Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors [0.03%]
时空谱分析揭示了CAR-T和CAR-NKT细胞对抗实体瘤的不同动力学和检查点调节机制
Yan-Ruide Li,Miao Li,Yuning Chen et al.
Yan-Ruide Li et al.
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapies have demonstrated remarkable efficacy in hematologic malignancies; however, their clinical performance in solid tumors remains limited due to suboptimal tumor infiltration,...
Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial [0.03%]
随机二期试验通过重复捐赠者粪便移植调节肠道菌群可改善帕金森病患者的运动和胃肠道症状
Rui Zhang,Renyi Feng,Jiuqi Wang et al.
Rui Zhang et al.
The gut-brain axis is increasingly recognized as a critical contributor to Parkinson's disease (PD) pathogenesis, yet the therapeutic impact of microbiota modulation remains unclear due to lack of clinical trials in drug-naïve patients. We...
Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy [0.03%]
环鸟苷酸-蛋白激酶G信号通过ULK1介导的自噬减轻主动脉瓣钙化
Yan Wang,Fei Xu,Chengxiang Song et al.
Yan Wang et al.
Calcific aortic valve disease (CAVD) is a prevalent age-related valvulopathy characterized by high morbidity and mortality. CAVD pathogenesis involves maladaptive differentiation of valvular interstitial cells (VICs) into profibrotic and os...
Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer [0.03%]
泛素介导的KDM5B蛋白稳定通过抑制双重特异性磷酸酶4诱导卵巢癌耐药性
Jung Yoo,Go Woon Kim,Yu Hyun Jeon et al.
Jung Yoo et al.
Despite advances in therapeutic regimens for managing cancer progression, ovarian cancer (OVC) still depends on platinum-based chemotherapy as its first-line treatment. Acquired resistance is accompanied by abnormal alterations in epigeneti...
Phase 1 pilot study for hemophilia-A: AAV8 vector with prophylactic tacrolimus-glucocorticoid achieves therapeutic FVIII activity [0.03%]
AAV8载体联合预防性他克莫司-糖皮质激素方案治疗甲型血友病I期试点研究取得突破：血液八因子活性水平达到临床疗效阈值
Wei Liu,Xiaolei Pei,Tenghui Yu et al.
Wei Liu et al.
This prospective phase 1 pilot study evaluated the safety and efficacy of GS001, an adeno-associated virus serotype 8 (AAV8)-based vector encoding B-domain-deleted factor VIII with exploratory assessment of prophylactic immunosuppression. T...
Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapy [0.03%]
一种天然启发的限域级联酶纳米反应器用于动脉粥样硬化治疗
Yuehuang Wu,Hongping Xia,He Ding et al.
Yuehuang Wu et al.
Oxidative stress and excessive inflammatory responses are major drivers of atherosclerosis (AS) formation and progression. In this study, we report a nature-inspired nanoreactor (named USPB@SeDMSN@NM) with superoxide dismutase (SOD), catala...
Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: preclinical and clinical analysis [0.03%]
针对Claudin18.2的IL-7/XCL1武装CAR-T细胞在消化道肿瘤中的疗效和免疫调节作用：前期临床和临床分析
Xuan Zhao,Jinyan Liu,Zhen Zhang et al.
Xuan Zhao et al.
Chimeric antigen receptor (CAR)-T cell therapy exerts limited therapeutic efficacy in solid tumors including digestive tract cancer (DTC), which is largely attributable to the suppressive tumor microenvironment (TME) and the functional defi...
Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets [0.03%]
细胞毒性的CD4+T细胞：起源、生物学功能、疾病和治疗靶点
Longyong Lai,Shuan Ran,Yuan Li et al.
Longyong Lai et al.
Cytotoxic CD4+ T lymphocytes are a unique subset of CD4+ T cells characterized by their cytokine secretion and cytolytic activity. Unlike traditional CD4+ helper T cells, cytotoxic CD4+ T lymphocytes exhibit similar cytotoxicity to that of ...
Synergistic immunotherapeutic effects of irreversible electroporation and CAR-NK cell therapy against hepatocellular carcinoma [0.03%]
不可逆电穿孔联合CAR-NK细胞治疗对肝癌的协同免疫效应
Joo Dong Park,Ha Eun Shin,Hye Jung Jang et al.
Joo Dong Park et al.
Chimeric antigen receptor natural killer (CAR-NK) cell therapy has emerged as a promising immunotherapeutic modality with potent cytotoxicity and a favorable safety profile. However, its therapeutic efficacy is often limited by poor infiltr...
Exocyst complex regulates fungal-mediated IL-33 release from cancer cells [0.03%]
异源七聚体外泌体复合物调节癌细胞来源的IL-33释放
Aftab Alam,Shyamananda Singh Mayengbam,Scott I Abrams et al.
Aftab Alam et al.