Population-level analyses identify host and environmental variables influencing the vaginal microbiome [0.03%]
人群分析鉴别影响阴道微生物群的宿主和环境因素
Lang Qin,Tianyong Sun,Xiao Li et al.
Lang Qin et al.
The vaginal microbiome is critical for the reproductive health of women, yet the differential impacts exerted by the host and by ambient environmental variables on the vaginal microbiome remain largely unknown. Here, we conducted a comprehe...
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification [0.03%]
格列苯脲通过代谢调控的表观遗传修饰将MDH2作为靶点以缓解衰老表型
Zhifan Mao,Wenwen Liu,Rong Zou et al.
Zhifan Mao et al.
Mitochondrial metabolism-regulated epigenetic modification is a driving force of aging and a promising target for therapeutic intervention. Mitochondrial malate dehydrogenase (MDH2), an enzyme in the TCA cycle, was identified as an anti-agi...
Ruth Nussinov,Bengi Ruken Yavuz,Hyunbum Jang
Ruth Nussinov
Aggressive tumors pose ultra-challenges to drug resistance. Anti-cancer treatments are often unsuccessful, and single-cell technologies to rein drug resistance mechanisms are still fruitless. The National Cancer Institute defines aggressive...
ACE-Breast-02: a randomized phase III trial of ARX788 versus lapatinib plus capecitabine for HER2-positive advanced breast cancer [0.03%]
ACE-Breast-02：ARX788与拉帕替尼联合卡培他滨治疗HER2阳性晚期乳腺癌的随机III期试验
Xichun Hu,Qingyuan Zhang,Leiping Wang et al.
Xichun Hu et al.
This phase III trial aimed to compare ARX788, a site-specific, construct-homogeneous antibody-drug conjugate, with lapatinib plus capecitabine in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer ...
Successful treatment of transfusion-dependent β-thalassemia: multiple paths to reach potential cure [0.03%]
成功治疗输血依赖性β-地中海贫血：通向潜在治愈的多种路径
Michael Morgan,Axel Schambach
Michael Morgan
Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM [0.03%]
紧凑型CRISPR-Cas效应子Cas12h1的分子见解及其广谱PAM的合理工程化
Weiwei Zheng,Hongyu Li,Mengxi Liu et al.
Weiwei Zheng et al.
Cas12h1 is a compact CRISPR-associated nuclease from functionally diverse type V CRISPR-Cas effectors and recognizes a purine-rich protospacer adjacent motif (PAM) distinct from that of other type V Cas effectors. Here, we report the nickas...
Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicing [0.03%]
胆囊癌全长转录组图谱揭示了由ERBB2可变剪接引起的曲妥珠单抗耐药性
Ziyi Wang,Li Gao,Ziheng Jia et al.
Ziyi Wang et al.
Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate cancer progression. Here, we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues...
Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status [0.03%]
生理和病理状态下胰内分泌和外分泌的信号及相互作用
Chenglin Hu,Yuan Chen,Xinpeng Yin et al.
Chenglin Hu et al.
The pancreas, an organ with dual functions, regulates blood glucose levels through the endocrine system by secreting hormones such as insulin and glucagon. It also aids digestion through the exocrine system by secreting digestive enzymes. C...
Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight [0.03%]
恢复供应线：消除脂肪酸摄取的障碍可增强T细胞驱动的抗癌效果
Jeremy G Baldwin,Caio R F Silveira,Luca Gattinoni
Jeremy G Baldwin
Jie Chen,Ziyue Huang,Ya Chen et al.
Jie Chen et al.
Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation and fate regulation in physiological and pathological settings, particularly in intricate conditions such as cancer. Specifical...