GPR54 regulates non-small cell lung cancer development via dopa decarboxylase [0.03%]
GPR54通过多巴脱羧酶调节非小细胞肺癌的发生发展
Hyun-Ha Hwang,Seo Yeon Lee,Chanhee Lee et al.
Hyun-Ha Hwang et al.
Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is a leading cause of cancer death. G protein-coupled receptor 54 (GPR54) plays a role in cancer development by interacting with its endogenous ligand kisspeptin encod...
Efficacy and safety of bofanglutide, a GLP-1 receptor agonist, in Chinese adults with overweight or obesity: a randomized, double-blind, placebo-controlled phase 2b trial [0.03%]
勃法利肽治疗中国超重或肥胖成人受试者的有效性和安全性：一项随机、双盲、安慰剂对照II期临床试验
Linong Ji,Leili Gao,Junhang Tian et al.
Linong Ji et al.
Bofanglutide is a novel biweekly (once every two weeks; Q2W) glucagon-like peptide-1 receptor agonist. We evaluated the efficacy and safety of bofanglutide in Chinese adults with overweight or obesity in a randomized, double-blind, placebo-...
Targeting fused in sarcoma (FUS): a novel antisense strategy for treating idiopathic pulmonary fibrosis [0.03%]
针对融合在恶性 schwann瘤中的FUS蛋白：特发性肺间质纤维化的新型反义寡核苷酸治疗策略
Bhavika B Katariya,Shashipavan Chillappagari,Lisa Arnold et al.
Bhavika B Katariya et al.
Fused in sarcoma (FUS) is a highly conserved RNA-binding protein with essential roles in RNA processing and genomic stability. While extensively studied in the context of neurodegeneration, its involvement in fibrotic diseases, particularly...
Coronary atherosclerotic plaque intervention with Tongxinluo capsule (TXL-CAP): a multicenter, randomized, double-blind and placebo-controlled study [0.03%]
通心络胶囊干预冠脉动脉粥样硬化斑块随机、双盲、安慰剂平行对照的多中心试验
Mei Ni,Yun Ti,Huai Yu et al.
Mei Ni et al.
Clinical evidence of traditional Chinese medicine Tongxinluo capsule therapy on coronary plaque vulnerability is lacking. To investigate whether Tongxinluo may increase coronary plaque stability in patients admitted with acute coronary synd...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Feb 24;11(1):72. DOI:10.1038/s41392-026-02581-z 2026
Antiviral drug discovery and development: challenges and future directions [0.03%]
抗病毒药物发现与开发：挑战与未来方向
Shaoqing Du,Xueping Hu,Ping Li et al.
Shaoqing Du et al.
The coronavirus disease 2019 (COVID-19) pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins for viral infe...
Concordance analysis of DNA and RNA profiling: The MD Anderson IMPACT2 study in precision oncology [0.03%]
DNA与RNA谱分析的同贯性分析：精准肿瘤学中的安德森癌症中心IMPACT2研究项目
Stephanie T Schmidt,Mehmet A Baysal,Siqing Fu et al.
Stephanie T Schmidt et al.
DNA profiling is an established method for cancer treatment selection, while RNA profiling remains investigational. We explored associations between DNA and RNA alterations and between the number of genes with altered expression and overall...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Feb 24;11(1):68. DOI:10.1038/s41392-026-02580-0 2026
Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease [0.03%]
染料木素gaylussacin通过调节颗粒物诱导的巨噬细胞染色质重塑抑制慢性阻塞性肺疾病的发展
Jeong Yeon Sim,Jee Hwan Ahn,Hye-Young Min et al.
Jeong Yeon Sim et al.
Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer [0.03%]
癌症神经科学：癌症的信号通路及新的治疗策略
Sihui Zhang,Lin Yuan,Ping Lin et al.
Sihui Zhang et al.
From a neuroscience perspective, cancer neuroscience has emerged as a subfield of cancer research. Presumable mechanisms underlying cancer-related neuronal activity (termed neurosciences) include the induction and modulation of signaling pa...
Parathyroid hormone-related protein is a therapeutic target in idiopathic pulmonary fibrosis [0.03%]
特发性肺纤维化治疗靶点——甲状旁腺激素相关蛋白
Xue-Quan Fang,Suha Lim,Yoon-Mi Lee et al.
Xue-Quan Fang et al.
The crosstalk between immune or alveolar epithelial cells and fibroblasts mediated by paracrine signaling molecules is associated with the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, studies investigating the active involv...
Heyang Cui,Zhongxu Zhu,Enwei Xu et al.
Heyang Cui et al.
Esophageal squamous cell carcinoma (ESCC) lacks a standardized classification system, resulting in inconsistent clinical management and a suboptimal prognosis. This study addresses the urgent need for a robust consensus taxonomy to facilita...