Krüppel-like factor 4 downregulation during esophageal cancer formation facilitates immune evasion and impairs immunotherapy [0.03%]
Krüppel样因子4在食管癌发生过程中的下调促进了免疫逃逸并影响了免疫治疗
Xiao Hu,Chenying Li,Dongxu Li et al.
Xiao Hu et al.
Impaired antigen processing and presentation are critical for cancer immune evasion, but the underlying mechanism is not fully known. Here, we show that downregulation of Krüppel-like factor 4 (KLF4) expression during the development of ca...
Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf [0.03%]
声音效果：范式基因疗法使出生失聪的儿童和青少年恢复听力
Juliane W Schott,Michael Morgan,Axel Schambach
Juliane W Schott
Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses [0.03%]
组合型原位癌症疫苗：释放广谱且增强的抗肿瘤反应
Weihsuan Chen,Juwon Baig,Hyebeen Choi et al.
Weihsuan Chen et al.
In situ cancer vaccination, also termed intratumoral immunotherapy, transforms the tumor microenvironment into an endogenous vaccine platform by leveraging the tumor itself as a source of antigens. Unlike conventional tumor-associated antig...
Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics [0.03%]
个性化癌症疫苗：连接免疫肿瘤学和精确医学以实现先进治疗
Leiguang Ye,Guo Zhao,Jiaxiu Ma et al.
Leiguang Ye et al.
Despite advancements in therapeutic cancer vaccines, clinical translation has been hindered by limited efficacy, with Sipuleucel-T remaining the only FDA-approved therapeutic cancer vaccine to date. However, recent advances in personalized ...
Hakjin Kim,Jongwon Byun,Taeho Kwon
Hakjin Kim
Modeling physiological insulin sensitivity and pre-diabetic insulin resistance in multiple hPSC-derived cell types [0.03%]
用多种诱导多能干细胞来源的细胞类型模拟生理胰岛素敏感性和糖尿病前期胰岛素抵抗
Max Friesen,Rudolf Jaenisch
Max Friesen
NOD1/2 signaling in macrophages drives adaptive immune resistance in cancer [0.03%]
肿瘤中的NOD1/2信号驱动适应性免疫抵抗反应
Xiduan Wei,Li Yang,Yuting Wang et al.
Xiduan Wei et al.
Therapeutic resistance remains a prevalent and intractable clinical challenge across a broad spectrum of human malignancies. Despite extensive investigations, the intricate molecular networks by which the tumor microenvironment (TME) mediat...
Connexin 43-dependent mesenchymal stem cell mitochondrial transfer activates PGC1α disrupting oxidative-inflammation axis in ischemia-reperfusion injury [0.03%]
缝隙连接蛋白43依赖性的间充质干细胞线粒体转移激活PGC1α干扰氧化炎症通路以应对缺血再灌注损伤
Abantika Ganguly,Jing Wang,Shobha Regmi et al.
Abantika Ganguly et al.
Ischemia-Reperfusion Injury-related Acute Kidney Injury (IRI-AKI) is a significant clinical challenge. Despite extensive research into the underlying mechanism for IRI-AKI, the development of effective therapeutic interventions remains chal...
Neurotransmitter modulation: a roadmap to precision neuro-immune oncology [0.03%]
神经递质调节：精确神经-免疫肿瘤学路线图
Jacob L Billingsley,Saahir Bhunnoo,Yannick D Benoit
Jacob L Billingsley
Dual-targeting pharmacological UFMylation inhibition reprograms tumor and immune microenvironments to achieve long-term glioblastoma regression [0.03%]
双重靶向药物UFMylation抑制剂可重塑肿瘤和免疫微环境实现胶质母细胞瘤的长期退缩
Pengcheng Tan,Zhimin Liu,Xiaodan Hu et al.
Pengcheng Tan et al.
UFMylation, a recently identified ubiquitin-like modification, is essential for cellular stress homeostasis, particularly endoplasmic reticulum (ER) stress regulation. However, its biological and therapeutic exploration has been hindered by...