An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates [0.03%]
全面评价从实验鼠到非人灵长类的药物偶联体治疗癌症的新方法
Minhui Su,Yuan Liu,Hongxin Lin et al.
Minhui Su et al.
Aptamers serve as unique targeting ligands, making aptamer-drug conjugates (ApDCs) an attractive strategy for targeted cancer therapy. This study performs a comprehensive evaluation from rodents to non-human primates (NHP) of a protein tyro...
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection [0.03%]
Ninjurin-1介导流感病毒感染过程中PANoptosis的细胞溶解和有害炎症反应
Yitian Xu,Ying Zheng,Yan Liu et al.
Yitian Xu et al.
Influenza A virus (IAV) induces ZBP1-mediated PANoptosis, a form of lytic inflammatory cell death characterized by concurrent activation of the pyroptosis, necroptosis and apoptosis pathways. Ninjurin-1 (NINJ1) is a recently identified medi...
Microbial metabolite facilitates virus control: inosine and T cells curb early-life influenza infection [0.03%]
微生物代谢产物促进病毒控制：次黄嘌呤和T细胞抑制早期流感感染
Lisa Sevenich,Thi Trang Le,Lukas F Mager
Lisa Sevenich
Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer [0.03%]
时空多组学分析揭示了NAD依赖的免疫抑制微环境引发早期胃癌
Pingting Gao,Chunman Zuo,Wei Yuan et al.
Pingting Gao et al.
Understanding the cellular origins and early evolutionary dynamics that drive the initiation of carcinogenesis is critical to advancing early detection and prevention strategies. By characterizing key molecular, cellular and niche events at...
Ben Wielockx,Diego Rodriguez,Peter Mirtschink
Ben Wielockx
Ultrasound activated herbal bio-heterojunctions for self-catalytic regulation and bacterial cuproptosis-like death in the treatment of implant infection [0.03%]
超声激活的草药生物异质结在植入物感染治疗中的自催化调节和细菌类似铜死效应
Yan Yue,Shuoyuan Li,Qiang Su et al.
Yan Yue et al.
Conventional antibiotic strategies often fail to consistently suppress escaping planktonic bacteria and even induce antibiotic resistance, allowing implant-associated infections (IAIs) to persist. In this study, we demonstrated an antibioti...
Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction [0.03%]
组蛋白乙酰化诱导活化Notch信号转导可逆转主动脉瓣细胞钙化
Gloria Garoffolo,Silvia Ferrari,Sara De Martino et al.
Gloria Garoffolo et al.
Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatmen...
Pantothenate kinase 4 controls lipid synthesis for T-cell proliferation by modulating coenzyme A and glutaminolysis [0.03%]
泛酸激酶4通过调节辅酶A和谷氨酰胺分解代谢控制脂质合成从而促进T细胞增殖
Jeong-Ryul Hwang,Chi Thi Ngoc Nguyen,Gwanghoon Ko et al.
Jeong-Ryul Hwang et al.
During T-cell-mediated inflammatory responses, T cells are activated upon recognizing specific antigens presented by antigen-presenting cells. This recognition initiates signaling through the TCR and CD28, leading to their activation and su...
Bone marrow B lymphopoiesis accelerates early cerebral amyloid pathology [0.03%]
骨髓B淋巴细胞生成加速早期脑淀粉样病变病理发展
Jing Zhang,Wenting Fang,Hanchen Liu et al.
Jing Zhang et al.
Bone marrow is a major source of hematogenous cells that orchestrate brain immunity. However, alterations in the bone marrow hematopoietic system in patients with Alzheimer's disease (AD) and their potential impacts on neuroinflammation and...
EchoBack-CAR T cells: a sonogenetic solution to the persistent challenges of solid tumor immunotherapy [0.03%]
声控CAR-T细胞（EchoBack-CAR T细胞）：实体肿瘤免疫治疗持久挑战的声遗传学解决方案
Kiseok Han,Jung-Soo Suh,Tae-Jin Kim
Kiseok Han