Modeling physiological insulin sensitivity and pre-diabetic insulin resistance in multiple hPSC-derived cell types [0.03%]
用多种诱导多能干细胞来源的细胞类型模拟生理胰岛素敏感性和糖尿病前期胰岛素抵抗
Max Friesen,Rudolf Jaenisch
Max Friesen
NOD1/2 signaling in macrophages drives adaptive immune resistance in cancer [0.03%]
肿瘤中的NOD1/2信号驱动适应性免疫抵抗反应
Xiduan Wei,Li Yang,Yuting Wang et al.
Xiduan Wei et al.
Therapeutic resistance remains a prevalent and intractable clinical challenge across a broad spectrum of human malignancies. Despite extensive investigations, the intricate molecular networks by which the tumor microenvironment (TME) mediat...
Connexin 43-dependent mesenchymal stem cell mitochondrial transfer activates PGC1α disrupting oxidative-inflammation axis in ischemia-reperfusion injury [0.03%]
缝隙连接蛋白43依赖性的间充质干细胞线粒体转移激活PGC1α干扰氧化炎症通路以应对缺血再灌注损伤
Abantika Ganguly,Jing Wang,Shobha Regmi et al.
Abantika Ganguly et al.
Ischemia-Reperfusion Injury-related Acute Kidney Injury (IRI-AKI) is a significant clinical challenge. Despite extensive research into the underlying mechanism for IRI-AKI, the development of effective therapeutic interventions remains chal...
Neurotransmitter modulation: a roadmap to precision neuro-immune oncology [0.03%]
神经递质调节：精确神经-免疫肿瘤学路线图
Jacob L Billingsley,Saahir Bhunnoo,Yannick D Benoit
Jacob L Billingsley
Dual-targeting pharmacological UFMylation inhibition reprograms tumor and immune microenvironments to achieve long-term glioblastoma regression [0.03%]
双重靶向药物UFMylation抑制剂可重塑肿瘤和免疫微环境实现胶质母细胞瘤的长期退缩
Pengcheng Tan,Zhimin Liu,Xiaodan Hu et al.
Pengcheng Tan et al.
UFMylation, a recently identified ubiquitin-like modification, is essential for cellular stress homeostasis, particularly endoplasmic reticulum (ER) stress regulation. However, its biological and therapeutic exploration has been hindered by...
Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets [0.03%]
肿瘤的进化：信号通路、分子机制及治疗靶点
Kun-Yu Zhang,Xiu-Zhi Zhu,Yu-Xin Yan et al.
Kun-Yu Zhang et al.
Cancer is one of the leading causes of global morbidity and mortality and is characterized by its high heterogeneity, genomic instability and adaptive plasticity. Applying Darwin's theory of evolution, the concept of tumor evolution has imp...
A ferroptosis-suppressive state drives resistance to bladder-preserving chemoradiotherapy in muscle-invasive bladder cancer [0.03%]
肌层浸润性膀胱癌保留膀胱的化学放疗耐药性的铁死亡抑制型态的研究
Takuya Tsujino,Shogo Yamazaki,Moritoshi Sakamoto et al.
Takuya Tsujino et al.
Bladder-preserving trimodality therapy (TMT) incorporating concurrent chemoradiotherapy (CRT) provides a curative-intent alternative to radical cystectomy for muscle-invasive bladder cancer (MIBC), yet its efficacy is frequently limited by ...
A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier [0.03%]
一个微生物组元转录体学分析流程鉴定出一种保护结肠上皮屏障的中性粒细胞弹性蛋白酶抑制剂
Bojan Stojkovic,Matthijs Bekkers,Jake P Violi et al.
Bojan Stojkovic et al.
Inflammatory Bowel Diseases (IBD) are lifelong conditions. Current therapeutic approaches target inflammatory signalling rather than improving barrier permeability or repair. The gut microbiome provides an exciting opportunity for novel dru...
Martin Culka,Jonathan Desponds,Jeanne Cheung et al.
Martin Culka et al.
The ability to predict T-cell receptor (TCR) specificity from sequences could transform immunotherapy, vaccine development, and our understanding of immune recognition. However, progress has been shaped by "edge cases", in which specificity...
Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer [0.03%]
衰老应激信号：肺癌的转移塑性和代谢脆弱性
Seung-Jae Lee,Jaehoon Bae,Ye Ji Cheon et al.
Seung-Jae Lee et al.