Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS [0.03%]
病毒蛋白触发的着丝粒DNA扩增激活核内cGAS传感器
Xavier Lahaye,Patrick Tran Van,Camellia Chakraborty et al.
Xavier Lahaye et al.
The cGAS-cGAMP-STING pathway is crucial for antiviral immunity. While cytosolic cGAS detects viral DNA, most DNA viruses shield their genome and invade the nucleus, where chromatin restricts cGAS activation. How viruses may activate nuclear...
Infrequent strong connections constrain connectomic predictions of neuronal function [0.03%]
罕见的强大连接限制了联结组预测神经元功能的能力
Timothy A Currier,Thomas R Clandinin
Timothy A Currier
How does circuit wiring constrain neural computation? Recent work has leveraged connectomic datasets to predict the functions of cells and circuits in the brains of multiple species. However, many of these hypotheses have not been compared ...
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE [0.03%]
微生物色氨酸-胆酸共轭代谢物通过孤儿受体MRGPRD改善糖稳态
Jun Lin,Qixing Nie,Jie Cheng et al.
Jun Lin et al.
Recently, microbial amino-acid-conjugated bile acids (MABAs) have been found to be prevalent in human samples. However, their physiological significance is still unclear. Here, we identify tryptophan-conjugated cholic acid (Trp-CA) as the m...
Serena Porcari,Siew C Ng,Laurence Zitvogel et al.
Serena Porcari et al.
Despite promising evidence in diagnostics and therapeutics, microbiome research is not yet implemented into clinical medicine. Several initiatives, including the standardization of microbiome research, the refinement of microbiome clinical ...
ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs [0.03%]
意料之外：RBCs 中的 NLRP3-caspase-8 依赖性细胞死亡
Rebecca E Tweedell,Thirumala-Devi Kanneganti
Rebecca E Tweedell
Red blood cell (RBC) lysis can cause morbidity and mortality. However, the molecular mechanisms underlying RBC lysis are not fully characterized, limiting therapeutic options. In this issue of Cell, Chen et al. identify a crucial role for t...
Alexandre P Magalhaes,Denes Hnisz
Alexandre P Magalhaes
Transcription factors can form nuclear condensates at genomic sites, and condensates are thought to enhance transcriptional activity. In this issue of Cell, Saad et al. suggest that DNA binding prevents rather than facilitates condensate fo...
Advancing proteomic analysis for understanding disease biology and biomarker discovery [0.03%]
促进蛋白质组分析以了解疾病生物学和生物标志物发现
Carlos Cruchaga
Carlos Cruchaga
Advances in proteomics research have enhanced our understanding of disease biology. In a recent issue of Cell, Malmström et al. constructed a comprehensive proteome atlas linking proteins to specific tissues and blood cells to enable track...
Cross-organ metabolite production and consumption in healthy and atherogenic conditions [0.03%]
健康和动脉硬化条件下的跨器官代谢物产生和消耗
Hosung Bae,Sunhee Jung,Johnny Le et al.
Hosung Bae et al.
Mammalian organs continuously produce and consume circulating metabolites for organismal health and survival. However, the landscape of this fundamental process and its perturbation by diet and disease is unknown. Using arteriovenous metabo...
Xin Wang,Yuan Liu,Zhenchao Wang et al.
Xin Wang et al.
A universal strategy to precisely control protein activation in living animals is crucial for gain-of-function study of proteins under in vivo settings. We herein report CAGE-Proxvivo, a computer-aided proximal decaging strategy for on-dema...
Personalized molecular signatures of insulin resistance and type 2 diabetes [0.03%]
胰岛素抵抗和2型糖尿病的个性化分子特征
Jeppe Kjærgaard,Ben Stocks,John Henderson et al.
Jeppe Kjærgaard et al.
Insulin resistance is a hallmark of type 2 diabetes, which is a highly heterogeneous disease with diverse pathology. Understanding the molecular signatures of insulin resistance and its association with individual phenotypic traits is cruci...