MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysm [0.03%]
MAPK14通过作用于关键转录调控因子促进腹主动脉瘤中血管平滑肌细胞的去分化
Xiaoliang Wu,Chunhui Wang,Nestor Ishimwe et al.
Xiaoliang Wu et al.
Vascular smooth muscle cell (VSMC) degeneration is a major mechanism underlying abdominal aortic aneurysm (AAA) formation. However, the upstream signaling pathways that converge on the transcriptional machinery to drive VSMC degeneration re...
A modular "Catch-and-Play" platform for rapid T-cell engager target assembly for personalised cancer treatment [0.03%]
一种模块化的“捕获并即玩”平台，可快速组装个性化的癌症治疗T细胞engage目标分子
Xi Xi,Yonghui Zhang,Daqing Zhao et al.
Xi Xi et al.
Double-strand break-free epigenetic programming: a safer path for T-cell therapies [0.03%]
无DNA双链断裂的表观遗传重编程：T细胞治疗的安全路径
Lanxin Deng,Yujia Yang,Assam El-Osta
Lanxin Deng
LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1 [0.03%]
长链非编码RNA Wee1-AS通过激活线粒体CDK1/CYCLIN B1来协调氧化型脂肪酸代谢
Hyeon-Ji Kim,Cheolhee Jeong,Sang-Heon Lee et al.
Hyeon-Ji Kim et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is steadily increasing with life-threatening complications, underscoring the need for new therapeutic targets. In this study, we identified a novel long noncoding RNA, Wee1-AS...
Cilium-by-cilium: unveiling hidden proteomic diversity and the molecular basis of ciliopathies [0.03%]
从纤毛到纤毛：揭示隐藏的蛋白质组多样性及纤毛疾病的分子基础
Mario Chiong,Hongliang Li,Sergio Lavandero
Mario Chiong
Correction: Signaling pathways and targeted therapy for pulmonary hypertension [0.03%]
关于肺动脉高压的信号通路与靶向治疗的更正论文
Joseph Adu-Amankwaah,Yue Shi,Hequn Song et al.
Joseph Adu-Amankwaah et al.
Universal scaling law: transcription factors homeostatically control promoter activity [0.03%]
普遍的标度定律：转录因子稳态地控制启动子活性
Minhao Gao,Aimin Wu,Min Wu
Minhao Gao
Jin Yang,Shimeng Wang,Xin Li et al.
Jin Yang et al.
Precancers, defined as normal-appearing or morphologically altered tissues with a risk of oncogenesis, exhibit various detectable manifestations across anatomical sites, including epithelial dysplasia, metaplasia, hyperplasia, and stromal f...
Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases [0.03%]
器官对话：疾病相关的分子机制、生物学功能及治疗干预措施
Huiting Che,Yidan Gao,Yonghu Xu et al.
Huiting Che et al.
Organ cross-talk, also known as the organ axis or organ interaction network, plays a vital role in maintaining physiological homeostasis and responding to environmental stimuli. This review comprehensively integrates cutting-edge observatio...
The role of ER-associated degradation and ER-phagy in health and disease [0.03%]
内质网相关降解和内质网自噬在健康与疾病中的作用
Young Joo Jeon,Ze&#x;ev A Ronai
Young Joo Jeon
The endoplasmic reticulum (ER) is a major cellular organelle for the synthesis and folding of secretory and transmembrane proteins, whose proper function underpins organellar homeostasis, proper tissue function, and organismal physiology. P...