Antonio R Cerullo
Antonio R Cerullo
Ferlin structures [0.03%]
费林结构
Suhaila Rahman
Suhaila Rahman
A nanobody-based therapeutic targeting Nipah virus limits viral escape [0.03%]
一种靶向 nipah 病毒的纳米抗体治疗性药物可限制病毒逃逸
Ariel Isaacs,Guillermo Valenzuela Nieto,Xinghai Zhang et al.
Ariel Isaacs et al.
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies. Here, we report on a highly potent bispecific therapeutic that combines an anti-fusion glycoprotein nanobody with an ...
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1 [0.03%]
甘油通过高尔基体糖蛋白Imh1介导代谢和转运之间的交叉对话
Wan-Yun Chiu,Yi-Hsun Wang,Ming-Chieh Lin et al.
Wan-Yun Chiu et al.
The golgins are long coiled-coil proteins involved in vesicular transport to the Golgi, a process that contributes to Golgi function and integrity. Previous studies have elucidated that their self-interaction and their interaction with smal...
Publisher Correction: ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage [0.03%]
出版更正：ATM 和 IRAK1 协调对 DNA 损伤产生 NF-κB 激活的两种不同机制
Elodie Bournique,Ambrocio Sanchez,Sunwoo Oh et al.
Elodie Bournique et al.
Published Erratum
Nature structural & molecular biology. 2025 Jul 7. DOI:10.1038/s41594-025-01638-x 2025
Structural insights into transcriptional regulation by the helicase RECQL5 [0.03%]
RECQL5解旋酶转录调控的结构洞察
Alfredo Jose Florez Ariza,Nicholas Z Lue,Patricia Grob et al.
Alfredo Jose Florez Ariza et al.
Transcription poses a major challenge for genome stability. The RECQL5 helicase helps safeguard genome integrity and is the only member of the human RecQ helicase family that directly binds to RNA polymerase II (Pol II) and affects its prog...
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation [0.03%]
RECQL5诱导的RNA聚合酶II转录制动及其随后激活的结构基础
Luojia Zhang,Yuliya Gordiyenko,Tomos Morgan et al.
Luojia Zhang et al.
Abnormally fast transcription elongation can lead to detrimental consequences such as transcription-replication collisions, altered alternative splicing patterns and genome instability. Therefore, elongating RNA polymerase II (Pol II) requi...
Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells [0.03%]
单细胞长读Hi-C技术scNanoHi-C2详细阐述了胚胎期生殖细胞中染色体三维基因组的重新组织
Jiansen Lu,Wen Li,Fuchou Tang
Jiansen Lu
During mouse development, embryonic-stage germ cells (EGCs) make crucial fate decisions, with female EGCs embarking on meiosis whereas male EGCs enter mitotic arrest until birth. Despite increasing understanding of the reprogramming of epig...
Yihu Xie,Yi Ren
Yihu Xie
Structural basis for the synergistic assembly of the snRNA export complex [0.03%]
snRNA输出复合物协同装配的结构基础
Etienne Dubiez,William Garland,Maja Finderup Brask et al.
Etienne Dubiez et al.
The nuclear cap-binding complex (CBC) and its partner Arsenite-Resistance Protein 2 (ARS2) regulate the fate of RNA polymerase II transcripts via mutually exclusive interactions with RNA effectors. One such effector is PHAX, which mediates ...