Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance [0.03%]
开发富含亮氨酸的重复序列蛋白15靶向放射免疫诊疗法以耗尽促肿瘤机制和免疫疗法耐药性
Claire M Storey,Mohamed Altai,Katharina Lückerath et al.
Claire M Storey et al.
Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and tre...
A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice [0.03%]
人BPIFB4基因的一个与长寿相关的变异体能够预防早老症小鼠的舒张功能障碍
Yan Qiu,Monica Cattaneo,Anna Maciag et al.
Yan Qiu et al.
Tumor microenvironment delineates differential responders to trastuzumab emtansine in HER2-positive metastatic breast cancer patients previously treated with pyrotinib: an exploratory biomarker analysis of a phase II study (NJMU-BC02) [0.03%]
吡咯替尼治疗后HER2阳性转移性乳腺癌患者T-DM1疗效差异的肿瘤微环境探索性生物标志物分析（南京医科大学BC02二期临床试验）
Hong Pan,Ji Wang,Yue Sun et al.
Hong Pan et al.
Trastuzumab emtansine (T-DM1) has been approved for the treatment of HER2-positive breast cancer. However, the efficacy of T-DM1 for patients after failure of pyrotinib and/or trastuzumab plus pertuzumab has not been clear. Additionally, no...
Consolidative nivolumab versus observation in unresectable stage III non-small cell lung cancer patients following neoadjuvant nivolumab plus chemotherapy and concurrent chemoradiotherapy (CA209-7AL): a randomized clinical trial [0.03%]
NEOSTAR：接受新辅助纳武利尤单抗联合化疗和同期放化疗后的不可切除III期非小细胞肺癌患者的维持治疗——纳武利尤单抗对比观察的一项随机临床试验
Bo Qiu,Yuanyuan Zhao,Wenzhuo He et al.
Bo Qiu et al.
CA209-7AL is a randomized, multicenter, phase 2 trial evaluating the efficacy and safety of consolidative nivolumab (NIVO) versus observation following neoadjuvant NIVO plus chemotherapy and concurrent chemoradiotherapy (CCRT) for unresecta...
Liquid biomarkers associate with TGF-β Type I receptor and hypoxia in kidney cancer [0.03%]
液体生物标志物与肾癌的TGF-βI型受体和缺氧相关
Pramod Mallikarjuna,Cemal Erdem,Ruben Ilundain Beorlegui et al.
Pramod Mallikarjuna et al.
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics [0.03%]
一种应激激素驱动的两层能量通量系统优先考虑心脏能量供给
Zhiheng Rao,Zhichao Chen,Yuxuan Bao et al.
Zhiheng Rao et al.
The heart, an organ with a continuously high demand for energy, inherently lacks substantial reserves. The precise mechanisms that prioritize energy allocation to cardiac mitochondria, ensuring steady-state ATP production amidst high-energy...
Reprogramming of cancer metabolism via photoresponsive nano-PROTAC enhances pyroptosis-mediated immunotherapy [0.03%]
基于光响应纳米分子的肿瘤蛋白质降解重编程癌症代谢以增强细胞焦亡介导的免疫治疗
Byeongmin Park,Jiwoong Choi,Jae-Hyeon Lee et al.
Byeongmin Park et al.
Photodynamic therapy (PDT) induces tumor cell pyroptosis, a form of programmed cell death that triggers antitumor immunity. However, high glucose metabolism and hypoxic conditions in the tumor microenvironment (TME) limit PDT efficiency and...
An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates [0.03%]
全面评价从实验鼠到非人灵长类的药物偶联体治疗癌症的新方法
Minhui Su,Yuan Liu,Hongxin Lin et al.
Minhui Su et al.
Aptamers serve as unique targeting ligands, making aptamer-drug conjugates (ApDCs) an attractive strategy for targeted cancer therapy. This study performs a comprehensive evaluation from rodents to non-human primates (NHP) of a protein tyro...
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection [0.03%]
Ninjurin-1介导流感病毒感染过程中PANoptosis的细胞溶解和有害炎症反应
Yitian Xu,Ying Zheng,Yan Liu et al.
Yitian Xu et al.
Influenza A virus (IAV) induces ZBP1-mediated PANoptosis, a form of lytic inflammatory cell death characterized by concurrent activation of the pyroptosis, necroptosis and apoptosis pathways. Ninjurin-1 (NINJ1) is a recently identified medi...
Microbial metabolite facilitates virus control: inosine and T cells curb early-life influenza infection [0.03%]
微生物代谢产物促进病毒控制：次黄嘌呤和T细胞抑制早期流感感染
Lisa Sevenich,Thi Trang Le,Lukas F Mager
Lisa Sevenich