Structurally defining neurokinin selectivity to improve NK2R agonists [0.03%]
通过结构定义神经激肽的选择性以改进NK2受体激动剂
Artem Pavlovskyi,Yinhang Ren,María Gestal-Mato et al.
Artem Pavlovskyi et al.
Incretin-based obesity pharmacotherapies have revolutionized patient care but act predominantly by reducing food intake. Approaches that increase energy expenditure could improve efficacy but remain challenging to harness. Recently, neuroki...
Ishan Deshpande,Nobuhiko Kayagaki
Ishan Deshpande
Structural basis of asymmetric transcription through a composite nucleosome formed by a hexasome and an octasome [0.03%]
六聚核小体和八聚核小体形成的复合核小体的不对称转录的结构基础
Zhihui Chen,Cheng-Han Ho,Hiroki Tanaka et al.
Zhihui Chen et al.
The overlapping dinucleosome (OLDN), a composite chromatin particle consisting of a hexasome and a canonical octasome, forms immediately downstream of transcription start sites, probably through chromatin remodeling activity, and has been p...
Structural basis of AtCas9 recognition of PAM mutants in underwound DNA topology [0.03%]
AtCas9在DNA超螺旋结构中识别PAM突变的机制研究
Min Duan,Bing Meng,Lei Zhou et al.
Min Duan et al.
The CRISPR-Cas9 system locates targets through guide RNA pairing and recognition of a protospacer-adjacent motif (PAM). Although PAM specificity is sequence-determined, DNA topology can relax PAM requirements and enable near-PAMless cleavag...
Catalytic activation of human Argonaute 2 requires RNA duplex deformation [0.03%]
人类Argonaute 2活化需要RNA双链变形催化
Sucharita Sarkar,Luca F R Gebert,Ian J MacRae
Sucharita Sarkar
Small interfering RNAs (siRNAs) are an expanding class of RNA therapeutics, with seven drugs approved by the US Food and Drug Administration and many more in development. Rational design, however, has been limited by incomplete understandin...
Structural basis of opioid receptor activation by PCP and ketamine [0.03%]
PCP和氯胺酮通过作用于阿片受体激活的结构基础研究
Qianru Jiang,Jianming Han,Eve J Fine et al.
Qianru Jiang et al.
Ketamine offers rapid relief for treatment-resistant depression and severe pain in the clinic, providing immediate benefits that traditional medications often fail to deliver. While its antagonistic action at the N-methyl-D-aspartate recept...
Dimitris Typas
Dimitris Typas
Sara Osman
Sara Osman
Structural insights into OSTα/β-mediated transport of bile acids and steroid conjugates [0.03%]
OSTα/β介导的胆汁酸和类固醇结合物转运的结构见解
Xicheng Sun,Taikun Tian,Minying Low et al.
Xicheng Sun et al.
Mammalian organic solute transporter α/β (OSTα/β) is crucial for the enterohepatic circulation of bile acids and the homeostasis of steroid conjugates, mediating their movement across membranes as an obligate heterodimer. Here we presen...