CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis [0.03%]
基于诱导多能干细胞的神经元CRISPR筛选揭示了tau蛋白稳态的基本原理
Avi J Samelson,Nabeela Ariqat,Justin McKetney et al.
Avi J Samelson et al.
Aggregation of the protein tau defines tauopathies, the most common age-related neurodegenerative diseases, which include Alzheimer's disease and frontotemporal dementia. Specific neuronal subtypes are selectively vulnerable to tau aggregat...
A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor [0.03%]
一种构建体内吸收不良生物传感器的拟杆菌合成生物学工具包
Giselle McCallum,Juan C Burckhardt,Jerry He et al.
Giselle McCallum et al.
The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet no...
A triple-node heart-brain neuroimmune loop underlying myocardial infarction [0.03%]
心肌梗死的三重节点心脏-大脑神经免疫环路
Saurabh Yadav,Van K Ninh,Jonathan W Lovelace et al.
Saurabh Yadav et al.
Myocardial infarction (MI) triggers adverse cardiac events, immune responses, and nervous system activation, but the neural and neuroimmune mechanisms remain understudied. Using single-cell RNA sequencing (scRNA-seq) and tissue clearing, we...
Xiaomeng Tang,Lu Qu,Florian Wilfling et al.
Xiaomeng Tang et al.
Many proteins localize in membraneless organelles. However, understanding the steps along membraneless organelle formation-and the structural impact on granule constituents-has been hindered by limited resolution of intracellular data. We a...
AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy [0.03%]
AAVLINK：基因治疗中强大的DNA重组方法用于递送大量货物
Jianbang Lin,Yunping Lin,Nana Liu et al.
Jianbang Lin et al.
Delivery of therapeutic genes is essential for successful gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying gene cargoes. However, the limited packaging capacity of AAVs poses a major challenge for large gene tra...
William Y Shi,Kevin J Liu,Mohammad S Esfahani et al.
William Y Shi et al.
Only some non-muscle-invasive bladder cancer (NMIBC) patients benefit from intravesical Bacillus Calmette-Guérin (BCG), and predictive biomarkers remain lacking. While urine tumor DNA (utDNA) analysis is promising, mutations in tumor-adjac...
An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery [0.03%]
一种用于精确细胞内给药的器官顺应性折纸式生物电子贴片
Yuqiong Wang,Lamei Du,Han Wu et al.
Yuqiong Wang et al.
Efficient and precise delivery of therapeutics toward target loci of organs is crucial for effective disease therapy. However, conventional devices face remarkable challenges to achieve clinically desirable conformality, spatial controllabi...
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator [0.03%]
一种多功能别构调节剂介导的GPCR-G蛋白-β仲态蛋白巨复合物
Guodong He,Qinxin Sun,Xinyu Xu et al.
Guodong He et al.
Approximately one-third of clinical drugs mediate their therapeutic effects through G protein-coupled receptors (GPCRs), highlighting their immense therapeutic relevance. Novel approaches to modulate GPCR activity have the potential to yiel...
Changzhen Liu,Qiangsheng Yu,Yunfan Jin et al.
Changzhen Liu et al.
Higher organisms spread external stimuli from the perceptive tissues to the whole body to achieve systemic responses. In plants, guard cells sense pathogens and close stomata to prevent their entry. We observed that pathogen-infected local ...
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS [0.03%]
PIKFYVE抑制作用可缓解多种类型ALS模型小鼠的症状
Shu-Ting Hung,Gabriel R Linares,Wen-Hsuan Chang et al.
Shu-Ting Hung et al.
Published Erratum
Cell. 2026 Jan 24:S0092-8674(26)00051-6. DOI:10.1016/j.cell.2026.01.004 2026