Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets [0.03%]
肿瘤的进化：信号通路、分子机制及治疗靶点
Kun-Yu Zhang,Xiu-Zhi Zhu,Yu-Xin Yan et al.
Kun-Yu Zhang et al.
Cancer is one of the leading causes of global morbidity and mortality and is characterized by its high heterogeneity, genomic instability and adaptive plasticity. Applying Darwin's theory of evolution, the concept of tumor evolution has imp...
A ferroptosis-suppressive state drives resistance to bladder-preserving chemoradiotherapy in muscle-invasive bladder cancer [0.03%]
肌层浸润性膀胱癌保留膀胱的化学放疗耐药性的铁死亡抑制型态的研究
Takuya Tsujino,Shogo Yamazaki,Moritoshi Sakamoto et al.
Takuya Tsujino et al.
Bladder-preserving trimodality therapy (TMT) incorporating concurrent chemoradiotherapy (CRT) provides a curative-intent alternative to radical cystectomy for muscle-invasive bladder cancer (MIBC), yet its efficacy is frequently limited by ...
A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier [0.03%]
一个微生物组元转录体学分析流程鉴定出一种保护结肠上皮屏障的中性粒细胞弹性蛋白酶抑制剂
Bojan Stojkovic,Matthijs Bekkers,Jake P Violi et al.
Bojan Stojkovic et al.
Inflammatory Bowel Diseases (IBD) are lifelong conditions. Current therapeutic approaches target inflammatory signalling rather than improving barrier permeability or repair. The gut microbiome provides an exciting opportunity for novel dru...
Martin Culka,Jonathan Desponds,Jeanne Cheung et al.
Martin Culka et al.
The ability to predict T-cell receptor (TCR) specificity from sequences could transform immunotherapy, vaccine development, and our understanding of immune recognition. However, progress has been shaped by "edge cases", in which specificity...
Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer [0.03%]
衰老应激信号：肺癌的转移塑性和代谢脆弱性
Seung-Jae Lee,Jaehoon Bae,Ye Ji Cheon et al.
Seung-Jae Lee et al.
Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer's disease [0.03%]
靶向小胶质细胞磷脂酰乙醇胺合成通路可促进阿尔茨海默病中GABARAP相关吞噬作用和Aβ清除
Seung Jae Hyeon,Seung Chan Kim,Jiyeon Chu et al.
Seung Jae Hyeon et al.
Alzheimer's disease (AD) is a major cause of dementia and a prevalent age-related neurodegenerative disorder characterized by progressive cognitive impairment and memory loss. Although metabolic activation or dysfunction of microglia is imp...
Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export [0.03%]
新型核RNA输出因子1衔接蛋白通过增加增殖刺激mRNA的输出来驱动肿瘤生长
Jin-Yu Liu,Huan-Hui Feng,Chen Xie et al.
Jin-Yu Liu et al.
mRNA nuclear export is an essential biological process that is mediated primarily by nuclear export factor 1 (NXF1). NXF1 exerts its mRNA transport activity by binding to adaptor proteins. In an effort to identify novel NXF1 adaptors involv...
Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures [0.03%]
多组学谱分析临床和新型双膦酸盐的反应发现对与衰老相关的特征有额外的非骨效应
Jinsen Lu,Srinivasa Rao Rao,Helen Knowles et al.
Jinsen Lu et al.
Bisphosphonates (BPs) have been used effectively to treat excessive bone loss for over 50 years. Recent clinical evidence suggests extra-skeletal benefits but how this occurs remains unknown. Here we use a panel of human, murine and cellula...
Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies [0.03%]
多器官功能障碍综合征：分子机制和治疗策略
Xuan Xu,Jinwen Chen,Yuqing Feng et al.
Xuan Xu et al.
Multiple organ dysfunction syndrome presents a significant challenge in clinical critical care, characterized by the progressive or simultaneous failure of two or more organ systems following severe insults such as infection, trauma, acute ...
RBM20 variants disrupt Ca2+ handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models [0.03%]
RBM20变异破坏扩张型和非 compaction心肌病干细胞模型中的Ca2+处理和代谢
Sabine Rebs,Farbod Sedaghat-Hamedani,Elham Kayvanpour et al.
Sabine Rebs et al.
Mutations in the splice-regulator RBM20 cause heart failure with reduced ejection fraction (HFrEF), typically manifesting as dilated cardiomyopathy (DCM). Mutations at position 634 in the RS-domain cause DCM with (R634L) or without (R634W) ...