Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystatin-c activation of TREM2 [0.03%]
外周癌症通过胱抑素激活TREM2减轻阿尔茨海默病的淀粉样蛋白病理损害
Xinyan Li,Xiaomei Tang,Jinyu Zeng et al.
Xinyan Li et al.
Alzheimer's disease (AD) and cancer are among the most devastating diseases worldwide. Epidemiological data indicate that the incidence of AD significantly decreases in patients with a history of cancer. However, whether and how peripheral ...
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids [0.03%]
MYC结合新生RNA通过R环衍生的RNA-DNA杂合体抑制天然免疫信号转导
Leonie Uhl,Amel Aziba,Sinah Löbbert et al.
Leonie Uhl et al.
In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC globally relocalizes from its canonical positions on DNA to nascent RNA upon accumulation of...
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder [0.03%]
脑溶酶体细胞类型蛋白质图谱鉴定出SLC45A1相关疾病是一种溶酶体疾病
Ali Ghoochani,Julia C Heiby,Eshaan S Rawat et al.
Ali Ghoochani et al.
Mutations in lysosomal genes cause neurodegeneration and neuronopathic lysosomal storage disorders (LSDs). Despite their essential role in brain homeostasis, the cell-type-specific composition and function of lysosomes remain poorly underst...
Fibroblasts of disparate developmental origins harbor anatomically variant scarring potential [0.03%]
不同发育起源的成纤维细胞具有不同的解剖学特异性瘢痕形成潜能
Michelle F Griffin,Dayan J Li,Kellen Chen et al.
Michelle F Griffin et al.
Progress toward anti-scarring therapies has been hampered by our limited understanding of fibroblast populations underlying fibrotic vs. regenerative healing. The site-dependent fibroblast heterogeneity acquired during development points to...
Establishing the relationship between brain cellular senescence and brain structure [0.03%]
建立大脑细胞衰老与大脑结构之间的关系
Anina N Lund,Brian H Kopell,Negar Golestani et al.
Anina N Lund et al.
Cellular senescence and brain atrophy are both associated with brain aging, suggesting these processes may share underlying biological mechanisms. This study investigated these mechanisms by integrating structural neuroimaging with gene and...
Mammalian genome writing: Unlocking new length scales for genome engineering [0.03%]
哺乳动物基因组写入：解锁新的尺度以进行基因组工程
Sudarshan Pinglay,John T Atwater,Ran Brosh et al.
Sudarshan Pinglay et al.
The ability to design and engineer mammalian genomes across arbitrary length scales would transform biology and medicine. Such capabilities would enable the systematic dissection of mechanisms governing gene regulation and the influence of ...
Alejandro De Los Angeles,Tim Bayne,Nissim Benvenisty et al.
Alejandro De Los Angeles et al.
Human stem-cell-based embryo models (SCBEMs) imperfectly mimic some-but not all-features of early human development. Yet as these models become increasingly sophisticated, they raise important ethical and regulatory questions. Despite their...
Discoveries beyond molecular mimicry describe how EBV drives multiple sclerosis [0.03%]
超出分子模拟的发现揭示了EB病毒如何驱动多发性硬化症的发展
Lawrence Steinman,Scott S Zamvil
Lawrence Steinman
In the current issue of Cell, three papers describe new mechanistic information about how EBV transforms B cells to become antigen-presenting cells in the brain that drive demyelinating disease.1,2,3. ...
Aaron Kilgallon,Rafael Tubelleza,Arutha Kulasinghe
Aaron Kilgallon
Multiplex immunofluorescence proteomics is a powerful method in spatial biology to decipher cell types, states, and architecture in tissues. In this issue of Cell, Valanarasu et al. develop GigaTIME, an expansive population-scale analysis o...
Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2 [0.03%]
人嗅觉受体OR6A2中气味分子的可逆共价连接的结构解码
Tian Wang,Yiran Wu,Ling Wang et al.
Tian Wang et al.
Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II OR, selectively senses medium-chain aldeh...