Yajun Li,Runhui Li,Junzhong Shang et al.
Yajun Li et al.
How evolution builds genes, how these genes attain enhanced expression, and how they integrate into existing regulatory networks to drive phenotypic diversification are all fascinating questions. Here, we generated chromosome-level genome a...
Benjamin Guinet,Nikolay Oskolkov,Kelsey Moreland et al.
Benjamin Guinet et al.
Ancient genomic studies have extensively explored human-microbial interactions, yet research on non-human animals remains limited. In this study, we analyzed ancient microbial DNA from 483 mammoth remains spanning over 1 million years, incl...
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution [0.03%]
Stereo-seq V2：以高分辨率在FFPE切片上进行总RNA的空间绘制
Yu Zhao,Young Li,Ying He et al.
Yu Zhao et al.
Performing total RNA profiling on formalin-fixed, paraffin-embedded (FFPE) samples, the predominant sample conservation method in clinical practice, remains challenging for current spatial transcriptomics techniques. Here, we introduce Ster...
Li Yang,Yu Zhang,Xin-Xin Yu et al.
Li Yang et al.
The liver undergoes metabolic adaptations during gestation and lactation to meet evolving physiological demands, yet the precise processes, regulatory mechanisms, and functions remain unclear. Using high-resolution single-cell RNA sequencin...
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity [0.03%]
用于治疗二型糖尿病和肥胖的偏向性肾上腺素受体激动剂
Aikaterini Motso,Benjamin Pelcman,Anastasia Kalinovich et al.
Aikaterini Motso et al.
Published Erratum
Cell. 2025 Aug 28:S0092-8674(25)00977-8. DOI:10.1016/j.cell.2025.08.022 2025
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles [0.03%]
分裂位点E3连接酶机制使ZNFX1能够泛素化并聚集单链RNA形成被泛素包被的核糖蛋白颗粒
Daniel B Grabarczyk,Eric J Aird,Vanessa Reznikow et al.
Daniel B Grabarczyk et al.
Eukaryotic cells use a multi-layered immune response to combat intracellular pathogens. The ubiquitin ligase ZNFX1 has emerged as a crucial yet little understood player that regulates the immune response while protecting against RNA viruses...
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation [0.03%]
基于距离的核糖体印记解析线粒体局部翻译规律
Jingchuan Luo,Stuti Khandwala,Jingjie Hu et al.
Jingchuan Luo et al.
Localized translation broadly enables spatiotemporal control of gene expression. Here, we present LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution ...
Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection [0.03%]
结构保守的人类抗A35抗体可保护小鼠和猕猴免受 mpox病毒感染
Bin Ju,Congcong Liu,Jingjing Zhang et al.
Bin Ju et al.
The A35 protein, expressed on the enveloped virion of monkeypox (mpox) virus (MPXV), is essential for viral infection and spread within the host, making it an effective antiviral target. In this study, we demonstrated two human anti-A35 mon...
Human monoclonal antibodies targeting A35 protect from death caused by mpox [0.03%]
靶向A35的单克隆抗体可防止猴痘死亡
Raianna F Fantin,Meng Yuan,Seok-Chan Park et al.
Raianna F Fantin et al.
The 2022 mpox outbreak highlighted the serious threat of monkeypox virus (MPXV), yet effective treatments are lacking. From an mpox-convalescent individual, we identified three high-affinity human monoclonal antibodies (mAbs) (named EV35-2,...
Extensive cross-species transmission of pathogens and antibiotic resistance genes in mammals neglected by public health surveillance [0.03%]
被公共卫生监测忽略的哺乳动物中的病原体和抗生素抗性基因的广泛跨种传播
Yuqi Shi,Yuxing Li,Haipeng Li et al.
Yuqi Shi et al.
Non-traditional farmed and wild mammals are often neglected in pathogen surveillance. Through metagenomic and metatranscriptomic sequencing of fecal and tissue samples from 973 asymptomatic mammals, we identified 128 viruses (30 novel), inc...