The conformational landscape of human transthyretin revealed by cryo-EM [0.03%]
冷冻电镜揭示的人类甲状腺转运蛋白构象变化景观
Benjamin Basanta,Karina Nugroho,Nicholas L Yan et al.
Benjamin Basanta et al.
Transthyretin (TTR) is a natively tetrameric thyroxine transporter in blood and cerebrospinal fluid whose misfolding and aggregation causes TTR amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndamax) ...
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility [0.03%]
ELL3通过调控纺锤体组装防止母系遗传的非整倍体和不孕症
Bernhard Magerl,Tommaso Cavazza
Bernhard Magerl
Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [0.03%]
揭示小鼠生殖细胞中时空特异性反应激活X染色体基因及表观遗传沉默的部位特异性保留现象
Clara Roidor,Laurène Syx,Emmanuelle Beyne et al.
Clara Roidor et al.
Random X-chromosome inactivation is a hallmark of female mammalian somatic cells. This epigenetic mechanism, mediated by the long noncoding RNA Xist, occurs in the early embryo and is stably maintained throughout life, although inactivation...
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47 [0.03%]
肉毒神经毒素通过激活OrfXs / P47利用宿主消化蛋白酶以增强其口服毒性
Linfeng Gao,Maria Barbara Nowakowska,Katja Selby et al.
Linfeng Gao et al.
Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orfX gene cluster that also encodes four nontoxic proteins (OrfX1, OrfX2, OrfX3 and P47). The orfX gene cluster is also f...
The structure and function of the ghrelin receptor coding for drug actions [0.03%]
胃饥饿素受体的结构与功能决定药物的作用机制
Yuki Shiimura,Dohyun Im,Ryosuke Tany et al.
Yuki Shiimura et al.
Drugs targeting the ghrelin receptor hold therapeutic potential in anorexia, obesity and diabetes. However, developing effective drugs is challenging. To tackle this common issue across a broad drug target, this study aims to understand how...
Structures of aberrant spliceosome intermediates on their way to disassembly [0.03%]
异常剪接体中间体在解离过程中的结构变化
Komal Soni,Attila Horvath,Olexandr Dybkov et al.
Komal Soni et al.
Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans. While key steps of the canonical spliceosome cycle have been revealed by combined structure-functi...
Fascin structural plasticity mediates flexible actin bundle construction [0.03%]
Fascin结构可塑性介导灵活的肌动蛋白丝束组装
Rui Gong,Matthew J Reynolds,Keith R Carney et al.
Rui Gong et al.
Fascin cross-links actin filaments (F-actin) into bundles that support tubular membrane protrusions including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration during metastasis, and fascin inhibitors are under ...
ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth [0.03%]
ERK-USP9X偶联调控胸苷激酶1促进其依赖于酶活性的和非依赖于酶活性的促肿瘤功能
Jingjing Tao,Zheng Wang,Rongkai Shi et al.
Jingjing Tao et al.
Thymidine kinase 1 (TK1), a crucial enzyme in DNA synthesis, is highly expressed in various cancers. However, the mechanisms underlying its elevated expression and the implications for tumor metabolism remain unclear. Here we demonstrate th...
Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling [0.03%]
参与溶酶体胆固醇信号转导的人源LYCHOS分子结构
Qi Xiong,Zhini Zhu,Tingting Li et al.
Qi Xiong et al.
Lysosomal membrane protein LYCHOS (lysosomal cholesterol signaling) translates cholesterol abundance to mammalian target of rapamycin activation. Here we report the 2.11-Å structure of human LYCHOS, revealing a unique fusion architecture c...
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS [0.03%]
低温电镜揭示胆固醇与溶酶体G蛋白偶联受体样蛋白LYCHOS的结合性质
Jie Zhao,Qingya Shen,Xihao Yong et al.
Jie Zhao et al.
Cholesterol plays a pivotal role in modulating the activity of mechanistic target of rapamycin complex 1 (mTOR1), thereby regulating cell growth and metabolic homeostasis. LYCHOS, a lysosome-localized G-protein-coupled receptor-like protein...