Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling [0.03%]
视黄醇结合蛋白4通过触发经典的NF-κB、JAK / STAT5和JNK信号激活潜伏的HIV-1病毒
Chiara Pastorio,Khumoekae Richard,Shariq Usmani et al.
Chiara Pastorio et al.
Reactivation of the latent viral reservoirs is crucial for a cure of HIV/AIDS. However, current latency reversing agents are inefficient, and the endogenous factors that have the potential to reactivate HIV in vivo remain poorly understood....
Limited SUMOylation inhibitor administration enhances eradication of Burkitt's lymphoma with CD19 CAR-T therapy [0.03%]
对SUMOylation抑制剂的限制性给药可增强CD19 CAR-T治疗对抗Burkitt淋巴瘤的效果
Hiroshi Kotani,Shigeki Sato,Seiji Yano et al.
Hiroshi Kotani et al.
Colony-stimulating factor 3 as a key mediator in the progression of idiopathic pulmonary fibrosis: a novel therapeutic target [0.03%]
colony刺激因子3作为特发性肺纤维化进展中的关键介质：一种新的治疗靶点
Seungmo Kim,Yongjoong Kim,Tae-Sung Kim et al.
Seungmo Kim et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by excessive ECM deposition and myofibroblast accumulation driven by cytokine dysregulation. This study identified granulocyte colony-stimulating factor 3 (CSF3) as a...
Imane Boutitah-Benyaich,Herena Eixarch,Javier Villacieros-Álvarez et al.
Imane Boutitah-Benyaich et al.
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal loss, and neuroinflammation, culminating in progressive neurological disability. Despite significant advances in u...
Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance [0.03%]
NaNO3通过介导巨噬细胞再平衡的岩藻糖苷酶保护机体免受代谢综合征侵害
Shaorong Li,Yaning Wang,Zihan Zhang et al.
Shaorong Li et al.
Metabolic syndrome, characterized by metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM), poses a significant threat to patients' health worldwide; however, efficient treatment is currently u...
Molecular signatures of skeletal muscle insulin resistance: bringing personalised diabetes treatment a step closer [0.03%]
骨骼肌胰岛素抵抗的分子特征：使个性化糖尿病治疗更近一步
Giovanni Levate,Roland H Stimson
Giovanni Levate
Inhibition of long interspersed nuclear element-1 by nucleoside reverse transcriptase inhibitors attenuates vascular calcification [0.03%]
核苷逆转录酶抑制剂通过抑制长散在核元素-1而减轻血管钙化
Jianshuai Ma,Dayu He,Mingxuan Zhang et al.
Jianshuai Ma et al.
Vascular calcification (VC) is a critical vascular pathological event, contributing to the rise in both the prevalence and fatality of cardiovascular diseases. However, the lack of effective therapeutic strategies for VC is attributed prima...
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance [0.03%]
开发富含亮氨酸的重复序列蛋白15靶向放射免疫诊疗法以耗尽促肿瘤机制和免疫疗法耐药性
Claire M Storey,Mohamed Altai,Katharina Lückerath et al.
Claire M Storey et al.
Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and tre...
A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice [0.03%]
人BPIFB4基因的一个与长寿相关的变异体能够预防早老症小鼠的舒张功能障碍
Yan Qiu,Monica Cattaneo,Anna Maciag et al.
Yan Qiu et al.
Tumor microenvironment delineates differential responders to trastuzumab emtansine in HER2-positive metastatic breast cancer patients previously treated with pyrotinib: an exploratory biomarker analysis of a phase II study (NJMU-BC02) [0.03%]
吡咯替尼治疗后HER2阳性转移性乳腺癌患者T-DM1疗效差异的肿瘤微环境探索性生物标志物分析（南京医科大学BC02二期临床试验）
Hong Pan,Ji Wang,Yue Sun et al.
Hong Pan et al.
Trastuzumab emtansine (T-DM1) has been approved for the treatment of HER2-positive breast cancer. However, the efficacy of T-DM1 for patients after failure of pyrotinib and/or trastuzumab plus pertuzumab has not been clear. Additionally, no...