Cancer cell cooperation: tumor cells team up to scavenge nutrients to ensure proliferation despite starvation [0.03%]
癌细胞协作：肿瘤细胞合作获取营养以保证在饥饿状态下的增殖
Susanne Sebens,Lisa-Marie Philipp,Dieter Adam
Susanne Sebens
Enhancing the anti-aging potential of the nigrostriatal dopamine system to counteract age-related motor decline [0.03%]
增强黑质纹状体多巴胺能系统的抗衰老潜力以对抗与年龄相关的运动功能减退
Youngpyo Nam,Sehwan Kim,Jun-Yeong Lee et al.
Youngpyo Nam et al.
Qing Xiao,Yi Liu,Tingting Li et al.
Qing Xiao et al.
The year 2024 marks the 60th anniversary of the discovery of the Epstein-Barr virus (EBV), the first virus confirmed to cause human cancer. Viral infections significantly contribute to the global cancer burden, with seven known Group 1 onco...
Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury [0.03%]
髓系CD38而不是肝细胞CD38是肝脏缺血再灌注损伤的关键驱动因素
Qi-Hang Zhao,Ya-Ting Zhang,Ke Wen et al.
Qi-Hang Zhao et al.
Hepatic ischemia-reperfusion injury (HIRI) is a critical condition that often occurs during liver transplantation and surgical liver resection. However, its mechanism has not been fully elucidated. Nicotinamide adenine dinucleotide (NAD+), ...
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer [0.03%]
铜离子在肿瘤发生发展中的分子机制及其介导的新型细胞死亡形式cuproptosis研究进展
Ziyu Guo,Danyao Chen,Lei Yao et al.
Ziyu Guo et al.
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-de...
Targeting cancer: tumor-specific splicing events give rise to immunogenic, tumor-wide neoantigens [0.03%]
靶向癌症：肿瘤特异性剪接事件产生免疫原性肿瘤广泛性新抗原
Nils Kosiol,Annkristin Heine,Peter Brossart
Nils Kosiol
Meningeal lymphatic drainage: novel insights into central nervous system disease [0.03%]
脑膜淋巴引流：中枢神经系统疾病的新见解
Qiang Zhang,Yin Niu,Yingpei Li et al.
Qiang Zhang et al.
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lympha...
Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia [0.03%]
NKG2A过表达导致复发性急性髓系白血病中的自然杀伤细胞耗竭
Juan Xie,Xue-Fei Liu,Tong Zhou et al.
Juan Xie et al.
Acute myeloid leukemia (AML) relapse is associated with poor prognosis. While natural killer (NK) cell therapy can induce leukemia remission, infused NK cells are prone to exhaustion. Elucidating the molecular mechanisms driving NK cell exh...