Bridge for lipid delivery [0.03%]
用于脂质递送的桥梁
Katarzyna A Ciazynska
Katarzyna A Ciazynska
CST complex promotes second-strand synthesis in break-induced replication [0.03%]
复制诱导的断裂中CST复合体促进第二链合成
Pilendra Thakre,Jeff Wang,Liping Liu et al.
Pilendra Thakre et al.
Break-induced DNA replication (BIR) is a highly mutagenic recombination pathway used by eukaryotic cells to repair single-ended DNA breaks, mediate mitotic DNA synthesis and promote telomerase-independent telomere maintenance in certain can...
Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs [0.03%]
胞质晶格存储发育待命的降解和细胞骨架复合物以维持哺乳动物卵母细胞的长寿
Yujie Li,Wei Zheng,Jiyeon Leem et al.
Yujie Li et al.
The cytoplasmic lattice (CPL) in mammalian eggs is essential for early embryonic development but its molecular components, structural organization and functional capacity have remained elusive. Here, using cryo-electron microscopy, we show ...
Promoter reinforcement supports transcriptional resilience in drug-resistant cancer [0.03%]
增强子的强化可支持耐药癌细胞的转录补偿能力
Vasumathi Kameswaran,Sayantanee Paul,Daniel Le et al.
Vasumathi Kameswaran et al.
In mammalian cells, gene-distal regulatory elements enable long-range gene regulation and support cell-type-specific transcriptional programs. This regulatory architecture is frequently perturbed in cancer, particularly when oncogenic trans...
Publisher Correction: Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription [0.03%]
出版更正：凝聚素和RNA聚合酶II在调节染色质相互作用和基因转录方面的相互作用
Minji Kim,Ping Wang,Patricia A Clow et al.
Minji Kim et al.
Published Erratum
Nature structural & molecular biology. 2026 Jul 3. DOI:10.1038/s41594-026-01850-3 2026
James M Jusuf,Jin H Yang,Jack Toppen et al.
James M Jusuf et al.
Three-dimensional genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these methods only measure three-dimensional interaction probabilities on a rel...
Adrian Henggeler,Fena Ochs
Adrian Henggeler
Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity [0.03%]
转录读穿现象从意外产物转变为潜在的治疗机会
Agata Stępień,Martyna Plens-Gałąska,Kinga Kamieniarz-Gdula
Agata Stępień