Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition [0.03%]
José Reyes,Isabella Del Priore,Andrea C Chaikovsky et al.
José Reyes et al.
The benign-to-malignant transition is a defining step in cancer progression. To investigate when and how malignancy initiation occurs and tissue reorganization proceeds, we combine single-cell and spatial transcriptomic profiling in mouse m...
Elisa de Launoit,Sophie Skriabine,Etienne Doumazane et al.
Elisa de Launoit et al.
The structure of the cerebral vasculature is immature at birth and undergoes significant postnatal remodeling and expansion. However, how vascularization progresses throughout the brain to integrate volumetric growth with neuronal circuit m...
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression [0.03%]
Junyeop Kim,Yerim Hwang,Sumin Kim et al.
Junyeop Kim et al.
Gaining precise control of gene expression is crucial in biomedical applications. However, spatiotemporal precision remains challenging. Here, we present a remotely controlled in vivo gene switch responsive to electromagnetic fields (EMFs) ...
Yu-Ying Liao,Jinxin Che,Yun-Tao Gao et al.
Yu-Ying Liao et al.
The cannabinoid receptor 1 (CB1) has emerged as a promising candidate for next-generation non-opioid therapies. However, the development of therapeutics targeting CB1 has been consistently hindered by significant adverse effects. Here, thro...
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia [0.03%]
泛素连接酶COP1通过降解小胶质细胞中的c/EBPβ抑制神经炎症作用
Ada Ndoja,Rohit Reja,Seung-Hye Lee et al.
Ada Ndoja et al.
Published Erratum
Cell. 2026 Apr 7:S0092-8674(26)00391-0. DOI:10.1016/j.cell.2026.04.002 2026
Clemens Hinterleitner,Hailey V Goldberg,Domhnall McHugh et al.
Clemens Hinterleitner et al.
Cellular senescence is a conserved stress-responsive program defined by durable proliferative arrest and extensive remodeling of chromatin, metabolism, intercellular signaling, and immune interactions. Initially described as a barrier to un...
Wenqiang Liu,Paul D Pang,Catherine A Wu et al.
Wenqiang Liu et al.
Traditional animal-based drug discovery has high failure rates, prompting the search for and adoption of human-centered new approach methodologies (NAMs). Rapid advances in stem cell-, organoid-, and in silico-based NAMs, supported by evolv...
Xiaozhi Fu
Xiaozhi Fu
Artificial intelligence has rapidly advanced molecular science, yet progress has largely unfolded through specialized models tailored to specific tasks. In this issue of Cell, Peng et al. introduce PocketXMol, a unified 3D generative framew...
Lijing Chang,Zhen Xu,Purong Deng et al.
Lijing Chang et al.
Nicotine, tobacco's addictive and potent insecticidal alkaloid, has shaped human history, agriculture, and the plants that produce it. However, the enzymatic steps and reaction mechanisms involved in nicotine biosynthesis remain elusive. He...
Robin Caire,Roberta Bordo,Francesca Zanconato et al.
Robin Caire et al.
The tissue-level processes underpinning metastatic outgrowth remain unclear. We combined single-cell RNA sequencing, spatial transcriptomics, and AI-supported 3D imaging in human breast cancer with functional investigations in mice to uncov...