Better SIFI than sorry [0.03%]
与其抱憾不如防患于未然
Sara Osman
Sara Osman
Dimitris Typas
Dimitris Typas
H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes [0.03%]
H2A.Z增强母源H3K4me3形成并在小鼠卵母细胞减数分裂进程中必不可少
Hailiang Mei,Ryoya Hayashi,Chisayo Kozuka et al.
Hailiang Mei et al.
Mammalian oocytes establish a unique landscape of histone modifications, some of which are inherited by early embryos. How histone variants shape the maternal histone landscape remains unknown. Here we map histone H2A variants in mouse full...
H2A.Z is essential for oocyte maturation and fertility in female mouse [0.03%]
H2A.Z对于雌性小鼠卵母细胞成熟和受孕能力的必要性
Qianhua Xu,Chunyi Huang,Jia Ming et al.
Qianhua Xu et al.
Oocyte maturation is essential for both gametogenesis and early development, when large amounts of transcripts are produced without DNA replication. Histone variants, which can be incorporated at cis-regulatory elements in a replication-ind...
Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP [0.03%]
利用MultiSTEP对分泌蛋白中变异效应的多重和多模态映射
Nicholas A Popp,Rachel L Powell,Melinda K Wheelock et al.
Nicholas A Popp et al.
Despite widespread advances in DNA sequencing, the functional consequences of most genetic variants remain poorly understood. Multiplexed assays of variant effect can measure the function of variants at scale but cannot readily be applied t...
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo [0.03%]
酵母菌Saccharomyces cerevisiae的内含子结构的全面分析
Ramya Rangan,Rui Huang,Oarteze Hunter et al.
Ramya Rangan et al.
Pre-mRNA secondary structures are hypothesized to regulate RNA processing pathways, but such structures have been difficult to visualize in vivo. Here, we characterize Saccharomyces cerevisiae pre-mRNA structures through transcriptome-wide ...
Remote on-off switching of protein activity by intrinsically disordered region [0.03%]
固有无序区域远程控制蛋白质活性开关功能
Tuo Ji,Piao Ge,Shan Zhang et al.
Tuo Ji et al.
While the regulation of protein function theoretically encompasses alterations in both structural conformation and dynamic properties, the latter aspect, specifically conformational entropy, remains relatively unexplored. Here we show that ...
Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2 [0.03%]
VGLUT2分子神经生物学及谷氨酸转运蛋白质质调控机制研究进展
Fei Li,Jacob Eriksen,Juan A Oses-Prieto et al.
Fei Li et al.
The concentration of neurotransmitters inside synaptic vesicles (SVs) underlies the quantal nature of synaptic transmission. Uptake of glutamate, the principal excitatory neurotransmitter, is driven by membrane potential. To prevent nonquan...