Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin [0.03%]
环境光通过工程化光能视紫红质缓解小鼠神经退行性病变
Run-Zhou Yang,Yiting Wang,Zhuanbin Wu et al.
Run-Zhou Yang et al.
The mitochondrial proton motive force (pmf) is a critical driver of cellular energy production and influences various cellular processes. Dysregulation of pmf is implicated in a range of diseases, including neurodegenerative diseases, mitoc...
Serotonin transporter: a potential new immune checkpoint for cytotoxic T cells [0.03%]
血清素转运蛋白：一个新的细胞毒T细胞免疫检查点的潜在靶标
Gerard P Ahern,Rosa L Miyares
Gerard P Ahern
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop [0.03%]
激活Piezo1可抑制骨髓脂肪细胞生成从而通过抑制机体内源性炎性的自分泌环路来预防骨质疏松症
Baile Wang,Jie Liu,Qin Wang et al.
Baile Wang et al.
With aging or osteoporosis, bone marrow adipogenesis is increased and inversely correlates with the loss of bone mass. Bone marrow adipocytes are derived from multipotent bone marrow mesenchymal stem cells (BMMSCs), which can differentiate ...
Gut-derived imidazole propionate promotes atherosclerosis through myeloid imidazoline-1 receptor signaling: new biomarker and therapeutic target [0.03%]
肠道来源的咪唑丙酸通过髓系受体伊马佐林-1信号通路促进动脉粥样硬化：新的生物标志物和治疗靶点
Weiqi Wang,Dilvin Semo,Rinesh Godfrey
Weiqi Wang
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations [0.03%]
蛋白质折叠与稳态的导航：从分子伴侣到治疗创新
Omer Faruk Kuzu,Lars Jørgen Tvenge Granerud,Fahri Saatcioglu
Omer Faruk Kuzu
Protein folding is a fundamental process ensuring that polypeptide chains acquire the correct three-dimensional structures required for biological function. This complex journey from nascent polypeptides to mature proteins is tightly regula...
Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation [0.03%]
肺泡巨噬细胞活化中过氧化氢酶体酶4调控PTEN/AKT信号轴的开关作用
Jia-Wei Zhou,Ying Bai,Jian-Qiang Guo et al.
Jia-Wei Zhou et al.
Phosphatase and tensin homolog (PTEN) is a critical inhibitor of the PI3K/AKT signaling pathway, yet its direct upstream regulators remain poorly defined. In this study, we investigated the role of peroxiredoxin 4 (PRDX4) in alveolar macrop...
Vascular dementia: novel insights through multiscale mechanistic modeling [0.03%]
血管性痴呆：通过多尺度机制模型获得的新见解
Qiying Ye,Seongjoon Won,Dongming Cai
Qiying Ye
Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction [0.03%]
增生性糖尿病视网膜病变亚型由免疫防御和内皮细胞线粒体功能障碍定义
Maximilian A McCann,Basma Baccouche,Yueru Li et al.
Maximilian A McCann et al.
Proliferative diabetic retinopathy (PDR) is a major complication of diabetes characterized by pathological angiogenesis in the retina. Standard treatment includes vitrectomy to remove these abnormal vessels, and the resulting clinical speci...
Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leakage-triggered cGAS-STING axis activation [0.03%]
凝聚纳米佐剂通过线粒体DNA泄漏激活cGAS-STING轴增强CD8⁺T细胞依赖性抗肿瘤免疫反应
Yu Tang,Zhiyuan Luo,Zhanni Ma et al.
Yu Tang et al.
The variety and functionality of current clinical vaccine adjuvants remain limited. Conventional aluminum-based adjuvants predominantly induce Th2-biased humoral immunity but exhibit a limited capacity to elicit Th1-mediated cellular immune...
Single-cell atlas of the esophageal squamous cell carcinoma immune ecosystem to predict immunotherapy response [0.03%]
食管鳞癌免疫图谱可预测免疫治疗反应
Xiankai Chen,Yahui Zhao,Yuhao Wang et al.
Xiankai Chen et al.
Esophageal squamous cell carcinoma (ESCC) evolves within a highly interactive tumor microenvironment (TME) that shapes therapeutic response. We utilized mass cytometry to analyze over 10 million cells from 25 ESCC tumors, 24 adjacent nontum...