Multi-adjuvant personalized neoantigen vaccines: Fine-tuning anti-cancer T cells [0.03%]
多联佐剂个性化新抗原疫苗：精制抗癌T细胞
Hejia Henry Wang,Neeha Zaidi
Hejia Henry Wang
Personalized cancer vaccines aim to broaden the anti-tumor T cell repertoire by targeting neoantigens unique to each patient's tumor, but immunogenicity has been inconsistent. In this issue of Cell, Blass, Keskin, Tu et al. evaluate NeoVaxM...
Makoto Someya,Ka-Yuet Liu,Kazumi Ohta et al.
Makoto Someya et al.
Evaluating the innate value of objects is critical for expressing adaptive behaviors. However, where and how this computation takes place in the brain remain elusive. By recording from virtually every neuron in Drosophila higher olfactory a...
Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn's disease strictures [0.03%]
克罗恩病狭窄肠道纤维化中脂肪来源的机械敏感成纤维细胞的侵袭作用
Khristian E Bauer-Rowe,Benjamin Pham,Michelle Griffin et al.
Khristian E Bauer-Rowe et al.
A significant complication of Crohn's disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the wrapping of mesenteric adipose tissue around diseased bowel, of which the role in CD stri...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration [0.03%]
植物再生过程中单个体细胞向全能状态时间分辨率重编程
Li Ping Tang,Li Ming Zhai,Jiming Li et al.
Li Ping Tang et al.
Totipotency enables single cells to regenerate an organism, yet how differentiated somatic cells reacquire this potential remains unclear. Here, we show that LEAFY COTYLEDON2 (LEC2) reprograms SPEECHLESS (SPCH)-expressing meristemoid mother...
Samson Glaser,Maxim I Molodtsov,John F X Diffley et al.
Samson Glaser et al.
Following eukaryotic genome replication, the ring-shaped cohesin complex embraces the two newly synthesized sister chromatids, enabling their faithful segregation during cell divisions. Replisome passage through cohesin rings has been envis...
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines [0.03%]
挖掘CD4抗原谱库用于下一代结核病疫苗的研发
Samuel J Vidal,Ninaad Lasrado,Lisa H Tostanoski et al.
Samuel J Vidal et al.
Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, and Bacillus Calmette-Guérin (BCG) remains the only clinically approved vaccine. An enduring challenge in TB vaccine development is systematic antigen selec...
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV [0.03%]
HIV患者CD8+T细胞免疫代谢缺陷破坏肠道屏障功能
Upasana Das Adhikari,Leah M Froehle,Alexandra N Pipkin et al.
Upasana Das Adhikari et al.
A hallmark of HIV infection is disruption of intestinal barrier integrity that persists in people with HIV (PWH) despite treatment with antiretroviral therapy (ART). This disruption is central to HIV disease progression, yet the causes rema...
Jose A Canovas,Li Wang,Ahmed A M Mohamed et al.
Jose A Canovas et al.
The innate attraction to sweet mediates appetitive and consummatory responses. Here, we dissected the circuit driving responses to sweet and showed that amygdala neurons tuned to sweet connect to the bed nucleus of the stria-terminalis (BNS...
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling [0.03%]
小胶质细胞-星形胶质细胞通过Wnt信号相互作用调节突触重塑
Travis E Faust,Yi-Han Lee,Ciara D O&#x;Connor et al.
Travis E Faust et al.
Astrocytes and microglia are emerging key regulators of activity-dependent synapse remodeling that engulf and remove synapses in response to changes in neural activity. Yet, the degree to which these cells communicate to coordinate this pro...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization [0.03%]
类壳感染颗粒可扩大噬菌体诱导的染色体岛转导的宿主范围
Lingchen He,Jonasz B Patkowski,Jinlong Wang et al.
Lingchen He et al.
Some mobile genetic elements spread among unrelated bacterial species through unknown mechanisms. Recently, we discovered that identical capsid-forming phage-inducible chromosomal islands (cf-PICIs), a new family of phage satellites, are pr...