Protecting cell cycle integrity: enhanced start-codon stringency in mitosis [0.03%]
保护细胞周期的完整性：有丝分裂中起始密码子严谨性增强
Omid Omrani,Kanstantsin Siniuk,Martin Fischer
Omid Omrani
Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis [0.03%]
单细胞转录组揭示了软骨细胞和骨细胞的亚型及其在膝关节炎发病机制中的作用
Yuan Liu,Wacili Da,Ming-Jie Xu et al.
Yuan Liu et al.
Research on treating knee osteoarthritis (KOA) is becoming more challenging due to a growing number of younger patients being affected. The pathogenesis of KOA is complex for being a multifactorial disease affecting the entire joint, with r...
Can Gan,Yuan Yuan,Haiyuan Shen et al.
Can Gan et al.
As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors includ...
Neutralizing antibody responses to three XBB protein vaccines in older adults [0.03%]
三种XBB蛋白疫苗在老年人群中诱导的中和抗体反应
Guo-Jian Yang,Mei Lu,Rui-Rui Chen et al.
Guo-Jian Yang et al.
The ongoing COVID-19 pandemic has underscored the importance of strong immune defenses against emerging SARS-CoV-2 variants. While COVID-19 vaccines containing XBB subvariants have proven effective in neutralizing new SARS-CoV-2 variants, a...
Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis [0.03%]
蛋白引路：JAK抑制剂成为毒性表皮坏死松解症的新治疗选择
Benjamin Klein,J Michelle Kahlenberg,Johann E Gudjonsson
Benjamin Klein
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases [0.03%]
神经退行性疾病中铁和其它金属离子的稳态与代谢
Leilei Chen,Qingqing Shen,Yingjuan Liu et al.
Leilei Chen et al.
As essential micronutrients, metal ions such as iron, manganese, copper, and zinc, are required for a wide range of physiological processes in the brain. However, an imbalance in metal ions, whether excessive or insufficient, is detrimental...
Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis [0.03%]
Artequine通过下调TLR4/MD2信号通路缓解心脏纤维化的作用研究
Lars Koch,Konrad Hoeft,Rafael Kramann
Lars Koch
Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, response-adapted study [0.03%]
新型新辅助吡咯替尼和曲妥珠单抗治疗HER2阳性乳腺癌无早期疗效的患者（NeoPaTHer）：前瞻性多中心疗效导向研究的疗效、安全性及生物标志物分析
Fei Wang,Yongjiu Wang,Bin Xiong et al.
Fei Wang et al.
The potential benefits of pyrotinib for patients with trastuzumab-insensitive, HER2-positive early-stage breast cancer remain unclear. This prospective, multicentre, response-adapted study evaluated the efficacy and safety of adding pyrotin...
Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages [0.03%]
针对包含KP.2和KP.3谱系的JN.1亚谱系，重组XBB.1.5加强针诱导出强大的中和反应
Jingyun Yang,Xuemei He,Huashan Shi et al.
Jingyun Yang et al.
The newly emerged variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) demonstrate resistance to present therapeutic antibodies as well as the capability to evade vaccination-elicited antibodies. JN.1 sublineages were de...
The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis [0.03%]
隐秘的长链非编码RNA编码微蛋白TPM3P9驱动致癌性转录剪接和肿瘤发生
Kun Meng,Yuying Li,Xiaoyi Yuan et al.
Kun Meng et al.
Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as noncoding might generate microproteins with oncogenic functions. However, the importance and underlying mechanisms of these microproteins in alternati...