Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress [0.03%]
两种应激响应蛋白激酶通过轻度氧化性压力下激活抗氧化程序来抑制铁死亡
Yumiko Fujikawa,Hirotatsu Imai,Tetsuo Onuki et al.
Yumiko Fujikawa et al.
Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce...
Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology [0.03%]
靶向免疫代谢轴可逆转正畸导致的全身病理变化
Yuning Zhang,Shengjie Jiang,Huimin Zheng et al.
Yuning Zhang et al.
Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently ex...
Cancer drug response and resistance: molecular mechanisms and combating strategies [0.03%]
抗癌药效和耐药性的分子机制及应对策略
Xiaoxia Cheng,Miaochun Xu,Juncheng Wei et al.
Xiaoxia Cheng et al.
Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resista...
BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage-fibroblast interactions to attenuate pulmonary fibrosis [0.03%]
BCL9抑制通过调节巨噬细胞-成纤维细胞相互作用促进成纤维细胞脂质生成以减轻肺纤维化
Wenjie Wang,Yuan Zhang,Fenglian He et al.
Wenjie Wang et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. T...
Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain [0.03%]
铁死亡调控增强新型化学鸡尾酒诱导的血肿脑星形胶质细胞重编程为神经元能力
Jingyi Wang,Shiling Chen,Jiarui Li et al.
Jingyi Wang et al.
Intracerebral hemorrhage (ICH) leads to significant neuronal loss and glial scar formation, but the regenerative capacity of the adult brain remains limited. Although small-molecule-induced astrocyte-to-neuron (AtN) conversion has shown pro...
Immunopeptidome profiling in pulmonary fibrosis: linking antigenicity to cytotoxic immunity and therapeutic targeting [0.03%]
免疫肽谱在肺纤维化中的作用：将抗原性与细胞毒性免疫和治疗靶向相联系
Theodoros Karampitsakos,Brenda M Juan-Guardela,Jose D Herazo-Maya
Theodoros Karampitsakos
p21-activated kinase 4 drives hepatic stellate cell activation and liver fibrosis through the phosphorylation of YAP at T428 [0.03%]
P21激活的激酶4通过T428位酪氨酸磷酸化诱导YAP活化驱动肝星状细胞活化和肝纤维化
Gil-Hwan Kim,Hyunsoo Rho,Chang Hun Lee et al.
Gil-Hwan Kim et al.
Understanding the molecular mechanisms that govern hepatic stellate cell (HSC) fate is essential for developing effective antifibrotic therapies. Yes-associated protein (YAP) plays a pivotal role in organ fibrogenesis and HSC activation, bu...
Mitochondrial quality control in health and disease: mechanisms and therapeutic targets [0.03%]
健康与疾病状态下的线粒体质量控制：机制和治疗靶点
Agustina Creus,Shrestha Mohapatra,Leonardo Ortega et al.
Agustina Creus et al.
Mitochondria are essential for cellular homeostasis, integrating various signals to control key cellular functions such as metabolism, apoptosis, inflammation, cell proliferation and redox balance. Given their multifaceted functions, it is ...
Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability [0.03%]
ALU元件介导的SPAST基因缺失导致高尔基体锌转运障碍并揭示潜在药物治疗靶点
Youngsun Lee,Onju Ham,Hana Lee et al.
Youngsun Lee et al.
Alu elements are primate-specific retrotransposons known to mediate structural genomic alterations associated with neurological disorders, yet their underlying disease mechanism remains incompletely understood. Here, we leveraged human plur...
The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 [0.03%]
癌相关的脂肪细胞的促肿瘤功能依赖于线粒体分子伴侣肿瘤坏死因子受配体蛋白1的功能
Nam Gu Yoon,So-Yeon Kim,So-Youn Jung et al.
Nam Gu Yoon et al.
Adipocytes are essential stromal components of the tumor microenvironment (TME) in breast cancer that play pivotal roles in cancer progression and chemoresistance. In close proximity to tumor cells, they undergo phenotypic reprogramming int...