Upasana Das Adhikari,Leah M Froehle,Alexandra N Pipkin et al.
Upasana Das Adhikari et al.
A hallmark of HIV infection is disruption of intestinal barrier integrity that persists in people with HIV (PWH) despite treatment with antiretroviral therapy (ART). This disruption is central to HIV disease progression, yet the causes rema...
Jose A Canovas,Li Wang,Ahmed A M Mohamed et al.
Jose A Canovas et al.
The innate attraction to sweet mediates appetitive and consummatory responses. Here, we dissected the circuit driving responses to sweet and showed that amygdala neurons tuned to sweet connect to the bed nucleus of the stria-terminalis (BNS...
Travis E Faust,Yi-Han Lee,Ciara D O&#x;Connor et al.
Travis E Faust et al.
Astrocytes and microglia are emerging key regulators of activity-dependent synapse remodeling that engulf and remove synapses in response to changes in neural activity. Yet, the degree to which these cells communicate to coordinate this pro...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization [0.03%]
类壳感染颗粒可扩大噬菌体诱导的染色体岛转导的宿主范围
Lingchen He,Jonasz B Patkowski,Jinlong Wang et al.
Lingchen He et al.
Some mobile genetic elements spread among unrelated bacterial species through unknown mechanisms. Recently, we discovered that identical capsid-forming phage-inducible chromosomal islands (cf-PICIs), a new family of phage satellites, are pr...
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution [0.03%]
人工智能镜像实验科学揭示基因转移机制对细菌进化至关重要
José R Penadés,Juraj Gottweis,Lingchen He et al.
José R Penadés et al.
Artificial intelligence (AI) models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging since an AI-generated hypothesis can take decades to validate. Here, we challenge the a...
Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition [0.03%]
基于长读取元基因组的无文化依赖性元泛基因组学揭示了与儿童营养不良的关系
Jeremiah J Minich,Nicholas Allsing,M Omar Din et al.
Jeremiah J Minich et al.
The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enab...
Peng Xie,Juan Shen,Yi Yang et al.
Peng Xie et al.
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial section...
Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium [0.03%]
Harbin猿人头骨牙结石中的丹尼索瓦人线粒体DNA
Qiaomei Fu,Peng Cao,Qingyan Dai et al.
Qiaomei Fu et al.
Denisovans have yet to be directly associated with a hominin cranium, limiting our understanding of their morphology and geographical distribution. We have attempted to retrieve DNA from a nearly complete Middle Pleistocene cranium from Har...
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics [0.03%]
HT SpaceM：一种用于小分子单细胞代谢组学的高通量和可重复的方法
Jeany Delafiori,Mohammed Shahraz,Andreas Eisenbarth et al.
Jeany Delafiori et al.
Single-cell metabolomics (SCM) promises to reveal metabolism in its complexity and heterogeneity, yet current methods struggle with detecting small-molecule metabolites, throughput, and reproducibility. Addressing these gaps, we developed H...
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity [0.03%]
白细胞介素-25诱导的记忆型2固有淋巴样细胞促进黏膜免疫
Victor S Cortez,Sara Viragova,Satoshi Koga et al.
Victor S Cortez et al.
Adaptation of intestinal helminths to vertebrates involved the evolution of strategies to attenuate host tissue damage to support parasite reproduction and dissemination of offspring to the environment. Helminths initiate the IL-25-mediated...