Immunogenic relationship mapping supports a minimal-set trivalent vaccine strategy for broad sarbecovirus protection [0.03%]
免疫相关性映射支持用于广谱sarbecovirus保护的三联疫苗最小组分策略
Yeqing Sun,Ziqi Cheng,Xi Wu et al.
Yeqing Sun et al.
Major outbreaks of severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19), together with the continuous risk of zoonotic spillover of animal sarbecoviruses, underscore the urgent need for vaccines that confer broad...
Spatial dynamics in health and disease: from neurodevelopment to therapeutic target identification for inflammatory diseases [0.03%]
从神经发育到炎症疾病的治疗靶点鉴定：健康和疾病的空间动态学研究
Matteo Barberis,Jinkun Xie
Matteo Barberis
Aromaticity-driven laser photo-responses and binding efficiency in IAF-conjugated natural products for neurodegenerative disease targets [0.03%]
芳香味激光光响应及IAF偶联天然产物神经退行性疾病靶点的结合效率
Nik Humaidi Nik Zulkarnine,Vahid Faramarzi,Michael Taeyoung Hwang
Nik Humaidi Nik Zulkarnine
It's a kind of MAGIC: uncovering the origins of chromosomal instability [0.03%]
它是一种魔力：揭开染色体不稳定的起源之谜
David Gómez-Peregrina,César Serrano
David Gómez-Peregrina
Danli Xiao,Huarong Zhang,Ye Liu et al.
Danli Xiao et al.
Oncolytic viruses (OVs) represent a promising strategy in cancer immunotherapy, as they selectively infect and lyse tumor cells while simultaneously triggering robust antitumor immune responses. By inducing immunogenic cell death, OVs enhan...
Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING [0.03%]
cyclic di-GMP通过靶向蛋白酶体26S亚基非ATP酶3抑制肿瘤转移独立于STING基因
Jieqiong Wang,Alexander Mrozek,Kewen Hu et al.
Jieqiong Wang et al.
Cancer metastasis is the primary cause of cancer-related mortality, yet effective treatments remain limited. There is an urgent need to develop novel therapeutic strategies to combat metastasis. In this study, we demonstrate that the bacter...
Region-resolved proteomic map of the human brain: functional interconnections and neurological implications [0.03%]
人类大脑区域蛋白质组图谱：功能连接和神经学意义
Pei-Pei Zhang,Man-Sheng Li,Jia Zhou et al.
Pei-Pei Zhang et al.
While progress has been made in transcriptomic profiling of the human brain, functional characterization of brain regions and their interactions on the basis of regional protein expression remains limited. Here, we constructed a proteomic m...
Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2 [0.03%]
诱导型CD147上调促进新冠病毒感染延长从而导致重症新冠肺炎（独立于ACE2）
Ke Wang,Peng Lin,Ruo Chen et al.
Ke Wang et al.
The high mortality caused by severe COVID-19 poses great challenges to the public health. However, the underlying pathogenesis of severe cases remains unclear. Here, we find that SARS-CoV-2 infection boosts CD147 inducible up-regulation in ...
Yanxi Yao,Yifei Zhu,Keji Chen et al.
Yanxi Yao et al.
The intricate relationship between the microbiota and cancer has recently emerged as a pivotal area of research, highlighting their critical roles in carcinogenesis, progression, and prognosis. With the increasing recognition of the therape...
Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis [0.03%]
角蛋白细胞中的Wnt相关DKK3介导放射诱导的增生、皮炎和皮肤纤维化
Li Li,Ramon Lopez Perez,Khuram Shehzad et al.
Li Li et al.
Radiotherapy remains a mainstay of cancer treatment. However, radiotherapy can also elicit acute and chronic adverse effects, including dermal inflammation and skin fibrosis. A comprehensive understanding of the underlying fibrotic processe...