Hypoxia induced VEGF secretion promotes resistance to bispecific T-cell engagers [0.03%]
缺氧诱导的VEGF分泌促进双特异性T细胞衔接子的抗性
Mengyao Xu,Syem K Barakzai,Raj Kumar et al.
Mengyao Xu et al.
Bispecific T-cell Engagers (BITEs) are a novel form of immunotherapy that overcome a deficiency of immune checkpoint inhibitors (ICI) by targeting a preidentified tumor associated antigen and redirecting a polyclonal population of effector ...
Repartitioning brain glucose: serine-nucleotide dependency sensitizes glioblastoma therapy [0.03%]
脑葡萄糖重新分布：依赖.serine-核苷酸的敏感性胶质母细胞瘤疗法
Yanggang Hong,Chunyan Hua,Min Wu
Yanggang Hong
Novel CDK2/4/6 inhibitor culmerciclib (TQB3616) plus fulvestrant in previously treated, HR-positive, HER2-negative advanced breast cancer: a randomized, double-blind, phase 3 trial [0.03%]
新型CDK2/4/6抑制剂曲拉西利(TQB3616)联合氟维司群治疗既往经治的激素受体阳性、HER2阴性晚期乳腺癌患者：一项随机、双盲、多中心III期临床试验
Yongmei Yin,Qingyuan Zhang,Tao Sun et al.
Yongmei Yin et al.
CDK2 is a principal mediator of CDK4/6 resistance. Concurrent CDK2/4/6 blockade may be effective in treating HR-positive, HER2-negative advanced breast cancer (ABC). This randomized, double-blind, parallel-controlled, phase 3 trial (Clinica...
Hypoglycemia induces brain metabolic reprogramming and neurodegeneration via serum response factor and myocardin-related transcription factor-A [0.03%]
低血糖通过血清反应因子和肌球蛋白相关转录因子A诱导大脑代谢重构和神经退行性病变
Minjeong Jang,Hyung Jin Choi,Hae-June Lee et al.
Minjeong Jang et al.
Hypoglycemia is a frequent and potentially severe complication that can result in significant brain injury in individuals with diabetes treated with insulin or other hypoglycemic agents and in those undergoing prolonged fasting. Despite its...
Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage [0.03%]
核受体Nur77通过组蛋白B依赖性GSDMC切割诱导血红素稳态失调和细胞焦亡
Liu-Zheng Wu,Ya-Ying Huang,Hai-Jing Hu et al.
Liu-Zheng Wu et al.
Pyroptosis plays a crucial role in physiological and pathological processes. As melanoma cells are resistant to apoptosis but express gasdermin proteins, it is appealing to counter melanoma with the induction of gasdermin-executed pyroptosi...
Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injury [0.03%]
Wnt2通过依赖于细胞质Nucleosome assembly protein-like 1降解的新型心脏保护机制对抗缺血/再灌注损伤
Ying Wang,Liming Chen,Jinyi Lin et al.
Ying Wang et al.
Wnt and its crosstalk signaling pathways are involved in the modulating ischemia‒reperfusion (I/R) injury. However, whether Wnt2 is a novel therapeutic agent for I/R injury is largely unknown. Here, we show that the downregulation of serum...
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses [0.03%]
选择性耗竭肿瘤相关SAMHD1可增强化疗疗效和抗肿瘤免疫反应
Jing Sun,Wenwen Zheng,Zheng-Guo Zhang et al.
Jing Sun et al.
SAMHD1 is a human deoxyribonucleoside triphosphatase (dNTPase) known for its role as a restriction factor that targets a wide spectrum of viruses, its involvement in autoimmune disease Aicardi-Goutières syndrome (AGS), and its participatio...
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions [0.03%]
消除异常糖酵结合作用可清除衰老细胞并缓解与衰老相关功能障碍
Takumi Mikawa,Masahiro Kameda,Sumiko Ikari et al.
Takumi Mikawa et al.
Cellular senescence is deeply involved in physiological homeostasis, development, tissue repair, aging, and diseases. Senescent cells (SnCs) accumulate in aged tissues and exert deleterious effects by secreting proinflammatory molecules tha...
Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trial [0.03%]
L-奥克雷司他治疗创伤性脑损伤患者认知功能的疗效和安全性：一项多中心、随机、双盲、三期临床试验
Tao Liu,Jiao Wang,Zhihao Zhao et al.
Tao Liu et al.
To assess the efficacy and safety of L-oxiracetam, a novel nootropic agent, in improving cognition in patients with TBI, we performed a multicentre, double-blind, randomized controlled trial in China. Participants aged 18 to 75 years with T...
Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies [0.03%]
STAT5活化的致癌基因诱导的Oncostatin M促进血液系统恶性肿瘤的发展进展
Michael Rassner,Tony Andreas Müller,Kirstyn Anne Crossley et al.
Michael Rassner et al.
Understanding the interplay between oncogenic mutations and the tumor microenvironment could help improve therapy for hematological malignancies. We found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce onco...