Correction to: Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair [0.03%]
Qiong Wang,You Wang,Li Chen et al.
Qiong Wang et al.
MARCO promotes cholangiocarcinogenesis by inducing immunosuppression and its targeting reduces tumor growth [0.03%]
Aloña Agirre-Lizaso,Maider Huici-Izagirre,Colm J O&#x;Rourke et al.
Aloña Agirre-Lizaso et al.
Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary malignant tumors with poor prognosis and limited therapeutic options. Recent studies have highlighted the role of the immune system in the development and progression of in...
Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer [0.03%]
Xiaofan Guo,Yuxiao Liu,Tianchen Li et al.
Xiaofan Guo et al.
Tumor-associated macrophages (TAMs) are pivotal in the immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC). The efficacy of targeting the CSF-1/CSF-1R axis in PDAC remains uncertain. Using single-cell RNA seq...
Jon K Obst,Carmen A Banuelos,Kunzhong Jian et al.
Jon K Obst et al.
Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR signaling. These mechanisms ...
Abexinostat, a histone deacetylases inhibitor, for patients with relapsed or refractory follicular lymphoma: a multi-center, single-arm phase 2 study [0.03%]
Lin Gui,Haifeng Liu,Huaqing Wang et al.
Lin Gui et al.
This phase 2, single-arm, multi-center study (NCT03934567) evaluates the efficacy and safety of abexinostat, a histone deacetylase inhibitor, in patients with relapsed or refractory (r/r) follicular lymphoma (FL). Eligible participants had ...
Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes [0.03%]
Nada S Aboelella,Ryan Park,Erting Tang et al.
Nada S Aboelella et al.
Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles in apoptosis, BCL-2 proteins a...
Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation [0.03%]
Yuan-Huan Ma,Geng-Bin Chen,Man-Feng Wu et al.
Yuan-Huan Ma et al.
A significant population of chronic stroke patients urgently requires more effective therapies because of functional plateaus and limited intervention options. Intermittent theta-burst stimulation (iTBS) has been increasingly adopted in chr...
Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis [0.03%]
Lianbo Shao,You Yu,Haoyue Huang et al.
Lianbo Shao et al.
Thoracic aortic dissection (TAD) is a highly lethal vascular condition closely associated with endothelial cell (EC) dysfunction. γ-Aminobutyric acid (GABA) can be synthesized in ECs and modulate cell functions; however, its underlying rol...
Ting Yuan,Xuebing Liu,Yucui Wu et al.
Ting Yuan et al.
Anemia is one of the most prevalent systemic complications in patients with cancer, substantially impairing quality of life and limiting the safe administration of cytoreductive therapies. Despite its clinical significance, the mechanisms b...
Michelle C C Lim,Gunter Maubach,Michael Naumann
Michelle C C Lim