Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis [0.03%]
固有免疫和代谢信号通过线粒体依赖性膜溶解诱导（即mitoxyperiosis）引发细胞死亡
Yaqiu Wang,Jianlin Lu,Alexandre F Carisey et al.
Yaqiu Wang et al.
The combination of innate immune activation and metabolic disruption plays critical roles in many diseases, often leading to mitochondrial dysfunction and oxidative stress that drive pathogenesis. However, mechanistic regulation under these...
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity [0.03%]
应激诱发的交感神经活化驱动毛囊坏死引发自身免疫反应
Emily Scott-Solomon,Shlomi Brielle,Alexander O Mann et al.
Emily Scott-Solomon et al.
Stress has profound effects on health, yet how it damages tissues remains poorly understood. Here, we show that acute stress triggers rapid hair loss and initiates autoimmunity. Under stress, hyperactivated sympathetic nerves release excess...
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells [0.03%]
热力学原理将体外转录因子亲和力与细胞中的单分子染色质状态联系起来
Julia M Schaepe,Torbjörn Fries,Benjamin R Doughty et al.
Julia M Schaepe et al.
The molecular details governing transcription factor (TF) binding and the formation of accessible chromatin are not yet quantitatively understood-including how sequence context modulates affinity, how TFs search DNA, the kinetics of TF occu...
Feeding from the sun-Successes and prospects in bioengineering photosynthesis for food security [0.03%]
太阳能培育粮食——仿生光合作研究进展及前景展望
Stephen P Long,Yu Wang,Elizabete Carmo-Silva et al.
Stephen P Long et al.
There is an urgent need for increased crop productivity to reduce food insecurity and improve sustainability. Photosynthesis converts sunlight energy into carbohydrates, providing the source of nearly all of humanity's food. Photosynthesis ...
Chetan Seshadri
Chetan Seshadri
M. tuberculosis is once again the leading infectious cause of death worldwide despite the existence of a licensed vaccine (BCG). In this issue of Cell, Vidal et al. systematically evaluate 42 candidate antigens and develop a trivalent mRNA ...
J Nicholas Betley
J Nicholas Betley
In this issue of Cell, Canovas and colleagues identify a consummatory dial in the brain that controls ingestion levels in a state-dependent manner. By continuing to trace the flow of sweet taste information, the authors identify a generaliz...
Activation-induced cytidine deaminase: The missing piece of many puzzles [0.03%]
激活诱导胞苷脱氨酶：解开众多谜题的关键因素
Thiago Carvalho,Sidonia Fagarasan,Masamichi Muramatsu
Thiago Carvalho
Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of antibody specificity, and a baffling human i...
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness [0.03%]
健康状况不佳时，IL-1R1阳性背缝核神经元介导自我隔离行为
Liu Yang,Matias L Andina,Mario Witkowski et al.
Liu Yang et al.
Sick animals exhibit behavioral changes that extend beyond physiological symptoms, such as appetite loss and hypoactivity, and include a decline in social interactions. While social isolation during sickness has been recognized to have the ...
David Shi,Pranav Reddy,McKayla Marrin et al.
David Shi et al.
The influence of the nervous system on the intestine is carried out by a combination of enteric, sensory, and autonomic innervation. However, disambiguating the functions of these physiologically distinct intestine-innervating neuronal popu...
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron [0.03%]
新型冠状病毒奥密克戎毒株感染性和免疫逃逸的结构与功能特征分析
Zhen Cui,Pan Liu,Nan Wang et al.
Zhen Cui et al.
Published Erratum
Cell. 2025 Nov 24:S0092-8674(25)01360-1. DOI:10.1016/j.cell.2025.11.025 2025