Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics [0.03%]
系统性红斑狼疮：发病机理、诊断、预防和治疗的最新见解
Xiaofeng Dai,Yuting Fan,Xing Zhao
Xiaofeng Dai
Systemic lupus erythematosus (SLE) is a chronic inflammatory illness with heterogeneous clinical manifestations covering multiple organs. Diversified types of medications have been shown effective for alleviating SLE syndromes, ranging from...
Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy [0.03%]
靶向肿瘤内在的S100钙结合蛋白A1可增强抗肿瘤免疫并提高免疫治疗疗效
Yufeng Guo,Rui Wan,Jianchun Duan et al.
Yufeng Guo et al.
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights the necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intri...
PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial [0.03%]
抗PD-1抗体卡瑞利珠单抗联合阿帕替尼和SOX作为AFP阳性胃或胃食管结合部腺癌患者一线治疗（CAP 06）：一项多中心、单臂、二期试验
Yakun Wang,Jialin Lu,Xiaoyi Chong et al.
Yakun Wang et al.
Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angiog...
Tina Kos,Dieter Saur
Tina Kos
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer [0.03%]
增强子转录谱分析揭示了前列腺癌中由增强子RNA驱动的铁死亡及新的治疗机会
Sheng Ma,Zixian Wang,Zezhong Xiong et al.
Sheng Ma et al.
Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we ...
Advances in the structures, mechanisms and targeting of molecular chaperones [0.03%]
分子伴侣的结构、机制及靶点研究进展
Jinying Gu,Yanyi He,Chenxi He et al.
Jinying Gu et al.
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage unde...
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study [0.03%]
沙利度胺为基础的治疗方案在大颗粒淋巴细胞白血病中展现出良好的疗效：多中心Ⅱ期临床试验
Ying Yu,Yuxi Li,Rui Cui et al.
Ying Yu et al.
Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells. Standard first-line immunosuppressive treatments have limitations, achieving complete remission (CR) rates of up...
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances [0.03%]
神经退行性疾病抗衰老策略：从机制到临床进展
Qiu Jiang,Jie Liu,Shan Huang et al.
Qiu Jiang et al.
In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer's disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for...
Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines [0.03%]
小核酸药物的前景：从实验台到临床作为下一代药物的发展进程
Mohan Liu,Yusi Wang,Yibing Zhang et al.
Mohan Liu et al.
The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even cura...
Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation [0.03%]
Epstein-Barr病毒通过KDM5B的上调驱动上皮恶性肿瘤进展的过程中对组蛋白去甲基化酶机制的利用
Ya-Qing Zhou,Jia-Xin Jiang,Shuai He et al.
Ya-Qing Zhou et al.
Epstein-Barr virus (EBV) is a significant epigenetic driver in the development of epithelial-origin nasopharyngeal carcinoma (NPC) and gastric cancer (GC), which together represent 80% of EBV-associated malignancies. Despite its known assoc...