M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation [0.03%]
Ming-Yu Zhang,Dong-Ni Ji,Wen-Yi Qi et al.
Ming-Yu Zhang et al.
Cardiac ischemia‒reperfusion (I/R) injury is a leading cause of disability and mortality worldwide, but the underlying mechanism remains largely unknown. Despite the emerging recognition of circular RNAs (circRNAs) as pivotal regulators of...
Jundong Lin,Huikang Yang,Zhihao Zou et al.
Jundong Lin et al.
Docetaxel (Doc), a widely used chemotherapeutic agent, was limited by suboptimal therapeutic efficacy and dose-limiting systemic toxicity due to the insufficiency of hydrophilicity and tumor-targeting specificity. To address this limitation...
DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling [0.03%]
Xinran Ma,Yang Zhang,Yao Wang et al.
Xinran Ma et al.
Primary resistance to chimeric antigen receptor (CAR) T-cell therapies has limited their widespread application. Our prior genome-wide CRISPR/Cas9 screening revealed that the loss of CD58, a crucial intrinsic resistance factor in tumors, re...
A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms [0.03%]
Xiaoya Huang,Yingjian Li,Jikai Deng et al.
Xiaoya Huang et al.
COVID-19 resulting from SARS-CoV-2 infection has presented significant challenges to global health over the past several years. Animal models are essential for studying the pathogenic mechanisms of SARS-CoV-2 and facilitating the developmen...
Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination [0.03%]
Yuqiao Wang,Hao Zhao,Ke Sun et al.
Yuqiao Wang et al.
Pyroptosis, which rapidly releases cellular contents through pyroptotic pores, is an ideal method for inducing in situ cancer vaccines, evoking systemic antitumor immunity, and suppressing primary and metastatic tumors. However, the clinica...
Deepak S Chauhan,Rajendra Prasad,Mukesh Dhanka et al.
Deepak S Chauhan et al.
Nanoparticle-based phototherapy represents a paradigm shift in precision medicine, harnessing light-activated mechanisms to modulate cellular pathways across a spectrum of diseases. By integrating nanoparticles, phototherapeutic modalities ...
Modulating fatty acid signaling to restore allopregnanolone balance: a novel strategy for anxiety disorders [0.03%]
Zhiqian Bi,Yawen Xie,Na Han et al.
Zhiqian Bi et al.
Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors [0.03%]
Yan-Ruide Li,Miao Li,Yuning Chen et al.
Yan-Ruide Li et al.
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapies have demonstrated remarkable efficacy in hematologic malignancies; however, their clinical performance in solid tumors remains limited due to suboptimal tumor infiltration,...
Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial [0.03%]
Rui Zhang,Renyi Feng,Jiuqi Wang et al.
Rui Zhang et al.
The gut-brain axis is increasingly recognized as a critical contributor to Parkinson's disease (PD) pathogenesis, yet the therapeutic impact of microbiota modulation remains unclear due to lack of clinical trials in drug-naïve patients. We...