The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 [0.03%]
Nam Gu Yoon,So-Yeon Kim,So-Youn Jung et al.
Nam Gu Yoon et al.
Adipocytes are essential stromal components of the tumor microenvironment (TME) in breast cancer that play pivotal roles in cancer progression and chemoresistance. In close proximity to tumor cells, they undergo phenotypic reprogramming int...
Weiqi Hong,Aqu Alu,Zhihao Zhang et al.
Weiqi Hong et al.
The mucosal system, which includes the respiratory, gastrointestinal, and urogenital tracts, serves as a primary entry point for pathogens, with a unique immune microenvironment and specialized defense mechanisms. In recent years, especiall...
Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy [0.03%]
Seoyoon Song,Dongjun Yu,Haneul Kang et al.
Seoyoon Song et al.
Although macrophages are a powerful cell-based platform for cancer immunotherapy, their antitumor functions, such as phagocytosis and inflammatory responses, are limited by the immunosuppressive tumor microenvironment. Here, we show that de...
Chenodeoxycholic acid restrains tumor growth via TGR5-dependent type 1 dendritic cells cross-priming [0.03%]
Fanlian Zeng,Fulei Zhao,Pei Zhou et al.
Fanlian Zeng et al.
Conventional type 1 dendritic cells (cDC1s) play a pivotal role in initiating CD8+ T-cell-mediated antitumor immunity, and their intratumoral abundance strongly correlates with immunotherapy efficacy. Here, we demonstrate that orally admini...
Huishan Sun,Shuofeng Li,Zhe Zhu et al.
Huishan Sun et al.
Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed or amplified in biliary tract cancer (BTC). Although NCCN clinical practice guidelines recommend HER2-targeted agents as subsequent-line therapy, drug resistance of...
Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma [0.03%]
肺癌腺癌远处转移的机制和治疗靶点
Tongji Xie,Lige Wu,Yan Li et al.
Tongji Xie et al.
Distant metastasis, characterized by organotropism, is a major cause of mortality in lung adenocarcinoma (LUAD). In this study, digital spatial profiling (DSP), multiplex immunofluorescence (mIF), and clinical data from 52 LUAD patients wer...
Krüppel-like factor 4 downregulation during esophageal cancer formation facilitates immune evasion and impairs immunotherapy [0.03%]
Krüppel样因子4在食管癌发生过程中的下调促进了免疫逃逸并影响了免疫治疗
Xiao Hu,Chenying Li,Dongxu Li et al.
Xiao Hu et al.
Impaired antigen processing and presentation are critical for cancer immune evasion, but the underlying mechanism is not fully known. Here, we show that downregulation of Krüppel-like factor 4 (KLF4) expression during the development of ca...
Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf [0.03%]
声音效果：范式基因疗法使出生失聪的儿童和青少年恢复听力
Juliane W Schott,Michael Morgan,Axel Schambach
Juliane W Schott
Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses [0.03%]
组合型原位癌症疫苗：释放广谱且增强的抗肿瘤反应
Weihsuan Chen,Juwon Baig,Hyebeen Choi et al.
Weihsuan Chen et al.
In situ cancer vaccination, also termed intratumoral immunotherapy, transforms the tumor microenvironment into an endogenous vaccine platform by leveraging the tumor itself as a source of antigens. Unlike conventional tumor-associated antig...
Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics [0.03%]
个性化癌症疫苗：连接免疫肿瘤学和精确医学以实现先进治疗
Leiguang Ye,Guo Zhao,Jiaxiu Ma et al.
Leiguang Ye et al.
Despite advancements in therapeutic cancer vaccines, clinical translation has been hindered by limited efficacy, with Sipuleucel-T remaining the only FDA-approved therapeutic cancer vaccine to date. However, recent advances in personalized ...