Peter Škrinjar,Jérôme Eberhardt,Gabriel Studer et al.
Peter Škrinjar et al.
Deep learning has driven major breakthroughs in protein structure prediction; however, one of the next critical steps forward is accurately predicting how proteins interact with small-molecule ligands, to enable real-world applications such...
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed [0.03%]
线粒体编码蛋白的膜插入调节核糖体解码速度
Thomas Schöndorf,Valentyn Petrychenko,Ilgin Kotan et al.
Thomas Schöndorf et al.
The human mitochondrial genome encodes 13 subunits of the oxidative phosphorylation system essential for energy metabolism to drive cellular activities. Translation of 11 mRNAs by membrane-bound ribosomes is coupled to insertion of the nasc...
Michele Brischigliaro,Antoni Barrientos
Michele Brischigliaro
Structural basis for recognition of diverse localizing mRNAs by Egl-BicD [0.03%]
Egl和BicD识别多种定位mRNA的分子机制
Kashish Singh,Sabila Chilaeva,Mark A McClintock et al.
Kashish Singh et al.
Localization of mRNAs is a widespread mechanism for dictating where proteins operate in cells and underpins many fundamental processes, from embryonic patterning to synaptic plasticity. This spatial control is mediated by the interaction of...
Florence Besse,Andres Ramos
Florence Besse
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types [0.03%]
整合的MINFLUX追踪在细胞类型间揭示了两种不同的染色质动态类别
Matteo Mazzocca,Domenic N Narducci,Simon Grosse-Holz et al.
Matteo Mazzocca et al.
Chromatin dynamics control the timescales of essential biological processes and reflect how chromatin is organized in the nucleus. Previous studies have reported widely varying degrees of chromatin subdiffusion without consensus. For robust...
Juan P Unfried,Igor Ulitsky
Juan P Unfried
Gene expression begins with transcription initiation. However, the control of gene activation encompasses events that precede transcription and extend beyond it, and that are prominently regulated by the noncoding genome. Here we discuss th...
Determinants of drug efficacy and the dynamics of G protein activation [0.03%]
药物疗效的影响因素及G蛋白激活的动力学研究
Henrik G Dohlman
Henrik G Dohlman
Hypervariable loop profiling decodes sequence determinants of antibody stability [0.03%]
超变环谱分析解码抗体稳定性的序列决定因素
Yue Wan,Jiahao Liang,Yile Dai et al.
Yue Wan et al.
Antibody folding and aggregation are major challenges in the development of relevant reagents and therapeutics. Antibodies face a biophysical trade-off; the immense diversity in complementarity-determining regions (CDRs), which is crucial f...
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway [0.03%]
刺猬信号通路非典型G蛋白偶联受体信号机制的结构基础
William P Steiner,Nathan Iverson,Guibing Liu et al.
William P Steiner et al.
The Hedgehog (Hh) pathway is fundamental to embryogenesis, tissue homeostasis and cancer. Hh signals are transduced through an unusual mechanism; upon agonist-induced phosphorylation, the noncanonical G-protein-coupled receptor (GPCR) Smoot...