Development and validation of dynamic clinical subphenotypes in acute pancreatitis patients using vital sign trajectories in intensive care units: a multinational cohort study [0.03%]
基于重症监护病房急性胰腺炎患者生命体征轨迹的临床亚型的发展和验证：一项跨国队列研究
Zichen Wang,Wen Wang,Jiayue Xu et al.
Zichen Wang et al.
Acute pancreatitis (AP) is a heterogeneous inflammatory condition. Although emerging therapeutic strategies targeting pathways such as calcium signaling, TNF-α, the NLRP3 inflammasome, and HMGB1 have shown promise, their efficacy may be li...
Therapeutic potential of tumor-associated neutrophils: dual role and phenotypic plasticity [0.03%]
肿瘤相关中性粒细胞的治疗潜力：双重作用和表型可塑性
Yanting Zhou,Guobo Shen,Xikun Zhou et al.
Yanting Zhou et al.
Neutrophils are the first line of defense in nonspecific immunity (innate immunity) and interact with other immune cells to participate in specific defense mechanisms (adaptive immunity). Studies have shown that the tumor microenvironment (...
Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment [0.03%]
人脐带间质干细胞来源外泌体雾化吸入治疗肺纤维化的临床研究
Meng Li,Huaping Huang,Xiaofei Wei et al.
Meng Li et al.
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are recognized as a promising strategy for cell-free therapy, however, their therapeutic role in pulmonary fibrosis remains unrevealed. Here, we report the safety and efficac...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2025 Jun 4;10(1):179. DOI:10.1038/s41392-025-02262-3 2025
Advanced bioartificial organs: genetically modified pig liver as a promising bridge for human liver failure [0.03%]
先进的生物人工器官：转基因猪肝在人类肝脏衰竭过渡治疗中的应用展望
Taeho Kwon,Sun-Uk Kim,Kyungjun Uh
Taeho Kwon
Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications [0.03%]
肿瘤中的神经免疫交叉对话：机制及治疗意义
Tianyi Pu,Jiazheng Sun,Guosheng Ren et al.
Tianyi Pu et al.
The nervous system precisely regulates physiological activities throughout the body, controlling not only muscle movement, sensory perception, cognition, and responses to external stimuli but also the immune system. In the tumor microenviro...
Yuanyuan Hou,Boyang Lv,Junbao Du et al.
Yuanyuan Hou et al.
The metabolic pathway of sulfur-containing amino acids in organisms begins with methionine, which is metabolized to produce important sulfur-containing biomolecules such as adenosylmethionine, adenosylhomocysteine, homocysteine, cystine, an...
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction [0.03%]
精氨酸酶1驱动缺血/缺氧诱导的血管功能障碍中的线粒体嵴重塑和PANoptosis
Han She,Jie Zheng,Guozhi Zhao et al.
Han She et al.
Ischemic/hypoxic injury significantly damages vascular function, detrimentally impacting patient outcomes. Changes in mitochondrial structure and function are closely associated with ischemia/hypoxia-induced vascular dysfunction. The mechan...
Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer's disease models [0.03%]
靶向神经元的腔蛋白1过表达可减轻阿尔茨海默病症状模型中的认知障碍和病理转录组变化
Dongsheng Wang,Andrei V Chernov,Ryan Lam et al.
Dongsheng Wang et al.
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive synaptic loss and cognitive decline. Gene therapy that augments intrinsic neuroprotective pathways offers a promising strategy to mitigate neu...
China Protocol for early screening, precise diagnosis, and individualized treatment of lung cancer [0.03%]
肺癌早期筛查、精准诊断和个体化治疗的中国专家共识
Chengdi Wang,Bojiang Chen,Shufan Liang et al.
Chengdi Wang et al.
Early screening, diagnosis, and treatment of lung cancer are pivotal in clinical practice since the tumor stage remains the most dominant factor that affects patient survival. Previous initiatives have tried to develop new tools for decisio...
Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial [0.03%]
特瑞普利单抗联合白蛋白紫杉醇及艾罗珠单抗联合环磷酰胺治疗三阴性乳腺癌Ⅱ期TREND试验疗效、安全性及探索性分析
Qiang Zhang,Mozhi Wang,Yumeng Li et al.
Qiang Zhang et al.
The optimal chemotherapy backbone and specific population of triple-negative breast cancer (TNBC) patients that benefit from neoadjuvant immunotherapy are not well established. This prospective, single-arm, phase II TREND trial assessed the...