CD8+ TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients [0.03%]
新辅助免疫化疗后肿瘤坏死组织中浸润的CD8+t细胞预测非小细胞肺癌患者的预后
Haifeng Lin,Yi Han,Lei Guo et al.
Haifeng Lin et al.
Neoadjuvant immunochemotherapy has shown promising results, with major pathologic response (MPR, ≤10% residual viable tumors [RVT]) as the primary outcome. However, %RVT showed limited predictive power in stratifying outcomes within the MP...
Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-containing vaccine booster [0.03%]
老年人在含XBB疫苗加强针六个月后的中和抗体持久性和新冠病毒感染
Rui-Rui Chen,Guo-Ping Cao,Xue-Dong Song et al.
Rui-Rui Chen et al.
The persistence of XBB-containing vaccine-induced immunity against evolving SARS-CoV-2 variants remains uncertain, particularly in older adults, who are at increased risk of severe outcomes and may experience more rapid immune decline. We p...
Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10-Notch signaling [0.03%]
α溶血素通过ADAM10-Notch信号调控树突状细胞的分化来增强免疫反应
Ke Wang,Jingwen Liao,Yue Yuan et al.
Ke Wang et al.
Alpha hemolysin, a pore-forming toxin from Staphylococcus aureus, is a critical virulence factor for bacteria. Previous studies have demonstrated that the Hla mutant H35A (HlaH35A) serves as a potent carrier protein for subunit vaccines, ye...
TGF-β1-triggered maladaptive bone marrow endothelium impedes hematopoietic recovery [0.03%]
转化生长因子-β1触发的骨髓内皮适应不良阻碍造血恢复
Zhong-Shi Lyu,Meng-Zhu Shen,Yuan-Ya Zhang et al.
Zhong-Shi Lyu et al.
Endothelial cells (ECs) form a critical bone marrow (BM) niche for hematopoietic stem cell regulation in homeostasis and stress states. However, BM ECs are frequently disrupted in hematologic diseases and their clinical interventions. Altho...
Z-DNA-binding protein 1 exacerbates myocardial ischemia‒reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis [0.03%]
Z-DNA结合蛋白1通过诱导非经典心肌细胞PANoptosis加剧心肌缺血再灌注损伤
Xiaokai Zhang,Shuai Song,Zihang Huang et al.
Xiaokai Zhang et al.
Myocardial ischemia‒reperfusion (I/R) injury is the primary factor that counteracts the beneficial effects of reperfusion therapy. Cardiomyocyte death serves as the fundamental pathological hallmark of I/R injury. However, targeting a sing...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood-brain barrier transport [0.03%]
通过多价调节血脑屏障转运快速清除淀粉样蛋白-β和认知恢复
Junyang Chen,Pan Xiang,Aroa Duro-Castano et al.
Junyang Chen et al.
The blood‒brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous system (CNS) from potentially harmful substances while regulating the transport of essential molecules. Its dysfunction is increas...
Transarterial chemoembolization plus atezolizumab and bevacizumab in patients with intermediate hepatocellular carcinoma: a single-arm, phase 2 trial [0.03%]
超动脉化疗栓塞联合阿特珠单抗和贝伐珠单抗治疗中危肝细胞癌患者的Ⅱ期单臂试验
Kang Wang,Jinkai Feng,Hongming Yu et al.
Kang Wang et al.
Transarterial chemoembolization (TACE) is the standard treatment for intermediate-stage hepatocellular carcinoma (HCC), yet its efficacy as a standalone therapy remains suboptimal. This phase 2 trial (ChiCTR2100049829) evaluated the feasibi...
A metabolic switch in the TCA cycle: a regulator of intestinal stem cell fate during tissue regeneration [0.03%]
肠道再生过程中调控肠干细胞命运的TCA循环代谢开关
Dong Gil You,Jae Hyung Park
Dong Gil You
Lactylation of the SARS-CoV-2 spike protein is required for viral infection [0.03%]
新冠病毒刺突蛋白的乳酰化对病毒感染是必需的
Jingguo Xin,Chunlei Wang,Zhaolong Li et al.
Jingguo Xin et al.