De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses [0.03%]
从头组装核压力体重新排列并增强NFIL3以抑制急性炎症反应
Xiao-Qi Liu,Pan Li,Bao-Qing Gao et al.
Xiao-Qi Liu et al.
The membrane-less nuclear stress bodies (nSBs), with satellite III (SatIII) RNAs as the hallmark, are present in primates upon sensing stresses. We report that SatⅢ DNAs, SatⅢ RNAs, and 30 nSB proteins assemble into well-organized structu...
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates [0.03%]
应激颗粒内TDP-43凝聚物的脱混生成病理聚集体
Xiao Yan,David Kuster,Priyesh Mohanty et al.
Xiao Yan et al.
Cytosolic aggregation of the nuclear protein TAR DNA-binding protein 43 (TDP-43) is associated with many neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we demonstrate that TDP-43 aggregation req...
Eva Breyer,Constanze Stix,Sophie Kilker et al.
Eva Breyer et al.
Metagenomic analysis has recently unveiled the widespread presence of pelagic fungi in the global ocean, yet their quantitative contribution to carbon stocks remains elusive, hindering their incorporation into biogeochemical models. Here, w...
Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses [0.03%]
近红外时空色彩视觉的人体试验及接触式上转换隐形眼镜
Yuqian Ma,Yunuo Chen,Sheng Wang et al.
Yuqian Ma et al.
Humans cannot perceive infrared light due to the physical thermodynamic properties of photon-detecting opsins. However, the capability to detect invisible multispectral infrared light with the naked eye is highly desirable. Here, we report ...
Jakob Trendel,Simon Trendel,Shuyao Sha et al.
Jakob Trendel et al.
In a human cell, DNA is packed with histones, RNA, and chromatin-associated proteins, forming a cohesive gel. At any given moment, only a subset of the proteome has physical access to the DNA and organizes its structure, transcription, repl...
Inheritance of acquired adaptive cold tolerance in rice through DNA methylation [0.03%]
水稻通过DNA甲基化继承获得性抗寒性
Xianwei Song,Shanjie Tang,Hui Liu et al.
Xianwei Song et al.
Epigenetic pathways could provide a mechanistic explanation for the inheritance of acquired characteristics, as proposed by Lamarck in 1802, but epigenetic alterations that endow adaptive hereditary traits have rarely been observed. Here, i...
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types [0.03%]
一组皮质细胞类型遗传访问的增强子AAV和转基因小鼠系
Yoav Ben-Simon,Marcus Hooper,Sujatha Narayan et al.
Yoav Ben-Simon et al.
The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential for understanding its function in health and dis...
Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis [0.03%]
五羟色胺转运蛋白通过调节肿瘤内五羟色胺轴抑制抗肿瘤免疫反应
Bo Li,James Elsten-Brown,Miao Li et al.
Bo Li et al.
Identifying additional immune checkpoints hindering antitumor T cell responses is key to the development of next-generation cancer immunotherapies. Here, we report the induction of serotonin transporter (SERT), a regulator of serotonin leve...
Integrating reproductive states and social cues in the control of sociosexual behaviors [0.03%]
整合生殖状态和社交线索以控制社会性行为
Yuping Wang,Xinli Song,Xiangmao Chen et al.
Yuping Wang et al.
Female sociosexual behaviors, essential for survival and reproduction, are modulated by ovarian hormones and triggered in the context of appropriate social cues. Here, we identify primary estrous-sensitive Cacna1h-expressing medial prefront...
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors [0.03%]
肠道菌群代谢饮食中的植物化学物质控制PI3K抑制剂的抗癌活性
Asael Roichman,Qianying Zuo,Sunghoon Hwang et al.
Asael Roichman et al.
Phosphatidylinositol 3-kinase (PI3K) signaling is both the effector pathway of insulin and among the most frequently activated pathways in human cancer. In murine cancer models, the efficacy of PI3K inhibitors is dramatically enhanced by a ...