Structures of radial spokes and associated complexes important for ciliary motility [0.03%]
径向辐条及其相关复合物对纤毛运动具有重要作用
Miao Gui,Meisheng Ma,Erica Sze-Tu et al.
Miao Gui et al.
In motile cilia, a mechanoregulatory network is responsible for converting the action of thousands of dynein motors bound to doublet microtubules into a single propulsive waveform. Here, we use two complementary cryo-EM strategies to determ...
Structural insights into assembly and function of the RSC chromatin remodeling complex [0.03%]
RSC 组蛋白重塑复合体的组装及功能机制研究
Richard W Baker,Janice M Reimer,Peter J Carman et al.
Richard W Baker et al.
SWI/SNF chromatin remodelers modify the position and spacing of nucleosomes and, in humans, are linked to cancer. To provide insights into the assembly and regulation of this protein family, we focused on a subcomplex of the Saccharomyces c...
Author Correction: The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma [0.03%]
作者更正：核小体酸性补丁和H2A泛素化在于滑膜肉瘤中mSWI/SNF募集的背后
Matthew J McBride,Nazar Mashtalir,Evan B Winter et al.
Matthew J McBride et al.
Published Erratum
Nature structural & molecular biology. 2021 Jan;28(1):118. DOI:10.1038/s41594-020-00540-y 2021
TET2 chemically modifies tRNAs and regulates tRNA fragment levels [0.03%]
TET2通过化学修饰tRNA并调节tRNA片段的水平发挥作用
Chongsheng He,Julianna Bozler,Kevin A Janssen et al.
Chongsheng He et al.
The ten-eleven translocation 2 (TET2) protein, which oxidizes 5-methylcytosine in DNA, can also bind RNA; however, the targets and function of TET2-RNA interactions in vivo are not fully understood. Using stringent affinity tags introduced ...
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB [0.03%]
MlaFEDB维持革兰氏阴性菌外膜不对称性的结构洞察
Xiaodi Tang,Shenghai Chang,Wen Qiao et al.
Xiaodi Tang et al.
The highly asymmetric outer membrane of Gram-negative bacteria functions in the defense against cytotoxic substances, such as antibiotics. The Mla pathway maintains outer membrane lipid asymmetry by transporting phospholipids between the in...
Author Correction: Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion [0.03%]
作者更正：Atg9 是一种脂质翻转酶，可介导自噬膜的扩张
Kazuaki Matoba,Tetsuya Kotani,Akihisa Tsutsumi et al.
Kazuaki Matoba et al.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published Erratum
Nature structural & molecular biology. 2020 Dec;27(12):1209. DOI:10.1038/s41594-020-00538-6 2020
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers [0.03%]
SARS-CoV-2包膜蛋白跨膜结构域的脂质双层结构及药物结合研究
Venkata S Mandala,Matthew J McKay,Alexander A Shcherbakov et al.
Venkata S Mandala et al.
An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity. Here we report a 2.1-Å structure and the drug-binding site of E's transmembrane domain (...
Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase [0.03%]
Mec1-ATR检查点激酶的自动抑制和激活机制
Elias A Tannous,Luke A Yates,Xiaodong Zhang et al.
Elias A Tannous et al.
In response to DNA damage or replication fork stalling, the basal activity of Mec1ATR is stimulated in a cell-cycle-dependent manner, leading to cell-cycle arrest and the promotion of DNA repair. Mec1ATR dysfunction leads to cell death in y...
Takashi Ishiuchi,Shusaku Abe,Kimiko Inoue et al.
Takashi Ishiuchi et al.
Epigenetic reprogramming of the zygote involves dynamic incorporation of histone variant H3.3. However, the genome-wide distribution and dynamics of H3.3 during early development remain unknown. Here, we delineate the H3.3 landscapes in mou...
Author Correction: Quantifying the dynamics of IRES and cap translation with single-molecule resolution in live cells [0.03%]
作者更正：在活细胞中具有单分子分辨率地量化IRES和帽的翻译动力学
Amanda Koch,Luis Aguilera,Tatsuya Morisaki et al.
Amanda Koch et al.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.