Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity [0.03%]
SHANK3寡聚化调控突触后致密带凝聚物的物理特性及突触可塑性
Bowen Jia,Zeyu Shen,Shihan Zhu et al.
Bowen Jia et al.
Cells contain numerous types of membraneless organelles or biological condensates formed via phase separation. Cellular biological condensates have broad material properties ranging from Newtonian fluids to elastic solids. How the material ...
Bacteriophages inhibit and evade cGAS-like immune function in bacteria [0.03%]
噬菌体抑制和逃避细菌中的cGAS样免疫功能
Erin Huiting,Xueli Cao,Jie Ren et al.
Erin Huiting et al.
Published Erratum
Cell. 2025 Aug 22:S0092-8674(25)00923-7. DOI:10.1016/j.cell.2025.08.009 2025
A receptor antagonist counterbalances multiple systemin phytocytokines in tomato [0.03%]
一种受体拮抗剂可抵消番茄中的多种系统素植物细胞生长素的作用
Lei Wang,Louis-Philippe Maier,Nga Pham et al.
Lei Wang et al.
Tight regulation of immune activation is crucial for plant health. How plants control the actions of their immunostimulatory phytocytokines is largely unknown. Here, we identify antiSYS as a natural inhibitor of the tomato cytokine systemin...
Zeguang Wu,Jinhong Shi,Qiezhong Lamao et al.
Zeguang Wu et al.
Despite the success of autologous chimeric antigen receptor (CAR)-T cell therapy, achieving persistence and avoiding rejection in allogeneic settings remains challenging. We showed that signal peptide peptidase-like 3 (SPPL3) deletion enabl...
Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals [0.03%]
哺乳动物的行为活动中多类神经元的高频电压动力学成像技术
Simon Haziza,Radosław Chrapkiewicz,Yanping Zhang et al.
Simon Haziza et al.
Published Erratum
Cell. 2025 Aug 21:S0092-8674(25)00924-9. DOI:10.1016/j.cell.2025.08.010 2025
Daniel Boehmer,Ivan Zanoni
Daniel Boehmer
Interferons (IFNs) are signaling proteins that play fundamental roles during health and disease. Although types I, II, and III IFNs are structurally and functionally different, all IFNs signal via an intricate network of Janus kinases, name...
Kevin K Yang,Ava P Amini
Kevin K Yang
When it comes to deep learning for protein engineering, there is strength in simplicity. In this issue of Cell, through thoughtful deployment of existing fixed-backbone sequence design models, Caixia Gao and colleagues engineer diverse geno...
Targeting myosin II to alter the disease course of challenging diseases [0.03%]
靶向肌球蛋白II以改变难治性疾病的发展进程
Douglas N Robinson
Douglas N Robinson
In this issue of Cell, Kenchappa et al. and Radnai et al. report the development of selective non-muscle myosin II inhibitors that show therapeutic potential in glioblastoma and methamphetamine use disorder, opening new avenues for targetin...
Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism [0.03%]
次黄嘌呤核苷酸脱氢酶和ADAL协调清除修饰腺苷以保障代谢安全
Akiko Ogawa,Satoshi Watanabe,Iuliia Ozerova et al.
Akiko Ogawa et al.
RNA contains diverse post-transcriptional modifications, and its catabolic breakdown yields numerous modified nucleosides requiring correct processing, but the mechanisms remain unknown. Here, we demonstrate that three RNA-derived modified ...
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia [0.03%]
一种从纤毛回收泛素化蛋白的保守机制
Sven M Lange,Jeremy A Bennett,Robyn J Eisert et al.
Sven M Lange et al.
The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways ...