CD45-targeted pan-leukocyte imaging: mapping whole-body inflammatory activity with specificity and translational promise [0.03%]
Seung Ho Baek,Jung Joo Hong
Seung Ho Baek
Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [0.03%]
Yue Liu,Huirui Wang,Jie Zhan et al.
Yue Liu et al.
The widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of t...
Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin [0.03%]
脂肪细胞通过β2微球蛋白指导肥胖相关性慢性炎症反应
Jie Li,Yuhao Li,Xiaoyang Zhou et al.
Jie Li et al.
Chronic inflammation in adipose tissue is widely recognized as a pivotal link connecting obesity to a spectrum of related chronic diseases, including type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular disorders. In this ...
Beyond barriers: when neurons act immune and immunity acts neural [0.03%]
跨越障碍：当神经元表现得像免疫细胞而免疫系统表现得像神经系统时
Sang Wha Kim,Seung Hyeok Seok
Sang Wha Kim
A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib [0.03%]
奥希替尼一线治疗失败的EGFR突变晚期非小细胞肺癌患者的前瞻性、多中心综合基因谱特征研究
Yuankai Shi,Dongqing Lv,Weineng Feng et al.
Yuankai Shi et al.
Osimertinib, the first approved third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), exhibits notable efficacy in EGFR-mutant non-small cell lung cancer (NSCLC). This is a prospective, multicenter, compr...
Integrative analysis of non-small cell lung cancer identifies Jumonji domain-containing 6/ETS homologous factor axis as a target to overcome radioresistance [0.03%]
整合分析非小细胞肺癌识别Jumonji结构域包含6/ETS同源因子轴作为克服放射耐药性的靶点
Manni Wang,Li Xu,Aqu Alu et al.
Manni Wang et al.
Radiation therapy (RT) is a key treatment strategy for lung cancer, yet its efficacy is frequently compromised by radioresistance. The combination of RT with targeted therapies enhances treatment outcomes for non-small cell lung cancer (NSC...
MUCIN 1 confers inflammatory memory of tyrosine kinase inhibitor resistance in non-small cell lung cancer [0.03%]
黏蛋白1使非小细胞肺癌上皮-间充质转化相关酪氨酸激酶抑制剂耐药炎症记忆化
Shinkichi Takamori,Naoki Haratake,Atrayee Bhattacharya et al.
Shinkichi Takamori et al.
Resistance of NSCLCs to osimertinib, an EGFR tyrosine kinase inhibitor (TKI), is mediated by pleotropic mechanisms that pose a significant challenge for subsequent treatment. We report that the oncogenic MUC1-C/M1C protein confers resistanc...
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels [0.03%]
脉冲电磁场通过膜张力介导的机械敏感性通道调节细胞焦亡从而抑制动脉粥样硬化
Hongxin Cheng,Qing Zhang,Wen Zhong et al.
Hongxin Cheng et al.
Atherosclerosis serves as the core pathological basis of cardiovascular, cerebrovascular, and peripheral arterial diseases, posing a serious threat to human health. However, current mainstream treatments such as statin drugs and stent impla...
Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges [0.03%]
靶向KRAS突变：协调癌症进化和治疗挑战
Khalil Choucair,Hafsa Imtiaz,Md Hafiz Uddin et al.
Khalil Choucair et al.
Activating KRAS mutations are highly relevant to various cancers, and KRAS is the most frequently altered oncogenic protein in solid tumors. While historically considered undruggable, two KRASG12C inactive state-selective inhibitors are cur...
Preoperative pembrolizumab (anti-PD-1 antibody) combined with chemoradiotherapy for esophageal squamous cell carcinoma: a phase 1/2 trial (PALACE-2) [0.03%]
帕博利珠单抗(PD-1抗体)联合术前放化疗治疗食管鳞癌的I/II期临床试验(PALACE-2)
Chengqiang Li,Yichao Han,Shengguang Zhao et al.
Chengqiang Li et al.
The role of preoperative anti-PD-1 antibody (pembrolizumab) plus chemoradiotherapy (PPCT) in locally advanced, resectable esophageal squamous cell carcinoma (ESCC) is still unclear. We aimed to investigate the therapeutic effect and safety ...