LISS enables immune evasion of colorectal cancers irrespective of MSI status [0.03%]
LISS使结直肠癌逃避免疫监视而不受MSI状态的影响
Qingyu Lin,Xingwen Wang,Weixu Zhao et al.
Qingyu Lin et al.
Despite being hailed as a significant advancement in cancer treatment, immune checkpoint blockade (ICB) has not yielded favorable outcomes in colorectal cancer, both in approximately 85% of cases characterized by microsatellite stability (M...
Allele-specific KRAS signaling: shaping tumor immunity and therapeutic response in lung adenocarcinoma [0.03%]
肺腺癌中特异性KRAS信号的等位基因调控塑造肿瘤免疫和治疗反应
Kostas A Papavassiliou,Dimitrios J Stravopodis,Athanasios G Papavassiliou
Kostas A Papavassiliou
Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis [0.03%]
果糖-1-磷酸通过抑制甘露糖-6-磷酸异构酶来抑制肝细胞癌发生
Yongqiang Wang,Xiangyang Zhang,Ningning Wang et al.
Yongqiang Wang et al.
Fructose consumption increases the risk of obesity-related metabolic diseases and some cancers, but its role in hepatocellular carcinogenesis (HCC) remains controversial. Animal studies suggest that high fructose promotes HCC, whereas human...
An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma [0.03%]
一种肿瘤发生因子M受体和氯离子细胞内通道1信号通路相互作用驱动胶质母细胞瘤关键致癌途径
Amir Hossein Mansourabadi,Dianbo Qu,Francesca Cianci et al.
Amir Hossein Mansourabadi et al.
Oncostatin M receptor (OSMR) plays diverse roles in several human malignancies, including brain, breast, and pancreatic cancer. In glioblastoma (GB), OSMR orchestrates a feedforward signaling mechanism with the truncated active mutant of ep...
The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects [0.03%]
体内CAR-T治疗药物的发展：挑战与监管展望
Jiaqi Lu,Jing Cui,Jing Dong et al.
Jiaqi Lu et al.
Chimeric antigen receptor T-cell (CAR-T) therapy, a groundbreaking advancement in cancer immunotherapy, has demonstrated remarkable efficacy in treating hematological malignancies and autoimmune diseases. However, conventional ex vivo CAR-T...
DNA origami-based virus-like particles: a new class of HIV vaccine candidates with superior immunogenic properties [0.03%]
基于DNA折纸技术的病毒样颗粒：一类具有优越免疫原性的HIV疫苗候选产品
Frauke Muecksch,Juan Hamdan,Oliver T Fackler
Frauke Muecksch
Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial [0.03%]
氟维司群与卡培他滨用作激素受体阳性、HER2阴性乳腺癌一线化疗后的维持治疗： FAMILY多中心、开放标签、随机III期试验
Wenjing Wu,Yaping Yang,Haizhu Chen et al.
Wenjing Wu et al.
Maintenance therapy is key in prolonging remission and improving quality of life for hormone receptor-positive (HR + ), HER-2 negative (HER2-) metastatic breast cancer (MBC), but optimal strategies remain debated. This multicenter, open-lab...
Lactate metabolism and lactylation in cancer: from pathogenesis to therapeutic advances [0.03%]
乳酸代谢与乳酰化在癌症中的作用：从发病机制到治疗进展
Chunyao Fang,Suiqing Zhou,Kai Yu et al.
Chunyao Fang et al.
Lactate and its mediated modification, lactylation, are receiving increasing attention in the field of tumor biology. This review provides a comprehensive overview of the mechanistic involvement of lactate and lactylation in key oncogenic p...
Targeting ZMIZ1 induces differentiation in acute myeloid leukemia via chromatin remodeling [0.03%]
靶向ZMIZ1通过表观遗传重编程可诱发急性髓系白血病细胞分化成熟
Huimin Li,Yabin Liu,Jiachen Cui et al.
Huimin Li et al.
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by profound transcriptional dysregulation and impaired hematopoietic differentiation. While differentiation therapy has revolutionized treatment in acute pro...