Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer [0.03%]
增强子转录谱分析揭示了前列腺癌中由增强子RNA驱动的铁死亡及新的治疗机会
Sheng Ma,Zixian Wang,Zezhong Xiong et al.
Sheng Ma et al.
Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we ...
Advances in the structures, mechanisms and targeting of molecular chaperones [0.03%]
分子伴侣的结构、机制及靶点研究进展
Jinying Gu,Yanyi He,Chenxi He et al.
Jinying Gu et al.
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage unde...
Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study [0.03%]
沙利度胺为基础的治疗方案在大颗粒淋巴细胞白血病中展现出良好的疗效：多中心Ⅱ期临床试验
Ying Yu,Yuxi Li,Rui Cui et al.
Ying Yu et al.
Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells. Standard first-line immunosuppressive treatments have limitations, achieving complete remission (CR) rates of up...
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances [0.03%]
神经退行性疾病抗衰老策略：从机制到临床进展
Qiu Jiang,Jie Liu,Shan Huang et al.
Qiu Jiang et al.
In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer's disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for...
Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines [0.03%]
小核酸药物的前景：从实验台到临床作为下一代药物的发展进程
Mohan Liu,Yusi Wang,Yibing Zhang et al.
Mohan Liu et al.
The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even cura...
Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation [0.03%]
Epstein-Barr病毒通过KDM5B的上调驱动上皮恶性肿瘤进展的过程中对组蛋白去甲基化酶机制的利用
Ya-Qing Zhou,Jia-Xin Jiang,Shuai He et al.
Ya-Qing Zhou et al.
Epstein-Barr virus (EBV) is a significant epigenetic driver in the development of epithelial-origin nasopharyngeal carcinoma (NPC) and gastric cancer (GC), which together represent 80% of EBV-associated malignancies. Despite its known assoc...
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets [0.03%]
组织巨噬细胞：起源、异质性、生物功能、疾病和治疗靶点
Fan Guan,Ruixuan Wang,Zhenjie Yi et al.
Fan Guan et al.
Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in immune defense, surveillance, and homeostasis. This review systematically discusses the types of hematopoietic progenitors that give rise...
Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies [0.03%]
急性呼吸窘迫综合症的进展：侧重于异质性、病理生理学和治疗策略
Wen Ma,Songling Tang,Peng Yao et al.
Wen Ma et al.
In recent years, the incidence of acute respiratory distress syndrome (ARDS) has been gradually increasing. Despite advances in supportive care, ARDS remains a significant cause of morbidity and mortality in critically ill patients. ARDS is...
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages [0.03%]
宿主FSTL1通过促进炎性巨噬细胞的早期募集在干细胞治疗肝纤维化中起重要作用
Xiaohong Zheng,Siyuan Tian,Ting Li et al.
Xiaohong Zheng et al.
Adult stem cell therapy holds great promise for treating decompensated liver cirrhosis on the basis of animal studies, despite uncertainty about its clinical therapeutic efficacy and unclear underlying mechanisms. Here, we investigated the ...
Redox regulation: mechanisms, biology and therapeutic targets in diseases [0.03%]
氧化还原调节：机制、生物学及其在疾病治疗中的靶点
Bowen Li,Hui Ming,Siyuan Qin et al.
Bowen Li et al.
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both the onset and progression of various diseases. Under physiological conditions, oxidative f...