Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics [0.03%]
人类眶额皮层神经活动与强迫症行为动力学相关联
Young-Hoon Nho,Liming Qiu,Robert L Seilheimer et al.
Young-Hoon Nho et al.
Biomarkers of obsessive-compulsive disorder (OCD) symptom dynamics and related behavior could advance personalized interventions. Aberrant activity in the orbitofrontal cortex (OFC) has been implicated in symptom exacerbation in OCD. We con...
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin [0.03%]
交感上皮交叉对话控制皮肤中驻留记忆T细胞的免疫监视作用
Peng Zhang,Juju Miao,Haoyue Yu et al.
Peng Zhang et al.
Effective host defense and immunosurveillance at barrier tissues require coordinated functions of multiple cell types. Here, we show that in the skin, sympathetic nerves engage with epidermal keratinocytes to regulate the local density of t...
Molecular features of human pathological tau distinguish tauopathy-associated dementias [0.03%]
人类病理性tau的分子特征可区分tau蛋白病相关性痴呆症
Mukesh Kumar,Christoph N Schlaffner,Shaojun Tang et al.
Mukesh Kumar et al.
In Alzheimer's disease (AD), pathological tau protein shows a progressive accumulation of post-translational modifications (PTMs), reflecting disease severity, progression, and prion-like activity. Although many neurodegenerative diseases w...
Douglas Hanahan
Douglas Hanahan
Cancer presents a remarkably instructive perturbation of mechanisms manifesting in our biology that have gone awry, eliciting a malady that is inexorably increasing in incidence and societal burden concomitant with healthier aging. The weal...
A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis [0.03%]
RFC在PCNA介导的连续DNA合成中的非催化作用
Gabriella N L Chua,Emily C Beckwitt,Victoria Miller-Browne et al.
Gabriella N L Chua et al.
The ring-shaped sliding clamp proliferating cell nuclear antigen (PCNA) enables DNA polymerases to perform processive DNA synthesis during replication and repair. The loading of PCNA onto DNA is catalyzed by the ATPase clamp-loader replicat...
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens [0.03%]
Ro60和La自身抗原介导的RNA分子伴侣作用的机制研究
Hyeyeon Nam,Justin C Deme,Soyeong Sim et al.
Hyeyeon Nam et al.
Although ATP-independent chaperones assist RNA folding, the mechanisms by which they function remain elusive. Here, we demonstrate how two RNA chaperones collaborate to unfold misfolded noncoding RNAs (ncRNAs). The ring-shaped Ro60 protein ...
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis [0.03%]
基于诱导多能干细胞的神经元CRISPR筛选揭示了tau蛋白稳态的基本原理
Avi J Samelson,Nabeela Ariqat,Justin McKetney et al.
Avi J Samelson et al.
Aggregation of the protein tau defines tauopathies, the most common age-related neurodegenerative diseases, which include Alzheimer's disease and frontotemporal dementia. Specific neuronal subtypes are selectively vulnerable to tau aggregat...
A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor [0.03%]
一种构建体内吸收不良生物传感器的拟杆菌合成生物学工具包
Giselle McCallum,Juan C Burckhardt,Jerry He et al.
Giselle McCallum et al.
The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet no...
A triple-node heart-brain neuroimmune loop underlying myocardial infarction [0.03%]
心肌梗死的三重节点心脏-大脑神经免疫环路
Saurabh Yadav,Van K Ninh,Jonathan W Lovelace et al.
Saurabh Yadav et al.
Myocardial infarction (MI) triggers adverse cardiac events, immune responses, and nervous system activation, but the neural and neuroimmune mechanisms remain understudied. Using single-cell RNA sequencing (scRNA-seq) and tissue clearing, we...
Xiaomeng Tang,Lu Qu,Florian Wilfling et al.
Xiaomeng Tang et al.
Many proteins localize in membraneless organelles. However, understanding the steps along membraneless organelle formation-and the structural impact on granule constituents-has been hindered by limited resolution of intracellular data. We a...