Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations [0.03%]
蛋白质折叠与稳态的导航：从分子伴侣到治疗创新
Omer Faruk Kuzu,Lars Jørgen Tvenge Granerud,Fahri Saatcioglu
Omer Faruk Kuzu
Protein folding is a fundamental process ensuring that polypeptide chains acquire the correct three-dimensional structures required for biological function. This complex journey from nascent polypeptides to mature proteins is tightly regula...
Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation [0.03%]
肺泡巨噬细胞活化中过氧化氢酶体酶4调控PTEN/AKT信号轴的开关作用
Jia-Wei Zhou,Ying Bai,Jian-Qiang Guo et al.
Jia-Wei Zhou et al.
Phosphatase and tensin homolog (PTEN) is a critical inhibitor of the PI3K/AKT signaling pathway, yet its direct upstream regulators remain poorly defined. In this study, we investigated the role of peroxiredoxin 4 (PRDX4) in alveolar macrop...
Vascular dementia: novel insights through multiscale mechanistic modeling [0.03%]
血管性痴呆：通过多尺度机制模型获得的新见解
Qiying Ye,Seongjoon Won,Dongming Cai
Qiying Ye
Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction [0.03%]
增生性糖尿病视网膜病变亚型由免疫防御和内皮细胞线粒体功能障碍定义
Maximilian A McCann,Basma Baccouche,Yueru Li et al.
Maximilian A McCann et al.
Proliferative diabetic retinopathy (PDR) is a major complication of diabetes characterized by pathological angiogenesis in the retina. Standard treatment includes vitrectomy to remove these abnormal vessels, and the resulting clinical speci...
Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leakage-triggered cGAS-STING axis activation [0.03%]
凝聚纳米佐剂通过线粒体DNA泄漏激活cGAS-STING轴增强CD8⁺T细胞依赖性抗肿瘤免疫反应
Yu Tang,Zhiyuan Luo,Zhanni Ma et al.
Yu Tang et al.
The variety and functionality of current clinical vaccine adjuvants remain limited. Conventional aluminum-based adjuvants predominantly induce Th2-biased humoral immunity but exhibit a limited capacity to elicit Th1-mediated cellular immune...
Single-cell atlas of the esophageal squamous cell carcinoma immune ecosystem to predict immunotherapy response [0.03%]
食管鳞癌免疫图谱可预测免疫治疗反应
Xiankai Chen,Yahui Zhao,Yuhao Wang et al.
Xiankai Chen et al.
Esophageal squamous cell carcinoma (ESCC) evolves within a highly interactive tumor microenvironment (TME) that shapes therapeutic response. We utilized mass cytometry to analyze over 10 million cells from 25 ESCC tumors, 24 adjacent nontum...
Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients [0.03%]
循环肿瘤DNA指导小细胞肺癌患者免疫巩固治疗获益
Yin Yang,Yuqi Wu,Jingjing Zhao et al.
Yin Yang et al.
Despite the lack of predictive biomarkers and a prognostic stratification strategy, immune checkpoint inhibitor (ICI) has shown promise in improving outcomes for patients with limited-stage small cell lung cancer (LS-SCLC). We evaluated the...
In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance [0.03%]
用于降解AR和HSP90以克服去势抵抗性前列腺癌的体内自组装纳米型PROTAC
Fei-Ya Yang,Ni-Yuan Zhang,Yang Yang et al.
Fei-Ya Yang et al.
Castration-resistant prostate cancer demonstrates intrinsic or acquired resistance to second-generation androgen-targeted therapies, posing a challenge in clinical treatment. In this study, on the basis of in vivo self-assembly nanotechnolo...
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential [0.03%]
稳态与疾病下的调节性T细胞：分子机制和治疗潜力
Lingling Wang,Ying Liang,Chunxia Zhao et al.
Lingling Wang et al.
Regulatory T cells (Treg cells or Tregs), a subset of CD4⁺ T cells with immunosuppressive properties, are essential for immune homeostasis and self-tolerance. Characterized by their immunosuppressive capabilities and reliance on the transc...