Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics [0.03%]
通过单细胞转录组学解开肝纤维化相关马洛里-登克体病理发生的HGF/MET轴机制
Xiaoping Tang,Yi Shi,Jia Pan et al.
Xiaoping Tang et al.
Mallory-Denk bodies (MDBs) are protein aggregates commonly observed in chronic liver diseases, including liver fibrosis. However, the intrahepatic crosstalk driving MDB pathogenesis and fibrosis progression remains poorly understood. Using ...
Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis [0.03%]
靶向NFATc1调节的MTHFD2一碳代谢以抑制类风湿关节炎中持续的T细胞介导炎症反应
Theodora Manolakou,Jianyu Shen,Sanjaykumar Boddul et al.
Theodora Manolakou et al.
T cells are central drivers of inflammation across autoimmune and inflammatory diseases, yet current therapies inadequately target pathogenic T-cell pathways, limiting durable disease control. Here, we identified a novel, targetable transcr...
Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis [0.03%]
工程化tRNA可减少Leber先天性黑蒙小鼠模型的视力丧失
Pawan K Shahi,Enes Akyuz,Lionel Gissot et al.
Pawan K Shahi et al.
Premature termination codons (PTCs) are a major class of pathogenic variants that underlie rare inherited disorders, including forms of childhood blindness. Therapeutic suppression of these "nonsense mutations" offers a gene- and position-a...
Efficacy and safety of toripalimab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): a phase 1b/2 study [0.03%]
特瑞普利单抗联合西妥昔单抗治疗复发或转移性鼻咽癌（R/M NPC）的疗效和安全性：Ib/II期临床研究
Ye Guo,Zhendong Li,Liqiong Xue et al.
Ye Guo et al.
This open-label, multicenter, phase 1b/2 trial assessed the safety and efficacy of toripalimab plus cetuximab in patients with platinum-refractory (Cohort A) or previously untreated programmed cell death-ligand 1 (PD-L1)-positive (Cohort B)...
Pulmonary surfactant camouflage lipid nanoparticles for efficient mRNA lung delivery [0.03%]
用于有效肺部输送mRNA的肺表面活性剂伪装脂质纳米颗粒
Weilun Sun,Ti-Qiang Zhou,Yuanyu Huang et al.
Weilun Sun et al.
Turning the clock: mRNA-encoded thymic factors restore aged immunity [0.03%]
逆转时钟：mRNA编码的胸腺因子恢复衰老免疫功能
Muhammad Naveed Khan,Hui Li,Xiaosong Li
Muhammad Naveed Khan
Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases [0.03%]
人类疾病的蛋白质稳态机制与治疗的新观点
Ankush Borlepawar,Marco Neu,Ziqi Ma et al.
Ankush Borlepawar et al.
Cellular protein homeostasis, or proteostasis, underpins the integrity, adaptability, and survival of all cells by balancing protein synthesis, folding, trafficking, and degradation. This multilayered network is sustained by coordinated act...
Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom [0.03%]
工程化AIEgen-CRISPR/Cas9平台重塑肿瘤微环境并增强胶质母细胞瘤光免疫治疗响应
Guanghong Luo,Fulong Ma,Yaoqiang Yang et al.
Guanghong Luo et al.
Glioblastoma remains one of the most lethal brain tumors. Although immunotherapy and other therapeutic modalities has achieved significant therapeutic success in several malignancies, its efficacy in glioblastoma remains limited primarily d...
Glycobiology-driven therapeutic targeting of glycan-binding proteins: mechanisms, diseases, and clinical translation [0.03%]
糖生物学驱动的糖基结合蛋白治疗靶向：机制、疾病和临床转化
Alyanna M Popatia,Ahmad Sharanek,Arezu Jahani-Asl
Alyanna M Popatia
Galectins are glycan-binding proteins that interact with diverse glycoconjugates and protein networks to regulate intracellular and extracellular signaling pathways governing fundamental biological processes. Increasing evidence implicates ...
Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors [0.03%]
组蛋白去乙酰酶抑制剂的抗癌作用机制并非都是通过抑制组蛋白去乙酰酶的酶活性来实现的
Chaitra Rai,Hang Ruan,Xue Li et al.
Chaitra Rai et al.
Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly u...