Xiaoying Chen,Licheng Yuan,Han Wen et al.
Xiaoying Chen et al.
Broad-range thermal receptor 1 (BRTNaC1), activated by heat at low extracellular pH, was recently identified in myriapods. Although the overexpression of BRTNaC1 leads to robust heat-activated current with a cation selectivity profile, the ...
Local structural flexibility drives oligomorphism in computationally designed protein assemblies [0.03%]
局部结构柔性驱动了计算设计的蛋白质组装中的寡形态现象
Alena Khmelinskaia,Neville P Bethel,Farzad Fatehi et al.
Alena Khmelinskaia et al.
Many naturally occurring protein assemblies have dynamic structures that allow them to perform specialized functions. Although computational methods for designing novel self-assembling proteins have advanced substantially over the past deca...
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics [0.03%]
人源THIK-1 K2P K+通道的低温电镜结构揭示了由脂质和麻醉剂调控的一个低Y门控
Karin E J Rödström,Bisher Eymsh,Peter Proks et al.
Karin E J Rödström et al.
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K+ channel implicated in microglial activation and neuroinflammation, and a current target for the treatment of neurodegenerative disorders, for exam...
Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin [0.03%]
DEK如何通过结合核小体来促进染色质中H3K27三甲基化的结构洞察
Tomoya Kujirai,Kenta Echigoya,Yusuke Kishi et al.
Tomoya Kujirai et al.
Structural diversity of the nucleosome affects chromatin conformations and regulates eukaryotic genome functions. Here we identify DEK, whose function is unknown, as a nucleosome-binding protein. In embryonic neural progenitor cells, DEK co...
CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association [0.03%]
CTCF/RAD21组织染色质-核斑点关联的基态
Ruofan Yu,Shelby Roseman,Allison P Siegenfeld et al.
Ruofan Yu et al.
Recent findings indicate that nuclear speckles, a distinct type of nuclear body, interact with certain chromatin regions in a ground state. Here, we report that the chromatin structural factors CTCF and cohesin are required for full ground-...
Chad W Hicks,Colin R Gliech,Sanim Rahman et al.
Chad W Hicks et al.
Phosphorylation of histone H3 threonine 3 (H3T3) by Haspin recruits the chromosomal passenger complex to the inner centromere and ensures proper cell cycle progression through mitosis. The mechanism by which Haspin binds to nucleosomes to p...
Julia A Rocereta,Toni Sturhahn,Ruth A Pumroy et al.
Julia A Rocereta et al.
The transient receptor potential vanilloid 2 (TRPV2) cation channel is a key player in cardiovascular physiology and pathophysiology. Probenecid (PBC), an FDA-approved uricosuric agent thought to activate TRPV2, has shown promise in enhanci...
Meng Zhang,Yaxu Wang,M Madan Babu
Meng Zhang