BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants [0.03%]
大脑磁图谱：用于解释非编码变异的功能基因组学图谱
Ruizhi Deng,Elena Perenthaler,Anita Nikoncuk et al.
Ruizhi Deng et al.
Genome-wide assessment of genetic variation is becoming routine in genetics, yet functional interpretation of non-coding single nucleotide variants in both common and rare diseases remains a major challenge. Here, we used chromatin immunopr...
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy [0.03%]
靶向巨噬细胞的免疫细胞因子利用髓系、T和NK细胞协同作用进行癌症免疫治疗
Michelle von Locquenghien,Pascale Zwicky,Ken Xie et al.
Michelle von Locquenghien et al.
Tumor-associated macrophages (TAMs) expressing the myeloid checkpoint TREM2 are key immunosuppressive cells in the tumor microenvironment (TME), driving tumor progression and contributing to poor prognosis in cancer patients. Due to their p...
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia [0.03%]
血红素生物合成抑制触发急性髓系白血病细胞铜死亡机制研究
Alexander C Lewis,Emily Gruber,Rheana Franich et al.
Alexander C Lewis et al.
The ubiquitous metabolite heme has diverse enzymatic and signaling functions in most mammalian cells. Through integrated analyses of mouse models, human cell lines, and primary patient samples, we identify de novo heme biosynthesis as a sel...
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells [0.03%]
I型滤泡辅助性T细胞通过IgA介导长效免疫记忆响应黏膜病毒感染
Kei Haniuda,Natalie M Edner,Yuko Makita et al.
Kei Haniuda et al.
Although immunoglobulin A (IgA)+ long-lived plasma cells (LLPCs) generated following mucosal viral infection provide durable protection against reinfection, little is known about their generation. Here, we show that rotavirus (RV) infection...
Nutrient competition predicts gut microbiome restructuring under drug perturbations [0.03%]
营养竞争决定药物干扰下的肠道菌群重塑预测
Handuo Shi,Daniel P Newton,Taylor H Nguyen et al.
Handuo Shi et al.
Human gut bacteria are routinely exposed to stresses, and community-level responses are difficult to predict. To interrogate these effects, we screened stool-derived in vitro communities with 707 clinically relevant drugs. Across ∼5,000 co...
Emilio Mármol-Sánchez,Bastian Fromm,Nikolay Oskolkov et al.
Emilio Mármol-Sánchez et al.
Ancient DNA has revolutionized the study of extinct and extant organisms that lived up to 2 million years ago, enabling the reconstruction of genomes from multiple extinct species, as well as the ecosystems where they once thrived. However,...
Single-cell susceptibility to viral infection is driven by variable cell states [0.03%]
细胞对病毒感染的敏感性由不同的细胞状态驱动
Sam Reffsin,Jesse Miller,Kasirajan Ayyanathan et al.
Sam Reffsin et al.
The ability of a virus to infect a cell is partly determined by host factors required for the viral life cycle. However, not every cell of a given type is equally susceptible to infection. Profiling susceptible subsets of cells could reveal...
Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function [0.03%]
从单细胞到器官的桥梁：介尺度模块作为组织功能的基本单元
Yun Chen,Ronald N Germain,Ginger L Hunter et al.
Yun Chen et al.
Recent studies at molecular and genomic scales have enriched our understanding of life's most fundamental building block: the cell. However, bridging the gap between single-cell phenotypes and the emergent functions of tissues and organs re...
Vera Gorbunova,Andrei Seluanov
Vera Gorbunova
Age-dependent exhaustion of endogenous stem cell pools-and the resulting decline in tissue regeneration and homeostatic maintenance-is a hallmark of organismal aging and age-related pathology. In a study published in Cell, Liu and collabora...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome [0.03%]
贯穿人类蛋白质组的预测内在无序区域的分子语法
Kiersten M Ruff,Matthew R King,Alexander W Ying et al.
Kiersten M Ruff et al.
Intrinsically disordered regions (IDRs) of proteins are defined by molecular grammars. This refers to IDR-specific non-random amino acid compositions and non-random patterning of distinct pairs of amino acid types. Here, we introduce gramma...