Chunmei Cai,Guohua Ni,Lei Chen et al.
Chunmei Cai et al.
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availabil...
Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma [0.03%]
奥西替尼通过抑制MYLK4介导的CDKAL1磷酸化来抑制横纹肌肉瘤干细胞样特性及化疗耐药性
Takuto Itano,Rongsheng Huang,Toshifumi Ozaki et al.
Takuto Itano et al.
Lenvatinib plus transarterial chemoembolization and PD-1 inhibitors as conversion therapies for unresectable intermediate-advanced hepatocellular carcinoma: a phase 2 trial and exploratory biomolecular study [0.03%]
仑伐替尼联合经动脉化疗栓塞和PD-1抑制剂作为不可切除的中晚期肝细胞癌新辅助/转化治疗的II期临床研究及探索性生物标志物研究
Xiaoyun Zhang,Haozheng Cai,Wei Peng et al.
Xiaoyun Zhang et al.
Conversion therapy remains an uncommon strategy for managing unresectable hepatocellular carcinoma (uHCC) due to limited evidence supporting its efficacy. To address this gap, we initiated a prospective phase 2 multicenter trial (NCT0499785...
Multiomics Mendelian randomization identifies serpin family G member 1 as a chronic obstructive pulmonary disease modulator [0.03%]
多组学孟德尔随机化鉴定出蛋白酶抑制剂家族G成员1是慢性阻塞性肺疾病的调节因子
Erkang Yi,Jieda Cui,Hairong Wang et al.
Erkang Yi et al.
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, lacks effective disease-modifying therapies, partly because of complex gene-environment interactions and extensive missing heritability. Here, we appl...
May Bakr,Mohamed Salama
May Bakr
Glycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma [0.03%]
糖酵解异质性驱动胰腺导管腺癌代谢靶向治疗
Ugo Chianese,Chiara Papulino,Gerardo Saggese et al.
Ugo Chianese et al.
Pancreatic ductal adenocarcinoma is traditionally characterized as a glycolytic tumor. However, the extent and clinical relevance of its metabolic heterogeneity remain poorly understood. In this study, we investigated whether glycolytic act...
Correction: Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients [0.03%]
纠正：循环肿瘤DNA可优化有限期小细胞肺癌患者的免疫巩固治疗
Yin Yang,Yuqi Wu,Jingjing Zhao et al.
Yin Yang et al.
Diabetes and its complications: molecular mechanisms, prevention and treatment [0.03%]
糖尿病及其并发症的分子机制、预防和治疗措施
Lijun Zhao,Jiamin Yuan,Qing Yang et al.
Lijun Zhao et al.
Diabetic complications represent a formidable clinical challenge characterized by hyperglycemia-induced multiorgan dysfunction and dysregulated intercellular signaling networks. Advances in spatial multiomics and single-cell transcriptomic ...
Astrocytic noncanonical WNT5B signaling modulates extracellular matrix remodeling and neuropathology in Huntington's disease [0.03%]
astrocyte非经典WNT5B信号通路调节亨廷顿病中的细胞外基质重塑及神经病理学变化
Phuong Thi Thanh Nguyen,Ali Yousefian-Jazi,Seung Jae Hyeon et al.
Phuong Thi Thanh Nguyen et al.
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by a triad of behavioral symptoms: involuntary movement, emotional change, and cognitive dysfunction. Although alterations in WNT signaling have been reported in ...
A microbiota-dependent bile acid reprograms alveolar macrophages to control lung inflammation [0.03%]
一种依赖微生物群的胆汁酸重新编程肺泡巨噬细胞以控制肺部炎症
Magdalena Wolska,Pilar Rodríguez-Viso,Anna Świątkowska et al.
Magdalena Wolska et al.