Daniel P Bondeson
Daniel P Bondeson
Transposon-triggered epigenetic chromatin dynamics modulate EFR-related pathogen response [0.03%]
转座子触发的表观遗传染色质动力学调节EFR相关病原体响应
Regina Mencia,Agustín L Arce,Candela Houriet et al.
Regina Mencia et al.
Infectious diseases drive wild plant evolution and impact crop yield. Plants, like animals, sense biotic threats through pattern recognition receptors (PRRs). Overly robust immune responses can harm plants; thus, understanding the tuning of...
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families [0.03%]
结构相关TMC、TMEM16和TMEM63家族中的离子通道和脂质 scramblase 的广泛细胞功能
Lily Yeh Jan,Yuh Nung Jan
Lily Yeh Jan
Calcium (Ca2+)-activated ion channels and lipid scramblases in the transmembrane protein 16 (TMEM16) family are structurally related to mechanosensitive ion channels in the TMEM63 and transmembrane channel-like (TMC) families. Members of th...
Dimitris Typas
Dimitris Typas
Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues [0.03%]
小鼠胚胎组织三维基因组和表观基因组图的整合分析
Miao Yu,Nathan R Zemke,Ziyin Chen et al.
Miao Yu et al.
While a rich set of putative cis-regulatory sequences involved in mouse fetal development have been annotated recently on the basis of chromatin accessibility and histone modification patterns, delineating their role in developmentally regu...
Structural insights into context-dependent inhibitory mechanisms of chloramphenicol in cells [0.03%]
氯霉素在细胞中的上下文依赖的抑制机制的结构见解
Liang Xue,Christian M T Spahn,Magdalena Schacherl et al.
Liang Xue et al.
Ribosome-targeting antibiotics represent an important class of antimicrobial drugs. Chloramphenicol (Cm) is a well-studied ribosomal peptidyl transferase center (PTC) binder and growing evidence suggests that its inhibitory action depends o...
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1 [0.03%]
非洲血统神经退行性病变风险变异干扰GBA1内含子分支点
Pilar Álvarez Jerez,Peter Wild Crea,Daniel M Ramos et al.
Pilar Álvarez Jerez et al.
Recently, an African ancestry-specific Parkinson disease (PD) risk signal was identified at the gene encoding glucocerebrosidase (GBA1). This variant ( rs3115534 -G) is carried by ~50% of West African PD cases and imparts a dose-dependent i...
Structural basis of human γ-secretase inhibition by anticancer clinical compounds [0.03%]
抗癌临床化合物的人γ分泌酶结构基础
Xuefei Guo,Haotian Li,Xiaoli Lu et al.
Xuefei Guo et al.
Aberrant activation of Notch signaling, mediated by the Notch intracellular domain (NICD), is linked to certain types of cancer. The NICD is released through γ-secretase-mediated cleavage of the Notch receptor. Therefore, development of a ...