Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription [0.03%]
调控染色质相互作用和基因转录的粘连素与RNA聚合酶II之间的互作关系
Minji Kim,Ping Wang,Patricia A Clow et al.
Minji Kim et al.
Cohesin is required for chromatin loop formation. However, its precise role in regulating gene transcription remains largely debated. Here we investigated the relationship between cohesin and RNA polymerase II (RNAPII) using single-molecule...
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity [0.03%]
氧化还原驱动的ADAR1活化促进Okazaki片段成熟和DNA复制完整性
Bin Chen,Guangchao Sun,Jake A Kloeber et al.
Bin Chen et al.
Okazaki fragment maturation requires efficient removal of RNA primers to form a continuous lagging strand, yet how mismatched primers introduced by error-prone primase are corrected remains unresolved. Here, we show that physiological level...
Cell-cycle-dependent repression of histone gene transcription by histone H4 [0.03%]
组蛋白H4在细胞周期依赖性地抑制组蛋白基因转录
Kami Ahmad,Matt Wooten,Brittany N Takushi et al.
Kami Ahmad et al.
In all eukaryotes, DNA replication is coupled to histone synthesis to coordinate chromatin packaging of the genome. Canonical histone genes coalesce in the nucleus into the histone locus body (HLB), where gene transcription and 3' mRNA proc...
Tommy O&#x;Haren,Leila E Rieder
Tommy O&#x;Haren
Evolution of promoter-proximal pausing enabled a new layer of transcription control [0.03%]
promoters-proximal暂停的进化使转录控制的新层次成为可能
Alexandra G Chivu,Brent A Basso,Abderhman Abuhashem et al.
Alexandra G Chivu et al.
Promoter-proximal pausing of RNA polymerase (Pol) II is a key regulatory step during transcription. Despite the central role of pausing in gene regulation, we do not understand the evolutionary processes that led to the emergence of Pol II ...
Ifigenia Tsitsa,Anja Conev,Alessia David et al.
Ifigenia Tsitsa et al.
Jianwei Zeng,Yong Fu,Pengge Qian et al.
Jianwei Zeng et al.
Apicomplexan parasites, responsible for toxoplasmosis, cryptosporidiosis and malaria, invade host cells through a unique gliding motility mechanism powered by actomyosin motors and a dynamic organelle called the conoid. Here, using cryo-ele...
Tao Li,Ji Chen,Hao Li et al.
Tao Li et al.
Cryo-electron microscopy (cryo-EM) has become the mainstream technique for macromolecular structure determination. However, because of intrinsic resolution heterogeneity, accurate modeling of all-atom structure from cryo-EM maps remains cha...