A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade [0.03%]
一种新颖的长效C5a阻断环形肽通过有效阻断炎症级联反应预防脓毒症引起的器官功能障碍
Zimiao Luo,Pengfei Luo,Haoyu Gu et al.
Zimiao Luo et al.
Sepsis is a life-threatening syndrome characterized by dysregulated host responses to infection, leading to severe organ dysfunction and a high mortality rate. Reducing the incidence of sepsis is of paramount importance. Given that sepsis-a...
Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer's disease therapy [0.03%]
小胶质细胞来源的纳米囊泡通过同步自噬和分子伴侣介导的自噬用于阿尔茨海默病治疗
Min Li,Shuang Chen,Rong Guo et al.
Min Li et al.
Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preced...
Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research [0.03%]
一种多激酶抑制剂奥勒雷马替尼通过调节脂质代谢治疗琥珀酸脱氢酶缺陷型晚期胃肠间质瘤的Ib期临床研究及转化医学研究
Hai-Bo Qiu,Zhiyan Liang,Jing Yang et al.
Hai-Bo Qiu et al.
Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) are generally resistant to targeted therapy with tyrosine kinase inhibitors (TKIs), such as imatinib, and there are no standard therapeutic options for advanced...
Correction: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury [0.03%]
Correction: SARS-CoV-2触发的肥大细胞快速脱颗粒诱导肺泡上皮炎症和肺损伤
Meng-Li Wu,Feng-Liang Liu,Jing Sun et al.
Meng-Li Wu et al.
Alpha-enolase influences ATP pool of cytoplasm and lactate homeostasis by regulating glycolysis in gastric cancer [0.03%]
α-烯醇化酶通过调节胃癌糖酵解影响细胞质ATP池和乳酸稳态
Xiong Shu,Shiya Liu,Ting Yang et al.
Xiong Shu et al.
Glycolysis is crucial for maintaining cancer stemness. This study demonstrated the role of the glycolytic enzyme alpha-enolase (ENO1) in glycolysis and stemness in gastric cancer (GC). High ENO1 expression was associated with poor prognosis...
Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin [0.03%]
环境光通过工程化光能视紫红质缓解小鼠神经退行性病变
Run-Zhou Yang,Yiting Wang,Zhuanbin Wu et al.
Run-Zhou Yang et al.
The mitochondrial proton motive force (pmf) is a critical driver of cellular energy production and influences various cellular processes. Dysregulation of pmf is implicated in a range of diseases, including neurodegenerative diseases, mitoc...
Serotonin transporter: a potential new immune checkpoint for cytotoxic T cells [0.03%]
血清素转运蛋白：一个新的细胞毒T细胞免疫检查点的潜在靶标
Gerard P Ahern,Rosa L Miyares
Gerard P Ahern
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop [0.03%]
激活Piezo1可抑制骨髓脂肪细胞生成从而通过抑制机体内源性炎性的自分泌环路来预防骨质疏松症
Baile Wang,Jie Liu,Qin Wang et al.
Baile Wang et al.
With aging or osteoporosis, bone marrow adipogenesis is increased and inversely correlates with the loss of bone mass. Bone marrow adipocytes are derived from multipotent bone marrow mesenchymal stem cells (BMMSCs), which can differentiate ...
Gut-derived imidazole propionate promotes atherosclerosis through myeloid imidazoline-1 receptor signaling: new biomarker and therapeutic target [0.03%]
肠道来源的咪唑丙酸通过髓系受体伊马佐林-1信号通路促进动脉粥样硬化：新的生物标志物和治疗靶点
Weiqi Wang,Dilvin Semo,Rinesh Godfrey
Weiqi Wang
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations [0.03%]
蛋白质折叠与稳态的导航：从分子伴侣到治疗创新
Omer Faruk Kuzu,Lars Jørgen Tvenge Granerud,Fahri Saatcioglu
Omer Faruk Kuzu
Protein folding is a fundamental process ensuring that polypeptide chains acquire the correct three-dimensional structures required for biological function. This complex journey from nascent polypeptides to mature proteins is tightly regula...