Why machines don't speak biology: Toward native biological language models [0.03%]
为什么机器不懂生物学：迈向原生的生物语言模型
Yonatan Stelzer,Amos Tanay
Yonatan Stelzer
Recent advances in AI inspire visions of universal models of biology. Yet living systems are evolved, emergent processes whose behaviors cannot be inferred from their parts alone. We propose grounding AI in canonical biological processes, c...
Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system [0.03%]
协同的RNA和蛋白质模板的双链DNA合成由双重逆转录酶免疫系统完成
Megan Wang,Kanta Yoneyama,Rimantė Žedaveinytė et al.
Megan Wang et al.
Defense-associated reverse transcriptase (DRT) systems mediate antiviral immunity through distinct modes of cDNA synthesis: class 1 DRTs catalyze untemplated synthesis, whereas class 2 DRTs polymerize non-coding RNA-templated products. Howe...
Advancing cancer detection and treatment using longitudinal routine clinical data [0.03%]
利用纵向常规临床数据推动癌症的检测与治疗
Fei Liu,Kai Wang,Hui Xu et al.
Fei Liu et al.
Cancer management remains fragmented across its continuum, from late-stage diagnosis and salvage therapies to non-personalized surveillance. Here, we present Oncoformer, a unified multimodal transformer model trained on the China Oncology M...
UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling [0.03%]
基于分子表征到表型建模的药物基因组学跨领域泛化研究
Yiming Li,Min Zeng,Jun Zhu et al.
Yiming Li et al.
Systematically simulating and predicting phenotypic effects of diverse interventions across heterogeneous cellular environments is central to the vision of artificial intelligence virtual cell (AIVC). However, disparities in perturbagen mod...
Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4 [0.03%]
动态二聚体-of-二聚体结构定义了人类CNNM4中的Mg2+转运过程
Zhiyong Bai,X Edward Zhou,Wei Lü et al.
Zhiyong Bai et al.
Mg2+ is essential for all living organisms, yet its transport across mammalian membranes remains poorly understood. Here, we present cryoelectron microscopy (cryo-EM) structures of a full-length mammalian Mg2+ transporter on the plasma memb...
Haifu Tu,Qian Liu,Tiantian Ye et al.
Haifu Tu et al.
Drought threatens crop productivity, yet enhancing tolerance often compromises yield. Abscisic acid (ABA) signaling is central to drought response, but its deep conservation can constrain adaptive flexibility. Here, we identify ROAD1 (rice ...
Trichoderma swollenin activates AtABCB5-dependent auxin efflux to promote plant development [0.03%]
芽枝霉菌Swollenin通过激活AtABCB5依赖的生长素外排促进植物生长发育
Jiaxin Lu,Jing Liu,Siqi Jiang et al.
Jiaxin Lu et al.
The beneficial fungus Trichoderma enhances plant growth and stress tolerance through poorly understood mechanisms. Here, we show that Trichoderma harzianum swollenin ThSWO contributes to efficient root colonization and plant growth promotio...
Alex Chan,Wearn-Xin Yee,Deepto Mozumdar et al.
Alex Chan et al.
Bacteriophage genomes are densely packed with coding sequences and frequently encode genes of unknown function. Unbiased phage functional genomics approaches are therefore needed, particularly for large lytic phages. Here, we harness the ma...
Auxin signaling [0.03%]
生长素信号转导
Jiashu Chu,Aaron Chun Hou Ang,Martijn de Roij et al.
Jiashu Chu et al.
Following its discovery nearly a century ago, the signaling molecule auxin has captured the interest of plant scientists. Mostly through genetics, key components of the auxin response were identified, and these were rapidly connected in a t...
Paul Bastard,Tyler Hulett,Karl Smith-Byrne et al.
Paul Bastard et al.
Why cancer arises, progresses, or proves fatal in some people but not others remains largely unresolved. Antibody repertoires, including autoantibodies targeting immune pathways, may shape cancer immunosurveillance. Mapping antibody landsca...