A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery [0.03%]
统一的细胞图谱揭示了血管植物的基本细胞类型和加速基因发现的功能基因
Hao-Chen Xue,Zhou-Geng Xu,Yu-Jie Liu et al.
Hao-Chen Xue et al.
The pace of gene discovery in plants has slowed as forward genetic screens reach saturation. To address this, we built a unified single-cell atlas of shoot apices from six vascular plant species spanning major evolutionary groups. This cros...
Jenny Sachweh,Mandy Börmel,Sven Klumpe et al.
Jenny Sachweh et al.
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin building blocks and exemplify the structural complexity of macromolecular assemblies. To ensure...
De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy [0.03%]
从头设计肽类调制剂以逆转与心律失常和癫痫相关的心脏钠通道功能障碍
Ryan Mahling,Bence Hegyi,Erin R Cullen et al.
Ryan Mahling et al.
Ion channels orchestrate electrical signaling in excitable cells. In nature, ion channel function is customized by modulatory proteins that have evolved to fulfill distinct physiological needs. Yet, engineering synthetic modulators that pre...
Chengtao Xu,Xiaolin Niu,Haifeng Sun et al.
Chengtao Xu et al.
RNA-guided RNA editing represents an attractive alternative to DNA editing. However, the prevailing tool, CRISPR-Cas13, has collateral RNA cleavage activity that causes undesirable cytotoxicity in human cells. Here, we report an ultracompac...
RNA Pol II inhibition activates cell death independently from the loss of transcription [0.03%]
RNA聚合酶II抑制独立于转录丢失激活细胞死亡
Nicholas W Harper,Gavin A Birdsall,Megan E Honeywell et al.
Nicholas W Harper et al.
RNA Pol II-mediated transcription is essential for eukaryotic life. Although loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here, we show that death following the...
Daoming Chen,Zhou Yu,Wenbo Wu et al.
Daoming Chen et al.
Hair loss affects millions globally, significantly impacting quality of life and psychological well-being. Despite its prevalence, effective strategies for promoting human hair growth remain elusive. By investigating congenital generalized ...
Aarti Krishnan,Melis N Anahtar,Jacqueline A Valeri et al.
Aarti Krishnan et al.
The antimicrobial resistance crisis necessitates structurally distinct antibiotics. While deep learning approaches can identify antibacterial compounds from existing libraries, structural novelty remains limited. Here, we developed a genera...
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming [0.03%]
广泛存在的衰老和疾病间充质转移可由部分重编程逆转
Jinlong Y Lu,William B Tu,Ronghui Li et al.
Jinlong Y Lu et al.
The loss of cellular and tissue identity is a hallmark of aging and numerous diseases, but the underlying mechanisms are not well understood. Our analysis of gene expression data from over 40 human tissues and 20 diseases reveals a pervasiv...
Inner speech in motor cortex and implications for speech neuroprostheses [0.03%]
运动皮层中的内部言语及其对言语神经假体的启示
Erin M Kunz,Benyamin Abramovich Krasa,Foram Kamdar et al.
Erin M Kunz et al.
Speech brain-computer interfaces (BCIs) show promise in restoring communication to people with paralysis but have also prompted discussions regarding their potential to decode private inner speech. Separately, inner speech may be a way to b...
Systematic profiling reveals betaine as an exercise mimetic for geroprotection [0.03%]
系统性分析发现甘氨酸是一种类运动的抗衰老物质
Lingling Geng,Jiale Ping,Ruochen Wu et al.
Lingling Geng et al.
Published Erratum
Cell. 2025 Aug 12:S0092-8674(25)00852-9. DOI:10.1016/j.cell.2025.07.030 2025