Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models [0.03%]
Ke Xiong,Guanghua Wang,Desheng Li et al.
Ke Xiong et al.
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulatin...
Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation [0.03%]
Jiang Wang,Hanlin Wang,Runhua Du et al.
Jiang Wang et al.
Epigenetic dysregulation is a fundamental cancer hallmark, and lysine demethylase 1 (LSD1) is a central target for cancer intervention. Developing novel LSD1 inhibitors with high selectivity, favorable bioavailability, and safety for acute ...
Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates [0.03%]
Josephine Hallundbæk Ruders,Shamaila Munir Ahmad,Rasmus Erik Johansson Mortensen et al.
Josephine Hallundbæk Ruders et al.
Transforming growth factor beta (TGFβ) plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) progression by promoting immune suppression, fibrosis, and metastasis. Given its central role in shaping the tumor microenvironment, TGF...
Kyungjun Uh,Yonggyu Kim,Taeho Kwon
Kyungjun Uh
Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility [0.03%]
Xiaohan Zhong,Dongjie Li,Yuanfei Zhao et al.
Xiaohan Zhong et al.
Aortic dissection (AD) is a life-threatening vascular disease with a high mortality rate. Surgery is essential in the acute phase but carries significant risks, whereas elective surgery during the chronic phase yields better outcomes. Howev...
SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial [0.03%]
Herui Yao,Min Yan,Zhongsheng Tong et al.
Herui Yao et al.
SHR-A1811, an antibody‒drug conjugate consisting of the anti-HER2 antibody trastuzumab conjugated via a cleavable linker to a topoisomerase I inhibitor payload, demonstrated substantial antitumor activity in patients with heavily treated H...
Cleaved SREBP-2 C-terminal fragment noncanonically drives interleukin-1 receptor-associated kinase 1-dependent apoptosis [0.03%]
MyeongHoon Yeon,Won-Kyung Kim,Hyeon-Bin Shin et al.
MyeongHoon Yeon et al.
Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer [0.03%]
Zheran Liu,Zijian Qin,Huilin Li et al.
Zheran Liu et al.
Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent and lethal cancers worldwide. Despite multimodal therapeutic advances, long-term survival remains poor, underscoring the need to identify novel molecular drivers of ...
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation [0.03%]
Ming-Yu Zhang,Dong-Ni Ji,Wen-Yi Qi et al.
Ming-Yu Zhang et al.
Cardiac ischemia‒reperfusion (I/R) injury is a leading cause of disability and mortality worldwide, but the underlying mechanism remains largely unknown. Despite the emerging recognition of circular RNAs (circRNAs) as pivotal regulators of...
Jundong Lin,Huikang Yang,Zhihao Zou et al.
Jundong Lin et al.
Docetaxel (Doc), a widely used chemotherapeutic agent, was limited by suboptimal therapeutic efficacy and dose-limiting systemic toxicity due to the insufficiency of hydrophilicity and tumor-targeting specificity. To address this limitation...