Ablation plus immunotherapy versus immunotherapy alone in patients of advanced NSCLC who develop oligo-residual disease after anti-PD-1/L1 therapy (BOOSTER): a randomized phase 2 trial [0.03%]
抗PD-1/L1治疗后发展为寡残留病灶的晚期NSCLC患者中放疗联合免疫治疗对比单用免疫治疗：一项随机II期临床试验（BOOSTER研究）
Shuo Yang,Xinyu Liu,Jia Yu et al.
Shuo Yang et al.
Local consolidative therapy (LCT) has been demonstrated to enhance the survival benefits of immunotherapy in non-small cell lung cancer (NSCLC) patients with oligometastatic or oligoprogressive disease. This randomized, phase 2 trial invest...
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma [0.03%]
KAT2A驱动的SRSF11琥珀酰化通过促进RAD52剪接和同源重组介导肝癌放疗抵抗
Jun Wu,Jingsheng Yuan,Zijian Liu et al.
Jun Wu et al.
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized....
CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer [0.03%]
靶向CDK7的疗法可有效干扰头颈癌的细胞周期进程和致癌信号转导
María Otero-Rosales,Miguel Álvarez-González,Irene Pazos et al.
María Otero-Rosales et al.
Head and neck squamous cell carcinoma (HNSCC) remains a prevalent and aggressive malignancy, characterized by a lack of targeted therapies and limited clinical benefits. Here, we conducted an optimized whole-genome CRISPR screen across five...
A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade [0.03%]
一种新颖的长效C5a阻断环形肽通过有效阻断炎症级联反应预防脓毒症引起的器官功能障碍
Zimiao Luo,Pengfei Luo,Haoyu Gu et al.
Zimiao Luo et al.
Sepsis is a life-threatening syndrome characterized by dysregulated host responses to infection, leading to severe organ dysfunction and a high mortality rate. Reducing the incidence of sepsis is of paramount importance. Given that sepsis-a...
Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer's disease therapy [0.03%]
小胶质细胞来源的纳米囊泡通过同步自噬和分子伴侣介导的自噬用于阿尔茨海默病治疗
Min Li,Shuang Chen,Rong Guo et al.
Min Li et al.
Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preced...
Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research [0.03%]
一种多激酶抑制剂奥勒雷马替尼通过调节脂质代谢治疗琥珀酸脱氢酶缺陷型晚期胃肠间质瘤的Ib期临床研究及转化医学研究
Hai-Bo Qiu,Zhiyan Liang,Jing Yang et al.
Hai-Bo Qiu et al.
Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) are generally resistant to targeted therapy with tyrosine kinase inhibitors (TKIs), such as imatinib, and there are no standard therapeutic options for advanced...
Correction: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury [0.03%]
Correction: SARS-CoV-2触发的肥大细胞快速脱颗粒诱导肺泡上皮炎症和肺损伤
Meng-Li Wu,Feng-Liang Liu,Jing Sun et al.
Meng-Li Wu et al.
Alpha-enolase influences ATP pool of cytoplasm and lactate homeostasis by regulating glycolysis in gastric cancer [0.03%]
α-烯醇化酶通过调节胃癌糖酵解影响细胞质ATP池和乳酸稳态
Xiong Shu,Shiya Liu,Ting Yang et al.
Xiong Shu et al.
Glycolysis is crucial for maintaining cancer stemness. This study demonstrated the role of the glycolytic enzyme alpha-enolase (ENO1) in glycolysis and stemness in gastric cancer (GC). High ENO1 expression was associated with poor prognosis...
Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin [0.03%]
环境光通过工程化光能视紫红质缓解小鼠神经退行性病变
Run-Zhou Yang,Yiting Wang,Zhuanbin Wu et al.
Run-Zhou Yang et al.
The mitochondrial proton motive force (pmf) is a critical driver of cellular energy production and influences various cellular processes. Dysregulation of pmf is implicated in a range of diseases, including neurodegenerative diseases, mitoc...
Serotonin transporter: a potential new immune checkpoint for cytotoxic T cells [0.03%]
血清素转运蛋白：一个新的细胞毒T细胞免疫检查点的潜在靶标
Gerard P Ahern,Rosa L Miyares
Gerard P Ahern