Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity [0.03%]
可移动元件-基因嵌合体的图谱绘制、起源及增强转录组多样性的潜在作用
Youngseo Cheon,Erik Glen Alvstad,Denis Torre et al.
Youngseo Cheon et al.
Transposable elements (TEs) in the human genome are the heritage of ancient parasitic infections. While most of human DNA comprises TEs and TE-derived elements, their repetitive nature poses technical challenges; thus, little is known about...
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs [0.03%]
基于METALoci的染色质空间分析揭示性别决定的三维调控中心
Irene Mota-Gómez,Juan Antonio Rodríguez,Shannon Dupont et al.
Irene Mota-Gómez et al.
Mammalian sex is determined by opposing networks of ovarian and testicular genes that are well characterized; however, its epigenetic regulation is still largely unknown. Here we explore the 3D chromatin landscape of sex determination in vi...
The AlphaGenome deep learning model predicts effects of non-coding variants [0.03%]
AlphaGenome深度学习模型预测非编码变异的影响
Dennis Gankin,Pedro Beltrao
Dennis Gankin
Global reorganization of genome architecture at the transition to gametogenesis [0.03%]
配子发生过渡时期的基因组架构的全球性重新组织
Tien-Chi Huang,Maria Rigau,Valeriya Malysheva et al.
Tien-Chi Huang et al.
Global epigenetic resetting in the gonadal primordial germ cells (PGCs) enables transition from early PGCs to gametogenesis and eventual restoring of totipotency after fertilization. This reprogramming process involves global DNA demethylat...
Tetsuya Kotani,Hitoshi Nakatogawa
Tetsuya Kotani
Autophagy is a conserved intracellular degradation system essential for maintaining cellular homeostasis and adapting to a variety of environmental or metabolic cues. Different types of autophagy are induced in response to various physiolog...
M Jasnauskaitė,J Juozapaitis,T Liegutė et al.
M Jasnauskaitė et al.
Retrons are prokaryotic reverse transcriptase systems that produce multicopy single-stranded DNA (msDNA), yet the principles by which they mediate antiviral defense remain largely unresolved. Here we investigate the mechanism of Escherichia...
Author Correction: Phosphorylation-dependent tuning of mRNA deadenylation rates [0.03%]
作者更正：磷酸化依赖的mrna去多聚腺苷酸化速率调节
James A W Stowell,Conny W H Yu,Zhuo A Chen et al.
James A W Stowell et al.
Published Erratum
Nature structural & molecular biology. 2026 Feb 18. DOI:10.1038/s41594-026-01774-y 2026
Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization [0.03%]
Z-DNA形成调控全能性状态并诱导Zscan4依赖的染色质区室化
Shireen Shajahan,Yann Loe-Mie,Laure Asselin et al.
Shireen Shajahan et al.
The progression from the one-cell to the two-cell stage constitutes a remarkable transition, accompanied by the activation of a specific set of embryonic genes, epigenome reprogramming and nuclear architecture reorganization. Some of these ...
Computation and deep-learning-driven advances in CRISPR genome editing [0.03%]
计算与深度学习驱动的CRISPR基因组编辑进展
Chinmai Pindi,Giulia Palermo
Chinmai Pindi
Genome editing with CRISPR-Cas systems is revolutionizing medicine, molecular biology and biotechnology. In this Review, we discuss the contributions of deep learning-based structure prediction algorithms, physics-based simulations, neural ...