Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer's disease models [0.03%]
靶向神经元的腔蛋白1过表达可减轻阿尔茨海默病症状模型中的认知障碍和病理转录组变化
Dongsheng Wang,Andrei V Chernov,Ryan Lam et al.
Dongsheng Wang et al.
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive synaptic loss and cognitive decline. Gene therapy that augments intrinsic neuroprotective pathways offers a promising strategy to mitigate neu...
China Protocol for early screening, precise diagnosis, and individualized treatment of lung cancer [0.03%]
肺癌早期筛查、精准诊断和个体化治疗的中国专家共识
Chengdi Wang,Bojiang Chen,Shufan Liang et al.
Chengdi Wang et al.
Early screening, diagnosis, and treatment of lung cancer are pivotal in clinical practice since the tumor stage remains the most dominant factor that affects patient survival. Previous initiatives have tried to develop new tools for decisio...
Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial [0.03%]
特瑞普利单抗联合白蛋白紫杉醇及艾罗珠单抗联合环磷酰胺治疗三阴性乳腺癌Ⅱ期TREND试验疗效、安全性及探索性分析
Qiang Zhang,Mozhi Wang,Yumeng Li et al.
Qiang Zhang et al.
The optimal chemotherapy backbone and specific population of triple-negative breast cancer (TNBC) patients that benefit from neoadjuvant immunotherapy are not well established. This prospective, single-arm, phase II TREND trial assessed the...
De novo induction of tertiary lymphoid structures: an immunotherapeutic strategy in pancreatic cancer [0.03%]
从头诱导生发中心：胰腺癌免疫治疗策略
Azaz Ahmed,Christoph Springfeld,Niels Halama
Azaz Ahmed
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study [0.03%]
探索性生物标志物分析：帕博利珠单抗联合化疗一线治疗广泛期小细胞肺癌的局部和系统免疫特征差异响应者的评估研究
Mengqing Xie,Minwei Bao,Xiaorong Dong et al.
Mengqing Xie et al.
While chemo-immunotherapy has been established as the frontline therapeutic regimen for extensive-stage small cell lung cancer (ES-SCLC), durable responses persist predominantly in a minor population of patients. This underscores critical n...
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis [0.03%]
牙龈卟啉单胞菌通过促进泡沫细胞坏死性凋亡加重动脉粥样硬化斑块不稳定性
Xiaofei Huang,Mengru Xie,Yixuan Wang et al.
Xiaofei Huang et al.
At advanced phases of atherosclerosis, the rupture and thrombogenesis of vulnerable plaques emerge as primary triggers for acute cardiovascular events and fatalities. Pathogenic infection such as periodontitis-associated Porphyromonas gingi...
The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications [0.03%]
免疫系统与心血管疾病：从基本机制到治疗意义
Xiaoyan Wang,Liming Chen,Jianming Wei et al.
Xiaoyan Wang et al.
Immune system plays a crucial role in the physiological and pathological regulation of the cardiovascular system. The exploration history and milestones of immune system in cardiovascular diseases (CVDs) have evolved from the initial discov...
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma [0.03%]
PKMYT1激酶通过改善骨肉瘤对顺铂的敏感性来抑制疾病进展
Binfeng Liu,Wei Li,Wenchao Zhang et al.
Binfeng Liu et al.
Cisplatin (DDP) remains a cornerstone therapy for osteosarcoma (OS); however, pervasive resistance severely limits its clinical efficacy and worsens patient outcomes. Developing strategies to enhance the chemotherapeutic responsiveness of O...
Targeting conserved epitopes in structural proteins: a next-generation vaccine strategy against the newly identified HKU5-CoV-2 virus [0.03%]
针对结构蛋白的保守表位进行靶向：一种下一代抗新发现HKU5-CoV-2病毒疫苗策略
Leonardo Pereira de Araújo,Evandro Neves Silva,André Luiz Caliari Costa et al.
Leonardo Pereira de Araújo et al.
Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation [0.03%]
老化中性粒细胞的大囊泡：促进炎症消退的新机制
Christopher Dietz-Fricke,Florian R Greten
Christopher Dietz-Fricke