Cleaved SREBP-2 C-terminal fragment noncanonically drives interleukin-1 receptor-associated kinase 1-dependent apoptosis [0.03%]
裂解的SREBP-2 C末端片段非经典驱动IL-1受体相关激酶1依赖性凋亡
MyeongHoon Yeon,Won-Kyung Kim,Hyeon-Bin Shin et al.
MyeongHoon Yeon et al.
Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer [0.03%]
Spi-1原癌基因调节头颈癌的mRNA过度转录和恶性进展
Zheran Liu,Zijian Qin,Huilin Li et al.
Zheran Liu et al.
Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent and lethal cancers worldwide. Despite multimodal therapeutic advances, long-term survival remains poor, underscoring the need to identify novel molecular drivers of ...
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation [0.03%]
circArhgap26通过抑制斑心蛋白1棕榈酰化修饰缓解心肌缺血再灌注损伤
Ming-Yu Zhang,Dong-Ni Ji,Wen-Yi Qi et al.
Ming-Yu Zhang et al.
Cardiac ischemia‒reperfusion (I/R) injury is a leading cause of disability and mortality worldwide, but the underlying mechanism remains largely unknown. Despite the emerging recognition of circular RNAs (circRNAs) as pivotal regulators of...
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis [0.03%]
化疗光热协同作用通过铁死亡诱发抗肿瘤免疫反应
Jundong Lin,Huikang Yang,Zhihao Zou et al.
Jundong Lin et al.
Docetaxel (Doc), a widely used chemotherapeutic agent, was limited by suboptimal therapeutic efficacy and dose-limiting systemic toxicity due to the insufficiency of hydrophilicity and tumor-targeting specificity. To address this limitation...
DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling [0.03%]
DUSP6缺失通过活化AP-1信号转导恢复肿瘤CD58丢失引起的CAR-T细胞活性损伤
Xinran Ma,Yang Zhang,Yao Wang et al.
Xinran Ma et al.
Primary resistance to chimeric antigen receptor (CAR) T-cell therapies has limited their widespread application. Our prior genome-wide CRISPR/Cas9 screening revealed that the loss of CD58, a crucial intrinsic resistance factor in tumors, re...
A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms [0.03%]
一种生物安全的鼠类模型可更逼真地模拟SARS-CoV-2感染和COVID-19症状
Xiaoya Huang,Yingjian Li,Jikai Deng et al.
Xiaoya Huang et al.
COVID-19 resulting from SARS-CoV-2 infection has presented significant challenges to global health over the past several years. Animal models are essential for studying the pathogenic mechanisms of SARS-CoV-2 and facilitating the developmen...
Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination [0.03%]
导电配位纳米酶前药精准触发焦亡、铜依赖性细胞死亡和铁依赖性细胞死亡用于原位癌症疫苗治疗
Yuqiao Wang,Hao Zhao,Ke Sun et al.
Yuqiao Wang et al.
Pyroptosis, which rapidly releases cellular contents through pyroptotic pores, is an ideal method for inducing in situ cancer vaccines, evoking systemic antitumor immunity, and suppressing primary and metastatic tumors. However, the clinica...
Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications [0.03%]
基于纳米粒子的光疗系统：分子机制及临床应用
Deepak S Chauhan,Rajendra Prasad,Mukesh Dhanka et al.
Deepak S Chauhan et al.
Nanoparticle-based phototherapy represents a paradigm shift in precision medicine, harnessing light-activated mechanisms to modulate cellular pathways across a spectrum of diseases. By integrating nanoparticles, phototherapeutic modalities ...
Modulating fatty acid signaling to restore allopregnanolone balance: a novel strategy for anxiety disorders [0.03%]
调制脂肪酸信号恢复别孕烯醇酮平衡：焦虑症的一种新策略
Zhiqian Bi,Yawen Xie,Na Han et al.
Zhiqian Bi et al.