Xiaochi Sun,Xinmeng Wang,Ruikun Jia et al.
Xiaochi Sun et al.
The rise of biologics, including recombinant proteins, gene therapies, and cell therapies, is reshaping the landscape of modern therapeutics, offering new strategies to address previously "undruggable" targets. Cardiovascular diseases (CVDs...
Correction: Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir [0.03%]
关于新型溴西多福韦和(S)-9-[3-羟基-2-(膦酸甲氧基)丙基]鸟苷衍生物的更正：这些化合物比溴西多福韦更高效地抑制正痘病毒和人类腺病毒
Yifan Zhang,Yanmin Wan,Cuiyuan Guo et al.
Yifan Zhang et al.
Heli Wang,Zhuang Miao,Chang Zhao et al.
Heli Wang et al.
Opioid analgesics provide potent pain relief but are limited by severe adverse effects, tolerance, and interindividual genetic variability in response. Poly-pharmacology and allosteric modulation of opioid receptors offer promising strategi...
Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer [0.03%]
以CD98hc为靶点的抗体药物偶联物在卵巢癌中的抗肿瘤活性
Juan Carlos Montero,Verónica Fraile Rivero,María José Doyague et al.
Juan Carlos Montero et al.
Ovarian cancer remains a challenging malignancy with high recurrence rates and limited long-term therapeutic success. Antibody-drug conjugates (ADCs) represent a promising therapeutic class capable of delivering potent cytotoxic agents sele...
TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity [0.03%]
TWIK-1在控制机械敏感性和神经病理性超敏反应的脊髓和外周感觉电路中发挥不同的作用
Seo Young Yang,Tery Yun,Yunjeong Lee et al.
Seo Young Yang et al.
Ion channels are essential for sensing somatic stimuli, and their dysregulation can cause chronic conditions such as neuropathic pain. Although the potassium channel Twik-1 has been linked to sensory processing, its specific roles in the so...
Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses [0.03%]
利巴韦林喷鼻清除鼻部共生病毒治疗过敏性鼻炎
Ye Zhou,Tianyu Wang,Yiwen Fan et al.
Ye Zhou et al.
Much attention has focused on commensal bacteria in health and disease, but the role of commensal viruses is largely unexplored. Although commensal viruses are suggested in some organs such as intestine to maintain tissue homeostasis, it is...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Jun 26;11(1):249. DOI:10.1038/s41392-026-02744-y 2026
TCR-mimic bispecific nanobody-based T cell engager targeting intracellular tumor antigens for cancer immunotherapy [0.03%]
一种双特异性纳米抗体靶向胞内肿瘤抗原的T细胞连接剂用于癌症免疫治疗
Ziqiang Ding,Shuyang Sun,Xiaomei Yang et al.
Ziqiang Ding et al.
T cell engager (TCE) immunotherapies have revolutionized the landscape of cancer treatment; however, their efficacy remains limited by the inaccessibility of intracellular tumor antigens. Conventional bispecific T cell engagers, typically c...
Engineering T cells with a novel PD-L1-specific TCR targeting immune and cancer cells [0.03%]
工程化T细胞：新型PD-L1特异性TCR靶向免疫和肿瘤细胞
Thomas Landkildehus Lisle,Emilie Bülow Jacobsen,Shamaila Munir Ahmad et al.
Thomas Landkildehus Lisle et al.
Novel post-transcriptional dimension of glucocorticoid action through mRNA translation and P-body remodeling [0.03%]
通过mRNA翻译和P体重塑的糖皮质激素作用的新转录后维度
Victoria J Nicolini;FRENCH GR-P-BODY NETWORK;Patrick Brest
Victoria J Nicolini;FRENCH GR-P-BODY NETWORK;Patrick Brest
Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting [0.03%]
基于大规模高分辨率质谱的蛋白质组学定义鼻咽癌治疗靶点分子亚型
Yi-Ping Wu,Yao-Hui He,Guo-Sheng Hu et al.
Yi-Ping Wu et al.
Challenges in the precise diagnosis and treatment of nasopharyngeal carcinoma (NPC) remain, mainly due to the absence of a multi-omics-based molecular classification and effective targeted therapies. In this study, we performed proteomic an...