Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation [0.03%]
Kenan Zhang,Lin He,Yizhou Wang et al.
Kenan Zhang et al.
Approximately 70% of clear cell renal cell carcinoma (ccRCC) patients harbor von Hippel‒Lindau (VHL) deficiency, which drives pseudohypoxia and metabolic reprogramming. Here, we report a histone H4 lysine 12 lactylation (H4K12la)-fueled ph...
(Giga)TIME for the era of AI: virtual multiplex immunofluorescence from routine H&E for large populations [0.03%]
Shao-Ping Yang,Dihua Yu
Shao-Ping Yang
Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder [0.03%]
Yaping Shao,Jing Wang,Yaping Liu et al.
Yaping Shao et al.
Rapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinson's disease (PD), affecting 40-50% of PD patients. PD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more sever...
PRIME-HFrEF Trial: a randomized, double-blind, multi-dose umbilical cord-derived mesenchymal stem cell regimen for heart failure [0.03%]
Wei Han,Yuheng Jiao,Wei Chen et al.
Wei Han et al.
The safety of multi-dose mesenchymal stem cell (MSC) regimens has seldom been systematically investigated. The PRIME-HFrEF (Prospective Randomized Controlled Study of Multiple Intravenous Infusions of Umbilical Cord-derived MSCs in Patients...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Mar 26;11(1):112. DOI:10.1038/s41392-026-02678-5 2026
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer [0.03%]
Fang Yang,Meng Wang,Shaofan Hu et al.
Fang Yang et al.
Reprogramming of lipid metabolism and cyclic GMP‒AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is associated with cancer development. However, whether and how fatty acid metabolism regulates the cGAS‒STING pathway i...
Hailong Duan,Xin Peng,Sha Qin et al.
Hailong Duan et al.
Micronuclei are small, independent cytoplasmic structures containing nuclear material. They typically form during cell division due to DNA damage or division abnormalities, serve as biomarkers of genetic damage, and are closely associated w...
Sharmin Akter,Rajesh Madhuvilakku,Anik Kumar Kar et al.
Sharmin Akter et al.
Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation...
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease [0.03%]
Soonbong Baek,Jaemyung Jang,Seungeun Yeo et al.
Soonbong Baek et al.
Oligodendrocyte precursor cells (OPCs) rapidly respond to neural injury, becoming activated to preserve myelin homeostasis and interacting with diverse cell types in the central nervous system (CNS). However, the molecular basis of OPC comm...
Christos P Kotanidis,Charalambos Antoniades
Christos P Kotanidis
Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models [0.03%]
Ke Xiong,Guanghua Wang,Desheng Li et al.
Ke Xiong et al.
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulatin...