Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury [0.03%]
单次和重复性创伤性脑损伤中特异性蛋白质标志物及神经退行性风险的评估
Sarah Mantash,Soulaimane Aboulouard,Hassan Dakik et al.
Sarah Mantash et al.
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underl...
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity [0.03%]
TSC22家族成员3通过自然杀伤细胞将药物超敏反应与CD8⁺T细胞介导的免疫应答联系在一起
Lele Sun,Pengcheng Huai,Zhenzhen Wang et al.
Lele Sun et al.
Severe cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors inf...
Qilong Li,Tong Liu,Kunying Lv et al.
Qilong Li et al.
Malaria, caused by Plasmodium parasites and transmitted by Anopheles mosquitoes, greatly impacts public health and socioeconomic development, particularly in sub-Saharan African countries. Despite advances in malaria treatment and preventio...
Gerard J Nuovo,Esmerina Tili,Carlo M Croce
Gerard J Nuovo
Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation [0.03%]
一项II期试验：在具有KRAS G12C突变的晚期实体瘤中，GARSORASIB（一种KRAS G12C抑制剂）联合或不联合西妥昔单抗（EGFR抗体）用于结直肠癌患者的临床研究
Dan-Yun Ruan,Hao-Xiang Wu,Ye Xu et al.
Dan-Yun Ruan et al.
Mutations in the KRAS gene have long been implicated in the pathogenesis of colorectal cancer (CRC). KRAS G12C inhibitors overcome the "undruggable" challenge, enabling precision therapy. Garsorasib (D-1553), a highly potent and selective K...
Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage [0.03%]
嘌呤核苷磷酸酶通过嘌呤补救途径主导流感病毒的复制和宿主过度炎症反应
Yang Yue,Qingyu Li,Changguo Chen et al.
Yang Yue et al.
Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown. By integrating the plasma proteomics data of the IAV-i...
Qing Huang,Yuanxiang Li,Yingdan Huang et al.
Qing Huang et al.
Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitabl...
Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting [0.03%]
茎环结合蛋白通过-1程序化核糖体框移促进SARS-CoV-2复制
Tanxiu Chen,Ruimin Zhu,Tingfu Du et al.
Tanxiu Chen et al.
The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins. To date, the host factors influencing this process re...
Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer [0.03%]
利用双效ENPP1/ATM敲低削弱DNA修复能力提高放免疗疗效以治疗三阴性乳腺癌的研究
Borja Ruiz-Fernández de Córdoba,Karmele Valencia,Connor Welch et al.
Borja Ruiz-Fernández de Córdoba et al.
The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNBC), primarily by contributing to tumor cell survival and treatment resistance. However, the precise mechanisms rem...
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances [0.03%]
氧化应激、炎症和衰老情况下的线粒体：从机制到治疗进展
Xieyang Xu,Yan Pang,Xianqun Fan
Xieyang Xu
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces...