Region-resolved proteomic map of the human brain: functional interconnections and neurological implications [0.03%]
人类大脑区域蛋白质组图谱：功能连接和神经学意义
Pei-Pei Zhang,Man-Sheng Li,Jia Zhou et al.
Pei-Pei Zhang et al.
While progress has been made in transcriptomic profiling of the human brain, functional characterization of brain regions and their interactions on the basis of regional protein expression remains limited. Here, we constructed a proteomic m...
Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2 [0.03%]
诱导型CD147上调促进新冠病毒感染延长从而导致重症新冠肺炎（独立于ACE2）
Ke Wang,Peng Lin,Ruo Chen et al.
Ke Wang et al.
The high mortality caused by severe COVID-19 poses great challenges to the public health. However, the underlying pathogenesis of severe cases remains unclear. Here, we find that SARS-CoV-2 infection boosts CD147 inducible up-regulation in ...
Yanxi Yao,Yifei Zhu,Keji Chen et al.
Yanxi Yao et al.
The intricate relationship between the microbiota and cancer has recently emerged as a pivotal area of research, highlighting their critical roles in carcinogenesis, progression, and prognosis. With the increasing recognition of the therape...
Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis [0.03%]
角蛋白细胞中的Wnt相关DKK3介导放射诱导的增生、皮炎和皮肤纤维化
Li Li,Ramon Lopez Perez,Khuram Shehzad et al.
Li Li et al.
Radiotherapy remains a mainstay of cancer treatment. However, radiotherapy can also elicit acute and chronic adverse effects, including dermal inflammation and skin fibrosis. A comprehensive understanding of the underlying fibrotic processe...
First-line Aumolertinib (EGFR tyrosine kinase inhibitor) plus apatinib (VEGFR inhibitor) versus aumolertinib in EGFR-mutant non-small cell lung cancer patients: a randomized, multicenter, phase II trial [0.03%]
奥美替尼联合阿帕替尼对比奥美替尼一线治疗EGFR突变型非小细胞肺癌患者：一项随机、多中心Ⅱ期临床试验
Fan Zhang,Zhendong Zheng,Hongmei Zhang et al.
Fan Zhang et al.
Inactivating vascular endothelial growth factor receptor (VEGFR) may improve the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). The ATTENTION study (p...
Employing epigenetic protein degradation techniques to block CCL5-mediated photodynamic therapy via a programmed delivery platform [0.03%]
利用表观遗传学蛋白质降解技术通过程序化递送平台阻断CCL5介导的光动力疗法
Tingting Yang,Yuzhu Hu,Anjie Guo et al.
Tingting Yang et al.
Despite the significant potential of photodynamic therapy (PDT) in cancer treatment, further refinement is needed to address challenges such as poor tumor-specific accumulation of photosensitizers and the development of therapeutic resistan...
CXCR4-modification enhances CAR-T efficacy by improving tumor tracking and bone marrow homing in B-cell malignancies [0.03%]
CXCR4修饰通过提高B细胞恶性肿瘤的肿瘤追踪和骨髓归巢增强CAR-T疗效
Pei Shu,Fuchun Guo,Diyuan Qin et al.
Pei Shu et al.
Hematological malignancies of B cell origin are characterized by frequent expression of CXCR4. The CXCR4-CXCL12 axis facilitates the in vivo dissemination of B cell lymphoma and multiple myeloma (MM). It is also a pivotal regulator in the m...
Deciphering the regulatory landscape of enhancer RNAs in health and disease [0.03%]
解析增强子RNA在健康与疾病中的调控景观
Qian Wang,Peter Ten Dijke,Chuannan Fan
Qian Wang
Enhancers are distal cis-regulatory elements that orchestrate spatiotemporal gene expression patterns in response to developmental cues and environmental stimuli. Genetic and epigenetic alterations in enhancers are associated with the initi...
Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications [0.03%]
针对癌症代谢-表观遗传-免疫轴的分子机制和治疗意义
Xing Wang,Xiyuan Luo,Ruiling Xiao et al.
Xing Wang et al.
Cancer cells orchestrate a highly dynamic and interconnected network spanning metabolic, epigenetic, and immune mechanisms to drive adaptive plasticity and continuous development. This review synthesizes emerging insights into the coevoluti...
Chunmei Cai,Guohua Ni,Lei Chen et al.
Chunmei Cai et al.
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availabil...