Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinoma [0.03%]
酸性卷曲螺旋结构域含跨膜区蛋白3介导的脂质代谢重组抑制肝细胞癌CD8⁺T细胞的胞毒性作用
Ying Li,Zule Chen,Dongdong Wang et al.
Ying Li et al.
Recent evidence has highlighted immune checkpoint inhibitors as among the most promising immunotherapies for various malignancies. However, a significant proportion of HCC patients exhibit poor responses. Lipid metabolic heterogeneity is co...
Disarming a molecular brake: cAMP-responsive element modulator deletion supercharges CAR-NK cells [0.03%]
解除分子制动:cAMP反应元件调节物的缺失可增强CAR-NK细胞功能
Sudheendra Hebbar Subramanyam,Klaus Tenbrock
Sudheendra Hebbar Subramanyam
Adjuvant icotinib for resected EGFR-mutated stage II-IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study [0.03%]
术后EGFR突变II至IIIA期非小细胞肺癌患者辅助艾坦治疗研究（ICTAN，GASTO1002）：一项随机对照研究
Ning Li,Wei Ou,Chao Cheng et al.
Ning Li et al.
The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with resected EGFR-mutated non-small-cell lung cancer (NSCLC) were not known until 2014, whe...
Enrichment of Streptococcus oralis in respiratory microbiome enhance innate immunity and protects against influenza infection [0.03%]
口腔链球菌增强呼吸道微生物组可增强先天免疫并预防流感感染
Xiaohui Zou,Hongyun Cao,Lizhe Hong et al.
Xiaohui Zou et al.
Respiratory microbial dysbiosis has been implicated in the occurrence and progression of community-acquired pneumonia (CAP). However, the dynamic variation in the respiratory microbiota and its interaction with the host response remain poor...
Pain management beyond opioids: a β-arrestin2-biased allosteric GPCR modulator opens new avenues for drug development [0.03%]
阿片类止痛药之外的新途径：一种偏向性激活受体的调节剂开创药物研发新方向
Eline Pottie,Sophie A M Steinmüller,Michael Decker
Eline Pottie
Bone marrow microenvironment in autoimmune hemolytic anemia: from trephine biopsy to single cell RNA sequencing [0.03%]
自身免疫性溶血性贫血的骨髓微环境：从活检到单细胞RNA测序
Bruno Fattizzo,Matteo Claudio Da Vià,Francesca Lazzaroni et al.
Bruno Fattizzo et al.
The role of bone marrow (BM) compensatory response in autoimmune hemolytic anemias (AIHAs) is emerging and inadequate reticulocytosis has been associated with more severe disease and adverse outcomes. However, few is known about the BM immu...
Ultrasound-enhanced Pt-coordinated polymer immunopotentiators and heterogenic fusion membrane-based multifunctional tumor vaccine nanoplatforms for melanoma treatment [0.03%]
用于黑色素瘤治疗的超声增强型Pt配位聚合物免疫佐剂和异源融合膜型多功能肿瘤疫苗纳米平台
Ruiqian Guo,Fangxue Du,Xi Xiang et al.
Ruiqian Guo et al.
A tumor cell membrane (CM)-based biomimetic membrane tumor vaccine is an emerging prevention and treatment strategy in tumor immunotherapy. However, a single CM mostly has a weak immune-boosting effect. Here, a heterogenic fusion membrane t...
High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming [0.03%]
高果糖摄入通过诱导代谢重编促进效应T细胞生成从而加剧炎症反应
Xiao Ma,Jiao Chen,Fang Wang et al.
Xiao Ma et al.
The intake of sugars, especially glucose and fructose, has significantly increased with the change of lifestyle. Excessive intake of sugar has been proven to be associated with tumors and inflammatory diseases. Fructose directly mediates in...
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments [0.03%]
肿瘤相关巨噬细胞在肿瘤微环境中的双重作用及治疗靶向性研究
Jiasheng Xu,Lei Ding,Jianfeng Mei et al.
Jiasheng Xu et al.
Tumor-associated macrophages (TAMs), derived from circulating monocytes recruited to tumor sites via chemotactic signals such as C-C motif ligand 2 (CCL2) and colony-stimulating factor-1 (CSF-1), are pivotal components of the tumor microenv...
Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction [0.03%]
COVID-19感染人类大脑中的主要神经病理学：炎症、血管周细胞主要功能障碍和小胶质细胞功能障碍
Peter Illes,Hai-Yan Yin,Yong Tang
Peter Illes