Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
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The Unc-51-like kinase protein kinase complex (ULK1C) is the most upstream and central player in the initiation of macroautophagy in mammals. Here, we determined the cryo-electron microscopy structure of the human ULK1C core at amino-acid-level resolution. We ... ...
