Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges [0.03%]
靶向KRAS突变：协调癌症进化和治疗挑战
Khalil Choucair,Hafsa Imtiaz,Md Hafiz Uddin et al.
Khalil Choucair et al.
Activating KRAS mutations are highly relevant to various cancers, and KRAS is the most frequently altered oncogenic protein in solid tumors. While historically considered undruggable, two KRASG12C inactive state-selective inhibitors are cur...
Preoperative pembrolizumab (anti-PD-1 antibody) combined with chemoradiotherapy for esophageal squamous cell carcinoma: a phase 1/2 trial (PALACE-2) [0.03%]
帕博利珠单抗(PD-1抗体)联合术前放化疗治疗食管鳞癌的I/II期临床试验(PALACE-2)
Chengqiang Li,Yichao Han,Shengguang Zhao et al.
Chengqiang Li et al.
The role of preoperative anti-PD-1 antibody (pembrolizumab) plus chemoradiotherapy (PPCT) in locally advanced, resectable esophageal squamous cell carcinoma (ESCC) is still unclear. We aimed to investigate the therapeutic effect and safety ...
Induction of cuproptosis enhances sensitivity and overcomes resistance to osimertinib in lung cancer [0.03%]
诱导铜死亡可增强肺癌对奥希替尼的敏感性并克服耐药问题
Yi-Bo Gao,Jia-Ming Xie,Yan-Nan Yang et al.
Yi-Bo Gao et al.
Anti-CD38 monoclonal antibody CM313 for systemic lupus erythematosus: a randomized, double-blind, placebo-controlled phase Ib/IIa trial [0.03%]
抗CD38单克隆抗体CM313治疗系统性红斑狼疮 Ib/IIa期随机双盲安慰剂对照临床试验
Jiuliang Zhao,Changsong Lin,Qibing Xie et al.
Jiuliang Zhao et al.
CD38 is highly expressed on various immune cells, including long-lived plasma cells, making it a potential therapeutic target in autoimmune diseases. This phase Ib/IIa study aimed to explore the safety, pharmacokinetics, pharmacodynamics, a...
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury [0.03%]
适应组织的Treg细胞利用炎症信号促进由治疗引起的肠道损伤修复
Julius C Fischer,Sascha Göttert,Maximilian Giller et al.
Julius C Fischer et al.
Intestinal stem cells (ISCs) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses, such as interferon γ (IFNγ)-...
Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1 [0.03%]
社会记忆的维持依赖于神经粘附分子neuroligin 1在社交互动中的加工过程
An Liu,Xingcan Li,Mei Zhuang et al.
An Liu et al.
Proper social behaviors are essential for survival and success, and deficits in these behaviors are associated with many brain disorders. However, the mechanisms underlying the formation and maintenance of social memory remain poorly unders...
Pig-to-human lung xenotransplantation: advancing xenogeneic respiratory transplantation and clinical translation [0.03%]
猪肺移植到人体：异基因呼吸器官移植及临床转化研究进展
Taeho Kwon,Bong-Seok Song,Kyung Seob Lim
Taeho Kwon
Starving tumor, feeding metastasis: a warning about low-carbohydrate diets in cancer therapy [0.03%]
饥饿肿瘤，喂养转移：关于癌症治疗中低碳水化合物饮食的警告
Byeongsoo Kim,BuHyun Youn
Byeongsoo Kim
Circulating miR-18b-3p is a novel biomarker predicting chemo-radiotherapy induced oral mucositis in head and neck cancer [0.03%]
循环miR-18b-3p是预测头颈部癌症放化疗诱导的口腔粘膜炎的新生物标志物
Claudio Pulito,Renata Brandi,Rosanna Sestito et al.
Claudio Pulito et al.
Dynamic transcriptional immune landscape in response to NK-cell therapy combined with gemcitabine plus S-1 in advanced pancreatic cancer: a phase 1b/2 trial [0.03%]
针对晚期胰腺癌的NK细胞疗法联合吉西他滨和S-1治疗的动态转录免疫图谱：一项 Ib/II期临床试验
Qin Tan,Yifei Li,Caixia Liu et al.
Qin Tan et al.
Despite advancements in several malignancies, the treatment atlas of natural killer (NK) cell therapy for pancreatic cancer remains inadequate, and the dynamic immune landscape underlying the various responses is still incompletely understo...