Andreas C Joerger,Thorsten Stiewe
Andreas C Joerger
Jianhong Zhang,Heng Li,Shuo Ru et al.
Jianhong Zhang et al.
Tumor heterogeneity is a fundamental hallmark of cancer that drives progression, metastasis and therapeutic resistance. This diversity originates from persistent genomic instability, dynamic clonal evolution, and cancer stem cell plasticity...
Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production [0.03%]
兼备PD-L1和HLA-E靶向及内源性IL15产生的多功能工程NK细胞能克服肿瘤免疫抑制作用
Piera Filomena Fiore,Sergio Forcelloni,Lorenzo Moretta et al.
Piera Filomena Fiore et al.
The immunosuppressive tumor microenvironment (TME) poses a significant challenge to effective cancer immunotherapy, as it enables tumor escape through redundant checkpoint pathways, metabolic constraints, and direct inhibition of effector c...
Discovery of dynamic tumor microenvironment architecture with targeted agents in the multiplex implantable microdevice assay [0.03%]
基于多重植入式微设备测定法利用靶向药物发现动态的肿瘤微环境结构
Juraj Jakubik,Zuzana Tatarova
Juraj Jakubik
A lipid-tuned bile acid exporter: structural insight into intestinal bile acid efflux [0.03%]
一种经脂质调节的胆汁酸出口蛋白：肠腔排泄胆汁酸的结构洞察
Hak Min Kim,Sang Won Nam,Jung Ki Jo
Hak Min Kim
Switching tumor-derived extracellular vesicles off and on via targeted proteolysis to shift toward immunogenic phenotypes [0.03%]
通过靶向蛋白水解开关肿瘤衍生的细胞外囊泡以向免疫原性表型转变
Yeongji Jang,Byeongmin Park,Jiwoong Choi et al.
Yeongji Jang et al.
Despite compelling evidence that tumor-derived extracellular vesicles (TEVs) exhibit either pro- or antitumorigenic phenotypes, pharmacological efforts have focused primarily on their indiscriminate suppression. Here, we propose a strategy ...
Qiucheng Li,Yau-Tuen Chan,Junyu Wu et al.
Qiucheng Li et al.
Deciphering the mechanistic links between aging and cancer remains a central challenge in biomedical research. This review begins by presenting recent epidemiological data on cancer incidence across age groups, underscoring the complex and ...
Tumor-draining lymph nodes shape the tumor microenvironment through enrichment of tumor-reactive effector-exhausted CD8+ T cells [0.03%]
肿瘤引流淋巴结通过富含肿瘤反应性效应耗竭的CD8+t细胞来塑造肿瘤微环境
Deyang Kong,Lin Feng,Yu Sun et al.
Deyang Kong et al.
Tumor-draining lymph nodes are central to anti-tumor immunity and influence the response to immunotherapy. Colorectal cancers with microsatellite instability and microsatellite stability differ substantially in tumor biology, prognosis and ...
Oladapo F Fagbohun
Oladapo F Fagbohun
Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma [0.03%]
靶向内质网转运可破坏多发性骨髓瘤的代谢适应力
Utku Horzum,Herbert Oberacher,Margot Haun et al.
Utku Horzum et al.
Multiple myeloma (MM) is characterized by the production and secretion of large quantities of immunoglobulins, making this malignancy highly dependent on mechanisms that maintain cellular proteostasis. While significant clinical progress ha...