Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches [0.03%]
癌症免疫逃逸：机制和前沿治疗策略
Muhammad Tufail,Can-Hua Jiang,Ning Li
Muhammad Tufail
Immune evasion represents a significant challenge in oncology. It allows tumors to evade immune surveillance and destruction, thereby complicating therapeutic interventions and contributing to suboptimal patient outcomes. This review addres...
Dynamics of neutralizing antibodies against COVID-19 Omicron subvariants following breakthrough infection in southwest China between December 2022 and April 2024 [0.03%]
2022年12月至2024年4月中国西南地区突破感染后针对COVID-19奥密克戎亚变体的中和抗体动态变化
Yongquan He,Yi Yin,Yi Zhang et al.
Yongquan He et al.
From December 2022 to January 2023, the SARS-CoV-2 Omicron BA.5/BF.7 variant significantly impacted mainland China. While most COVID-19 patients experienced mild symptoms and were treated as outpatients or at home, some cases progressed to ...
Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights [0.03%]
间充质基质细胞治疗失代偿期肝硬化的剂量递增研究：I 期 a/Ib 结果和免疫调节见解
Lei Shi,Ziying Zhang,Song Mei et al.
Lei Shi et al.
Decompensated liver cirrhosis (DLC) is characterized by severe liver dysfunction and immune dysregulation, posing significant treatment challenges. Mesenchymal stromal cell (MSC) therapy has shown promise in DLC treatment, but the optimal d...
Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions [0.03%]
核受体的信号通路、生物功能及药物干预在健康与疾病中的作用
Ping Jin,Xirui Duan,Zhao Huang et al.
Ping Jin et al.
Nuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands, including steroid hormones, thyroid hormone, ...
Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder [0.03%]
星形胶质细胞γ-氨基丁酸失调节作为创伤后应激障碍的治疗靶点
Sujung Yoon,Woojin Won,Suji Lee et al.
Sujung Yoon et al.
Post-traumatic stress disorder (PTSD) remains a debilitating psychiatric condition with limited pharmacological treatment options. Identifying novel therapeutic targets is critical for addressing its unmet clinical needs. Through our compre...
Genetic subtype-guided immunochemotherapy in relapsed and refractory diffuse large B cell lymphoma: a phase 2 investigator-initiated nonrandomized clinical trial (GUIDANCE-06) [0.03%]
复发/难治性弥漫大B细胞淋巴瘤的遗传亚型导向免疫化疗：一项II期非随机临床研究（GUIDANCE-06）
Yi-Ge Shen,Qing Shi,Wei Tang et al.
Yi-Ge Shen et al.
Improving the outcome of relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) remained an unmet need. The aim of this single-center, phase 2 trial was to evaluate the efficacy and safety of genetic subtype-guided immunochemother...
Efficacy and safety of IBI351 (fulzerasib) monotherapy in KRASG12C inhibitor-naïve Chinese patients with KRASG12C-mutated metastatic colorectal cancer: a pooled analysis from phase I part of two studies [0.03%]
一项关于评价IBI351（福瑞替尼）单药治疗KRASG12C抑制剂初治的中国携带KRAS G12C突变的转移性结直肠癌患者的疗效和安全性：来自两个I期研究的汇总分析
Ying Yuan,Yanhong Deng,Yongdong Jin et al.
Ying Yuan et al.
IBI351 (also known as fulzerasib or GFH925), an irreversible covalent inhibitor of KRASG12C, has demonstrated promising anti-tumour activity in patients with solid tumours. In this study, data were pooled from the phase I part of two clinic...
Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasis [0.03%]
环孢素D抑制假缺氧诱导的HIF1α稳定促进黑色素瘤转移
Hye-Kyung Park,Sung Hu,So Yeon Kim et al.
Hye-Kyung Park et al.
Stabilization of hypoxia-inducible factor 1 alpha (HIF1α), which plays a pivotal role in regulating cellular responses to insufficient oxygen, is implicated in cancer progression, particularly epithelial-mesenchymal transition and metastat...
Molecular mechanisms of unique therapeutic potential of CUDC-907 for MEF2D fusion-driven BCP-ALL [0.03%]
靶向MEF2D融合阳性B细胞急性淋巴细胞白血病的候选药物CUDC-907的分子机制研究
Qing Xue,Ming Zhang,Yixiao Mo et al.
Qing Xue et al.
MEF2D fusions are found in a special subtype of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis. In this study, we conducted high-throughput drug screenings using cell line and ex vivo cell model harboring, respe...
Current landscape of innovative drug development and regulatory support in China [0.03%]
中国创新药研发及监管支持现状分析
Ruirong Tan,Hua Hua,Siyuan Zhou et al.
Ruirong Tan et al.
The global pharmaceutical landscape remains dynamic and competitive, shaped by advancements in first-in-class therapies and breakthrough technologies. The United States has maintained its leadership in first-in-class therapies and breakthro...