TGF-β1-triggered maladaptive bone marrow endothelium impedes hematopoietic recovery [0.03%]
转化生长因子-β1触发的骨髓内皮适应不良阻碍造血恢复
Zhong-Shi Lyu,Meng-Zhu Shen,Yuan-Ya Zhang et al.
Zhong-Shi Lyu et al.
Endothelial cells (ECs) form a critical bone marrow (BM) niche for hematopoietic stem cell regulation in homeostasis and stress states. However, BM ECs are frequently disrupted in hematologic diseases and their clinical interventions. Altho...
Z-DNA-binding protein 1 exacerbates myocardial ischemia‒reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis [0.03%]
Z-DNA结合蛋白1通过诱导非经典心肌细胞PANoptosis加剧心肌缺血再灌注损伤
Xiaokai Zhang,Shuai Song,Zihang Huang et al.
Xiaokai Zhang et al.
Myocardial ischemia‒reperfusion (I/R) injury is the primary factor that counteracts the beneficial effects of reperfusion therapy. Cardiomyocyte death serves as the fundamental pathological hallmark of I/R injury. However, targeting a sing...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood-brain barrier transport [0.03%]
通过多价调节血脑屏障转运快速清除淀粉样蛋白-β和认知恢复
Junyang Chen,Pan Xiang,Aroa Duro-Castano et al.
Junyang Chen et al.
The blood‒brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous system (CNS) from potentially harmful substances while regulating the transport of essential molecules. Its dysfunction is increas...
Transarterial chemoembolization plus atezolizumab and bevacizumab in patients with intermediate hepatocellular carcinoma: a single-arm, phase 2 trial [0.03%]
超动脉化疗栓塞联合阿特珠单抗和贝伐珠单抗治疗中危肝细胞癌患者的Ⅱ期单臂试验
Kang Wang,Jinkai Feng,Hongming Yu et al.
Kang Wang et al.
Transarterial chemoembolization (TACE) is the standard treatment for intermediate-stage hepatocellular carcinoma (HCC), yet its efficacy as a standalone therapy remains suboptimal. This phase 2 trial (ChiCTR2100049829) evaluated the feasibi...
A metabolic switch in the TCA cycle: a regulator of intestinal stem cell fate during tissue regeneration [0.03%]
肠道再生过程中调控肠干细胞命运的TCA循环代谢开关
Dong Gil You,Jae Hyung Park
Dong Gil You
Lactylation of the SARS-CoV-2 spike protein is required for viral infection [0.03%]
新冠病毒刺突蛋白的乳酰化对病毒感染是必需的
Jingguo Xin,Chunlei Wang,Zhaolong Li et al.
Jingguo Xin et al.
Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling [0.03%]
视黄醇结合蛋白4通过触发经典的NF-κB、JAK / STAT5和JNK信号激活潜伏的HIV-1病毒
Chiara Pastorio,Khumoekae Richard,Shariq Usmani et al.
Chiara Pastorio et al.
Reactivation of the latent viral reservoirs is crucial for a cure of HIV/AIDS. However, current latency reversing agents are inefficient, and the endogenous factors that have the potential to reactivate HIV in vivo remain poorly understood....
Limited SUMOylation inhibitor administration enhances eradication of Burkitt's lymphoma with CD19 CAR-T therapy [0.03%]
对SUMOylation抑制剂的限制性给药可增强CD19 CAR-T治疗对抗Burkitt淋巴瘤的效果
Hiroshi Kotani,Shigeki Sato,Seiji Yano et al.
Hiroshi Kotani et al.
Colony-stimulating factor 3 as a key mediator in the progression of idiopathic pulmonary fibrosis: a novel therapeutic target [0.03%]
colony刺激因子3作为特发性肺纤维化进展中的关键介质：一种新的治疗靶点
Seungmo Kim,Yongjoong Kim,Tae-Sung Kim et al.
Seungmo Kim et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by excessive ECM deposition and myofibroblast accumulation driven by cytokine dysregulation. This study identified granulocyte colony-stimulating factor 3 (CSF3) as a...