Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results [0.03%]
Antonin Levy,Daphné Morel,Matthieu Texier et al.
Antonin Levy et al.
Immunoradiotherapy holds promise for improving outcomes in patients with advanced solid tumors, including in soft-tissue sarcoma (STS). However, the ideal combination of treatment modalities remains to be determined, and reliable biomarkers...
Systemic lupus erythematosus: updated insights on the pathogenesis, diagnosis, prevention and therapeutics [0.03%]
Xiaofeng Dai,Yuting Fan,Xing Zhao
Xiaofeng Dai
Systemic lupus erythematosus (SLE) is a chronic inflammatory illness with heterogeneous clinical manifestations covering multiple organs. Diversified types of medications have been shown effective for alleviating SLE syndromes, ranging from...
Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy [0.03%]
Yufeng Guo,Rui Wan,Jianchun Duan et al.
Yufeng Guo et al.
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights the necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intri...
PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial [0.03%]
Yakun Wang,Jialin Lu,Xiaoyi Chong et al.
Yakun Wang et al.
Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angiog...
Tina Kos,Dieter Saur
Tina Kos
Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer [0.03%]
Sheng Ma,Zixian Wang,Zezhong Xiong et al.
Sheng Ma et al.
Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we ...
Jinying Gu,Yanyi He,Chenxi He et al.
Jinying Gu et al.
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage unde...
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study [0.03%]
Ying Yu,Yuxi Li,Rui Cui et al.
Ying Yu et al.
Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells. Standard first-line immunosuppressive treatments have limitations, achieving complete remission (CR) rates of up...
Qiu Jiang,Jie Liu,Shan Huang et al.
Qiu Jiang et al.
In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer's disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for...
Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines [0.03%]
Mohan Liu,Yusi Wang,Yibing Zhang et al.
Mohan Liu et al.
The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even cura...