Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury [0.03%]
髓系CD38而不是肝细胞CD38是肝脏缺血再灌注损伤的关键驱动因素
Qi-Hang Zhao,Ya-Ting Zhang,Ke Wen et al.
Qi-Hang Zhao et al.
Hepatic ischemia-reperfusion injury (HIRI) is a critical condition that often occurs during liver transplantation and surgical liver resection. However, its mechanism has not been fully elucidated. Nicotinamide adenine dinucleotide (NAD+), ...
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer [0.03%]
铜离子在肿瘤发生发展中的分子机制及其介导的新型细胞死亡形式cuproptosis研究进展
Ziyu Guo,Danyao Chen,Lei Yao et al.
Ziyu Guo et al.
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-de...
Targeting cancer: tumor-specific splicing events give rise to immunogenic, tumor-wide neoantigens [0.03%]
靶向癌症：肿瘤特异性剪接事件产生免疫原性肿瘤广泛性新抗原
Nils Kosiol,Annkristin Heine,Peter Brossart
Nils Kosiol
Meningeal lymphatic drainage: novel insights into central nervous system disease [0.03%]
脑膜淋巴引流：中枢神经系统疾病的新见解
Qiang Zhang,Yin Niu,Yingpei Li et al.
Qiang Zhang et al.
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lympha...
Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia [0.03%]
NKG2A过表达导致复发性急性髓系白血病中的自然杀伤细胞耗竭
Juan Xie,Xue-Fei Liu,Tong Zhou et al.
Juan Xie et al.
Acute myeloid leukemia (AML) relapse is associated with poor prognosis. While natural killer (NK) cell therapy can induce leukemia remission, infused NK cells are prone to exhaustion. Elucidating the molecular mechanisms driving NK cell exh...
Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment [0.03%]
单细胞转录组分析揭示肠道微生物群通过调节肿瘤微环境增强免疫治疗效力
Minyuan Cao,Yun Deng,Qing Hao et al.
Minyuan Cao et al.
The gut microbiota crucially regulates the efficacy of immune checkpoint inhibitor (ICI) based immunotherapy, but the underlying mechanisms remain unclear at the single-cell resolution. Using single-cell RNA sequencing and subsequent valida...
Branched-chain amino acids alleviate sepsis-induced myocardial dysfunction via inhibition of protein tyrosine phosphatase-6 [0.03%]
支链氨基酸通过抑制蛋白酪氨酸磷酸酶-6改善脓毒症诱导的心肌功能障碍
Shu-Rui Pang,Yu-Tong Zhu,Hou-Zao Chen et al.
Shu-Rui Pang et al.
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival [0.03%]
脂溶性聚(β-氨基酯)miR-590-3p纳米微RNA多管齐下抑制SMAD通路并抑制间充质型胶质母细胞瘤的生长和延长生存期
Jack Korleski,Sophie Sall,Kathryn M Luly et al.
Jack Korleski et al.
Despite aggressive therapy, glioblastoma (GBM) recurs in almost all patients and treatment options are very limited. Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remain in our ab...