Ekaterina Voronina
Ekaterina Voronina
Distinct tau filament folds in human MAPT mutants P301L and P301T [0.03%]
人类MAPT突变体P301L和P301T中不同的tau丝状折叠方式
Manuel Schweighauser,Yang Shi,Alexey G Murzin et al.
Manuel Schweighauser et al.
Mutations in MAPT, the tau gene, give rise to frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), with abundant filamentous tau inclusions in brain cells. Mutations that encode missense variants of residue P301 are t...
Structural basis of GluK2 kainate receptor activation by a partial agonist [0.03%]
谷氨酸kainate受体GluK2的部分激动剂激活机制的结构基础
Guadalupe Segura-Covarrubias,Changping Zhou,Nebojša Bogdanović et al.
Guadalupe Segura-Covarrubias et al.
Kainate receptors (KARs) belong to the family of ionotropic glutamate receptors that regulate neurotransmitter release and excitatory synaptic transmission in the central nervous system. Despite their critical roles in synaptic signaling an...
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex [0.03%]
人类自噬起始ULK1C:PI3KC3-C1超级复合体的结构与激活机制研究
Minghao Chen,Thanh N Nguyen,Xuefeng Ren et al.
Minghao Chen et al.
The Unc-51-like kinase protein kinase complex (ULK1C) is the most upstream and central player in the initiation of macroautophagy in mammals. Here, we determined the cryo-electron microscopy structure of the human ULK1C core at amino-acid-l...
A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA [0.03%]
竞争性的Chd1重塑酶调节机制对扭曲核小体DNA至关重要
Ilana M Nodelman,Heather J Folkwein,Wesley S Glime et al.
Ilana M Nodelman et al.
The Chd1 chromatin remodeler repositions nucleosomes into evenly spaced arrays, a characteristic of most eukaryotic genes. Here we show that the yeast Chd1 remodeler requires two activating segments to distort nucleosomal DNA into an A-form...
UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis [0.03%]
ARPC4的泛素化促进细胞突膜形成并促进肿瘤转移
Miao Wang,Yu-Sheng Cong
Miao Wang
Kailiang Zhao,Hao Hu,Debao Fang et al.
Kailiang Zhao et al.
The role of modification by ubiquitin-fold modifier ('UFMylation') in regulating metastasis has remained enigmatic. Cell migration, a critical step in metastasis, is driven by actin polymerization mediated by actin-related proteins 2 and 3 ...
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains [0.03%]
TRIP12结构揭示HECT型E3形成K29连接及泛素支链
Samuel A Maiwald,Laura A Schneider,Ronnald Vollrath et al.
Samuel A Maiwald et al.
Regulation by ubiquitin depends on E3 ligases forging chains of specific topologies, yet the mechanisms underlying the generation of atypical linkages remain largely elusive. Here we utilize biochemistry, chemistry, and cryo-EM to define th...
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization [0.03%]
TRIM37通过肽基序识别和底物依赖性寡聚化防止星体非正常装配
Andrew Bellaart,Amanda Brambila,Jiawei Xu et al.
Andrew Bellaart et al.
Tightly controlled duplication of centrosomes, the primary microtubule-organizing centers of animal cells, ensures bipolarity of the mitotic spindle and accurate chromosome segregation. The RING-B-box-coiled coil ubiquitin ligase tripartite...
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37 [0.03%]
E3连接酶TRIM37对微管组织中心的介尺度调节作用
Zhong Y Yeow,Sonia Sarju,Fang-Chi Chang et al.
Zhong Y Yeow et al.
Centrosomes ensure accurate chromosome segregation during cell division. Although the regulation of centrosome number is well established, less is known about the suppression of noncentrosomal microtubule-organizing centers (ncMTOCs). The E...