Mitochondrial quality control in health and disease: mechanisms and therapeutic targets [0.03%]
健康与疾病状态下的线粒体质量控制：机制和治疗靶点
Agustina Creus,Shrestha Mohapatra,Leonardo Ortega et al.
Agustina Creus et al.
Mitochondria are essential for cellular homeostasis, integrating various signals to control key cellular functions such as metabolism, apoptosis, inflammation, cell proliferation and redox balance. Given their multifaceted functions, it is ...
Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability [0.03%]
ALU元件介导的SPAST基因缺失导致高尔基体锌转运障碍并揭示潜在药物治疗靶点
Youngsun Lee,Onju Ham,Hana Lee et al.
Youngsun Lee et al.
Alu elements are primate-specific retrotransposons known to mediate structural genomic alterations associated with neurological disorders, yet their underlying disease mechanism remains incompletely understood. Here, we leveraged human plur...
The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 [0.03%]
癌相关的脂肪细胞的促肿瘤功能依赖于线粒体分子伴侣肿瘤坏死因子受配体蛋白1的功能
Nam Gu Yoon,So-Yeon Kim,So-Youn Jung et al.
Nam Gu Yoon et al.
Adipocytes are essential stromal components of the tumor microenvironment (TME) in breast cancer that play pivotal roles in cancer progression and chemoresistance. In close proximity to tumor cells, they undergo phenotypic reprogramming int...
Weiqi Hong,Aqu Alu,Zhihao Zhang et al.
Weiqi Hong et al.
The mucosal system, which includes the respiratory, gastrointestinal, and urogenital tracts, serves as a primary entry point for pathogens, with a unique immune microenvironment and specialized defense mechanisms. In recent years, especiall...
Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy [0.03%]
模仿细菌的癌细胞通过多种模式识别受体途径重新编程巨噬细胞用于癌症免疫治疗
Seoyoon Song,Dongjun Yu,Haneul Kang et al.
Seoyoon Song et al.
Although macrophages are a powerful cell-based platform for cancer immunotherapy, their antitumor functions, such as phagocytosis and inflammatory responses, are limited by the immunosuppressive tumor microenvironment. Here, we show that de...
Chenodeoxycholic acid restrains tumor growth via TGR5-dependent type 1 dendritic cells cross-priming [0.03%]
鹅去氧胆酸通过TGR5依赖的I型树突状细胞交叉激活抑制肿瘤生长
Fanlian Zeng,Fulei Zhao,Pei Zhou et al.
Fanlian Zeng et al.
Conventional type 1 dendritic cells (cDC1s) play a pivotal role in initiating CD8+ T-cell-mediated antitumor immunity, and their intratumoral abundance strongly correlates with immunotherapy efficacy. Here, we demonstrate that orally admini...
Lenvatinib enhances the response of biliary tract cancer to anti-HER2 therapy [0.03%]
仑伐替尼可增强抗HER2治疗对胆道癌的疗效
Huishan Sun,Shuofeng Li,Zhe Zhu et al.
Huishan Sun et al.
Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed or amplified in biliary tract cancer (BTC). Although NCCN clinical practice guidelines recommend HER2-targeted agents as subsequent-line therapy, drug resistance of...
Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma [0.03%]
肺癌腺癌远处转移的机制和治疗靶点
Tongji Xie,Lige Wu,Yan Li et al.
Tongji Xie et al.
Distant metastasis, characterized by organotropism, is a major cause of mortality in lung adenocarcinoma (LUAD). In this study, digital spatial profiling (DSP), multiplex immunofluorescence (mIF), and clinical data from 52 LUAD patients wer...
Krüppel-like factor 4 downregulation during esophageal cancer formation facilitates immune evasion and impairs immunotherapy [0.03%]
Krüppel样因子4在食管癌发生过程中的下调促进了免疫逃逸并影响了免疫治疗
Xiao Hu,Chenying Li,Dongxu Li et al.
Xiao Hu et al.
Impaired antigen processing and presentation are critical for cancer immune evasion, but the underlying mechanism is not fully known. Here, we show that downregulation of Krüppel-like factor 4 (KLF4) expression during the development of ca...
Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf [0.03%]
声音效果：范式基因疗法使出生失聪的儿童和青少年恢复听力
Juliane W Schott,Michael Morgan,Axel Schambach
Juliane W Schott