Anti-CD38 monoclonal antibody CM313 for systemic lupus erythematosus: a randomized, double-blind, placebo-controlled phase Ib/IIa trial [0.03%]
Jiuliang Zhao,Changsong Lin,Qibing Xie et al.
Jiuliang Zhao et al.
CD38 is highly expressed on various immune cells, including long-lived plasma cells, making it a potential therapeutic target in autoimmune diseases. This phase Ib/IIa study aimed to explore the safety, pharmacokinetics, pharmacodynamics, a...
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury [0.03%]
Julius C Fischer,Sascha Göttert,Maximilian Giller et al.
Julius C Fischer et al.
Intestinal stem cells (ISCs) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses, such as interferon γ (IFNγ)-...
Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1 [0.03%]
社会记忆的维持依赖于神经粘附分子neuroligin 1在社交互动中的加工过程
An Liu,Xingcan Li,Mei Zhuang et al.
An Liu et al.
Proper social behaviors are essential for survival and success, and deficits in these behaviors are associated with many brain disorders. However, the mechanisms underlying the formation and maintenance of social memory remain poorly unders...
Pig-to-human lung xenotransplantation: advancing xenogeneic respiratory transplantation and clinical translation [0.03%]
猪肺移植到人体：异基因呼吸器官移植及临床转化研究进展
Taeho Kwon,Bong-Seok Song,Kyung Seob Lim
Taeho Kwon
Starving tumor, feeding metastasis: a warning about low-carbohydrate diets in cancer therapy [0.03%]
饥饿肿瘤，喂养转移：关于癌症治疗中低碳水化合物饮食的警告
Byeongsoo Kim,BuHyun Youn
Byeongsoo Kim
Circulating miR-18b-3p is a novel biomarker predicting chemo-radiotherapy induced oral mucositis in head and neck cancer [0.03%]
循环miR-18b-3p是预测头颈部癌症放化疗诱导的口腔粘膜炎的新生物标志物
Claudio Pulito,Renata Brandi,Rosanna Sestito et al.
Claudio Pulito et al.
Dynamic transcriptional immune landscape in response to NK-cell therapy combined with gemcitabine plus S-1 in advanced pancreatic cancer: a phase 1b/2 trial [0.03%]
针对晚期胰腺癌的NK细胞疗法联合吉西他滨和S-1治疗的动态转录免疫图谱：一项 Ib/II期临床试验
Qin Tan,Yifei Li,Caixia Liu et al.
Qin Tan et al.
Despite advancements in several malignancies, the treatment atlas of natural killer (NK) cell therapy for pancreatic cancer remains inadequate, and the dynamic immune landscape underlying the various responses is still incompletely understo...
Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury [0.03%]
靶向补体抑制可缓解重复性轻度闭合性脑损伤的病理和认知预后恶化
Khalil Mallah,Carsten Krieg,Devin Hatchell et al.
Khalil Mallah et al.
Repeated mild closed head injury (rmCHI) is a significant public health concern, and this type of repetitive injury is garnering increasing attention, not least because of its increasing incidence in sports. The underlying neuroimmune mecha...
Multidimensional tumor-blood profiling uncovers systemic lymphocyte-monocyte imbalance in pituitary neuroendocrine tumors [0.03%]
多维度肿瘤-血液检测发现垂体神经内分泌瘤存在系统性淋巴细胞-单核细胞失衡现象
Yuting Dai,Shaojian Lin,Junchen Wu et al.
Yuting Dai et al.
Pituitary neuroendocrine tumors (PitNETs) are pathologically characterized by dysregulation of neuroendocrine function and systemic disruption of hormonal homeostasis, yet their regulatory effects on peripheral immune networks remain poorly...
Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome [0.03%]
丙酮酸激酶M2介导的组蛋白乳酸化可改变多囊卵巢综合征中的三维基因组结构
Chuanjin Yu,Tingting Liu,Yishu Wang et al.
Chuanjin Yu et al.
Polycystic ovary syndrome (PCOS) is a frequent endocrine and metabolic imbalance that typically occurs in women of reproductive age. Its molecular pathophysiology is yet unknown, especially the ovarian cellular metabolic inefficiency that c...