F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair [0.03%]
F-box/LRR重复蛋白12通过重新调控小胶质细胞抑制瘢痕形成并实现成人脊髓损伤修复
Xu Xu,Feng Gao,Qixin Chen et al.
Xu Xu et al.
Scarring is an insurmountable obstacle for axonal regeneration in recovery from spinal cord injury (SCI). It impedes the repair effects of therapeutic targets in cortical neurons, such as PTEN-/- and hyper-IL-6, which cannot break through d...
NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts [0.03%]
NADPH氧化酶1/4双抑制作用可削弱转化生长因子-β在胆管癌相关成纤维细胞中的促肿瘤生成效应
Josep Amengual,Ester Gonzalez-Sanchez,Mariana Yáñez-Bartolome et al.
Josep Amengual et al.
Transforming growth factor beta (TGF-β) signalling has become an attractive therapeutic target due to its pro-tumorigenic actions on epithelial cells and its immunosuppressive effects in the tumour microenvironment. In intrahepatic cholang...
DNA/RNA-binding protein KIN17 supports esophageal cancer progression via resolving noncanonical STING activation induced by R-loop [0.03%]
DNA/RNA结合蛋白KIN17通过解析R-loop诱导的非经典STING激活支持食管癌进展
Zichao Wei,Ning Zhao,Lu Kuang et al.
Zichao Wei et al.
Targeting the DNA damage response (DDR) exhibits potent efficacy in inducing immune activation and enhancing patient prognosis. However, the benefits of DDR regulation are not universally observed across all patients, owing to the intricate...
Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis [0.03%]
单细胞RNA测序鉴定出腺肌症治疗新靶点 prolactin receptor
Runze Wang,Shuai Xu,Qionghua Cui et al.
Runze Wang et al.
Adenomyosis is a complex gynecological disease characterized by endometrial tissue invasion into the myometrium. Current interventions, such as hormonal therapy or hysterectomy, are associated with significant side effects and compromise fe...
Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies [0.03%]
基于细胞外囊泡的药物概览：研究现状、质量控制及非临床评价策略
Gangling Xu,Jing Jin,Zhihao Fu et al.
Gangling Xu et al.
Extracellular vesicles share lipid‒protein membranes with their parent cells, allowing for the targeted transfer of bioactive cargo to recipient cells for functional modulation. The biological features allow extracellular vesicles to serve...
Both inhibitory and activating KIRs recognize RIFINs: a dual-edged mechanism of NK cell control in malaria [0.03%]
抑制性和活化性KIR识别RIFINS：疟疾中NK细胞调控的双重机制
Angelica Cuapio,Hans-Gustaf Ljunggren
Angelica Cuapio
Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease [0.03%]
免疫突触：结构、分子机制及其在疾病治疗中的应用
Zheng Chao,Qi Mei,Chunguang Yang et al.
Zheng Chao et al.
The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells. Its dysregulation is thought to be a key...
AAV for gene therapy drives a nephrotoxic response via NFκB in kidney organoids [0.03%]
腺相关病毒载体基因治疗通过NFκB诱导肾脏类器官发生肾毒性反应
Navin Gupta,Ke Zhang,Venkata Sabbisetti et al.
Navin Gupta et al.
Yichu Fu,Binhan Wang,Aqu Alu et al.
Yichu Fu et al.
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of...
Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial [0.03%]
派姆利尤单抗联合贝伐珠单抗作为晚期肝细胞癌一线治疗的疗效：一项随机II/III期试验
Chuanhua Zhao,Yanqiao Zhang,Gang Wang et al.
Chuanhua Zhao et al.
We aimed to assess the tolerability and efficacy of finotonlimab (an anti-programmed cell death protein-1 antibody) in combination with SCT510, a bevacizumab biosimilar, versus sorafenib in unresectable advanced HCC. This randomized phase 2...