Francesca Chandler,Poli Adi Narayana Reddy,Smita Bhutda et al.
Francesca Chandler et al.
Deubiquitylases (DUBs) are crucial in cell signaling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signaling by cleaving K63-linked polyubiquitin chains on t...
A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance [0.03%]
Pu Lu,Boyuan Deng,Xinru Li et al.
Pu Lu et al.
Biomolecular condensates, such as stress and germ granules, often contain subcompartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is composed of at least f...
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
Melina Casadio
Melina Casadio
Michelle Korda
Michelle Korda
Author Correction: Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants [0.03%]
Anshumali Mittal,Matthew F Martin,Elena J Levin et al.
Anshumali Mittal et al.
Published Erratum
Nature structural & molecular biology. 2025 Mar 6. DOI:10.1038/s41594-025-01528-2 2025
Yuenan Zhou,Chong Tong,Zuokun Shi et al.
Yuenan Zhou et al.
The U1 small nuclear ribonucleoprotein (snRNP) has an essential role in initiating spliceosome assembly, yet the mechanism underlying its synergy with other splicing regulators for efficient spliceosome assembly remains elusive. Here we ide...
Publisher Correction: Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition [0.03%]
出版商更正：启动子近端RNA聚合酶II终止在人类细胞类型转换过程中调节转录
Kseniia Lysakovskaia,Arjun Devadas,Björn Schwalb et al.
Kseniia Lysakovskaia et al.
Published Erratum
Nature structural & molecular biology. 2025 Mar 5. DOI:10.1038/s41594-025-01521-9 2025
Chao Qi,Sofia Lövestam,Alexey G Murzin et al.
Chao Qi et al.
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the most common forms of early-onset dementia. Unlike AD, FTD begins with behavioral changes before the development of cognitive impairment. Dominantly inherited mutations in MA...