Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor [0.03%]
溶质载体家族38成员6功能缺失变异与原发性震颤相关联
Zhangqi Yuan,Qiying Sun,Junyu Luo et al.
Zhangqi Yuan et al.
Essential tremor (ET) is a common neurological disease that is characterized by 4-12 Hz kinetic tremors of the upper limbs and high genetic heterogeneity. Although numerous candidate genes and loci have been reported, the etiology of ET rem...
Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers [0.03%]
小细胞肺癌的外在和内在特征及其治疗弱点的鉴定
Gui-Zhen Wang,Zheng Wang,Shi-Hao Bai et al.
Gui-Zhen Wang et al.
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. High...
Epidemiological and phylogenetic characteristics of human metapneumovirus in Beijing, China, 2014-2024 [0.03%]
2014-2024年北京市人副流感病毒第三型的流行病学和基因特征研究
Aihua Li,Cheng Gong,Liang Wang et al.
Aihua Li et al.
In November 2024, there was an unusual surge in human metapneumovirus (hMPV) infection cases in Beijing. We performed an epidemiological investigation among cases with acute respiratory tract infection (ARTI). We enrolled ARTI cases from 35...
Correction: Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis [0.03%]
脂肪酸羟化酶调控鞘氨醇代谢失常会暴露癌症转移的代谢脆弱性以进行靶向治疗（校正）
Xuantong Zhou,Furong Huang,Gang Ma et al.
Xuantong Zhou et al.
Dopamine as a teaching signal: understanding its role in shaping individual behavior [0.03%]
多巴胺作为教学信号：理解其在塑造个体行为中的作用
Seung Chan Kim,Sehwan Kim,Sang Ryong Kim
Seung Chan Kim
Targeting TRPV6/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone [0.03%]
靶向TRPV6 / CXCR4复合物可防止去势抵抗性前列腺癌骨转移
Clément Cordier,Aurélien Haustrate,Adriana Mihalache et al.
Clément Cordier et al.
Bone metastasis most commonly occurs in castration-resistant prostate cancer (CRPC). The TRPV6 calcium channel is absent in healthy prostate tissue, but its expression increases considerably during cancer progression. We hypothesized that c...
UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune activation and tumor immune evasion [0.03%]
UGCG和糖脂雷斯塔特：调控免疫激活和肿瘤免疫逃逸的代谢检查点
Sumei Chen,Xiang Wang,Youssef Jounaidi
Sumei Chen
Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs [0.03%]
辐射诱发的神经炎症毒性的认识以及按需设计靶向肽纳米药物
Yue Shang,Xueyin Hu,Meixia Ren et al.
Yue Shang et al.
Radiation-induced brain injury (RIBI) represents a severe complication of cranial radiotherapy, substantially diminishing patients' quality of life. Unlike conventional brain injuries, RIBI evokes a unique chronic neuroinflammatory response...
Correction: Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness [0.03%]
订正：癌细胞采用微环境神经信号活化核线粒体协调以获得干细胞特性
Bin He,Rui Gao,Shasha Lv et al.
Bin He et al.
Pancancer outcome prediction via a unified weakly supervised deep learning model [0.03%]
基于统一的弱监督深度学习模型的泛癌预后预测
Wei Yuan,Yijiang Chen,Biyue Zhu et al.
Wei Yuan et al.
Accurate prognosis prediction is essential for guiding cancer treatment and improving patient outcomes. While recent studies have demonstrated the potential of histopathological images in survival analysis, existing models are typically dev...