A coupled TOM-TIM22 supercomplex in human mitochondrial protein import [0.03%]
人类线粒体蛋白质导入的TOM-TIM22联合超级复合物
Doron Rapaport,Johannes M Herrmann
Doron Rapaport
Dalmira Hubrich,Jesus Alvarado Valverde,Chop Yan Lee et al.
Dalmira Hubrich et al.
Variant effect prediction remains a key challenge in precision medicine. Computational models are increasingly successful in the characterization of missense variants in folded protein regions. However, 37% of all annotated missense variant...
Factors modulating the assembly of human β2-adrenergic receptor-β-arrestin complexes [0.03%]
调节人β2肾上腺素受体-β-arrestin复合物装配的因素
Florian M Wilhelm,Kristyna Pluhackova,John Janetzko et al.
Florian M Wilhelm et al.
β-arrestins, pivotal regulators of G protein-coupled receptor (GPCR) signaling, assemble with hundreds of GPCRs. How this assembly rises to functionally distinct complexes in which β-arrestin engages the GPCR tail, core or both, remains a...
Protein thiol alterations drive pathologic liquid-liquid phase separation in the aging brain [0.03%]
蛋白质巯基变化驱动衰老大脑中的病理液-液相分离现象
Thibaut Vignane,Martín Hugo,Christian Hoffmann et al.
Thibaut Vignane et al.
Cellular homeostasis relies on regulation of processes, including protein post-translational modifications (PTMs) and biomolecular condensation. Aging disrupts the equilibrium of these processes, increasing susceptibility to disease and mor...
Yves Barral,Manuel Mendoza
Yves Barral
Direct coupling of human TOM and TIM22 complexes drives mitochondrial carrier import [0.03%]
人TOM和TIM22复合体的直接偶联驱动膜间腔定位于外膜的载体蛋白的导入
Xiaolong Liu,Hongjun Cai,Hao Wang et al.
Xiaolong Liu et al.
Metabolite carriers that control essential metabolite transport are imported into mitochondria through the TOM and TIM22 complexes. How TOM and TIM22 coordinate in human mitochondria has remained largely unknown. Here we show that human TOM...
Structural mechanism of TOPBP1 activating the ATR-ATRIP replication checkpoint kinase [0.03%]
TOPBP1激活ATR-ATRIP复制检查点激酶的结构机制
Buren Li,Ayat Yaseen,Nikola P Pavletich
Buren Li
The ATR protein kinase preserves genomic integrity during DNA replication by controlling checkpoints needed for the orderly progression of S phase and for the responses to replication stress. ATR, with its obligate partner ATRIP, is activat...
François Major
François Major
Yingying Hu,Joleen Csuka,Presha Rajbhandari et al.
Yingying Hu et al.
Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation, and it has emerged as a potential therapeutic vulnerability of cancer. Here we identify the secretory phospholipase PLA2G2F (phospholipase A2...
Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter [0.03%]
χ-石房蛤毒素AoIA在去甲肾上腺素转运蛋白水平发挥镇痛作用的结构和功能基础研究
Oliver J V Belleza,Heng Zhang,Helmut Schmidhammer et al.
Oliver J V Belleza et al.
The χ-conotoxins are venom-derived peptides that specifically target the noradrenaline transporter (also known as norepinephrine transporter, NET). Regulation of noradrenergic signaling by NET affects neurophysiological processes, includin...