Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease [0.03%]
自身抗体诱发的足细胞膜芽突起驱动自身免疫性肾脏病
Karen Lahme,Wiebke Sachs,Sarah Froembling et al.
Karen Lahme et al.
Chronic kidney disease affects 1 in 10 people worldwide, with damage to specialized blood filter cells of the kidney, called podocytes, playing a critical role. In membranous nephropathy (MN), a major cause of nephrotic syndrome, circulatin...
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis [0.03%]
GPX4中的一个类似fin-loop的结构可介导铁死亡下的神经保护作用
Svenja M Lorenz,Adam Wahida,Mark J Bostock et al.
Svenja M Lorenz et al.
Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous antioxidant defenses. Glutathione peroxidase 4 (G...
Rose Z Hill,Jonathan W Nelson,Georgina Gyarmati et al.
Rose Z Hill et al.
Renin synthesis and release is the rate-limiting step of the renin-angiotensin-aldosterone system (RAAS) that controls fluid homeostasis. A major activator of the RAAS is a decrease in perfusion pressure within the kidneys, suggesting a lin...
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells [0.03%]
撤稿通知：基于CRISPR的转录组RNA靶向筛选发现人类细胞中的功能必需型长链非编码RNA
Wen-Wei Liang,Simon Müller,Sydney K Hart et al.
Wen-Wei Liang et al.
Published Erratum
Cell. 2025 Dec 3:S0092-8674(25)01367-4. DOI:10.1016/j.cell.2025.11.032 2025
Fertilization triggers early proteomic symmetry breaking in mammalian embryos [0.03%]
受精触发哺乳动物胚胎早期蛋白组对称性破缺
Lisa K Iwamoto-Stohl,Aleksandra A Petelski,Baiyi Quan et al.
Lisa K Iwamoto-Stohl et al.
While non-mammalian embryos often rely on spatial pre-patterning, mammalian development has long been thought to begin with equivalent blastomeres. However, emerging evidence challenges this. Here, using multiplexed and label-free single-ce...
The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism [0.03%]
独特的毒素分子架构可令细菌之间相互拮抗时采取双层分子下注策略
Qinqin Zhao,Jiri Vlach,Young-Jun Park et al.
Qinqin Zhao et al.
Bacteria exist in competitive and rapidly changing environments in which the nature of future threats cannot be easily predicted. Streptomyces coelicolor produces three antibacterial umbrella particles that harbor distinct polymorphic toxin...
A stepwise decoding mechanism for heat sensing in plants connects lipid remodeling to a nuclear signaling cascade [0.03%]
植物热感应的逐步解码机制将脂质重塑连接到核信号级联中
Yi Kan,Xiao-Rui Mu,Fangfang Qu et al.
Yi Kan et al.
Heat stress triggers cell membrane lipid remodeling, yet whether this signals plants to perceive high temperatures and how such physical signals are decoded into biological signals remains unclear. Here, we demonstrate that diacylglycerol k...
pTα enhances mRNA translation and potentiates CAR T cells for solid tumor eradication [0.03%]
pTα增强信使RNA的翻译并增强CAR-T细胞对实体瘤的杀伤作用
Yuzhe Shi,Michael A Lopez,Ivan S Kotchetkov et al.
Yuzhe Shi et al.
Current chimeric antigen receptor (CAR) therapies are effective against a range of hematological malignancies and autoimmune disorders but have shown limited activity against solid tumors. In searching for effective means to enhance the fun...
Avik Mukherjee,Yanqing Huang,Jens Elgeti et al.
Avik Mukherjee et al.
Mechanical forces influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting membrane potential have been observed in development, differentiation, regeneration, and ca...
The effect of shingles vaccination at different stages of the dementia disease course [0.03%]
带状疱疹疫苗在痴呆病程不同阶段的效果
Min Xie,Markus Eyting,Christian Bommer et al.
Min Xie et al.
Using natural experiments, we have previously reported that live-attenuated herpes zoster (HZ) vaccination appears to have prevented or delayed dementia diagnoses in both Wales and Australia. Here, we find that HZ vaccination also reduces m...