Matthew McCallum,James Brett Case,Jack T Brown et al.
Matthew McCallum et al.
The protease TMPRSS2 facilitates coronavirus infections, yet its mechanism of viral glycoprotein recognition remains unclear. Here we show that, following ACE2 engagement of the SARS-CoV-2 spike (S) inducing the early fusion intermediate co...
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation [0.03%]
RAD51旁系同源物交换调节RAD51丝状结构形成的机制见解
Yashpal Rawal,Youngho Kwon,Lijia Jia et al.
Yashpal Rawal et al.
Homologous recombination (HR) repairs DNA double-strand breaks and stabilizes stressed replication forks, and HR deficiency promotes genome instability and cancer. HR requires assembly of RAD51 nucleoprotein filaments on single-stranded DNA...
Cracking the code of native amyloid fibrils: advances and next steps to enable pathology-informed therapeutic and diagnostic [0.03%]
破解天然淀粉样纤维的密码：推进以病理学为导向的治疗和诊断方法的研究进展与下一步措施
Hilal A Lashuel
Hilal A Lashuel
Cryo-electron microscopy studies on amyloid fibrils formed by different proteins and isolated from the brains of persons with neurodegenerative diseases have consistently shown that their core structure is distinct from that of fibrils form...
Sara Osman
Sara Osman
Structural insights into coffee bitter taste perception by TAS2R43 receptor [0.03%]
咖啡苦味感知TAS2R43受体结构的见解
Yoojoong Kim,Ryan H Gumpper,Yuxuan Zhuang et al.
Yoojoong Kim et al.
Bitter taste functions as a means of both protection against potentially toxic compounds and savoring bitter tasting foods and beverages. Among the 26 bitter taste receptors, taste receptor type 2 member 43 (TAS2R43) has been identified as ...
Evgenii Ziaikin,Nitsan Dallal,Masha Y Niv
Evgenii Ziaikin
Qiuxiang Tan,Yu Yu,Xuteng Han et al.
Qiuxiang Tan et al.
Bitter taste receptors (T2Rs) are considered attractive drug targets. However, the ligand recognition and selectivity of these receptors remain elusive, hampering their drug development. Here we present seven structures of human T2R14 and T...
Calcium dependent activation of the TMEM16F scramblase and ion channel [0.03%]
钙离子激活的TMEM16F通道蛋白的翻转酶和离子通道活性
Zhang Feng,Omar E Alvarenga,Eleonora Di Zanni et al.
Zhang Feng et al.
The ubiquitous transmembrane protein 16F (TMEM16F) Ca2+-activated channel and scramblase catalyzes phosphatidylserine externalization to enable blood coagulation, membrane fusion and brain immune surveillance. Despite its importance, the mo...
Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency [0.03%]
Cas12f同源物的比较表征揭示了增强基因组编辑效率的机制特征
Kaoling Guan,Rodrigo Fregoso Ocampo,Paula B Matheus Carnevali et al.
Kaoling Guan et al.
Miniature CRISPR-Cas12f nucleases are attractive candidates for therapeutic genome editing because of their compact size and compatibility with adeno-associated virus (AAV) delivery. However, editing efficiencies in mammalian cells are lowe...