The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism [0.03%]
独特的毒素分子架构可令细菌之间相互拮抗时采取双层分子下注策略
Qinqin Zhao,Jiri Vlach,Young-Jun Park et al.
Qinqin Zhao et al.
Bacteria exist in competitive and rapidly changing environments in which the nature of future threats cannot be easily predicted. Streptomyces coelicolor produces three antibacterial umbrella particles that harbor distinct polymorphic toxin...
A stepwise decoding mechanism for heat sensing in plants connects lipid remodeling to a nuclear signaling cascade [0.03%]
植物热感应的逐步解码机制将脂质重塑连接到核信号级联中
Yi Kan,Xiao-Rui Mu,Fangfang Qu et al.
Yi Kan et al.
Heat stress triggers cell membrane lipid remodeling, yet whether this signals plants to perceive high temperatures and how such physical signals are decoded into biological signals remains unclear. Here, we demonstrate that diacylglycerol k...
pTα enhances mRNA translation and potentiates CAR T cells for solid tumor eradication [0.03%]
pTα增强信使RNA的翻译并增强CAR-T细胞对实体瘤的杀伤作用
Yuzhe Shi,Michael A Lopez,Ivan S Kotchetkov et al.
Yuzhe Shi et al.
Current chimeric antigen receptor (CAR) therapies are effective against a range of hematological malignancies and autoimmune disorders but have shown limited activity against solid tumors. In searching for effective means to enhance the fun...
Avik Mukherjee,Yanqing Huang,Jens Elgeti et al.
Avik Mukherjee et al.
Mechanical forces influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting membrane potential have been observed in development, differentiation, regeneration, and ca...
The effect of shingles vaccination at different stages of the dementia disease course [0.03%]
带状疱疹疫苗在痴呆病程不同阶段的效果
Min Xie,Markus Eyting,Christian Bommer et al.
Min Xie et al.
Using natural experiments, we have previously reported that live-attenuated herpes zoster (HZ) vaccination appears to have prevented or delayed dementia diagnoses in both Wales and Australia. Here, we find that HZ vaccination also reduces m...
An archaeal transcription factor bridges prokaryotic and eukaryotic regulatory paradigms [0.03%]
一个古菌转录因子连接了原核生物和真核生物的调控范式
Fernando Medina Ferrer,Dipti D Nayak
Fernando Medina Ferrer
Archaeal transcription is a hybrid of eukaryotic and prokaryotic features: an RNA polymerase II (RNAPII)-like polymerase transcribes genes organized in circular chromosomes within cells devoid of a nucleus. Consequently, archaeal genomes ar...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis [0.03%]
固有免疫和代谢信号通过线粒体依赖性膜溶解诱导（即mitoxyperiosis）引发细胞死亡
Yaqiu Wang,Jianlin Lu,Alexandre F Carisey et al.
Yaqiu Wang et al.
The combination of innate immune activation and metabolic disruption plays critical roles in many diseases, often leading to mitochondrial dysfunction and oxidative stress that drive pathogenesis. However, mechanistic regulation under these...
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity [0.03%]
应激诱发的交感神经活化驱动毛囊坏死引发自身免疫反应
Emily Scott-Solomon,Shlomi Brielle,Alexander O Mann et al.
Emily Scott-Solomon et al.
Stress has profound effects on health, yet how it damages tissues remains poorly understood. Here, we show that acute stress triggers rapid hair loss and initiates autoimmunity. Under stress, hyperactivated sympathetic nerves release excess...
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells [0.03%]
热力学原理将体外转录因子亲和力与细胞中的单分子染色质状态联系起来
Julia M Schaepe,Torbjörn Fries,Benjamin R Doughty et al.
Julia M Schaepe et al.
The molecular details governing transcription factor (TF) binding and the formation of accessible chromatin are not yet quantitatively understood-including how sequence context modulates affinity, how TFs search DNA, the kinetics of TF occu...
Feeding from the sun-Successes and prospects in bioengineering photosynthesis for food security [0.03%]
太阳能培育粮食——仿生光合作研究进展及前景展望
Stephen P Long,Yu Wang,Elizabete Carmo-Silva et al.
Stephen P Long et al.
There is an urgent need for increased crop productivity to reduce food insecurity and improve sustainability. Photosynthesis converts sunlight energy into carbohydrates, providing the source of nearly all of humanity's food. Photosynthesis ...