Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance [0.03%]
泛素化修饰的TLR3通过介导核转移促进肿瘤进展和化疗耐药
Zixin Wang,Yan Gu,Yanfang Liu et al.
Zixin Wang et al.
Aberrant expression and subcellular location of innate sensors in cancer cells, such as Toll-like receptors (TLRs), correlates with pro-tumoral inflammation and cancer progression, but the mechanism is still largely unknown. Deciphering the...
Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma [0.03%]
泛基因组和转录组分析揭示了食管鳞状细胞癌的预后分类
Jian Gao,Qiming Wang,Fangqiu Fu et al.
Jian Gao et al.
Recent large-scale multi-omics studies have characterized the heterogeneity of esophageal squamous cell carcinoma (ESCC), but inconsistent clinical management has hindered the identification of prognostic markers and patient stratification....
Bat organoid platform: revolutionizing zoonotic virus research and pandemic preparedness [0.03%]
蝙蝠器官模型平台：革新人畜共患病病毒研究和大流行病应对措施
Young-Ho Park,Sun-Uk Kim,Taeho Kwon
Young-Ho Park
DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation [0.03%]
TRIM28介导的DDX39B K63连接泛素化通过增强ECAD溶酶体降解促进非小细胞肺癌转移
Hang Yuan,Qin Li,Liang Li et al.
Hang Yuan et al.
Metastasis is a leading cause of treatment failure and high mortality in non-small cell lung cancer (NSCLC). Recently, we demonstrated that DEAD box helicase 39B (DDX39B) was upregulated and activated metabolic reprogramming in colorectal c...
Dual-immunotherapy triumphs: redefining deficient mismatch repair or high microsatellite instability metastatic colorectal cancer first-line treatment [0.03%]
双免疫治疗获胜：重新定义dMMR或高MSI转移性结直肠癌一线治疗
Zhijun Yuan,Saimeng Shi,Shanshan Weng
Zhijun Yuan
High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability [0.03%]
高水平线粒体DNA含量可识别氧化磷酸化驱动的急性髓系白血病并代表潜在治疗靶点
Diego A Pereira-Martins,Isabel Weinhäuser,Emmanuel Griessinger et al.
Diego A Pereira-Martins et al.
Metabolic reprogramming is a hallmark of cancer, with acute myeloid leukemia (AML) being no exception. Mitochondrial function, particularly its role in protecting tumor cells against chemotherapy, is of significant interest in AML chemoresi...
Pattern recognition receptors: function, regulation and therapeutic potential [0.03%]
模式识别受体：功能、调控及治疗潜力
Ruochan Chen,Ju Zou,Jiawang Chen et al.
Ruochan Chen et al.
Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). They serve as essential links between the innate and adaptive ...
Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy [0.03%]
CAR-T细胞治疗后的认知障碍及其他长期影响
Kathrin Gabriel,Sebastian Kobold
Kathrin Gabriel
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair [0.03%]
伊立替康通过抑制AARS1介导的BLM乳酸化及同源重组修复缓解蒽环类药物耐药性
Xinyuan Li,Chunlin Zhang,Yuhua Mei et al.
Xinyuan Li et al.
Chemoresistance remains the major barrier to cancer treatment. Metabolic and epigenetic reprogramming are involved in this process; however, the precise roles and mechanisms are largely unknown. Here, we report that lactate-induced lactylat...
Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery [0.03%]
肺腺癌中的CD155靶向治疗：基于A5纳米体的精准治疗和增强药物递送疗法
Kyunghee Noh,Soyeon Yi,Hyeran Kim et al.
Kyunghee Noh et al.
This study presents a novel approach targeting CD155, an overexpressed protein in lung adenocarcinoma (LUAD), using nanobodies with exceptional precision and efficacy. The significant upregulation of CD155 in LUAD, associated with poor pati...