This is IT: How accelerated intermittent theta burst stimulation relieves depression symptoms [0.03%]
这才是IT：加速间歇θ爆发刺激如何缓解抑郁症状
Morteza Salimi,Dhakshin S Ramanathan
Morteza Salimi
In this issue of Cell, Gongwer et al.1 and Johnson et al.2 identify the plasticity of intratelencephalic (IT) neuronal projections to anterior insula as a central substrate mediating the antidepressant effects of accelerated intermittent th...
Discovery and heterologous reconstitution of a plant noncanonical quasi-circadian gene regulatory network [0.03%]
植物非经典准昼夜基因调控网络的发现与异源重构
Shuyu Wang,Yanning Su,Yufeng Xu et al.
Shuyu Wang et al.
Circadian rhythms are mainly generated by a gene regulatory network (GRN) constituted by transcription factors (TFs). Comparisons between plant and mammalian circadian clock GRNs suggest conservation of the network architecture rather than ...
Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects [0.03%]
基于图像的汇集表型分析揭示了多维度的疾病特异性变异效应
Sriram Pendyala,Katie Partington,Nicholas Bradley et al.
Sriram Pendyala et al.
Genetic variants produce complex phenotypic effects that confound current assays and predictive models. We developed variant in situ sequencing (VIS-seq), a pooled, image-based method measuring variant effects on molecular and cellular phen...
D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response [0.03%]
D-SPIN算法通过单细胞基因表达数据构建调控网络模型并揭示干扰响应的组织原理
Jialong Jiang,Sisi Chen,Tiffany Tsou et al.
Jialong Jiang et al.
Gene regulatory networks modulate the expression of the genome in response to signals and environmental conditions. Reconstructions of such networks can reveal the control principles cells use to maintain homeostasis and execute cell-state ...
Galvanin (TMEM154) is an electric-field sensor for directed cell migration [0.03%]
伽瓦宁(TMEN154)是引导细胞迁移的电场传感器
Nathan M Belliveau,Matthew J Footer,Amy Platenkamp et al.
Nathan M Belliveau et al.
Directed migration of immune and epithelial cells is critical for rapid responses to tissue injury or infection. Endogenous electric fields, generated by disruption of the transepithelial potential across the skin, are thought to guide cell...
Weixu Wang,Zhiyuan Hu,Philipp Weiler et al.
Weixu Wang et al.
Cell fate transitions are driven by regulatory circuitry, yet RNA velocity models cellular dynamics without explicitly accounting for gene regulatory interactions, limiting mechanistic insight. Conversely, gene regulatory network (GRN) infe...
AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology [0.03%]
基于病理学的乳腺癌生物标志物的空间转录组学解锁人工智能预测
Eldad D Shulman,Emma M Campagnolo,Roshan Lodha et al.
Eldad D Shulman et al.
Spatial transcriptomics (ST) assays are transforming our understanding of tumor heterogeneity, but their high cost limits their application in large-scale biomarker discovery. Here, we present "Path2Space," a deep-learning model that predic...
Geraldine Veeckmans,Lene Devos,Nicholas Gilbo et al.
Geraldine Veeckmans et al.
Ischemia-reperfusion injury (IRI) is a major clinical challenge in transplantation, vascular surgeries, myocardial infarction, and stroke. Disruption of energy and redox homeostasis triggers ferroptosis, a regulated, iron-dependent form of ...
Zhanli Wang,Lu Han,Lei Gao et al.
Zhanli Wang et al.
Phytoalexins are core components of plant chemical defense against pathogens. However, the genetic basis and regulatory mechanisms governing their biosynthesis remain preliminary. Debneyol is a well-defined, broad-spectrum fungicidal phytoa...
Streptomyces enrichment in roots during drought is uncoupled from plant benefit and is driven by host suppression of iron uptake and immunity [0.03%]
植株在干旱期间轮枝菌根部富集与其植物益处脱钩，并且由宿主抑制铁吸收和免疫驱动
Connor R Fitzpatrick,Ryker Allen Smith,Junko Hige et al.
Connor R Fitzpatrick et al.
Drought reshapes the plant root microbiota, yet the mechanistic drivers and consequences of this observation remain unclear. We discovered that suppression of host immunity and iron homeostasis is required for Streptomyces enrichment in roo...