Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates [0.03%]
多表位TGFβ疫苗治疗胰腺癌的理论依据：来自免疫学和临床的相关证据
Josephine Hallundbæk Ruders,Shamaila Munir Ahmad,Rasmus Erik Johansson Mortensen et al.
Josephine Hallundbæk Ruders et al.
Transforming growth factor beta (TGFβ) plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) progression by promoting immune suppression, fibrosis, and metastasis. Given its central role in shaping the tumor microenvironment, TGF...
Kyungjun Uh,Yonggyu Kim,Taeho Kwon
Kyungjun Uh
Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility [0.03%]
纤原-Bmal1信号作为治疗靶点通过保持血管平滑肌细胞收缩性来限制主动脉夹层的发展
Xiaohan Zhong,Dongjie Li,Yuanfei Zhao et al.
Xiaohan Zhong et al.
Aortic dissection (AD) is a life-threatening vascular disease with a high mortality rate. Surgery is essential in the acute phase but carries significant risks, whereas elective surgery during the chronic phase yields better outcomes. Howev...
SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial [0.03%]
SHR-A1811新型抗HER2抗体药物偶联物治疗晚期实体瘤Ⅰ期临床研究（HORIZON-X）
Herui Yao,Min Yan,Zhongsheng Tong et al.
Herui Yao et al.
SHR-A1811, an antibody‒drug conjugate consisting of the anti-HER2 antibody trastuzumab conjugated via a cleavable linker to a topoisomerase I inhibitor payload, demonstrated substantial antitumor activity in patients with heavily treated H...
Cleaved SREBP-2 C-terminal fragment noncanonically drives interleukin-1 receptor-associated kinase 1-dependent apoptosis [0.03%]
裂解的SREBP-2 C末端片段非经典驱动IL-1受体相关激酶1依赖性凋亡
MyeongHoon Yeon,Won-Kyung Kim,Hyeon-Bin Shin et al.
MyeongHoon Yeon et al.
Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer [0.03%]
Spi-1原癌基因调节头颈癌的mRNA过度转录和恶性进展
Zheran Liu,Zijian Qin,Huilin Li et al.
Zheran Liu et al.
Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent and lethal cancers worldwide. Despite multimodal therapeutic advances, long-term survival remains poor, underscoring the need to identify novel molecular drivers of ...
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation [0.03%]
circArhgap26通过抑制斑心蛋白1棕榈酰化修饰缓解心肌缺血再灌注损伤
Ming-Yu Zhang,Dong-Ni Ji,Wen-Yi Qi et al.
Ming-Yu Zhang et al.
Cardiac ischemia‒reperfusion (I/R) injury is a leading cause of disability and mortality worldwide, but the underlying mechanism remains largely unknown. Despite the emerging recognition of circular RNAs (circRNAs) as pivotal regulators of...
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis [0.03%]
化疗光热协同作用通过铁死亡诱发抗肿瘤免疫反应
Jundong Lin,Huikang Yang,Zhihao Zou et al.
Jundong Lin et al.
Docetaxel (Doc), a widely used chemotherapeutic agent, was limited by suboptimal therapeutic efficacy and dose-limiting systemic toxicity due to the insufficiency of hydrophilicity and tumor-targeting specificity. To address this limitation...
DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling [0.03%]
DUSP6缺失通过活化AP-1信号转导恢复肿瘤CD58丢失引起的CAR-T细胞活性损伤
Xinran Ma,Yang Zhang,Yao Wang et al.
Xinran Ma et al.
Primary resistance to chimeric antigen receptor (CAR) T-cell therapies has limited their widespread application. Our prior genome-wide CRISPR/Cas9 screening revealed that the loss of CD58, a crucial intrinsic resistance factor in tumors, re...
A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms [0.03%]
一种生物安全的鼠类模型可更逼真地模拟SARS-CoV-2感染和COVID-19症状
Xiaoya Huang,Yingjian Li,Jikai Deng et al.
Xiaoya Huang et al.
COVID-19 resulting from SARS-CoV-2 infection has presented significant challenges to global health over the past several years. Animal models are essential for studying the pathogenic mechanisms of SARS-CoV-2 and facilitating the developmen...