Aditya Shreenivas,Adam Wahida,Razelle Kurzrock
Aditya Shreenivas
Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation [0.03%]
酰基辅酶a结合蛋白（ACBP）：脓毒症中的不良预后生物标志物及疾病缓解靶点
Flavia Lambertucci,Omar Motiño,Uxía Nogueira-Recalde et al.
Flavia Lambertucci et al.
Sepsis remains a major clinical challenge, with high mortality and long-term disability despite current interventions. Here, we identify the tissue hormone acyl-CoA-binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), as ...
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation [0.03%]
糖皮质激素通过抑制H4K12乳酸化提高透明细胞肾细胞癌对HIF-2α抑制剂的敏感性
Kenan Zhang,Lin He,Yizhou Wang et al.
Kenan Zhang et al.
Approximately 70% of clear cell renal cell carcinoma (ccRCC) patients harbor von Hippel‒Lindau (VHL) deficiency, which drives pseudohypoxia and metabolic reprogramming. Here, we report a histone H4 lysine 12 lactylation (H4K12la)-fueled ph...
Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder [0.03%]
伴有快动眼睡眠行为障碍的帕金森病患者特有的代谢组和蛋白质组特征
Yaping Shao,Jing Wang,Yaping Liu et al.
Yaping Shao et al.
Rapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinson's disease (PD), affecting 40-50% of PD patients. PD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more sever...
PRIME-HFrEF Trial: a randomized, double-blind, multi-dose umbilical cord-derived mesenchymal stem cell regimen for heart failure [0.03%]
关于脐带间充质干细胞治疗心力衰竭的随机、双盲、多剂量PRIME-HFREF试验
Wei Han,Yuheng Jiao,Wei Chen et al.
Wei Han et al.
The safety of multi-dose mesenchymal stem cell (MSC) regimens has seldom been systematically investigated. The PRIME-HFrEF (Prospective Randomized Controlled Study of Multiple Intravenous Infusions of Umbilical Cord-derived MSCs in Patients...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Mar 26;11(1):112. DOI:10.1038/s41392-026-02678-5 2026
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer [0.03%]
结直肠癌中短链酰基辅酶a脱氢酶触发线粒体DNA去甲基化和释放以促进抗肿瘤免疫反应
Fang Yang,Meng Wang,Shaofan Hu et al.
Fang Yang et al.
Reprogramming of lipid metabolism and cyclic GMP‒AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is associated with cancer development. However, whether and how fatty acid metabolism regulates the cGAS‒STING pathway i...
Hailong Duan,Xin Peng,Sha Qin et al.
Hailong Duan et al.
Micronuclei are small, independent cytoplasmic structures containing nuclear material. They typically form during cell division due to DNA damage or division abnormalities, serve as biomarkers of genetic damage, and are closely associated w...
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications [0.03%]
活性氧在癌症中的作用：从机制到治疗意义
Sharmin Akter,Rajesh Madhuvilakku,Anik Kumar Kar et al.
Sharmin Akter et al.
Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation...
Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease [0.03%]
少突前体细胞-小胶质细胞通过BMP4相互作用驱动小胶质细胞神经保护反应并缓解阿尔茨海默病
Soonbong Baek,Jaemyung Jang,Seungeun Yeo et al.
Soonbong Baek et al.
Oligodendrocyte precursor cells (OPCs) rapidly respond to neural injury, becoming activated to preserve myelin homeostasis and interacting with diverse cell types in the central nervous system (CNS). However, the molecular basis of OPC comm...