Engineered mitochondria in diseases: mechanisms, strategies, and applications [0.03%]
疾病相关的工程线粒体：机制、策略及应用
Mingyang Li,Limin Wu,Haibo Si et al.
Mingyang Li et al.
Mitochondrial diseases represent one of the most prevalent and debilitating categories of hereditary disorders, characterized by significant genetic, biological, and clinical heterogeneity, which has driven the development of the field of e...
Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation [0.03%]
通过c-Myc/NRF1激活，新白细胞介素-2/15装甲CAR-NK细胞在实体瘤中维持卓越的治疗效果
Jianhua Luo,Meng Guo,Mingyan Huang et al.
Jianhua Luo et al.
Adoptive transfer of chimeric antigen receptor (CAR)-modified natural killer (NK) cells represents a transformative approach that has significantly advanced clinical outcomes in patients with malignant hematological conditions. However, the...
Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial [0.03%]
HA121-28在晚期实体瘤和RET融合阳性非小细胞肺癌患者中的安全性，药代动力学和疗效：一项多中心，开放标签，单臂的1/2期试验
Dan-Yun Ruan,Wen-Wen Huang,Yongsheng Li et al.
Dan-Yun Ruan et al.
HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor...
A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants [0.03%]
重组蛋白疫苗诱导对SARS-CoV-2 JN.1和XBB谱系亚变异株的保护性免疫反应
Jingyun Yang,Weiqi Hong,Huashan Shi et al.
Jingyun Yang et al.
The emergence of XBB- and JN.1-lineages with remarkable immune evasion characteristics have led to rises in breakthrough infections within populations. In addition, the unfavorable impacts of immune imprinting, stemming from continuous expo...
Invasion and metastasis in cancer: molecular insights and therapeutic targets [0.03%]
癌症中的侵袭和转移：分子见解与治疗靶点
Yongxing Li,Fengshuo Liu,Qingjin Cai et al.
Yongxing Li et al.
The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting th...
A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy [0.03%]
首个选择性ERK1/2和ERK5抑制剂以单分子策略克服药物抗性问题
Huan Xiao,Aoxue Wang,Wen Shuai et al.
Huan Xiao et al.
Despite significant advancements in kinase-targeted therapy, the emergence of acquired drug resistance to targets such as KRAS and MEK remains a challenge. Extracellular-regulated kinase 1/2 (ERK1/2), positioned at the terminus of this path...
Precise targeting of transcriptional co-activators YAP/TAZ annihilates chemoresistant brCSCs by alteration of their mitochondrial homeostasis [0.03%]
转录共激活因子YAP/TAZ的精准定位通过改变线粒体稳态来根除化学抗性乳腺癌干细胞
Priyanka Dey Talukdar,Kunal Pramanik,Priya Gatti et al.
Priyanka Dey Talukdar et al.
Persistence of drug-resistant breast cancer stem cells (brCSCs) after a chemotherapeutic regime correlates with disease recurrence and elevated mortality. Therefore, deciphering mechanisms that dictate their drug-resistant phenotype is impe...
SARS-CoV-2 compromises blastocyst quality by modifying the ovarian microenvironment [0.03%]
SARS-CoV-2通过修改卵巢微环境来降低囊胚质量
Chen Geng,Min Zhang,Ning Wang et al.
Chen Geng et al.
Hui Liu,Shuo Wang,Jianhua Wang et al.
Hui Liu et al.
Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy ...
Xin Xiong,Le-Wei Zheng,Yu Ding et al.
Xin Xiong et al.
Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breast cancer have enhanc...