A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR [0.03%]
一种小分子稳定剂可修复G蛋白偶联受体错义突变几乎全部的表面表达缺陷
Taylor L Mighell,Ben Lehner
Taylor L Mighell
Reduced protein abundance is the most frequent mechanism by which rare missense variants cause disease. A promising therapeutic avenue for treating reduced abundance variants is pharmacological chaperones (PCs, also known as correctors or s...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking [0.03%]
人核糖体通过延迟同延伸_domains_的对接来调节多域蛋白的生物发生
Grant A Pellowe,Tomas B Voisin,Laura Karpauskaite et al.
Grant A Pellowe et al.
Proteins with multiple domains are intrinsically prone to misfold, yet fold efficiently during their synthesis on the ribosome. This is especially important in eukaryotes, where multidomain proteins predominate. Here we sought to understand...
Eli Arama,Katia Cosentino,Peter E Czabotar et al.
Eli Arama et al.
Phase separation promotes Atg8 lipidation and vesicle condensation for autophagy progression [0.03%]
相分离通过促进自噬相关脂化和囊泡浓缩来促进自噬体发育
Yuko Fujioka,Takuma Tsuji,Tetsuya Kotani et al.
Yuko Fujioka et al.
Upon starvation, the autophagy-initiating Atg1 complex undergoes phase separation to organize the preautophagosomal structure (PAS) in Saccharomyces cerevisiae, from which autophagosome formation is considered to proceed. However, the physi...
GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins [0.03%]
GluA4型AMPA受体的激活机制及其辅助蛋白调节作用
Carlos Vega-Gutiérrez,Javier Picañol-Párraga,Irene Sánchez-Valls et al.
Carlos Vega-Gutiérrez et al.
AMPA-type glutamate receptors, fundamental ion channels for fast excitatory neurotransmission and synaptic plasticity, contain a GluA tetrameric core surrounded by auxiliary proteins such as transmembrane AMPA receptor regulatory proteins (...
Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation [0.03%]
SPIN90二聚体在直线状肌动蛋白核生成中的Arp2/3复合体活化作用
Justus Francis,Achyutha Krishna Pathri,Kankipati Teja Shyam et al.
Justus Francis et al.
Arp2/3 complex is a key nucleator of actin filaments. It requires activation by nucleation-promoting factors (NPFs). WISH/DIP1/SPIN90 (WDS) proteins represent a unique class of NPFs that activate the Arp2/3 complex independently of preexist...
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers [0.03%]
SPIN90二聚体介导的由Arp2/3活化双向成肌动蛋白组装
Tianyang Liu,Luyan Cao,Miroslav Mladenov et al.
Tianyang Liu et al.
Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear a...
Cameron J Glasscock,Robert J Pecoraro,Ryan McHugh et al.
Cameron J Glasscock et al.
Sequence-specific DNA-binding proteins (DBPs) have critical roles in biology and biotechnology and there has been considerable interest in the engineering of DBPs with new or altered specificities for genome editing and other applications. ...