Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer [0.03%]
Anmbreen Jamroze,Xiaozhuo Liu,Surui Hou et al.
Anmbreen Jamroze et al.
BCL-2 has been implicated in prostate cancer (PCa) progression and development of castration-resistant disease (CRPC); however, it remains unclear how the BCL-2- and AR-expressing PCa cell populations evolve across the PCa continuum, how AR...
Bone morphogenetic protein signaling drives rete ridge morphogenesis: a distinct epidermal appendage program [0.03%]
Dong Gil Lee,Sun-Uk Kim,Young-Ho Park
Dong Gil Lee
BMAL1 regulates circadian rhythms via phase separation-mediated transcriptional hub formation [0.03%]
Wenzhen Gao,Li Zhu,Yali Wei et al.
Wenzhen Gao et al.
The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that forms dynamic biomolecular co...
Correction to: Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair [0.03%]
Qiong Wang,You Wang,Li Chen et al.
Qiong Wang et al.
MARCO promotes cholangiocarcinogenesis by inducing immunosuppression and its targeting reduces tumor growth [0.03%]
MARCO通过诱导免疫抑制促进胆管癌发生，靶向抑制MARCO可减少肿瘤生长
Aloña Agirre-Lizaso,Maider Huici-Izagirre,Colm J O&#x;Rourke et al.
Aloña Agirre-Lizaso et al.
Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary malignant tumors with poor prognosis and limited therapeutic options. Recent studies have highlighted the role of the immune system in the development and progression of in...
Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer [0.03%]
靶向损伤相关巨噬细胞中的GPR34可增强抗肿瘤免疫反应并提高舒格利单抗在胰腺癌中的治疗效果
Xiaofan Guo,Yuxiao Liu,Tianchen Li et al.
Xiaofan Guo et al.
Tumor-associated macrophages (TAMs) are pivotal in the immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC). The efficacy of targeting the CSF-1/CSF-1R axis in PDAC remains uncertain. Using single-cell RNA seq...
Jon K Obst,Carmen A Banuelos,Kunzhong Jian et al.
Jon K Obst et al.
Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR signaling. These mechanisms ...
Abexinostat, a histone deacetylases inhibitor, for patients with relapsed or refractory follicular lymphoma: a multi-center, single-arm phase 2 study [0.03%]
组蛋白去乙酰化酶抑制剂阿贝西诺司他治疗复发或难治性滤泡性淋巴瘤患者的多中心、单臂Ⅱ期研究
Lin Gui,Haifeng Liu,Huaqing Wang et al.
Lin Gui et al.
This phase 2, single-arm, multi-center study (NCT03934567) evaluates the efficacy and safety of abexinostat, a histone deacetylase inhibitor, in patients with relapsed or refractory (r/r) follicular lymphoma (FL). Eligible participants had ...
Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes [0.03%]
Nada S Aboelella,Ryan Park,Erting Tang et al.
Nada S Aboelella et al.
Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles in apoptosis, BCL-2 proteins a...
Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation [0.03%]
Yuan-Huan Ma,Geng-Bin Chen,Man-Feng Wu et al.
Yuan-Huan Ma et al.
A significant population of chronic stroke patients urgently requires more effective therapies because of functional plateaus and limited intervention options. Intermittent theta-burst stimulation (iTBS) has been increasingly adopted in chr...