De novo induction of tertiary lymphoid structures: an immunotherapeutic strategy in pancreatic cancer [0.03%]
从头诱导生发中心：胰腺癌免疫治疗策略
Azaz Ahmed,Christoph Springfeld,Niels Halama
Azaz Ahmed
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study [0.03%]
探索性生物标志物分析：帕博利珠单抗联合化疗一线治疗广泛期小细胞肺癌的局部和系统免疫特征差异响应者的评估研究
Mengqing Xie,Minwei Bao,Xiaorong Dong et al.
Mengqing Xie et al.
While chemo-immunotherapy has been established as the frontline therapeutic regimen for extensive-stage small cell lung cancer (ES-SCLC), durable responses persist predominantly in a minor population of patients. This underscores critical n...
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis [0.03%]
牙龈卟啉单胞菌通过促进泡沫细胞坏死性凋亡加重动脉粥样硬化斑块不稳定性
Xiaofei Huang,Mengru Xie,Yixuan Wang et al.
Xiaofei Huang et al.
At advanced phases of atherosclerosis, the rupture and thrombogenesis of vulnerable plaques emerge as primary triggers for acute cardiovascular events and fatalities. Pathogenic infection such as periodontitis-associated Porphyromonas gingi...
The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications [0.03%]
免疫系统与心血管疾病：从基本机制到治疗意义
Xiaoyan Wang,Liming Chen,Jianming Wei et al.
Xiaoyan Wang et al.
Immune system plays a crucial role in the physiological and pathological regulation of the cardiovascular system. The exploration history and milestones of immune system in cardiovascular diseases (CVDs) have evolved from the initial discov...
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma [0.03%]
PKMYT1激酶通过改善骨肉瘤对顺铂的敏感性来抑制疾病进展
Binfeng Liu,Wei Li,Wenchao Zhang et al.
Binfeng Liu et al.
Cisplatin (DDP) remains a cornerstone therapy for osteosarcoma (OS); however, pervasive resistance severely limits its clinical efficacy and worsens patient outcomes. Developing strategies to enhance the chemotherapeutic responsiveness of O...
Targeting conserved epitopes in structural proteins: a next-generation vaccine strategy against the newly identified HKU5-CoV-2 virus [0.03%]
针对结构蛋白的保守表位进行靶向：一种下一代抗新发现HKU5-CoV-2病毒疫苗策略
Leonardo Pereira de Araújo,Evandro Neves Silva,André Luiz Caliari Costa et al.
Leonardo Pereira de Araújo et al.
Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation [0.03%]
老化中性粒细胞的大囊泡：促进炎症消退的新机制
Christopher Dietz-Fricke,Florian R Greten
Christopher Dietz-Fricke
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives [0.03%]
血管内皮生长因子信号通路的健康与疾病：从分子机制到治疗视角
Chunsik Lee,Myung-Jin Kim,Anil Kumar et al.
Chunsik Lee et al.
Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maint...
Melatonin synergizes with prostaglandin E2 to enhance YAP-mediated regenerative epithelial cell emergence during intestinal repair [0.03%]
褪黑素通过与前列腺素E2协同作用增强YAP介导的再生上皮细胞在肠道修复过程中的出现
Yoojin Seo,Ji-Su Ahn,Hansong Lee et al.
Yoojin Seo et al.
Deep mining in the dorsal raphe: cholecystokinin-expressing neurons encode satiation-related cues to regulate meal size [0.03%]
脑干背缝核中的深度挖掘：胆囊收缩素阳性神经元通过编码饱腹感相关的线索来调节进食量
Niels Röhrdanz,Peer Wulff,Kira Balueva
Niels Röhrdanz