Timothy A Yap,H Charles Manning,Puja Sapra et al.
Timothy A Yap et al.
Genomic instability is a defining feature of cancer, which arises when the cellular systems that maintain DNA integrity falter, enabling the accumulation of genetic and epigenetic alterations that drive malignant transformation. It is both ...
Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers [0.03%]
Mengyao Shi,Gary J Patti,Marc J Gunter et al.
Mengyao Shi et al.
Cancer in younger adults is rising globally, with notable birth-cohort effects. This epidemiological shift underscores the urgent need to accelerate the identification of novel causes and underlying biological networks, with the aim of tran...
Ashley Mae Conard,Madeline Hughes,James Hall et al.
Ashley Mae Conard et al.
The Hallmarks of Cancer framework has played a seminal role in developing our understanding of cancer biology. By design, these hallmarks abstract cancer into a common set of functional capabilities. The hallmarks thus constitute an intenti...
Diwakar Davar,Hassane M Zarour,Georgio Trinchieri
Diwakar Davar
Recent clinical trials demonstrate that fecal microbiota transplantation (FMT) enhances first-line immune checkpoint inhibitor efficacy in renal cell carcinoma, cutaneous melanoma, and non-small cell lung cancer with acceptable safety. Bene...
Rebecca L Eccles,Gabriela Carreno,Lorenzo de la Rica et al.
Rebecca L Eccles et al.
Since the original Hallmarks of Cancer, our understanding of the complexity of the disease has expanded dramatically. Researching cancer is no longer simply a question of ever more sophisticated experiments but of delivering science in an e...
Andrea Anampa-Guzmán,Patrick McGuire,Fiorella S Gagliardi et al.
Andrea Anampa-Guzmán et al.
Patient advocacy has the potential to contribute to effective cancer care with real-world impact, regardless of a country's socioeconomic status. Here, we asked representatives of patient advocacy groups for key considerations to overcome c...
Lucas T Jae,Lillian L Siu,Lei Zhang et al.
Lucas T Jae et al.
In this Voices piece, we asked researchers to reflect on how the Hallmarks of Cancer have shaped their career paths, their research directions, and their broader perspectives on cancer. Their reflections show how the framework continues to ...
Zoë S Walters,Timothy J Underwood
Zoë S Walters
In choosing to merge two independent teams, we stepped into an unconventional model of co-leadership that reshaped our scientific lives. A clinician and a scientist leading together challenged academic norms, dissolved the loneliness of tra...
Cell Editorial Team
Cell Editorial Team
Twenty-five years after its publication, the Hallmarks of Cancer framework continues to illuminate tumor biology and drive therapeutic innovation. This special issue surveys how the concept has shaped our understanding of cancer, guided dru...
Zane R Thornburg,Andrew Maytin,Jiwoong Kwon et al.
Zane R Thornburg et al.
Published Erratum
Cell. 2026 Apr 15:S0092-8674(26)00392-2. DOI:10.1016/j.cell.2026.04.003 2026