Preventing trogocytosis by cathepsin B inhibition augments CAR T-cell function [0.03%]
通过猫氨酸B抑制防止细胞内吞作用可增强CAR-T细胞的功能
Kenneth A Dietze,Kiet Nguyen,Aashli Pathni et al.
Kenneth A Dietze et al.
Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in cancer treatment. Nevertheless, most patients receiving CAR T cells relapse within 5 years of treatment. CAR-mediated trogocytosis (CMT) is a potential tumor es...
Surface CD81 supports leukemia stem cell function and reveals a therapeutic vulnerability in acute myeloid leukemia [0.03%]
表面CD81支持白血病干细胞功能并揭示了急性髓系白血病的治疗弱点
Fanny Gonzales,Pauline Peyrouze,Djohana Laurent et al.
Fanny Gonzales et al.
Relapse remains the leading cause of mortality in acute myeloid leukemia (AML), largely due to the persistence of therapy-resistant leukemia stem cells (LSCs). However, surface determinants that sustain LSC function and disease aggressivene...
Sirolimus plus roxadustat synergistically enhances immunosuppression and erythropoiesis in pure red cell aplasia: a multicenter trial [0.03%]
西罗莫司联合罗沙克苏马刺激纯红细胞再生免疫抑制和促红细胞生成的协同作用：多中心试验
Hong Wang,Qingyuan Wang,Shan Liu et al.
Hong Wang et al.
Acquired pure red cell aplasia (aPRCA) is rare and challenging to treat. We investigated the efficacy and safety of sirolimus plus roxadustat in patients with aPRCA (Chinese Clinical Trial Register number, ChiCTR2200065107). We enrolled 82 ...
Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets [0.03%]
心血管衰老：标志物、信号通路、疾病及治疗靶点
Pingjing Zheng,Wendi Yan,Yangnan Ding et al.
Pingjing Zheng et al.
Cardiovascular disease (CVD) predominantly affects elderly individuals and is the leading cause of morbidity, disability, and mortality worldwide. Systemic ageing, especially cardiovascular ageing, contributes to the development of CVD phen...
Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition [0.03%]
缺氧诱导因子网络反映了糖尿病和钠-葡萄糖共转运抑制剂的肾脏疾病进展情况
Viji Nair,Akihiro Minakawa,Cathy Smith et al.
Viji Nair et al.
Hypoxia drives diabetic kidney disease (DKD) progression through Hypoxia Inducible Factor (HIF) signaling. The kidney's cellular heterogeneity and complex architecture pose challenges for directly assessing the pharmacologic effects on kidn...
Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline [0.03%]
靶向ATP11B-YAP轴修复线粒体功能并抑制神经元铁死亡以缓解与年龄相关的认知衰退
Wenxin Qi,Qian Liu,Naijun Dong et al.
Wenxin Qi et al.
Brain aging is accompanied by cognitive decline and an increased risk of neurodegenerative disease, with neuronal aging being a key causative factor. Studies have shown that the earliest damage to blood-brain barrier (BBB) integrity occurs ...
The cost of cure: cancer therapies sculpt somatic evolution and signaling landscapes in normal tissues [0.03%]
治愈的代价：癌症疗法重塑正常组织的体细胞进化和信号景观
Yu-Jeong Jeong,In-Sung Song,Sung-Wuk Jang
Yu-Jeong Jeong
Luisa Chocarro,Leticia Fernández-Rubio,Karina Ausin et al.
Luisa Chocarro et al.
mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formation [0.03%]
仑伐替尼耐药肝细胞癌驱动的mTOR增殖、整合素β4富集型细胞外囊泡通过成纤维细胞巢促进肺转移
Tiantian Zou,Xufeng Wang,Haoting Sun et al.
Tiantian Zou et al.
Tumor-derived extracellular vesicles (EVs) play crucial roles in facilitating the colonization and growth of metastatic cancer cells in distant organs. Nevertheless, the precise mechanisms by which EVs contribute to therapy-resistant cancer...
Reprogramming the tumor microenvironment with antibody against membrane-proximal AXL to overcome immune checkpoint blockade resistance [0.03%]
抗膜 proximal AXL抗体重编程肿瘤微环境以克服免疫检查点抑制剂耐药性
Zuming Yang,Shuaishuai Cao,Jiaen Zhang et al.
Zuming Yang et al.
Immune-cold tumors fail to respond to immunotherapy due to insufficient lymphocyte infiltration within the tumor tissue. Increasing the objective response rate remains an urgent challenge. Here, we report the development of a monoclonal ant...