Simon F Brunner,Iñigo Martincorena,Gregory Mannino et al.
Simon F Brunner et al.
Somatic mutations, or genetic changes occurring in cells after conception, are widespread in healthy tissues but are conventionally viewed as signs of pre-cancer or simply a consequence of aging. However, an emerging body of work has shown ...
Samuel J C McCullough,Taylor J Stevenson,Justin Rustenhoven
Samuel J C McCullough
Therapeutic delivery to the brain after stroke is limited by the blood-brain barrier. In this issue of Cell, Gao et al. bypass this obstacle by harnessing skull bone marrow immune cells to deliver drug-loaded nanoparticles to injured brain ...
Lili Zhu,Chen Yang,René Bernards et al.
Lili Zhu et al.
Immunotherapy resistance is associated with immune-privileged microenvironments, yet the interacting role of tumor-intrinsic genetics remains unclear. In this issue of Cell, Wang et al. introduce CLIM-TIME, a spatially resolved in vivo CRIS...
Joe McKellar,Aurélien Fouillen,Sébastien Lyonnais et al.
Joe McKellar et al.
Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expropriate glycoproteins from helper viruses to form infectious particles. Here, we challenge...
Dynamics of natural selection preceding human viral epidemics and pandemics [0.03%]
先于人类病毒大流行发生的自然选择动态机制
Jennifer L Havens,Sergei L Kosakovsky Pond,Jordan D Zehr et al.
Jennifer L Havens et al.
Using a phylogenetic framework to characterize natural selection, we investigate the hypothesis that zoonotic viruses require adaptation prior to zoonosis to sustain human-to-human transmission. Examining the zoonotic emergence of Ebola vir...
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis [0.03%]
选择性靶向内皮和血管周细胞的血管生成因子ROCK2治疗肝纤维化
Yan Hu,Biao Yang,Chengju Xiao et al.
Yan Hu et al.
Liver fibrosis is a prominent pathological process contributing to death from hepatic diseases, including metabolic dysfunction-associated steatohepatitis (MASH). There is limited treatment for liver fibrosis. Here, we find that upregulatio...
β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer [0.03%]
β-羟丁酸改善癌症CAR-T细胞的代谢适应性
Shan Liu,Puneeth Guruprasad,Ranjani Ramasubramanian et al.
Shan Liu et al.
The influence of lifestyle factors, such as diet, on the effectiveness of T cell-mediated cancer immunotherapies remains unclear. Here, we demonstrate that the ketogenic diet (KD)-induced ketone metabolite β-hydroxybutyrate (BHB) augments ...
Light-directed evolution of dynamic, multi-state, and computational protein functionalities [0.03%]
光驱动的蛋白质功能的动态、多状态和计算性进化
Vojislav Gligorovski,Marco Labagnara,Lorenzo Scutteri et al.
Vojislav Gligorovski et al.
Evolving dynamic, multi-state, and computational protein functionalities is challenging because it requires selection pressure on all the states of a protein of interest (POI) and the transitions between them. To create a continuous directe...
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema [0.03%]
代谢物门控血管收缩转换开关：OXGR1激活机制可使抗炎剂用于治疗酒渣鼻红斑
Wenqin Xiao,Yan Zhu,Xinjie Tang et al.
Wenqin Xiao et al.
Rosacea, an inflammatory skin disorder, poses a dilemma owing to limited effectiveness of treatments for pathological vasodilation-mediated erythema. Here, we identify oxoglutaric acid (α-KG) as a rosacea-associated metabolite elevated in ...
Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain [0.03%]
用于在活体大脑中可视化α-突触核蛋白病理的基因编码荧光报告系统
Li Zhang,Minhui Yu,Guoqing Chen et al.
Li Zhang et al.
Lewy bodies, a pathological hallmark of Parkinson's disease, are α-synuclein-enriched cytoplasmic inclusions that drive progressive neurodegeneration. A long-standing yet unmet goal has been the visualization of α-synuclein (α-Syn) inclu...