Joshua B Sheetz,Srividya Chandrasekhar,Michael Rapé
Joshua B Sheetz
As mitochondria have crucial roles in metabolism and signaling, their structure and function must be continuously monitored and rapidly adjusted to meet cellular demands. Critical to this regulation is a conserved stress response that detec...
The maternal PADI6-UHRF1-UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis [0.03%]
母体PADI6-UHRF1-UBE2D复合物在卵子成熟和胚胎发育过程中的泛素化调控中起作用
Jinhong Li,Yuechao Lu,Zhili Xia et al.
Jinhong Li et al.
Proteostasis in mammalian oocytes is vital for successful reproduction. The cytoplasmic lattices (CPLs) of oocytes store essential maternal proteins for early embryo development. Here we show that PADI6, a core component of CPLs, forms a co...
Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15 [0.03%]
OMA1介导DNAJC15降解以实现线粒体蛋白输入的应激适应性调节
Lara Kroczek,Hendrik Nolte,Yvonne Lasarzewski et al.
Lara Kroczek et al.
Mitochondria dynamically adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limit mitochondrial fusion and promote mitochondrial stress signaling ...
Author Correction: Structural basis for translational control by the human 48S initiation complex [0.03%]
作者更正：人类48S起始复合物翻译控制的结构基础
Valentyn Petrychenko,Sung-Hui Yi,David Liedtke et al.
Valentyn Petrychenko et al.
Published Erratum
Nature structural & molecular biology. 2026 Feb 26. DOI:10.1038/s41594-026-01777-9 2026
Arin Lalsare,Edward J Grow
Arin Lalsare
Integrator subunit INTS12 links ribotoxic stress to transcription-coupled nucleotide excision repair [0.03%]
INTS12整合子亚基将核糖毒性应激与转录耦联的核苷酸切除修复相连
Zhuo Li,Ran Li,Min Yang et al.
Zhuo Li et al.
Cells use transcription-coupled nucleotide excision repair (TC-NER) to efficiently resolve transcription-blocking DNA lesions caused by genotoxic stress such as ultraviolet (UV) irradiation. However, UV also induces RNA damage, triggering a...
M Jasnauskaitė,J Juozapaitis,T Liegutė et al.
M Jasnauskaitė et al.
Published Erratum
Nature structural & molecular biology. 2026 Feb 25. DOI:10.1038/s41594-026-01775-x 2026
Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity [0.03%]
可移动元件-基因嵌合体的图谱绘制、起源及增强转录组多样性的潜在作用
Youngseo Cheon,Erik Glen Alvstad,Denis Torre et al.
Youngseo Cheon et al.
Transposable elements (TEs) in the human genome are the heritage of ancient parasitic infections. While most of human DNA comprises TEs and TE-derived elements, their repetitive nature poses technical challenges; thus, little is known about...
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs [0.03%]
基于METALoci的染色质空间分析揭示性别决定的三维调控中心
Irene Mota-Gómez,Juan Antonio Rodríguez,Shannon Dupont et al.
Irene Mota-Gómez et al.
Mammalian sex is determined by opposing networks of ovarian and testicular genes that are well characterized; however, its epigenetic regulation is still largely unknown. Here we explore the 3D chromatin landscape of sex determination in vi...
The AlphaGenome deep learning model predicts effects of non-coding variants [0.03%]
AlphaGenome深度学习模型预测非编码变异的影响
Dennis Gankin,Pedro Beltrao
Dennis Gankin