Lina Wang,Qiaoling Liu,Siru Li et al.
Lina Wang et al.
Detection of DNA is a fundamental strategy for life to recognize non-self or abnormal-self to subsequently trigger the downstream responses. However, the mechanism underlying DNA sensing is incompletely understood. Here, we show that a key ...
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2 [0.03%]
SARS-CoV-2同时存在模板循环和RNA加帽的结构基础
Liming Yan,Yucen Huang,Yixiao Liu et al.
Liming Yan et al.
In the SARS-CoV-2 replication-transcription complex (RTC), the nascent template-product duplex is unwound into a template strand for recycling and a product strand that needs to be capped. Here, we determined structures of the SARS-CoV-2 RT...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome [0.03%]
泛修饰谱分析促进热调节的核糖体表转录组的跨进化解析
Miguel A Garcia-Campos,Joe Georgeson,Ronit Nir et al.
Miguel A Garcia-Campos et al.
Ribosomal RNA (rRNA) constitutes the core of ribosomes and is extensively chemically modified. Technical challenges have precluded systematically dissecting rRNA modifications and their dynamics. We develop Pan-Mod-seq, permitting inference...
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success [0.03%]
肿瘤微环境的腔隙结构促进CD8+T细胞浸润并预测免疫治疗效果
Aya Ludin,Georgia L Stirtz,Asaf Tal et al.
Aya Ludin et al.
T cell-mediated tumor killing underlies immunotherapy success. Here, we used long-term in vivo imaging and high-resolution spatial transcriptomics of zebrafish endogenous melanoma, as well as multiplex imaging of human melanoma, to identify...
Chen Zhou,Huican Li,Jiaxing Wang et al.
Chen Zhou et al.
Design of ion channels responsive to environmental cues has significant implications in modulating cellular activities and sensor development, but it remains a significant challenge due to the complexities involved in designing stimuli-indu...
Long shared haplotypes identify the southern Urals as a primary source for the 10th-century Hungarians [0.03%]
长共享单体型识别出南乌拉尔是匈牙利人的主要来源地（公元10世纪）
Balázs Gyuris,Leonid Vyazov,Attila Türk et al.
Balázs Gyuris et al.
The origins of the early medieval Magyars who appeared in the Carpathian Basin by the end of the 9th century CE remain incompletely understood. Previous archaeogenetic research identified the newcomers as migrants from the Eurasian steppe. ...
Patricia A Possik,David J Adams,Flavia C Aguiar et al.
Patricia A Possik et al.
Single-cell and spatial transcriptomics are revolutionizing science. Latin America's unique genetic diversity, environment, and endemic infectious diseases offer exceptional opportunities to deploy these technologies for societal and scient...
Heather D Hickman,Niki M Moutsopoulos
Heather D Hickman
In a recent issue of Nature Biomedical Engineering, Ingrole et al. explore a new approach for needle-free vaccine delivery through the mouth. They devise and test a dental-floss-based flu vaccine as an alternative mode of mucosal vaccinatio...
CRISPR meets AI-based robotics: Advancing sustainable agriculture [0.03%]
基于人工智能的机器人技术与CRISPR相遇：推动可持续农业发展
Fabienne Gehrke,Holger Puchta
Fabienne Gehrke
In this issue of Cell, Xu and colleagues develop an approach integrating genome editing, artificial intelligence, and robotics to enhance crop improvement. By reconfiguring reproductive traits for automated pollination in crops such as toma...
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis [0.03%]
针对进展型多发性硬化症患者的抗BCMA CAR-T疗法
Chuan Qin,Ming-Hao Dong,Luo-Qi Zhou et al.
Chuan Qin et al.
Progressive multiple sclerosis (PMS), which is characterized by relentless disease progression, lacks effective treatment. While recent studies have highlighted the importance of B cells in driving compartmentalized central nervous system (...