Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy [0.03%]
纳米颗粒劫持颅骨免疫细胞用于中枢神经系统药物输送和中风治疗
Xize Gao,Xiangrong Liu,Nanxing Wang et al.
Xize Gao et al.
The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells u...
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo [0.03%]
多模态超分子靶向嵌合体能够在活体内时空解析蛋白质降解
Ji Liu,Tianyu Ma,Rui Yao et al.
Ji Liu et al.
Targeted protein degradation (TPD) has transformed strategies for modulating protein function in both basic biology and therapeutic development. However, current strategies often lack the spatial and temporal precision required for in vivo ...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation [0.03%]
EB病毒潜伏膜蛋白1表达的B细胞在中枢神经系统中捕获髓鞘抗原导致脱髓鞘病灶形成
Hyein Kim,Mika Schneider,Yakine Raach et al.
Hyein Kim et al.
The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In mice, we observed that viral infections induce infiltration of B cells int...
EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation [0.03%]
EB病毒与HLA-DR15通过髓鞘肽呈递联合驱动多发性硬化症
Jian Wang,Yuhan Qiu,Zoe Marti et al.
Jian Wang et al.
Epstein-Barr virus (EBV) is involved in causing and probably also in perpetuating multiple sclerosis (MS). Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and prefere...
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis [0.03%]
EB病毒通过ANK2特异性T细胞与多发性硬化相联系
Olivia G Thomas,Urszula Rykaczewska,Marina Galešić et al.
Olivia G Thomas et al.
Epstein-Barr virus (EBV) infection constitutes a prerequisite for multiple sclerosis (MS) development, and cross-reactivity between EBV nuclear antigen 1 (EBNA1) and anoctamin-2 (ANO2) antibodies was previously demonstrated in persons with ...
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex [0.03%]
溶酶体KICSTOR-GATOR1-SAMTOR营养感受超级复合物的结构
Christopher J Lupton,Charles Bayly-Jones,Shuqi Dong et al.
Christopher J Lupton et al.
The guanosine triphosphate (GTP)-bound state of the heterodimeric Rag GTPases functions as a molecular switch regulating mechanistic target of rapamycin complex 1 (mTORC1) activation at the lysosome downstream of amino acid fluctuations. Un...
Chengyu Zou,Peiying Li,Bin Li et al.
Chengyu Zou et al.
Recent advances in regulatory T cell (Treg) biology and clinical application of Treg-based treatments show promise as a new generation of transforming therapeutics for immune-related disorders, positioning Tregs as a "living drug" to rebuil...
Andreas Linkermann
Andreas Linkermann
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respiratory chain to release copper and kill acu...
A trunkload of ancient RNA [0.03%]
一车满满的古rna
Sébastien Calvignac-Spencer,Carles Lalueza-Fox
Sébastien Calvignac-Spencer
Ancient DNA has become a workhorse for evolutionary biologists. In contrast, ancient RNA studies have been rare and often methodologically controversial. Mármol-Sánchez et al. provide compelling evidence that aRNA survived up to ca. 50,00...
EcDNA-borne structural variants drive oncogenic fusion transcript amplification [0.03%]
染色体外 DNA 诱导结构变异并驱动致癌融合转录本扩增
Hyerim Yi,Shu Zhang,Jason Swinderman et al.
Hyerim Yi et al.
Extrachromosomal DNA (ecDNA) amplifications are key drivers of human cancers. Here, we show that ecDNAs are major platforms for generating and amplifying oncogene fusion transcripts across diverse cancer types. By integrating analysis of wh...