AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution [0.03%]
人工智能镜像实验科学揭示基因转移机制对细菌进化至关重要
José R Penadés,Juraj Gottweis,Lingchen He et al.
José R Penadés et al.
Artificial intelligence (AI) models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging since an AI-generated hypothesis can take decades to validate. Here, we challenge the a...
Culture-independent meta-pangenomics enabled by long-read metagenomics reveals associations with pediatric undernutrition [0.03%]
基于长读取元基因组的无文化依赖性元泛基因组学揭示了与儿童营养不良的关系
Jeremiah J Minich,Nicholas Allsing,M Omar Din et al.
Jeremiah J Minich et al.
The human gut microbiome is linked to child malnutrition, yet traditional microbiome approaches lack resolution. We hypothesized that complete metagenome-assembled genomes (cMAGs), recovered through long-read (LR) DNA sequencing, would enab...
Peng Xie,Juan Shen,Yi Yang et al.
Peng Xie et al.
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial section...
Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium [0.03%]
Harbin猿人头骨牙结石中的丹尼索瓦人线粒体DNA
Qiaomei Fu,Peng Cao,Qingyan Dai et al.
Qiaomei Fu et al.
Denisovans have yet to be directly associated with a hominin cranium, limiting our understanding of their morphology and geographical distribution. We have attempted to retrieve DNA from a nearly complete Middle Pleistocene cranium from Har...
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics [0.03%]
HT SpaceM：一种用于小分子单细胞代谢组学的高通量和可重复的方法
Jeany Delafiori,Mohammed Shahraz,Andreas Eisenbarth et al.
Jeany Delafiori et al.
Single-cell metabolomics (SCM) promises to reveal metabolism in its complexity and heterogeneity, yet current methods struggle with detecting small-molecule metabolites, throughput, and reproducibility. Addressing these gaps, we developed H...
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity [0.03%]
白细胞介素-25诱导的记忆型2固有淋巴样细胞促进黏膜免疫
Victor S Cortez,Sara Viragova,Satoshi Koga et al.
Victor S Cortez et al.
Adaptation of intestinal helminths to vertebrates involved the evolution of strategies to attenuate host tissue damage to support parasite reproduction and dissemination of offspring to the environment. Helminths initiate the IL-25-mediated...
Coalescing single-cell genomes and transcriptomes to decode breast cancer progression [0.03%]
融合单细胞基因组和转录组以破译乳腺癌的进展
Kaile Wang,Rui Ye,Shanshan Bai et al.
Kaile Wang et al.
Understanding epithelial lineages of breast cancer and genotype-phenotype relationships requires direct measurements of the genome and transcriptome of the same single cells at scale. To achieve this, we developed wellDR-seq, a high-genomic...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views [0.03%]
重新思考RNA结合蛋白：核糖调节改变了以往的观点
Matthias W Hentze,Pia Sommerkamp,Venkatraman Ravi et al.
Matthias W Hentze et al.
RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as the ribosome and the spliceosome. Around 1,000 RBPs account for these functions in mammalia...
Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction [0.03%]
通过BBM-BAR1重编程小孢子命运实现高效的体内单倍体诱导
Ce Shi,Zifu Zhao,Yicheng Zhong et al.
Ce Shi et al.
Haploid induction (HI) through stress-treated microspore culture has gained significant attention for over half a century, yet the molecular mechanism underlying microspore fate transition for androgenesis remains poorly understood. Here, w...
Tumors hijack macrophages for iron supply to promote bone metastasis and anemia [0.03%]
肿瘤劫持巨噬细胞铁供应以促进骨转移和贫血发生
Yujiao Han,Hirak Sarkar,Zhan Xu et al.
Yujiao Han et al.
Bone marrow is both a primary site for hematopoiesis and a fertile niche for metastasis. The mechanism of the common occurrence of anemia among patients with bone metastasis remains poorly understood. Here, we show that a specialized popula...