Marito Hayashi
Marito Hayashi
In this issue of Cell, Jaschke and Luchsinger et al. uncover a gut-to-brain signaling mechanism that dynamically shapes protein intake. During recovery from extreme fasting, ammonia derived from the metabolism of specific dietary amino acid...
A 3D in vitro model for studying human implantation and implantation failure [0.03%]
一种研究人类着床和着床失败的三维体外模型
Qian Li,Yang Yuan,Wentao Zhao et al.
Qian Li et al.
A better understanding of human implantation is essential for improving assisted reproduction outcomes and addressing recurrent implantation failure (RIF). However, ethical constraints and limited access to human embryos make direct studies...
Matteo A Molè,Sarah Elderkin,Irene Zorzan et al.
Matteo A Molè et al.
Implantation of a human embryo into the endometrium is a crucial event in gestation, as it marks the initiation of a pregnancy and is prone to high failure rates. We have limited understanding of these stages because of the inaccessibility ...
Mapping cellular targets of covalent cancer drugs in the entire mammalian body [0.03%]
绘制整个哺乳动物机体中癌细胞靶向共价药物的作用图谱
Zhengyuan Pang,Verina H Leung,Cailynn C Wang et al.
Zhengyuan Pang et al.
As our understanding of biological systems reaches single-cell and high spatial resolutions, it becomes imperative that pharmacological approaches match this precision to understand drug actions. This need is particularly urgent for the tar...
Constantine N Tzouanas,Jessica E S Shay,Marc S Sherman et al.
Constantine N Tzouanas et al.
During chronic stress, cells must support both tissue function and their own survival. Hepatocytes perform metabolic, synthetic, and detoxification roles, but chronic nutrient imbalances can induce hepatocyte death and precipitate metabolic...
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases [0.03%]
核点蛋白形成内在的和MALAT1依赖性的微相分离现象
Min Kyung Shinn,Dylan T Tomares,Vicky Liu et al.
Min Kyung Shinn et al.
Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific sequence grammars. Such proteins include serine/arginine-rich splicing factors (SRSFs) and tr...
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense [0.03%]
dendritic细胞调节淋巴结中的固有适应性平衡以实现最佳宿主防御
Jessica Y Huang,Michael Y Gerner
Jessica Y Huang
Lymph nodes (LNs) enable innate defense to limit pathogen dissemination while also driving adaptive immunity. Yet, certain innate responses can restrict adaptive processes, suggesting that these must be tightly regulated. Here, we report th...
Gut microbiota promotes immune tolerance at the maternal-fetal interface [0.03%]
肠道微生物群促进母胎界面上的免疫耐受性
Julia A Brown,Mohammed Amir,Shui Yu et al.
Julia A Brown et al.
Immune tolerance at the maternal-fetal interface (MFI) is required for fetal development. Excessive maternal interferon-gamma (IFN-γ) and interleukin-17 (IL-17) are linked to pregnancy complications, but the regulation of maternal IFN-γ a...
Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma [0.03%]
靶向TFAP2β凝聚可抑制食管鳞癌发展
Zhaomin Deng,Lu Pu,Kai Deng et al.
Zhaomin Deng et al.
Exploring targeted therapies for esophageal squamous cell carcinoma (ESCC) remains challenging. Although investigating the roles and therapeutic applications of liquid-liquid phase separation (LLPS) is increasingly of interest, its relation...
Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain [0.03%]
发育哺乳动物大脑中神经元和免疫细胞动态的在体观察
Zhen Long,Yongzhen Yu,Chenyi He et al.
Zhen Long et al.
The mammalian brain contains diverse neuronal and immune cell types that exhibit dynamic motions in response to distinct extracellular environments. However, technical limitations make it difficult to investigate complex cellular motions in...