Ulcerative colitis: signaling pathways, therapeutic targets and interventional strategies [0.03%]
溃疡性结肠炎：信号传导途径、治疗靶点及干预策略
Jinhao Jia,Ying Liu,Dan Wang et al.
Jinhao Jia et al.
Ulcerative colitis (UC) is the most common chronic inflammatory disease of the intestinal tract in clinical practice, and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa, which may progress to mal...
Investigation of a clinical trial drug VV261 as a potent antiviral candidate against Chikungunya virus [0.03%]
VV261 抗 chikungunya 病毒临床试验研究探索性实验
Yumin Zhang,Sheng Tang,Lu Chen et al.
Yumin Zhang et al.
Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair [0.03%]
利用四面体DNA纳米结构递送生物可切换三miR-22实现眼内新生血管和神经退行病变的治疗
Qiong Wang,You Wang,Li Chen et al.
Qiong Wang et al.
Ocular neovascular and neurodegenerative diseases, such as diabetic retinopathy and age-related macular degeneration, are characterized by abnormal angiogenesis, vascular leakage, and progressive retinal neurodegeneration, ultimately leadin...
Immunogenic relationship mapping supports a minimal-set trivalent vaccine strategy for broad sarbecovirus protection [0.03%]
免疫相关性映射支持用于广谱sarbecovirus保护的三联疫苗最小组分策略
Yeqing Sun,Ziqi Cheng,Xi Wu et al.
Yeqing Sun et al.
Major outbreaks of severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19), together with the continuous risk of zoonotic spillover of animal sarbecoviruses, underscore the urgent need for vaccines that confer broad...
Spatial dynamics in health and disease: from neurodevelopment to therapeutic target identification for inflammatory diseases [0.03%]
从神经发育到炎症疾病的治疗靶点鉴定：健康和疾病的空间动态学研究
Matteo Barberis,Jinkun Xie
Matteo Barberis
Aromaticity-driven laser photo-responses and binding efficiency in IAF-conjugated natural products for neurodegenerative disease targets [0.03%]
芳香味激光光响应及IAF偶联天然产物神经退行性疾病靶点的结合效率
Nik Humaidi Nik Zulkarnine,Vahid Faramarzi,Michael Taeyoung Hwang
Nik Humaidi Nik Zulkarnine
It's a kind of MAGIC: uncovering the origins of chromosomal instability [0.03%]
它是一种魔力：揭开染色体不稳定的起源之谜
David Gómez-Peregrina,César Serrano
David Gómez-Peregrina
Danli Xiao,Huarong Zhang,Ye Liu et al.
Danli Xiao et al.
Oncolytic viruses (OVs) represent a promising strategy in cancer immunotherapy, as they selectively infect and lyse tumor cells while simultaneously triggering robust antitumor immune responses. By inducing immunogenic cell death, OVs enhan...
Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING [0.03%]
cyclic di-GMP通过靶向蛋白酶体26S亚基非ATP酶3抑制肿瘤转移独立于STING基因
Jieqiong Wang,Alexander Mrozek,Kewen Hu et al.
Jieqiong Wang et al.
Cancer metastasis is the primary cause of cancer-related mortality, yet effective treatments remain limited. There is an urgent need to develop novel therapeutic strategies to combat metastasis. In this study, we demonstrate that the bacter...
Region-resolved proteomic map of the human brain: functional interconnections and neurological implications [0.03%]
人类大脑区域蛋白质组图谱：功能连接和神经学意义
Pei-Pei Zhang,Man-Sheng Li,Jia Zhou et al.
Pei-Pei Zhang et al.
While progress has been made in transcriptomic profiling of the human brain, functional characterization of brain regions and their interactions on the basis of regional protein expression remains limited. Here, we constructed a proteomic m...