Lipocalin-2 drives brain metastatic progression through reciprocal tumor-microenvironment interactions in lung cancer [0.03%]
脂川蛋白-2通过肺癌脑转移瘤-微环境的相互作用驱动脑转移进展
Yixiang Zhu,Jian Zhang,Danming He et al.
Yixiang Zhu et al.
Brain metastasis is a major contributor to mortality in patients with lung cancer. The unique microenvironment of the brain plays a critical role in the initiation and progression of brain metastases (BM), yet the molecular mechanisms under...
Anti-MSLN chimeric antigen receptor-like NK cell therapy with tumor-penetrating capacity (uCAR-like NK) for solid tumors [0.03%]
具有肿瘤渗透能力的抗MSLN嵌合抗原受体样NK细胞疗法(uCAR-like NK)治疗实体瘤
Mengchao An,Ying Wang,Jie Shao et al.
Mengchao An et al.
Although natural killer (NK) cells are endowed with intrinsic cytotoxicity, their therapeutic application often faces limitations because of their lack of tumor-specific targeting ability and limited ability to infiltrate solid tumors. To o...
Xiaojuan Yang,Tian Lan,Buzhe Zhang et al.
Xiaojuan Yang et al.
Ubiquitination, a critical posttranslational modification (PTM), involves the enzymatic covalent attachment of ubiquitin to target proteins. This process is fundamental for maintaining cellular homeostasis and regulating key biological func...
Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling [0.03%]
靶向SKAP2通过调节线粒体排列和细胞骨架重塑恢复精子活力和形态
Shiming Gan,Lin Yin,Jiaming Zhou et al.
Shiming Gan et al.
Sperm motility and morphology are indispensable for sperm-egg interaction and successful fertilization. However, the RNA splicing mechanisms in an m6A-dependent manner regulating spermiogenesis-related genes remain poorly defined, and targe...
Scarless circular mRNA-based CAR-T cell therapy elicits superior antitumor efficacy [0.03%]
无scar环形mRNA递送的CAR-T细胞治疗展现优良抗肿瘤效果
Qinchao Hu,Hui Zhao,Kaicheng Zhou et al.
Qinchao Hu et al.
Messenger RNA (mRNA)-based transient expression of chimeric antigen receptors (CARs) results in optimal safety profiles and provides promising opportunities to address existing challenges associated with viral vector-based CAR-T-cell therap...
Oncolytic adenovirus delivery of neoantigens sensitizes low-mutation tumors to anti-PD-1 therapy and prevents metastasis [0.03%]
溶瘤腺病毒递送新抗原可使低突变肿瘤对anti-PD-1治疗敏感并预防转移
Ke-Yu Shen,Shi-Zhe Yu,Ying-Han Su et al.
Ke-Yu Shen et al.
Neoantigen vaccines and oncolytic viruses are emerging immunotherapies that can reshape the tumor microenvironment (TME). However, tumors with low mutation burdens often respond poorly to immunotherapies because of their limited immunogenic...
Working together: a multi-component intranasal vaccine provides synergistic protection against COVID-19 [0.03%]
联合行动：多组分鼻内疫苗在预防新冠肺炎方面具有协同作用
Jessica A Breznik,Chris P Verschoor
Jessica A Breznik
YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer [0.03%]
YTHDF1通过抑制NOTCH1诱导的肿瘤干细胞特性来调控结直肠癌化疗效果
Henley Cheung,Huarong Chen,Danyu Chen et al.
Henley Cheung et al.
N6-methyladenosine (m6A) modification of mRNAs is a predominant epigenetic regulatory mechanism in tumor initiation and progression. Cancer stem cells (CSCs) are the key drivers of colorectal cancer (CRC) initiation and chemotherapy resista...
A phase 1b/2 study of first-line anti-PD-L1/ TGF-βRII fusion protein SHR-1701 combined with nab-paclitaxel and gemcitabine for advanced pancreatic ductal adenocarcinoma [0.03%]
SHR-1701联合白蛋白结合型紫杉醇和吉西他滨治疗晚期胰腺导管腺癌 Ib/II 期临床研究
Ran Xue,Miaoyan Wei,Jiajia Yuan et al.
Ran Xue et al.
Nab-paclitaxel plus gemcitabine (AG) is the standard first-line chemotherapy for advanced or metastatic pancreatic ductal adenocarcinoma and has limited efficacy. This phase 1b/2 study aimed to evaluate SHR-1701 (an anti-PD-L1/TGF-βRII fus...
Anti-BCMA CAR-T cells attenuate microglial activation in progressive multiple sclerosis: indicating a plasma cell-microglia crosstalk [0.03%]
针对BCMA的CAR-T细胞可减轻进行性多发性硬化的微胶质细胞活化：提示浆细胞-微胶质细胞串扰
Fatme S Ismail,Hans-Peter Hartung,Nico Melzer
Fatme S Ismail