Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers [0.03%]
表观遗传调控的端粒RNA维持端粒酶驱动癌症中的异染色质
Jared D W Price,Frederick S Vizeacoumar,Omar Abuhussein et al.
Jared D W Price et al.
Tumor heterogeneity presents a major clinical challenge. Reactivation of telomerase (hTERT) is a near-universal hallmark of cancer, yet direct inhibition of hTERT has shown limited therapeutic benefit. To uncover tractable telomerase-relate...
Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer [0.03%]
时空程序化纳米药物工程解决三阴性乳腺癌免疫信号冲突问题
Xiuping Guo,Wensheng Zheng,Kaichao Song et al.
Xiuping Guo et al.
In triple-negative breast cancer (TNBC), chemotherapy-induced immunogenic cell death (ICD) often fails to trigger truly effective antitumor immunity. This failure primarily stems from the simultaneous release of damage-associated molecular ...
Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities [0.03%]
自噬的转录和表观遗传调控：机制、病理意义与治疗机会
Jieun Seo,Seo-Young Park,Dong Chul Lee et al.
Jieun Seo et al.
Autophagy is a tightly regulated catabolic process that is essential for cellular homeostasis, stress adaptation, and metabolic balance. Its dysregulation has been implicated in a wide range of diseases, including cancer, neurodegenerative ...
Innovative peptide-loaded hybrid membrane nanovaccine enables precise personalized immunotherapy for HPV-related cervical diseases [0.03%]
创新的肽载杂化膜纳米疫苗能够实现人乳头瘤病毒相关宫颈疾病的精准个性化免疫治疗
Renjie Wang,Jie Wang,Jinghan Ruan et al.
Renjie Wang et al.
Human papillomavirus (HPV)-associated cervical diseases pose significant health risks to women worldwide. Current clinical interventions face challenges in achieving complete viral clearance and controlling disease progression, with limited...
Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling [0.03%]
抗哮喘药物蒙特鲁卡斯通过干扰神经元视黄酸信号诱导自闭症行为
Zi-Jian Hao,Qiong-Hui Wu,Ya-Li Li et al.
Zi-Jian Hao et al.
Autism spectrum disorders (ASD) affect approximately 1.0% of children worldwide with still increasing global prevalence. The fact that genetic factors contribute to less than 50% of ASD suggests some critical yet enigmatic roles of non-gene...
Macrophage accumulation on the injured pulmonary surface promotes intrathoracic adhesions [0.03%]
肺损伤表面的巨噬细胞积聚促进胸内粘连形成
Yu Mori,Tomohisa Sakaue,Mikio Okazaki et al.
Yu Mori et al.
Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications [0.03%]
多组学与人工智能赋能的精准药物发现及临床应用潜力
Yuqing Liu,Kun Zhu,Weijun Peng et al.
Yuqing Liu et al.
The integration of multiomics technologies with artificial intelligence (AI) has become a transformative force in modern precision medicine, particularly within drug discovery. Multiomics approaches, including genome-wide association studie...
Single-cell identifies and validates human circulating Treg subtype/state Tregfci in non-small cell lung cancer [0.03%]
单细胞鉴定和验证非小细胞肺癌中的循环Tregs亚型/状态Tregfci
Xuanqi Liu,Yifei Liu,Wanxin Duan et al.
Xuanqi Liu et al.
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). ...
Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics [0.03%]
基于DNA四面体处理器的胞内逻辑运算实现精准肿瘤诊疗
Yang Gao,Yun Wang,Yunlong Qin et al.
Yang Gao et al.
The integration of molecular computation with nanomedicine holds transformative potential for precision cancer theranostics. However, achieving an intelligent, multi-input decision-making process within living cells remains a formidable cha...
Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity [0.03%]
LAG3定向白细胞介素-2可靶向肿瘤特异性T细胞，防止T细胞衰竭并重新激发抗肿瘤免疫反应
Xiaohong Yu,Huiping Liao,Jiaoyun Lv et al.
Xiaohong Yu et al.
LAG3 is a critical inhibitory receptor that is highly enriched on exhausted T cells within the tumor microenvironment (TME), where it acts as a key driver of T-cell exhaustion-an archetypal barrier to robust antitumor immunity. In a colon c...