Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses [0.03%]
选择性耗竭肿瘤相关SAMHD1可增强化疗疗效和抗肿瘤免疫反应
Jing Sun,Wenwen Zheng,Zheng-Guo Zhang et al.
Jing Sun et al.
SAMHD1 is a human deoxyribonucleoside triphosphatase (dNTPase) known for its role as a restriction factor that targets a wide spectrum of viruses, its involvement in autoimmune disease Aicardi-Goutières syndrome (AGS), and its participatio...
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions [0.03%]
消除异常糖酵结合作用可清除衰老细胞并缓解与衰老相关功能障碍
Takumi Mikawa,Masahiro Kameda,Sumiko Ikari et al.
Takumi Mikawa et al.
Cellular senescence is deeply involved in physiological homeostasis, development, tissue repair, aging, and diseases. Senescent cells (SnCs) accumulate in aged tissues and exert deleterious effects by secreting proinflammatory molecules tha...
Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trial [0.03%]
L-奥克雷司他治疗创伤性脑损伤患者认知功能的疗效和安全性：一项多中心、随机、双盲、三期临床试验
Tao Liu,Jiao Wang,Zhihao Zhao et al.
Tao Liu et al.
To assess the efficacy and safety of L-oxiracetam, a novel nootropic agent, in improving cognition in patients with TBI, we performed a multicentre, double-blind, randomized controlled trial in China. Participants aged 18 to 75 years with T...
Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies [0.03%]
STAT5活化的致癌基因诱导的Oncostatin M促进血液系统恶性肿瘤的发展进展
Michael Rassner,Tony Andreas Müller,Kirstyn Anne Crossley et al.
Michael Rassner et al.
Understanding the interplay between oncogenic mutations and the tumor microenvironment could help improve therapy for hematological malignancies. We found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce onco...
Urate-lowering therapy and kidney outcomes in patients with chronic kidney disease and hyperuricemia [0.03%]
慢性肾脏病合并高尿酸血症患者降尿酸治疗的肾脏结局研究
Sheng Nie,Shiyu Zhou,Ruixuan Chen et al.
Sheng Nie et al.
Hyperuricemia is considered a modifiable risk factor for the development and progression of chronic kidney disease (CKD). There remains controversy over the effects of urate-lowering therapy (ULT) on kidney outcomes in patients with CKD and...
Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to reprogram lipid metabolism [0.03%]
溶血磷脂酰乙醇胺18:1通过稳定SIRT6重新编程脂质代谢从而驱动透明细胞肾细胞癌
Nanxi Yue,Hongye Zhao,Yong Zhang et al.
Nanxi Yue et al.
Clear cell renal cell carcinoma (ccRCC) is characterized by profound lipid metabolic dysregulation, yet the mechanisms linking peritumoral adipose tissue (PAT)-derived lipid metabolites to tumor aggressiveness remain poorly defined. Here, w...
Bruceine A protects nuclear receptor 4A1 from ubiquitin-degradation to alleviate mesangial proliferative glomerulonephritis [0.03%]
Bruceine A通过保护核受体4A1免于泛素降解来缓解系膜增殖性肾小球肾炎
Huating Hu,Runze Li,Kancheng He et al.
Huating Hu et al.
The nuclear receptor 4A1(NR4A1) plays a crucial role in maintaining cellular homeostasis and is involved in various disease processes; however, its functional role and pharmacological potential in mesangial proliferative glomerulonephritis ...
CD45-targeted pan-leukocyte imaging: mapping whole-body inflammatory activity with specificity and translational promise [0.03%]
靶向CD45的泛白细胞成像：特异性地绘制全身炎性活性并具有转化前景
Seung Ho Baek,Jung Joo Hong
Seung Ho Baek
Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [0.03%]
CDC6和Tmod3的互作通过焦粘连装配促进帕利塔克巴耐药性生成
Yue Liu,Huirui Wang,Jie Zhan et al.
Yue Liu et al.
The widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of t...
Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin [0.03%]
脂肪细胞通过β2微球蛋白指导肥胖相关性慢性炎症反应
Jie Li,Yuhao Li,Xiaoyang Zhou et al.
Jie Li et al.
Chronic inflammation in adipose tissue is widely recognized as a pivotal link connecting obesity to a spectrum of related chronic diseases, including type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular disorders. In this ...