Concordance analysis of DNA and RNA profiling: The MD Anderson IMPACT2 study in precision oncology [0.03%]
DNA与RNA谱分析的同贯性分析：精准肿瘤学中的安德森癌症中心IMPACT2研究项目
Stephanie T Schmidt,Mehmet A Baysal,Siqing Fu et al.
Stephanie T Schmidt et al.
DNA profiling is an established method for cancer treatment selection, while RNA profiling remains investigational. We explored associations between DNA and RNA alterations and between the number of genes with altered expression and overall...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Feb 24;11(1):68. DOI:10.1038/s41392-026-02580-0 2026
Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease [0.03%]
染料木素gaylussacin通过调节颗粒物诱导的巨噬细胞染色质重塑抑制慢性阻塞性肺疾病的发展
Jeong Yeon Sim,Jee Hwan Ahn,Hye-Young Min et al.
Jeong Yeon Sim et al.
Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer [0.03%]
癌症神经科学：癌症的信号通路及新的治疗策略
Sihui Zhang,Lin Yuan,Ping Lin et al.
Sihui Zhang et al.
From a neuroscience perspective, cancer neuroscience has emerged as a subfield of cancer research. Presumable mechanisms underlying cancer-related neuronal activity (termed neurosciences) include the induction and modulation of signaling pa...
Parathyroid hormone-related protein is a therapeutic target in idiopathic pulmonary fibrosis [0.03%]
特发性肺纤维化治疗靶点——甲状旁腺激素相关蛋白
Xue-Quan Fang,Suha Lim,Yoon-Mi Lee et al.
Xue-Quan Fang et al.
The crosstalk between immune or alveolar epithelial cells and fibroblasts mediated by paracrine signaling molecules is associated with the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, studies investigating the active involv...
Heyang Cui,Zhongxu Zhu,Enwei Xu et al.
Heyang Cui et al.
Esophageal squamous cell carcinoma (ESCC) lacks a standardized classification system, resulting in inconsistent clinical management and a suboptimal prognosis. This study addresses the urgent need for a robust consensus taxonomy to facilita...
Ubiquitination at pericentromeric regions: directing heterochromatin reassembly during cell division [0.03%]
细胞分裂期间异染色质重组过程中发生在近端着丝粒区域的泛素化作用
Zhenxuan Chen,Tiebang Kang,Liwen Zhou
Zhenxuan Chen
Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation [0.03%]
谷氨酰胺代谢通过激活精.arg-mtorc1通路驱动衰老
Honghan Chen,Ning Huang,Weitong Xu et al.
Honghan Chen et al.
The catabolism of glutamine is essential for living organisms, so that its first step, driven by glutaminase 1 (GLS1), generally referred to as glutaminolysis, plays important roles in physiological metabolism. However, the status and impac...
Serpina3c protects against metabolic dysfunction-associated steatotic liver disease in offspring induced by prenatal prednisone exposure [0.03%]
孕期皮质醇暴露诱导子代肝脏糖脂代谢异常及SERPINA3C的保护作用机制研究
Yongguo Dai,Zhengjie Lu,Yu Peng et al.
Yongguo Dai et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major global public health problem, and its occurrence is associated with adverse environmental exposures during development. In this study, we investigated the i...
Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy [0.03%]
外源性EBNA1诱导ADAR1介导的肿瘤免疫治疗抵抗作用
Changlin Liu,Zhiqiang Sun,Chao Li et al.
Changlin Liu et al.
Immune checkpoint blockade (ICB) therapy continues to face limitations due to tumor resistance linked to suppressed interferon (IFN) signaling. This suppression can be attributed to multiple mechanisms, among which viral pathogens represent...
A novel necroptosis pathway: orchestrated by non-canonical STING-ZBP1 signaling [0.03%]
一种新的坏死性凋亡通路：由非经典STING-ZBP1信号传导介导
Xiangyu Zhu,Sijia Liu,Long Zhang
Xiangyu Zhu