CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success [0.03%]
肿瘤微环境的腔隙结构促进CD8+T细胞浸润并预测免疫治疗效果
Aya Ludin,Georgia L Stirtz,Asaf Tal et al.
Aya Ludin et al.
T cell-mediated tumor killing underlies immunotherapy success. Here, we used long-term in vivo imaging and high-resolution spatial transcriptomics of zebrafish endogenous melanoma, as well as multiplex imaging of human melanoma, to identify...
Chen Zhou,Huican Li,Jiaxing Wang et al.
Chen Zhou et al.
Design of ion channels responsive to environmental cues has significant implications in modulating cellular activities and sensor development, but it remains a significant challenge due to the complexities involved in designing stimuli-indu...
Long shared haplotypes identify the southern Urals as a primary source for the 10th-century Hungarians [0.03%]
长共享单体型识别出南乌拉尔是匈牙利人的主要来源地（公元10世纪）
Balázs Gyuris,Leonid Vyazov,Attila Türk et al.
Balázs Gyuris et al.
The origins of the early medieval Magyars who appeared in the Carpathian Basin by the end of the 9th century CE remain incompletely understood. Previous archaeogenetic research identified the newcomers as migrants from the Eurasian steppe. ...
Patricia A Possik,David J Adams,Flavia C Aguiar et al.
Patricia A Possik et al.
Single-cell and spatial transcriptomics are revolutionizing science. Latin America's unique genetic diversity, environment, and endemic infectious diseases offer exceptional opportunities to deploy these technologies for societal and scient...
Heather D Hickman,Niki M Moutsopoulos
Heather D Hickman
In a recent issue of Nature Biomedical Engineering, Ingrole et al. explore a new approach for needle-free vaccine delivery through the mouth. They devise and test a dental-floss-based flu vaccine as an alternative mode of mucosal vaccinatio...
CRISPR meets AI-based robotics: Advancing sustainable agriculture [0.03%]
基于人工智能的机器人技术与CRISPR相遇：推动可持续农业发展
Fabienne Gehrke,Holger Puchta
Fabienne Gehrke
In this issue of Cell, Xu and colleagues develop an approach integrating genome editing, artificial intelligence, and robotics to enhance crop improvement. By reconfiguring reproductive traits for automated pollination in crops such as toma...
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis [0.03%]
针对进展型多发性硬化症患者的抗BCMA CAR-T疗法
Chuan Qin,Ming-Hao Dong,Luo-Qi Zhou et al.
Chuan Qin et al.
Progressive multiple sclerosis (PMS), which is characterized by relentless disease progression, lacks effective treatment. While recent studies have highlighted the importance of B cells in driving compartmentalized central nervous system (...
Shaping pit structure in vessel walls sustains xylem hydraulics and grain yield [0.03%]
管状结构塑造维持木质部水分运输和籽粒产量
Lanjun Zhang,Yihong Gao,Zuopeng Xu et al.
Lanjun Zhang et al.
Plants have evolved a conduit system with reinforced walls and innovative wall structures that ensure efficient transport of water and nutrients. Vessel pits, fine three-dimensional (3D) cavities in conduit walls, are key determinants of pl...
The genomic footprints of wild Saccharum species trace domestication, diversification, and modern breeding of sugarcane [0.03%]
野生糖蔗物种的基因组印记追溯糖蔗的驯化、分化和现代育种历程
Olivier Garsmeur,Simon Rio,Nicolas Pompidor et al.
Olivier Garsmeur et al.
Sugarcane is a major crop of unclear origins due to its complex polyploid interspecific genome. We analyzed genome ancestries using whole-genome sequence data from 390 representative accessions based on repeated k-mers and chloroplast phylo...
Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson's disease [0.03%]
帕金森病诱导多巴胺能神经元的I/IIa期临床试验
Jin Woo Chang,Han Kyu Na,Kyung Won Chang et al.
Jin Woo Chang et al.
Parkinson's disease (PD) has long been considered an appropriate candidate for cell replacement therapy. We generated high-purity dopaminergic progenitors (A9-DPCs) from human embryonic stem cells and evaluated their safety and exploratory ...