Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature [0.03%]
肝脏分泌蛋白可逆年龄及阿尔茨海默病相关的记忆丧失的血管机制
Gregor Bieri,Karishma J B Pratt,Yasuhiro Fuseya et al.
Gregor Bieri et al.
Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-...
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life [0.03%]
巨DNA病毒编码真核生命的标志翻译起始复合物
J Maximilian Fels,Aidan B Hill,Richard Han et al.
J Maximilian Fels et al.
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA viruses encode a distinct and functional IF4F...
A single-cell time-series atlas of endothelial cell embryonic development [0.03%]
血管内皮细胞胚胎发育的单细胞时间序列图谱
Lihui Lin,Jing Zhong,Fuqing Jiang et al.
Lihui Lin et al.
Endothelial cells (ECs) are essential components of the vertebrate circulatory system; however, a comprehensive atlas characterizing how ECs acquire organ-specific transcriptomic heterogeneity has not been established. Here, we generated a ...
Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux [0.03%]
胞外基质感知调控肿瘤内自噬流的异质性
Mohamad Assi,Ruohong Wang,Emily A Kawaler et al.
Mohamad Assi et al.
Autophagy, a programmed self-eating process, underlies the progression of multifactorial diseases like pancreatic ductal adenocarcinoma (PDA). Except for nutrient availability, the contribution of microenvironmental factors to autophagy reg...
CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response [0.03%]
CLIM-TIME识别促进T细胞治疗反应的转移性肿瘤微环境调节因子
Yinghua Wang,Weiwei Hu,Rui Xia et al.
Yinghua Wang et al.
The tumor microenvironment (TME) poses a major barrier to effective immunotherapy, yet high-throughput perturbation-mapping approaches to dissect TME spatial complexity and its contextual immune modulators remain lacking. Here, we introduce...
Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial [0.03%]
溶瘤病毒治疗后胶质母细胞瘤患者T细胞的持续激活和细胞毒性作用
Maxime Meylan,Ye Tian,Lijian Wu et al.
Maxime Meylan et al.
A recent first-in-human clinical trial demonstrated that survival in glioblastoma (GBM) patients following rQNestin34.5v.2 oncolytic virus treatment was associated with immune activation signatures. This study was registered at ClinicalTria...
Planetary microbiome structure and generalist-driven gene flow across disparate habitats [0.03%]
地球微生物组结构及跨不同栖息地的通用型驱动基因流动
Chan Yeong Kim,Daniel Podlesny,Jonas Schiller et al.
Chan Yeong Kim et al.
Microbes are ubiquitous on Earth, forming microbiomes that sustain macroscopic life and biogeochemical cycles. Microbial dispersal, driven by natural processes and human activities, interconnects microbiomes across habitats, yet most compar...
Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells [0.03%]
偶然性癌症免疫治疗源于稀有但功能关键的火花T细胞
Emanuel Salazar-Cavazos,Dongya Jia,Yoann Missolo-Koussou et al.
Emanuel Salazar-Cavazos et al.
Cancer immunotherapies trigger highly variable responses in patients and in genetically identical mouse models. To assess the intrinsic stochasticity of these therapies, we performed thousands of well-controlled ex vivo immunoassays. We sho...
Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment [0.03%]
感觉神经元通过刺激乳腺癌肿瘤微环境中的致密细胞外基质促进免疫排斥反应
Si-Wei Zhang,Han Wang,Yi Xiao et al.
Si-Wei Zhang et al.
Innervation is critical in tumor progression. However, the involvement of sensory neurons in the ecosystem of triple-negative breast cancer (TNBC) remains poorly elucidated. Here, we decipher that sensory neurons, the dominant neuron type i...
Thomas H Naragon,Joani W Viliunas,Mina Yousefelahiyeh et al.
Thomas H Naragon et al.
Why symbiotic organisms evolve irreversible dependencies on hosts is an outstanding question. We report a biological stealth device in a beetle that permits infiltration of ant societies. Via transcriptional silencing, the beetle switches o...