Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer [0.03%]
以CD98hc为靶点的抗体药物偶联物在卵巢癌中的抗肿瘤活性
Juan Carlos Montero,Verónica Fraile Rivero,María José Doyague et al.
Juan Carlos Montero et al.
Ovarian cancer remains a challenging malignancy with high recurrence rates and limited long-term therapeutic success. Antibody-drug conjugates (ADCs) represent a promising therapeutic class capable of delivering potent cytotoxic agents sele...
TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity [0.03%]
TWIK-1在控制机械敏感性和神经病理性超敏反应的脊髓和外周感觉电路中发挥不同的作用
Seo Young Yang,Tery Yun,Yunjeong Lee et al.
Seo Young Yang et al.
Ion channels are essential for sensing somatic stimuli, and their dysregulation can cause chronic conditions such as neuropathic pain. Although the potassium channel Twik-1 has been linked to sensory processing, its specific roles in the so...
Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses [0.03%]
利巴韦林喷鼻清除鼻部共生病毒治疗过敏性鼻炎
Ye Zhou,Tianyu Wang,Yiwen Fan et al.
Ye Zhou et al.
Much attention has focused on commensal bacteria in health and disease, but the role of commensal viruses is largely unexplored. Although commensal viruses are suggested in some organs such as intestine to maintain tissue homeostasis, it is...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Jun 26;11(1):249. DOI:10.1038/s41392-026-02744-y 2026
TCR-mimic bispecific nanobody-based T cell engager targeting intracellular tumor antigens for cancer immunotherapy [0.03%]
一种双特异性纳米抗体靶向胞内肿瘤抗原的T细胞连接剂用于癌症免疫治疗
Ziqiang Ding,Shuyang Sun,Xiaomei Yang et al.
Ziqiang Ding et al.
T cell engager (TCE) immunotherapies have revolutionized the landscape of cancer treatment; however, their efficacy remains limited by the inaccessibility of intracellular tumor antigens. Conventional bispecific T cell engagers, typically c...
Engineering T cells with a novel PD-L1-specific TCR targeting immune and cancer cells [0.03%]
工程化T细胞：新型PD-L1特异性TCR靶向免疫和肿瘤细胞
Thomas Landkildehus Lisle,Emilie Bülow Jacobsen,Shamaila Munir Ahmad et al.
Thomas Landkildehus Lisle et al.
Novel post-transcriptional dimension of glucocorticoid action through mRNA translation and P-body remodeling [0.03%]
通过mRNA翻译和P体重塑的糖皮质激素作用的新转录后维度
Victoria J Nicolini;FRENCH GR-P-BODY NETWORK;Patrick Brest
Victoria J Nicolini;FRENCH GR-P-BODY NETWORK;Patrick Brest
Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting [0.03%]
基于大规模高分辨率质谱的蛋白质组学定义鼻咽癌治疗靶点分子亚型
Yi-Ping Wu,Yao-Hui He,Guo-Sheng Hu et al.
Yi-Ping Wu et al.
Challenges in the precise diagnosis and treatment of nasopharyngeal carcinoma (NPC) remain, mainly due to the absence of a multi-omics-based molecular classification and effective targeted therapies. In this study, we performed proteomic an...
Nab-paclitaxel plus S-1 induction chemotherapy for patients with locally advanced pancreatic cancer: a multicenter, open-label phase 2 study [0.03%]
纳米紫杉醇联合S-1新辅助化疗治疗局部晚期胰腺癌患者：一项多中心开放性Ⅱ期临床试验
Zhe Cao,Jiangdong Qiu,Wenhao Luo et al.
Zhe Cao et al.
Locally advanced pancreatic cancer (LAPC) is associated with a poor prognosis and limited therapeutic options. This study aimed to evaluate the efficacy and safety of nab-paclitaxel plus S-1 (SnP) as a first-line treatment in patients with ...
Activity-dependent antioxidant gene therapy protects against epileptogenesis [0.03%]
活性依赖型抗氧化基因疗法对癫痫发病的保护作用
Prince Kumar Singh,Gabriele Lignani,Matthew C Walker et al.
Prince Kumar Singh et al.
Spatially interpretable artificial intelligence framework to tailored neoadjuvant dual HER2 blockade in HER2-positive breast cancer [0.03%]
空间可解释的人工智能框架在HER2阳性乳腺癌新辅助治疗中靶向双重HER2阻断疗法的应用研究
Xiang-Rong Wu,Hong Lv,Shen Zhao et al.
Xiang-Rong Wu et al.
Neoadjuvant dual HER2 blockade with trastuzumab and pertuzumab plus chemotherapy represents the current standard-of-care for HER2-positive breast cancer. However, treatment responses remain heterogeneous, underscoring the lack of clinically...