Z-DNA formation regulates the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization [0.03%]
Z-DNA形成调控全能性状态并诱导Zscan4依赖的染色质区室化
Shireen Shajahan,Yann Loe-Mie,Laure Asselin et al.
Shireen Shajahan et al.
The progression from the one-cell to the two-cell stage constitutes a remarkable transition, accompanied by the activation of a specific set of embryonic genes, epigenome reprogramming and nuclear architecture reorganization. Some of these ...
Computation and deep-learning-driven advances in CRISPR genome editing [0.03%]
计算与深度学习驱动的CRISPR基因组编辑进展
Chinmai Pindi,Giulia Palermo
Chinmai Pindi
Genome editing with CRISPR-Cas systems is revolutionizing medicine, molecular biology and biotechnology. In this Review, we discuss the contributions of deep learning-based structure prediction algorithms, physics-based simulations, neural ...
Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex [0.03%]
酵母氨基酸感应SEAC-EGOC超级复合物的结构与功能
Lucas Tafur,Lenny Bonadei,Yiqiang Zheng et al.
Lucas Tafur et al.
The Seh1-associated complex (SEAC; GATOR in mammals) transduces amino acid signals to the Target of Rapamycin Complex 1 (TORC1), a master regulator of cell growth. The SEAC is composed of two subcomplexes, SEACIT (GATOR1), an inhibitor of T...
Julie Soutourina
Julie Soutourina
Mingxu Fang,Yajie Gu,Miron Leanca et al.
Mingxu Fang et al.
Circadian biological clocks evolved across kingdoms of life as an adaptation to predictable cycles of sunrise and sunset. In the cyanobacterium Synechococcus elongatus, a protein-based clock precisely controls when different genes are turne...
The filamentous ultrastructure of the PopZ condensate is required for its cellular function [0.03%]
丝状超结构对PopZ凝聚体的细胞功能是必不可少的
Daniel Scholl,Tumara Boyd,Andrew P Latham et al.
Daniel Scholl et al.
Biomolecular condensates have key roles in regulating cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We studied this relationship using the polar organizing protein Z (Po...
Naoto Nagahata,Kazuki Kato,Sota Yamada et al.
Naoto Nagahata et al.
RNA-guided DNA nucleases Cas9 and IscB (insertion sequences Cas9-like OrfB) are components of type II CRISPR-Cas adaptive immune systems and transposon-associated OMEGA (obligate mobile element-guided activity) systems, respectively. Sequen...
Xiaogen Zhou,Xiangyu Xu,Guijun Zhang
Xiaogen Zhou
Nataliya Petryk
Nataliya Petryk