John McCullough,Wesley I Sundquist
John McCullough
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling [0.03%]
抑制去泛素酶活性和炎症信号的分子粘合剂
Francesca Chandler,Poli Adi Narayana Reddy,Smita Bhutda et al.
Francesca Chandler et al.
Deubiquitylases (DUBs) are crucial in cell signaling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signaling by cleaving K63-linked polyubiquitin chains on t...
A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance [0.03%]
核孔锚定的凝聚物使生殖颗粒组织和跨代表观遗传继承成为可能
Pu Lu,Boyuan Deng,Xinru Li et al.
Pu Lu et al.
Biomolecular condensates, such as stress and germ granules, often contain subcompartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is composed of at least f...
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
PYROXD1介导的人tRNA连接酶复合物抵抗氧化失活的机制基础
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
Melina Casadio
Melina Casadio
Michelle Korda
Michelle Korda