Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer [0.03%]
胰腺癌中细胞外小泡衍生的miRNA-182-5p使巨噬细胞向免疫抑制表型分化
Baldev Singh,Pankaj Gaur,Pritha Bose et al.
Baldev Singh et al.
Reprogramming the immunosuppressive milieu in pancreatic cancer (PaCa) remains an important yet unmet therapeutic goal. Although tumor-associated macrophages (TAMs) are known to promote tumor growth and metastasis, little is known about the...
Perioperative penpulimab-based combination therapy in patients with resectable non-small cell lung cancer (ALTER-L043): an open-label, multicenter, randomized, phase II trial [0.03%]
可切除非小细胞肺癌患者围手术期派安普利单抗联合治疗：一项开放性、多中心、随机II期试验（ALTER-L043）
Meng Wang,Weiran Liu,Hongbo Guo et al.
Meng Wang et al.
Although perioperative immunotherapy combined with neoadjuvant chemotherapy has improved the clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC), the optimal combination strategy remains unknown. This multicente...
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology [0.03%]
芳烃受体：结构、信号转导及其生理和病理作用
Xavier Coumoul,Robert Barouki,Charlotte Esser et al.
Xavier Coumoul et al.
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family. In this review, we explore the multifaceted roles of AHR in both health and disease, tracing its recognition as a xenobiotic sens...
The dysadherin/carbonic anhydrase 9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression [0.03%]
粘附不良蛋白/碳酸酐酶9轴塑造酸性肿瘤微环境以促进结直肠癌进展
Choong-Jae Lee,Hyeon-Ji Yun,Tae-Young Jang et al.
Choong-Jae Lee et al.
The tumor microenvironment (TME) plays a central role in cancer progression and metastasis. A key feature of the TME is extracellular acidity, which promotes disease progression, immune evasion, and drug resistance. Tumor acidity is increas...
Qian Hu,Yue Hu,Chunlu Tan et al.
Qian Hu et al.
Acute pancreatitis is a complex inflammatory condition characterized by sudden onset and rapid progression, with severe cases often associated with high mortality. In recent years, the global incidence of acute pancreatitis has been increas...
Yuting Tan,Rui Xue,Yuwei Pan et al.
Yuting Tan et al.
The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different t...
MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysm [0.03%]
MAPK14通过作用于关键转录调控因子促进腹主动脉瘤中血管平滑肌细胞的去分化
Xiaoliang Wu,Chunhui Wang,Nestor Ishimwe et al.
Xiaoliang Wu et al.
Vascular smooth muscle cell (VSMC) degeneration is a major mechanism underlying abdominal aortic aneurysm (AAA) formation. However, the upstream signaling pathways that converge on the transcriptional machinery to drive VSMC degeneration re...
A modular "Catch-and-Play" platform for rapid T-cell engager target assembly for personalised cancer treatment [0.03%]
一种模块化的“捕获并即玩”平台，可快速组装个性化的癌症治疗T细胞engage目标分子
Xi Xi,Yonghui Zhang,Daqing Zhao et al.
Xi Xi et al.
Double-strand break-free epigenetic programming: a safer path for T-cell therapies [0.03%]
无DNA双链断裂的表观遗传重编程：T细胞治疗的安全路径
Lanxin Deng,Yujia Yang,Assam El-Osta
Lanxin Deng
LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1 [0.03%]
长链非编码RNA Wee1-AS通过激活线粒体CDK1/CYCLIN B1来协调氧化型脂肪酸代谢
Hyeon-Ji Kim,Cheolhee Jeong,Sang-Heon Lee et al.
Hyeon-Ji Kim et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is steadily increasing with life-threatening complications, underscoring the need for new therapeutic targets. In this study, we identified a novel long noncoding RNA, Wee1-AS...