Engineering crop flower morphology facilitates robotization of cross-pollination and speed breeding [0.03%]
工程改造作物花的形态可促进异交授粉和速繁育的机器人化
Yue Xie,Tinghao Zhang,Minghao Yang et al.
Yue Xie et al.
Artificial intelligence (AI) and robots offer vast opportunities in shifting toward precision agriculture to enhance crop yields, reduce costs, and promote sustainable practices. However, many crop traits obstruct the application of AI-base...
Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage [0.03%]
羊青铜时代的耶尔森氏鼠疫菌基因组揭示了史前鼠疫菌系的宿主及其进化过程
Ian Light-Maka,Taylor R Hermes,Raffaela Angelina Bianco et al.
Ian Light-Maka et al.
Most human pathogens are of zoonotic origin. Many emerged during prehistory, coinciding with domestication providing more opportunities for spillover into human populations. However, we lack direct DNA evidence linking animal and human infe...
Zikun Zhu,Saurav Mallik,Taylor A Stevens et al.
Zikun Zhu et al.
Nearly all mitochondrial proteins are translated on cytosolic ribosomes. How these proteins are subsequently delivered to mitochondria remains poorly understood. Using selective ribosome profiling, we show that nearly 20% of mitochondrial p...
NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants [0.03%]
NRT1.1B充当植物整合复合环境信号的脱落酸受体
Xiaojun Ma,Wei Wang,Jingyi Zhang et al.
Xiaojun Ma et al.
Abscisic acid (ABA) is the most crucial phytohormone for plants in adapting to environmental conditions. While the ABA signaling network in plants has been extensively explored, our understanding of the diverse ABA sensing systems remains l...
Molecular and neural control of social hierarchy by a forebrain-thalamocortical circuit [0.03%]
前脑-丘脑皮层环路调控社交等级的分子与神经机制
Adam C Nelson,Vikrant Kapoor,Eric Vaughn et al.
Adam C Nelson et al.
Many animal groups are organized hierarchically, which generates behavioral states that facilitate social interactions. Although generally stable, social status can change, underscoring the plasticity of underlying neural circuits. We exami...
VIVIT: Resolving trans-scale volumetric biological architectures via ionic glassy tissue [0.03%]
利用离子玻璃组织技术解析跨尺度体积生物结构
Yixiao Gao,Fengyuan Xin,Tao Wang et al.
Yixiao Gao et al.
Biological structures across scales integrate seamlessly to perform essential functions. While various histological methods have been developed to reveal these intricate structures, preserving the integrity of large-volume architectures whi...
Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline [0.03%]
通过AI辅助流程鉴定肠道微生物胆汁酸代谢酶
Yong Ding,Xi Luo,Jiasheng Guo et al.
Yong Ding et al.
The modifications of bile acids (BAs) are fundamental to their role in host physiology and pathology. Identifying their synthetases is crucial for uncovering the diversity of BAs and developing targeted interventions, yet it remains a signi...
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility [0.03%]
从青铜时代到早期中世纪的南高加索地区的遗传历史：五千年遗传连续性与高度流动性并存
Eirini Skourtanioti,Xiaowen Jia,Nino Tavartkiladze et al.
Eirini Skourtanioti et al.
The Caucasus was a hub for cultural and technological innovation in prehistory, yet the population history between the Greater and Lesser Caucasus remains insufficiently understood. We present genome-wide data of 205 individuals from modern...
A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells [0.03%]
化学诱导的胚胎干细胞支持的小鼠整个胚胎发育模型至器官形成期
Huanhuan Li,Wei Guan,Jiahui Huang et al.
Huanhuan Li et al.
Embryo models offer opportunities for understanding development and advancing medicine but rely on intricate procedures with limitations in efficiency and developmental fidelity. Here, we employ a small-molecule-only approach to induce mous...
Aliesha Garrett,Naama Darzi,Ashlesha Deshmukh et al.
Aliesha Garrett et al.
Cancer-associated cachexia (CAC) is a multifactorial and currently incurable syndrome responsible for nearly one-third of cancer-related deaths. It contributes to therapy resistance and increases mortality among affected patients. In this s...