Chetan Seshadri
Chetan Seshadri
M. tuberculosis is once again the leading infectious cause of death worldwide despite the existence of a licensed vaccine (BCG). In this issue of Cell, Vidal et al. systematically evaluate 42 candidate antigens and develop a trivalent mRNA ...
J Nicholas Betley
J Nicholas Betley
In this issue of Cell, Canovas and colleagues identify a consummatory dial in the brain that controls ingestion levels in a state-dependent manner. By continuing to trace the flow of sweet taste information, the authors identify a generaliz...
Activation-induced cytidine deaminase: The missing piece of many puzzles [0.03%]
激活诱导胞苷脱氨酶：解开众多谜题的关键因素
Thiago Carvalho,Sidonia Fagarasan,Masamichi Muramatsu
Thiago Carvalho
Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of antibody specificity, and a baffling human i...
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness [0.03%]
健康状况不佳时，IL-1R1阳性背缝核神经元介导自我隔离行为
Liu Yang,Matias L Andina,Mario Witkowski et al.
Liu Yang et al.
Sick animals exhibit behavioral changes that extend beyond physiological symptoms, such as appetite loss and hypoactivity, and include a decline in social interactions. While social isolation during sickness has been recognized to have the ...
David Shi,Pranav Reddy,McKayla Marrin et al.
David Shi et al.
The influence of the nervous system on the intestine is carried out by a combination of enteric, sensory, and autonomic innervation. However, disambiguating the functions of these physiologically distinct intestine-innervating neuronal popu...
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron [0.03%]
新型冠状病毒奥密克戎毒株感染性和免疫逃逸的结构与功能特征分析
Zhen Cui,Pan Liu,Nan Wang et al.
Zhen Cui et al.
Published Erratum
Cell. 2025 Nov 24:S0092-8674(25)01360-1. DOI:10.1016/j.cell.2025.11.025 2025
Yingying Hu,Hai-Xi Sun,Masahiro Sakurai et al.
Yingying Hu et al.
Creating interspecies chimeras with human pluripotent stem cells (hPSCs) offers a promising strategy for modeling human development and generating donor organs; however, poor human cell integration remains a major barrier. Most existing eff...
Catherine E Newman,Micah A Gygi,Haleh Alimohamadi et al.
Catherine E Newman et al.
BAX is a pro-apoptotic BCL-2 protein that resides in the cytosol as a monomer until triggered by cellular stress to form an oligomer that permeabilizes mitochondria and induces apoptosis. The paradigm for apoptotic blockade involves heterod...
Fate and state transitions during human blood vessel organoid development [0.03%]
人类血管器官体发育过程中的命运和状态转变
Marina T Nikolova,Zhisong He,Makiko Seimiya et al.
Marina T Nikolova et al.
Published Erratum
Cell. 2025 Nov 21:S0092-8674(25)01314-5. DOI:10.1016/j.cell.2025.11.018 2025
Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment [0.03%]
阐明途径选择性偏向性CCKBR激动剂用于阿尔茨海默病治疗
Jia-Le Wang,Xue-Ying Sha,Yue Shao et al.
Jia-Le Wang et al.
Expressed in the entorhinal cortex (EC), the cholecystokinin (CCK) B receptor (CCKBR) plays an important role in memory and learning. Here, we identify that CCKBR-Gs and -Gq signaling, rather than CCKBR-Gi signaling, are beneficial for Alzh...