A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease [0.03%]
一种供者G-CSF动员的PD-1+CD8+ TSCM样调节性T细胞亚群可减轻受者急性移植物抗宿主病
Dan Liu,Xue Wang,Yuheng Han et al.
Dan Liu et al.
Donor selection determines the occurrence of acute graft-versus-host-disease (aGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). To optimize the current clinical donor selection criteria and identify putative d...
Yeyu Cai,Tian Chai,William Nguyen et al.
Yeyu Cai et al.
Phototherapy has emerged as a promising modality in cancer treatment, garnering considerable attention for its minimal side effects, exceptional spatial selectivity, and optimal preservation of normal tissue function. This innovative approa...
C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness [0.03%]
血管平滑肌细胞中的C/EBPβ活化促进高脂血症诱导的表型转换和动脉僵硬
Jun Ma,Xiangyu Yang,Yanan Li et al.
Jun Ma et al.
Arterial stiffness is a critical factor in cardiovascular and cerebrovascular events, yet clinical practice lacks specific therapeutic targets and biomarkers for its assessment. Hyperlipidemia closely correlates with arterial stiffness, and...
CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection [0.03%]
编码保守结构/包膜蛋白的CHIKV mRNA疫苗可广泛交叉预防感染
Xiaoming Liang,Yanan Zhou,Yun Yang et al.
Xiaoming Liang et al.
With the broad spread of the chikungunya virus (CHIKV), there is an increasing demand for more effective and broadly protective vaccines. Here, we designed CHIKV mRNA vaccines containing full-length structural proteins or part of structural...
Molecular classification of hormone receptor-positive /HER2-positive breast cancer reveals potential neoadjuvant therapeutic strategies [0.03%]
激素受体阳性/HER2阳性乳腺癌的分子分类揭示了潜在的新辅助治疗策略
Chao Liu,Lisha Sun,Nan Niu et al.
Chao Liu et al.
Significant heterogeneity exists in hormone receptor (HR)-positive/HER2-positive (HR+/HER2+) breast cancer, contributing to suboptimal pathological complete response rates with conventional neoadjuvant treatment regimens. Overcoming this ch...
Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy [0.03%]
用于肺癌治疗的能够激起强大T细胞反应的鼻内注射RNA疫苗方案
Hongjian Li,Yating Hu,Jingxuan Li et al.
Hongjian Li et al.
The rapid success of RNA vaccines in preventing SARS-CoV-2 has sparked interest in their use for cancer immunotherapy. Although many cancers originate in mucosal tissues, current RNA cancer vaccines are mainly administered non-mucosally. He...
Fibroblastic niches in action: CCL19+ reticular cells drive anti-tumor immunity in lung cancer [0.03%]
纤维状生态位的作用：CCL19+网状细胞驱动肺癌的抗肿瘤免疫反应
Alessandro Ianni,Alejandro Vaquero,Thomas Braun
Alessandro Ianni
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs [0.03%]
通过代谢药物针对乳腺癌中的PI3K抑制剂耐药性问题
Niklas Gremke,Isabelle Besong,Alina Stroh et al.
Niklas Gremke et al.
Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K in...
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy [0.03%]
BCL2家族：从细胞凋亡机制到靶向治疗的新进展
Meike Vogler,Yannick Braun,Victoria M Smith et al.
Meike Vogler et al.
The B cell lymphoma 2 (BCL2) protein family critically controls apoptosis by regulating the release of cytochrome c from mitochondria. In this cutting-edge review, we summarize the basic biology regulating the BCL2 family including canonica...
An unexpected player in organ tropism: aspartate functions as signalling molecule to drive lung metastasis [0.03%]
器官特异性的意外参与者：天冬氨酸作为信号分子驱动肺转移
Felix C E Vogel,Almut Schulze
Felix C E Vogel