A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants [0.03%]
重组蛋白疫苗诱导对SARS-CoV-2 JN.1和XBB谱系亚变异株的保护性免疫反应
Jingyun Yang,Weiqi Hong,Huashan Shi et al.
Jingyun Yang et al.
The emergence of XBB- and JN.1-lineages with remarkable immune evasion characteristics have led to rises in breakthrough infections within populations. In addition, the unfavorable impacts of immune imprinting, stemming from continuous expo...
Invasion and metastasis in cancer: molecular insights and therapeutic targets [0.03%]
癌症中的侵袭和转移：分子见解与治疗靶点
Yongxing Li,Fengshuo Liu,Qingjin Cai et al.
Yongxing Li et al.
The progression of malignant tumors leads to the development of secondary tumors in various organs, including bones, the brain, liver, and lungs. This metastatic process severely impacts the prognosis of patients, significantly affecting th...
A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy [0.03%]
首个选择性ERK1/2和ERK5抑制剂以单分子策略克服药物抗性问题
Huan Xiao,Aoxue Wang,Wen Shuai et al.
Huan Xiao et al.
Despite significant advancements in kinase-targeted therapy, the emergence of acquired drug resistance to targets such as KRAS and MEK remains a challenge. Extracellular-regulated kinase 1/2 (ERK1/2), positioned at the terminus of this path...
Precise targeting of transcriptional co-activators YAP/TAZ annihilates chemoresistant brCSCs by alteration of their mitochondrial homeostasis [0.03%]
转录共激活因子YAP/TAZ的精准定位通过改变线粒体稳态来根除化学抗性乳腺癌干细胞
Priyanka Dey Talukdar,Kunal Pramanik,Priya Gatti et al.
Priyanka Dey Talukdar et al.
Persistence of drug-resistant breast cancer stem cells (brCSCs) after a chemotherapeutic regime correlates with disease recurrence and elevated mortality. Therefore, deciphering mechanisms that dictate their drug-resistant phenotype is impe...
SARS-CoV-2 compromises blastocyst quality by modifying the ovarian microenvironment [0.03%]
SARS-CoV-2通过修改卵巢微环境来降低囊胚质量
Chen Geng,Min Zhang,Ning Wang et al.
Chen Geng et al.
Hui Liu,Shuo Wang,Jianhua Wang et al.
Hui Liu et al.
Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy ...
Xin Xiong,Le-Wei Zheng,Yu Ding et al.
Xin Xiong et al.
Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breast cancer have enhanc...
Population-level analyses identify host and environmental variables influencing the vaginal microbiome [0.03%]
人群分析鉴别影响阴道微生物群的宿主和环境因素
Lang Qin,Tianyong Sun,Xiao Li et al.
Lang Qin et al.
The vaginal microbiome is critical for the reproductive health of women, yet the differential impacts exerted by the host and by ambient environmental variables on the vaginal microbiome remain largely unknown. Here, we conducted a comprehe...
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification [0.03%]
格列苯脲通过代谢调控的表观遗传修饰将MDH2作为靶点以缓解衰老表型
Zhifan Mao,Wenwen Liu,Rong Zou et al.
Zhifan Mao et al.
Mitochondrial metabolism-regulated epigenetic modification is a driving force of aging and a promising target for therapeutic intervention. Mitochondrial malate dehydrogenase (MDH2), an enzyme in the TCA cycle, was identified as an anti-agi...
Ruth Nussinov,Bengi Ruken Yavuz,Hyunbum Jang
Ruth Nussinov
Aggressive tumors pose ultra-challenges to drug resistance. Anti-cancer treatments are often unsuccessful, and single-cell technologies to rein drug resistance mechanisms are still fruitless. The National Cancer Institute defines aggressive...