Combating small extracellular vesicle-mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides [0.03%]
Chan Ho Kim,Hyewon Ko,Jae Ah Lee et al.
Chan Ho Kim et al.
Tumor cell-derived small extracellular vesicles (TDEs) play a critical role in immune evasion, including the establishment of an immunosuppressive tumor microenvironment (TME), and form a substantial barrier to effective cancer immunotherap...
PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasis [0.03%]
Cong-Cong He,Ming-Xing Lei,Jing-Wei Jiang et al.
Cong-Cong He et al.
Psoriasis is a common immune-mediated skin disease driven largely by interleukin-17A (IL-17A). Although IL-17A plays a key role in disease pathogenesis, the underlying mechanisms remain incompletely understood. Through bioinformatic analysi...
Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy [0.03%]
Frederik E Deiman,Nils Bömer,Pia Davidsson et al.
Frederik E Deiman et al.
Phospholamban (PLN) p.Arg14del (R14Δ/+, also known as R14del) is a pathogenic variant that causes inherited cardiomyopathy. RNA therapy improves cardiac function and survival in murine PLN R14Δ/+. However, the molecular disease mechanisms...
Qingyu Lin,Xingwen Wang,Weixu Zhao et al.
Qingyu Lin et al.
Despite being hailed as a significant advancement in cancer treatment, immune checkpoint blockade (ICB) has not yielded favorable outcomes in colorectal cancer, both in approximately 85% of cases characterized by microsatellite stability (M...
Allele-specific KRAS signaling: shaping tumor immunity and therapeutic response in lung adenocarcinoma [0.03%]
Kostas A Papavassiliou,Dimitrios J Stravopodis,Athanasios G Papavassiliou
Kostas A Papavassiliou
Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis [0.03%]
果糖-1-磷酸通过抑制甘露糖-6-磷酸异构酶来抑制肝细胞癌发生
Yongqiang Wang,Xiangyang Zhang,Ningning Wang et al.
Yongqiang Wang et al.
Fructose consumption increases the risk of obesity-related metabolic diseases and some cancers, but its role in hepatocellular carcinogenesis (HCC) remains controversial. Animal studies suggest that high fructose promotes HCC, whereas human...
An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma [0.03%]
一种肿瘤发生因子M受体和氯离子细胞内通道1信号通路相互作用驱动胶质母细胞瘤关键致癌途径
Amir Hossein Mansourabadi,Dianbo Qu,Francesca Cianci et al.
Amir Hossein Mansourabadi et al.
Oncostatin M receptor (OSMR) plays diverse roles in several human malignancies, including brain, breast, and pancreatic cancer. In glioblastoma (GB), OSMR orchestrates a feedforward signaling mechanism with the truncated active mutant of ep...
The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects [0.03%]
体内CAR-T治疗药物的发展：挑战与监管展望
Jiaqi Lu,Jing Cui,Jing Dong et al.
Jiaqi Lu et al.
Chimeric antigen receptor T-cell (CAR-T) therapy, a groundbreaking advancement in cancer immunotherapy, has demonstrated remarkable efficacy in treating hematological malignancies and autoimmune diseases. However, conventional ex vivo CAR-T...
DNA origami-based virus-like particles: a new class of HIV vaccine candidates with superior immunogenic properties [0.03%]
基于DNA折纸技术的病毒样颗粒：一类具有优越免疫原性的HIV疫苗候选产品
Frauke Muecksch,Juan Hamdan,Oliver T Fackler
Frauke Muecksch
Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial [0.03%]
氟维司群与卡培他滨用作激素受体阳性、HER2阴性乳腺癌一线化疗后的维持治疗： FAMILY多中心、开放标签、随机III期试验
Wenjing Wu,Yaping Yang,Haizhu Chen et al.
Wenjing Wu et al.
Maintenance therapy is key in prolonging remission and improving quality of life for hormone receptor-positive (HR + ), HER-2 negative (HER2-) metastatic breast cancer (MBC), but optimal strategies remain debated. This multicenter, open-lab...