影响复杂疾病的多变表现型
Matthew Jensen,Corrine Smolen,Anastasia Tyryshkina et al.
Matthew Jensen et al.
Variable expressivity of disease-associated variants implies a role for secondary variants that modify clinical features. We assessed the effects of modifier variants on the clinical outcomes of 2,455 individuals with primary variants. Amon...
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains [0.03%]
时间解析荧光蛋白可扩展荧光显微的时间和频谱领域
Zizhu Tan,Chia-Heng Hsiung,Jiahui Feng et al.
Zizhu Tan et al.
Published Erratum
Cell. 2025 Oct 2:S0092-8674(25)01124-9. DOI:10.1016/j.cell.2025.09.024 2025
ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism [0.03%]
ABP1/AHX3-TMK1生长素信号转导调控根向地性中的生长素极性运输
Lesia Rodriguez,Lukáš Fiedler,Minxia Zou et al.
Lesia Rodriguez et al.
Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a prerequisite for (1) self-organizing processes, including vas...
Cecilia Xi Zhang,Ruby Yun-Ju Huang,Guojun Sheng et al.
Cecilia Xi Zhang et al.
Epithelial-mesenchymal transition (EMT) is a fundamental mechanism involved in the morphogenesis of metazoans. Through this evolutionarily conserved multi-stage process, cells acquire quasi-epithelial to multiple intermediate morphologies w...
Decoding Alzheimer's disease at the cellular level reveals promising combination therapy [0.03%]
从细胞层面解读阿尔茨海默病表明联合疗法颇具前景
Kyle Coleman,Nicholas P Tatonetti
Kyle Coleman
Alzheimer's disease (AD) has long resisted effective treatments due to its pathological heterogeneity and cell-type-specific regulatory changes. In this issue of Cell, Li et al. leverage single-cell RNA sequencing and drug repurposing to pr...
Genomic atlas of 8,105 accessions reveals stepwise domestication, global dissemination, and improvement trajectories in soybean [0.03%]
基于8,105份大豆种质资源的基因组图谱揭示了大豆渐进式驯化、全球传播和改良过程
Zhou Zhu,Yalin Wang,Shulin Liu et al.
Zhou Zhu et al.
After millennia of domestication, dissemination, and improvement, soybean has evolved into a globally significant leguminous crop. Addressing how soybeans adapt to diverse planting environments and breeding objectives will facilitate future...
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution [0.03%]
无需测序的单分子分辨率全基因组空间转录组学
Yubao Cheng,Shengyuan Dang,Yuan Zhang et al.
Yubao Cheng et al.
Recent breakthroughs in spatial transcriptomics technologies have enhanced our understanding of diverse cellular identities, spatial organizations, and functions. Yet existing spatial transcriptomics tools are still limited in either transc...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [0.03%]
免疫蛋白酶体扰乱神经元代谢并驱动多发性硬化症中的神经退行性病变
Marcel S Woo,Johannes Brand,Lukas C Bal et al.
Marcel S Woo et al.
Published Erratum
Cell. 2025 Sep 30:S0092-8674(25)01087-6. DOI:10.1016/j.cell.2025.09.019 2025
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance [0.03%]
结核分枝杆菌转录调控的进化与传播增强和耐药相关
Peter H Culviner,Abigail M Frey,Qingyun Liu et al.
Peter H Culviner et al.
Mycobacterium tuberculosis (Mtb) has co-evolved with humans for thousands of years and is characterized by variation in virulence, transmissibility, and disease phenotypes. To identify bacterial contributors to phenotypic diversity, we deve...