Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications [0.03%]
多组学与人工智能赋能的精准药物发现及临床应用潜力
Yuqing Liu,Kun Zhu,Weijun Peng et al.
Yuqing Liu et al.
The integration of multiomics technologies with artificial intelligence (AI) has become a transformative force in modern precision medicine, particularly within drug discovery. Multiomics approaches, including genome-wide association studie...
Single-cell identifies and validates human circulating Treg subtype/state Tregfci in non-small cell lung cancer [0.03%]
单细胞鉴定和验证非小细胞肺癌中的循环Tregs亚型/状态Tregfci
Xuanqi Liu,Yifei Liu,Wanxin Duan et al.
Xuanqi Liu et al.
Regulatory T cells (Treg) play immunosuppressive roles in lung cancer and are key biomarkers in cancer immunology. Using scRNA-seq and stereo-seq, we aimed to identify a novel circulating Treg subtype in non-small cell lung cancer (NSCLC). ...
Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics [0.03%]
基于DNA四面体处理器的胞内逻辑运算实现精准肿瘤诊疗
Yang Gao,Yun Wang,Yunlong Qin et al.
Yang Gao et al.
The integration of molecular computation with nanomedicine holds transformative potential for precision cancer theranostics. However, achieving an intelligent, multi-input decision-making process within living cells remains a formidable cha...
Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity [0.03%]
LAG3定向白细胞介素-2可靶向肿瘤特异性T细胞，防止T细胞衰竭并重新激发抗肿瘤免疫反应
Xiaohong Yu,Huiping Liao,Jiaoyun Lv et al.
Xiaohong Yu et al.
LAG3 is a critical inhibitory receptor that is highly enriched on exhausted T cells within the tumor microenvironment (TME), where it acts as a key driver of T-cell exhaustion-an archetypal barrier to robust antitumor immunity. In a colon c...
Elongation of spinal cord reactive astrocytes via LRP1/TRK signaling [0.03%]
LRP1/TRK信号调控脊髓星形胶质细胞反应性增生
Francisco Javier Rodriguez-Jimenez,Francisca Selles,Pavla Jendelova et al.
Francisco Javier Rodriguez-Jimenez et al.
Necroptosis triggers inflammatory interferon signatures in patient-derived metastatic breast cancer organoids [0.03%]
患者衍生的转移性乳腺癌类器官中坏死性凋亡触发炎症干扰素特征
Kaja Nicole Wächtershäuser,Jana V Schneider,Alec Gessner et al.
Kaja Nicole Wächtershäuser et al.
Breast cancer (BC) is the most common type of cancer among women worldwide and underlies relapse, disease progression, and metastasis. Resistance to chemotherapy and programmed cell death (PCD), including apoptosis, strongly affects BC ther...
Insights into the therapeutic strategies for aging and aging-associated diseases [0.03%]
衰老及老年相关疾病的治疗策略新见解
Ruifang Dong,Qiming Wu,Juntao Kan et al.
Ruifang Dong et al.
Aging is a complex biological process characterized by progressive functional decline, driving the incidence of age-related diseases such as neurodegeneration, metabolic disorders, and cardiovascular diseases. Therapeutic strategies targeti...
Sintilimab plus concurrent chemoradiotherapy for treatment of locally advanced small cell lung cancer (SINCE-01): a phase II clinical trial [0.03%]
sintilla单抗联合同期放化疗治疗局部晚期小细胞肺癌(SINCE-01):一项II期临床试验
Qian Zhao,Yintao Li,Hongjiao Zhang et al.
Qian Zhao et al.
Patients diagnosed with limited-stage small cell lung cancer (LS-SCLC) face dismal long-term outcomes, as relapse occurs frequently even after standard concurrent chemoradiotherapy. Integrating immune checkpoint blockade into chemoradiother...
Haoyi Yang,Huafeng Zhang,Ni Xia et al.
Haoyi Yang et al.
As immunoregulatory cells, regulatory T cells (Tregs) play pivotal roles in maintaining immune tolerance and preventing autoimmunity. However, Tregs exhibit distinct functions across different diseases. In cancer, Tregs are most likely to s...
Dual epitope anti-LILRB4 synthetic T-cell receptor and antigen receptor (STAR)-T-cell therapy for relapsed/refractory acute myeloid leukemia [0.03%]
用于复发/难治性急性髓系白血病的双表位抗LILRB4合成T细胞受体和抗原受体（STAR）-T细胞疗法
Meng Lv,Hongli Zheng,Xuying Pei et al.
Meng Lv et al.
Acute myeloid leukemia (AML) is a rapidly progressive malignancy with poor prognosis. To date, chimeric antigen receptor (CAR) T-cell therapy in AML has been limited by the lack of antigens with high specificity for AML cells. Here, we deve...