BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis [0.03%]
BMX抑制通过ERK1/2-Cyclin D1/CDK4/6轴稳定E2F1来克服小细胞肺癌的化疗耐药性
Ting Wu,Shuang Qi,Chenliang Shi et al.
Ting Wu et al.
Chemotherapy resistance remains a critical bottleneck limiting its clinical efficacy in small cell lung cancer (SCLC), with its core mechanisms and targeted intervention strategies urgently requiring breakthroughs. Our study revealed that t...
Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma [0.03%]
神经生长因子信号的激活限制了肝细胞癌对仑伐替尼的反应
Minghao Xu,Yimin Zheng,Longtao Zhao et al.
Minghao Xu et al.
Resistance to lenvatinib remains a major barrier in the treatment of advanced hepatocellular carcinoma (HCC), underscoring the urgent need to elucidate the underlying mechanisms and identify actionable therapeutic targets. In this study, we...
Anti-PD-1 antibody penpulimab plus chemotherapy for recurrent or metastatic nasopharyngeal carcinoma: a randomized, double-blind phase 3 study [0.03%]
派安普利单抗联合化疗治疗复发或转移性鼻咽癌 III 期临床研究
Shuang Huang,Feng Liu,Song Qu et al.
Shuang Huang et al.
In this phase 3 trial, penpulimab combined with chemotherapy was assessed against a regimen of placebo plus chemotherapy for the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). 291 patients were randomise...
Triggering multiple sclerosis: infection with Epstein-Barr virus activates multiple pre-existing autoreactive B and T cells [0.03%]
触发多发性硬化症：Epstein-Barr病毒感染激活多个预先存在的自身反应性B和T细胞
Edgar Meinl,Christian Münz
Edgar Meinl
Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma [0.03%]
前列腺素E2驱动的施万细胞去分化导致胰腺导管腺癌的癌周神经侵犯
Ling Wang,Qicai Liu,Zhibo Zhang et al.
Ling Wang et al.
Perineural invasion (PNI), a prominent pathological feature of pancreatic ductal adenocarcinoma (PDAC), is closely associated with poor prognosis. Clarifying its mechanism is therefore critical for developing new therapies. Recent research ...
Suppression of mitochondrial energy production by a photosynthetic bacterial cupredoxin peptide inhibits tumor growth [0.03%]
光合细菌铜蓝蛋白肽通过抑制线粒体能量生成抑制肿瘤生长
Samer A Naffouje,Duy Binh Tran,David J Rademacher et al.
Samer A Naffouje et al.
Accumulating evidence shows that bacteria influence cancer homeostasis, yet the effects of tumor‑associated microbes and their products remain largely unexplored. We previously reported that P. aeruginosa-cancer crosstalk suppresses tumors...
p53: from understanding its structure to advances in therapeutic targeting [0.03%]
从认识p53结构到精准药物研发的进展
Wenhua Wang,Xia Liu,Hengqi Liu et al.
Wenhua Wang et al.
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers and has been a popular area of research in the field of oncology. The p53 protein, encoded by the TP53 gene, not only binds to many targeted genes but also ...
Aditya Shreenivas,Adam Wahida,Razelle Kurzrock
Aditya Shreenivas
Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation [0.03%]
酰基辅酶a结合蛋白（ACBP）：脓毒症中的不良预后生物标志物及疾病缓解靶点
Flavia Lambertucci,Omar Motiño,Uxía Nogueira-Recalde et al.
Flavia Lambertucci et al.
Sepsis remains a major clinical challenge, with high mortality and long-term disability despite current interventions. Here, we identify the tissue hormone acyl-CoA-binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), as ...
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation [0.03%]
糖皮质激素通过抑制H4K12乳酸化提高透明细胞肾细胞癌对HIF-2α抑制剂的敏感性
Kenan Zhang,Lin He,Yizhou Wang et al.
Kenan Zhang et al.
Approximately 70% of clear cell renal cell carcinoma (ccRCC) patients harbor von Hippel‒Lindau (VHL) deficiency, which drives pseudohypoxia and metabolic reprogramming. Here, we report a histone H4 lysine 12 lactylation (H4K12la)-fueled ph...