Charles C Query,Jadwiga Meissner,Maria M Konarska
Charles C Query
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling [0.03%]
干扰素-γ信号转导的染色质修饰的遗传维持赋予转录记忆
Pawel Mikulski,Sahar S H Tehrani,Anna Kogan et al.
Pawel Mikulski et al.
Interferon-γ (IFNγ) transiently activates genes related to inflammation and innate immunity. A subset of targets retain a mitotically heritable memory of prior IFNγ exposure, resulting in hyperactivation upon re-exposure through poorly u...
Author Correction: DELE1 oligomerization promotes integrated stress response activation [0.03%]
作者更正：DELE1低聚物化促进综合压力反应激活
Jie Yang,Kelsey R Baron,Daniel E Pride et al.
Jie Yang et al.
Published Erratum
Nature structural & molecular biology. 2025 Apr 2. DOI:10.1038/s41594-025-01547-z 2025
Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex [0.03%]
AP5-SPG11-SPG15复合体重塑质膜的结构基础
Xinyi Mai,Yang Wang,Xi Wang et al.
Xinyi Mai et al.
The human spastizin (spastic paraplegia 15, SPG15) and spatacsin (spastic paraplegia 11, SPG11) complex is involved in the formation of lysosomes, and mutations in these two proteins are linked with hereditary autosomal-recessive spastic pa...
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide [0.03%]
OGT通过限制基因组范围内的TET活性来防止DNA去甲基化并抑制异染色质中转座元件的表达
Hugo Sepulveda,Xiang Li,Leo J Arteaga-Vazquez et al.
Hugo Sepulveda et al.
O-GlcNAc transferase (OGT) interacts robustly with all three mammalian TET methylcytosine dioxygenases. Here we show that deletion of the Ogt gene in mouse embryonic stem (mES) cells results in a widespread increase in the TET product 5-hyd...
John McCullough,Wesley I Sundquist
John McCullough