Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation [0.03%]
基于距离的核糖体印记解析线粒体局部翻译规律
Jingchuan Luo,Stuti Khandwala,Jingjie Hu et al.
Jingchuan Luo et al.
Localized translation broadly enables spatiotemporal control of gene expression. Here, we present LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution ...
Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection [0.03%]
结构保守的人类抗A35抗体可保护小鼠和猕猴免受 mpox病毒感染
Bin Ju,Congcong Liu,Jingjing Zhang et al.
Bin Ju et al.
The A35 protein, expressed on the enveloped virion of monkeypox (mpox) virus (MPXV), is essential for viral infection and spread within the host, making it an effective antiviral target. In this study, we demonstrated two human anti-A35 mon...
Human monoclonal antibodies targeting A35 protect from death caused by mpox [0.03%]
靶向A35的单克隆抗体可防止猴痘死亡
Raianna F Fantin,Meng Yuan,Seok-Chan Park et al.
Raianna F Fantin et al.
The 2022 mpox outbreak highlighted the serious threat of monkeypox virus (MPXV), yet effective treatments are lacking. From an mpox-convalescent individual, we identified three high-affinity human monoclonal antibodies (mAbs) (named EV35-2,...
Extensive cross-species transmission of pathogens and antibiotic resistance genes in mammals neglected by public health surveillance [0.03%]
被公共卫生监测忽略的哺乳动物中的病原体和抗生素抗性基因的广泛跨种传播
Yuqi Shi,Yuxing Li,Haipeng Li et al.
Yuqi Shi et al.
Non-traditional farmed and wild mammals are often neglected in pathogen surveillance. Through metagenomic and metatranscriptomic sequencing of fecal and tissue samples from 973 asymptomatic mammals, we identified 128 viruses (30 novel), inc...
Mitochondrial activity tunes nociceptor resilience to excitotoxicity [0.03%]
线粒体活性调节伤害性感觉神经元对兴奋毒性损伤的耐受能力
Lin Yuan,Navdeep S Chandel,David Julius
Lin Yuan
The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway. Overactivation of TRPV1 leads to cellular damage or death through calcium entry and e...
Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers [0.03%]
肿瘤转录组表达分类器可预测晚期前列腺癌的治疗敏感性
Emily Grist,Peter Dutey-Magni,Marina A Parry et al.
Emily Grist et al.
Advanced prostate cancers respond to hormone therapy but outcomes vary and no predictive tests exist for informed treatment selection. To identify novel biomarker-treatment pairings, we examined associations between biological pathways and ...
Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS [0.03%]
针对C9orf72相关ALS的反义寡核苷酸治疗的分子影响
Zachary T McEachin,Mingee Chung,Sabrina A Stratton et al.
Zachary T McEachin et al.
C9orf72-associated amyotrophic lateral sclerosis (c9ALS) is caused by an intronic G4C2 repeat expansion that leads to toxic RNA transcripts and dipeptide repeat proteins (DPRs). A clinical trial using the antisense oligonucleotide (ASO) BII...
Raya Faigenbaum-Romm,Noam Yedidi,Orit Gefen et al.
Raya Faigenbaum-Romm et al.
Uncovering phenotypic heterogeneity is fundamental to understanding processes such as development and stress responses. Due to the low mRNA abundance in single bacteria, determining biologically relevant heterogeneity remains a challenge. U...
Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection [0.03%]
痘病毒融合调节和抗A16/G9抗体介导的中和与保护的作用机制及其结构基础
Annalisa Meola,Riccardo Vernuccio,Leandro Battini et al.
Annalisa Meola et al.
Monkeypox virus (MPXV) is a poxvirus endemic to Central and West Africa with high epidemic potential. Poxviruses enter host cells via a conserved entry-fusion complex (EFC), which mediates viral fusion to the cell membrane. The EFC is a pro...
Kevin C Allan,Jesse J Zhan,Andrew R Morton et al.
Kevin C Allan et al.
Cellular maturation is a crucial step for tissue formation and function, distinct from the initial steps of differentiation and cell fate specification. In the central nervous system, failure of oligodendrocyte maturation is linked to disea...