Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation [0.03%]
老化中性粒细胞的大囊泡：促进炎症消退的新机制
Christopher Dietz-Fricke,Florian R Greten
Christopher Dietz-Fricke
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives [0.03%]
血管内皮生长因子信号通路的健康与疾病：从分子机制到治疗视角
Chunsik Lee,Myung-Jin Kim,Anil Kumar et al.
Chunsik Lee et al.
Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maint...
Melatonin synergizes with prostaglandin E2 to enhance YAP-mediated regenerative epithelial cell emergence during intestinal repair [0.03%]
褪黑素通过与前列腺素E2协同作用增强YAP介导的再生上皮细胞在肠道修复过程中的出现
Yoojin Seo,Ji-Su Ahn,Hansong Lee et al.
Yoojin Seo et al.
Deep mining in the dorsal raphe: cholecystokinin-expressing neurons encode satiation-related cues to regulate meal size [0.03%]
脑干背缝核中的深度挖掘：胆囊收缩素阳性神经元通过编码饱腹感相关的线索来调节进食量
Niels Röhrdanz,Peer Wulff,Kira Balueva
Niels Röhrdanz
Platelets and diseases: signal transduction and advances in targeted therapy [0.03%]
血小板与疾病：信号转导及靶向治疗进展
Yuchen Tian,Yao Zong,Yidan Pang et al.
Yuchen Tian et al.
Platelets are essential anucleate blood cells that play pivotal roles in hemostasis, tissue repair, and immune modulation. Originating from megakaryocytes in the bone marrow, platelets are small in size but possess a highly specialized stru...
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction [0.03%]
通过诱导杀老细胞和免疫反应消除巨大型先天性黑色素痣的BCL2靶向治疗
Boxuan Wei,Qingxiong Yu,Jiamin Jin et al.
Boxuan Wei et al.
Giant congenital melanocytic nevus (GCMN) is a RAS/RAF mutation-driven syndrome characterized by extensive melanocytic lesions, posing psychological challenges and a lifelong risk of malignancy. Existing treatments like surgical resection a...
Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies [0.03%]
芳烃受体丢失通过促进BRAFV600E靶向治疗抵抗来增强肿瘤细胞的耐药性
Mourad Zerfaoui,Dharmeshkumar Patel,Yueqi Zhang et al.
Mourad Zerfaoui et al.
Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk [0.03%]
乳腺癌与心脏病理交叉对话促进蒽环类药物心脏毒性的外泌体pro-吡咯丁酸miR-216a-5p的转移
Yan Ma,Yongjun Wang,Renzheng Chen et al.
Yan Ma et al.
Doxorubicin (DOX) is the most effective chemotherapeutic for breast cancer, but it is usually associated with severe cardiotoxicity. Further investigation to alleviate its side effects is essential. The present study investigated the mechan...
Cancer cell cooperation: tumor cells team up to scavenge nutrients to ensure proliferation despite starvation [0.03%]
癌细胞协作：肿瘤细胞合作获取营养以保证在饥饿状态下的增殖
Susanne Sebens,Lisa-Marie Philipp,Dieter Adam
Susanne Sebens