Hailong Duan,Xin Peng,Sha Qin et al.
Hailong Duan et al.
Micronuclei are small, independent cytoplasmic structures containing nuclear material. They typically form during cell division due to DNA damage or division abnormalities, serve as biomarkers of genetic damage, and are closely associated w...
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications [0.03%]
活性氧在癌症中的作用：从机制到治疗意义
Sharmin Akter,Rajesh Madhuvilakku,Anik Kumar Kar et al.
Sharmin Akter et al.
Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation...
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease [0.03%]
少突前体细胞-小胶质细胞通过BMP4相互作用驱动小胶质细胞神经保护反应并缓解阿尔茨海默病
Soonbong Baek,Jaemyung Jang,Seungeun Yeo et al.
Soonbong Baek et al.
Oligodendrocyte precursor cells (OPCs) rapidly respond to neural injury, becoming activated to preserve myelin homeostasis and interacting with diverse cell types in the central nervous system (CNS). However, the molecular basis of OPC comm...
Arterial inflammation after myocardial infarction: regulating the immune system [0.03%]
心肌梗死后动脉炎症：调节免疫系统
Christos P Kotanidis,Charalambos Antoniades
Christos P Kotanidis
Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models [0.03%]
VISN-like蛋白1通过扰乱钙稳态促进人类及小鼠房颤发生
Ke Xiong,Guanghua Wang,Desheng Li et al.
Ke Xiong et al.
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, is closely linked to disturbed intracellular Ca2+ homeostasis. Visinin-like protein 1 (VILIP-1), newly identified in cardiomyocytes, has been implicated in modulatin...
Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation [0.03%]
potent和选择性LSD1抑制剂DC551040显示了针对AML组合疗法的希望，揭示了表观遗传失调的见解
Jiang Wang,Hanlin Wang,Runhua Du et al.
Jiang Wang et al.
Epigenetic dysregulation is a fundamental cancer hallmark, and lysine demethylase 1 (LSD1) is a central target for cancer intervention. Developing novel LSD1 inhibitors with high selectivity, favorable bioavailability, and safety for acute ...
Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates [0.03%]
多表位TGFβ疫苗治疗胰腺癌的理论依据：来自免疫学和临床的相关证据
Josephine Hallundbæk Ruders,Shamaila Munir Ahmad,Rasmus Erik Johansson Mortensen et al.
Josephine Hallundbæk Ruders et al.
Transforming growth factor beta (TGFβ) plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) progression by promoting immune suppression, fibrosis, and metastasis. Given its central role in shaping the tumor microenvironment, TGF...
Kyungjun Uh,Yonggyu Kim,Taeho Kwon
Kyungjun Uh
Fibrinogen-Bmal1 signaling as a therapeutic target to limit aortic dissection by preserving VSMC contractility [0.03%]
纤原-Bmal1信号作为治疗靶点通过保持血管平滑肌细胞收缩性来限制主动脉夹层的发展
Xiaohan Zhong,Dongjie Li,Yuanfei Zhao et al.
Xiaohan Zhong et al.
Aortic dissection (AD) is a life-threatening vascular disease with a high mortality rate. Surgery is essential in the acute phase but carries significant risks, whereas elective surgery during the chronic phase yields better outcomes. Howev...
SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial [0.03%]
SHR-A1811新型抗HER2抗体药物偶联物治疗晚期实体瘤Ⅰ期临床研究（HORIZON-X）
Herui Yao,Min Yan,Zhongsheng Tong et al.
Herui Yao et al.
SHR-A1811, an antibody‒drug conjugate consisting of the anti-HER2 antibody trastuzumab conjugated via a cleavable linker to a topoisomerase I inhibitor payload, demonstrated substantial antitumor activity in patients with heavily treated H...