Platelets and diseases: signal transduction and advances in targeted therapy [0.03%]
血小板与疾病：信号转导及靶向治疗进展
Yuchen Tian,Yao Zong,Yidan Pang et al.
Yuchen Tian et al.
Platelets are essential anucleate blood cells that play pivotal roles in hemostasis, tissue repair, and immune modulation. Originating from megakaryocytes in the bone marrow, platelets are small in size but possess a highly specialized stru...
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction [0.03%]
通过诱导杀老细胞和免疫反应消除巨大型先天性黑色素痣的BCL2靶向治疗
Boxuan Wei,Qingxiong Yu,Jiamin Jin et al.
Boxuan Wei et al.
Giant congenital melanocytic nevus (GCMN) is a RAS/RAF mutation-driven syndrome characterized by extensive melanocytic lesions, posing psychological challenges and a lifelong risk of malignancy. Existing treatments like surgical resection a...
Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies [0.03%]
芳烃受体丢失通过促进BRAFV600E靶向治疗抵抗来增强肿瘤细胞的耐药性
Mourad Zerfaoui,Dharmeshkumar Patel,Yueqi Zhang et al.
Mourad Zerfaoui et al.
Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk [0.03%]
乳腺癌与心脏病理交叉对话促进蒽环类药物心脏毒性的外泌体pro-吡咯丁酸miR-216a-5p的转移
Yan Ma,Yongjun Wang,Renzheng Chen et al.
Yan Ma et al.
Doxorubicin (DOX) is the most effective chemotherapeutic for breast cancer, but it is usually associated with severe cardiotoxicity. Further investigation to alleviate its side effects is essential. The present study investigated the mechan...
Cancer cell cooperation: tumor cells team up to scavenge nutrients to ensure proliferation despite starvation [0.03%]
癌细胞协作：肿瘤细胞合作获取营养以保证在饥饿状态下的增殖
Susanne Sebens,Lisa-Marie Philipp,Dieter Adam
Susanne Sebens
Enhancing the anti-aging potential of the nigrostriatal dopamine system to counteract age-related motor decline [0.03%]
增强黑质纹状体多巴胺能系统的抗衰老潜力以对抗与年龄相关的运动功能减退
Youngpyo Nam,Sehwan Kim,Jun-Yeong Lee et al.
Youngpyo Nam et al.
Qing Xiao,Yi Liu,Tingting Li et al.
Qing Xiao et al.
The year 2024 marks the 60th anniversary of the discovery of the Epstein-Barr virus (EBV), the first virus confirmed to cause human cancer. Viral infections significantly contribute to the global cancer burden, with seven known Group 1 onco...
Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury [0.03%]
髓系CD38而不是肝细胞CD38是肝脏缺血再灌注损伤的关键驱动因素
Qi-Hang Zhao,Ya-Ting Zhang,Ke Wen et al.
Qi-Hang Zhao et al.
Hepatic ischemia-reperfusion injury (HIRI) is a critical condition that often occurs during liver transplantation and surgical liver resection. However, its mechanism has not been fully elucidated. Nicotinamide adenine dinucleotide (NAD+), ...
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer [0.03%]
铜离子在肿瘤发生发展中的分子机制及其介导的新型细胞死亡形式cuproptosis研究进展
Ziyu Guo,Danyao Chen,Lei Yao et al.
Ziyu Guo et al.
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-de...