CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics [0.03%]
脑蛛网膜开启结构调节嗅束脑脊液清除功能的研究
Seon Pyo Hong,Cheolhwa Jin,Myung Jin Yang et al.
Seon Pyo Hong et al.
Meningeal (dural) lymphatics are essential for cerebrospinal fluid (CSF) clearance to cervical lymph nodes, yet the precise pathway is incompletely understood. Using a multifaceted approach in mice, we examined tracer dynamics and the CSF o...
A domestication-selected enhancer coordinates source-sink balance to improve harvest index and yield in maize [0.03%]
一个被驯化的增强子协调源-库平衡以提高玉米的收获指数和产量
Li Guo,Jinliang Xia,Junxiang Tang et al.
Li Guo et al.
Crop yield is fundamentally determined by the harvest index, the proportion of photosynthates allocated to grain. However, its genetic and evolutionary basis remains elusive. Here, we show that the maize harvest index increased by 81% durin...
Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy [0.03%]
病毒蛋白酶触发的裂解性细胞死亡作为通用抗病毒mRNA疗法
Lin Li,Xiu-Li Yan,Hao-Yang Wang et al.
Lin Li et al.
While gasdermin (GSDM)-mediated pyroptosis is a potent immune effector, its antiviral potential remains largely untapped. Here, we introduce viral protease-initiated lytic cell death (VID), a universal mRNA therapeutic platform inspired by ...
A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death [0.03%]
一种连接乙酰转移酶和促癌细胞死亡的双价分子胶粘剂
Meredith N Nix,Sai Gourisankar,Kevin J Bowman et al.
Meredith N Nix et al.
Developing cancer therapies that induce specific death of malignant cells is critical for preventing relapse. Highly effective strategies, such as immunotherapy, exemplify this principle. Here, we provide the mechanistic basis for a small-m...
Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context [0.03%]
染色质原生环境下的增强子、促进子和启动子的稳健调控互作关系
Zhou Zhou,Yang Cheng,Jaret Lieberth et al.
Zhou Zhou et al.
Enhancers are abundant and critical gene-distal cis-regulatory elements with distinct architectural features; however, a mechanistic understanding of their interactions within endogenous chromatin contexts remains challenging. Here, we deve...
Zhikai Wang,Xinping Jin,Yue Wu et al.
Zhikai Wang et al.
Peripheral nerves regulate skin homeostasis by secreting neurotransmitters, but their role during skin aging remains incompletely understood. Here, we report that cutaneous denervation accelerates skin aging, as evidenced by collagen reduct...
Boron-bridged GIPCs stabilize cell wall anchoring and PIN polar domains [0.03%]
硼桥GIPC稳定细胞壁锚定位和PIN极性区域
Mingliang He,Cheng Zhang,Zihan Li et al.
Mingliang He et al.
Boron (B) is an essential plant micronutrient whose deficiency impairs global crop yields. Glycosylinositol phosphorylceramides (GIPCs) are major lipids in the plasma membrane (PM), and PIN-FORMED (PIN) proteins mediate polar auxin transpor...
Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues [0.03%]
组织中单细胞的全长转录组剪接本分辨率空间成像技术
Limor Cohen,Aaron R Halpern,Timothy R Blosser et al.
Limor Cohen et al.
Cell and tissue functions arise from complex interactions among numerous genes, and a systematic understanding of these functions requires isoform-resolved transcriptomic analysis of single cells with high spatial resolution. Here, we intro...
Spatial proximity sequencing maps developmental dynamics in the germinal center [0.03%]
空间接近性测序描绘生发中心的发育动力学
Huili Wang,Junjie Xia,Peer Mohamed Suhail Mujibur Rahman et al.
Huili Wang et al.
Spatial profiling of proteins and protein interactions facilitates understanding of cell functions within tissues and is essential for studies in signaling, immunity, and cancer. We present spatial proximity sequencing (Sprox-seq) for simul...
Xin Man,Wen-Ting Zhang,Yu-Di Zhang et al.
Xin Man et al.
Spliceosomal introns impose a universal processing burden on eukaryotes and obstruct genome minimization because their essentiality remains unresolved. By exploiting Spo11-independent meiosis in synthetic single-chromosome Saccharomyces cer...