The role of ER-associated degradation and ER-phagy in health and disease [0.03%]
内质网相关降解和内质网自噬在健康与疾病中的作用
Young Joo Jeon,Ze&#x;ev A Ronai
Young Joo Jeon
The endoplasmic reticulum (ER) is a major cellular organelle for the synthesis and folding of secretory and transmembrane proteins, whose proper function underpins organellar homeostasis, proper tissue function, and organismal physiology. P...
Immunoglobulin heavy-chain status and stromal interactions shape ferroptosis sensitivity in chronic lymphocytic leukemia [0.03%]
免疫球蛋白恒定链状态和基质相互作用塑造慢性淋巴细胞白血病的铁死亡敏感性
Martin Böttcher,Lea Reemts,Paul J Hengeveld et al.
Martin Böttcher et al.
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B cells. Although targeted therapies have improved outcomes, resistance remains a challenge, particularly in high-risk patients with TP53 mutations or unmutat...
Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion [0.03%]
T细胞的复苏：克服T细胞耗竭的突破与挑战
Yiran Wu,Yuchen Wu,Zhengyu Gao et al.
Yiran Wu et al.
T cell exhaustion is a prevalent phenomenon in chronic infections and tumor microenvironments, severely compromising the effectiveness of antitumor and antiviral immunity. In recent years, there has been significant progress in understandin...
Remodeling the tumor dormancy ecosystem to prevent recurrence and metastasis [0.03%]
重塑肿瘤休眠生态系统以预防复发和转移
Yu Liang,Wo-Ming Chen,Youming Zhang et al.
Yu Liang et al.
Dormant tumor cells, major contributors to tumor recurrence and metastasis, are characterized by cell cycle arrest and reactivation potential. Tumor dormancy arises from the dynamic interplay between intrinsic tumor properties and extrinsic...
Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis [0.03%]
撤回 notice: BICC1通过诱导VEGF非依赖性血管生成驱动胰腺癌进展
Chongbiao Huang,Hui Li,Yang Xu et al.
Chongbiao Huang et al.
Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies [0.03%]
胰腺癌的分子病理和新的治疗策略
Enrique Rozengurt,Guido Eibl
Enrique Rozengurt
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which there is no effective treatment. A deep understanding of the mechanisms underlying the molecular pathogenesis, signaling pathways and risk factors leading to PDAC is...
Hayley M Sabol,Lorenzo Galluzzi,Lucia Borriello
Hayley M Sabol
mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics [0.03%]
mTOR信号网络：疾病治疗中的机制见解和转化前沿
Hanxiao Zhang,Xia Xiao,Zhenrui Pan et al.
Hanxiao Zhang et al.
The mammalian target of rapamycin (mTOR) pathway is a central regulator of cellular growth, metabolism, and homeostasis, integrating a wide array of intracellular and extracellular cues, including nutrient availability, growth factors, and ...
When vaccines reset tumors: SARS-CoV-2 mRNA shots create a transient checkpoint-sensitive state [0.03%]
当疫苗重置肿瘤时：SARS-CoV-2 mRNA疫苗产生一种短暂的检查点敏感状态
Hao Chi,Michele Carbone,Youping Deng
Hao Chi
Low density lipoprotein receptor-related protein 8: a critical receptor for tick-borne encephalitis virus entry [0.03%]
低密度脂蛋白受体相关蛋白8：一种重要的发热性伴血小板减少综合征病毒宿主细胞受体
Pengtao Jiao,Lin Du,Yan Zeng
Pengtao Jiao