Drugging the intrinsically disordered transactivation domain of androgen receptor [0.03%]
靶向作用于雄激素受体内在无序转录激活域的药物研究进展
Jon K Obst,Carmen A Banuelos,Kunzhong Jian et al.
Jon K Obst et al.
Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR signaling. These mechanisms ...
Abexinostat, a histone deacetylases inhibitor, for patients with relapsed or refractory follicular lymphoma: a multi-center, single-arm phase 2 study [0.03%]
一项关于复发或难治滤泡性淋巴瘤患者使用Abexinostat（组蛋白去乙酰化酶抑制剂）的多中心、单臂二期临床试验
Lin Gui,Haifeng Liu,Huaqing Wang et al.
Lin Gui et al.
This phase 2, single-arm, multi-center study (NCT03934567) evaluates the efficacy and safety of abexinostat, a histone deacetylase inhibitor, in patients with relapsed or refractory (r/r) follicular lymphoma (FL). Eligible participants had ...
Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes [0.03%]
在嵌合抗原受体T细胞生成过程中对BCL-2的治疗靶向通过非凋亡型适应性改变增强作用力
Nada S Aboelella,Ryan Park,Erting Tang et al.
Nada S Aboelella et al.
Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles in apoptosis, BCL-2 proteins a...
Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation [0.03%]
慢性卒中猴骨髓间充质干细胞移植联合间歇重复经颅磁刺激后稳健的神经再生现象
Yuan-Huan Ma,Geng-Bin Chen,Man-Feng Wu et al.
Yuan-Huan Ma et al.
A significant population of chronic stroke patients urgently requires more effective therapies because of functional plateaus and limited intervention options. Intermittent theta-burst stimulation (iTBS) has been increasingly adopted in chr...
Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis [0.03%]
内皮GABA通过抑制内皮和线粒体功能障碍维持血管稳态来预防主动脉夹层
Lianbo Shao,You Yu,Haoyue Huang et al.
Lianbo Shao et al.
Thoracic aortic dissection (TAD) is a highly lethal vascular condition closely associated with endothelial cell (EC) dysfunction. γ-Aminobutyric acid (GABA) can be synthesized in ECs and modulate cell functions; however, its underlying rol...
Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance [0.03%]
肿瘤来源的DNA通过促进网织红细胞清除来驱动癌症相关性贫血
Ting Yuan,Xuebing Liu,Yucui Wu et al.
Ting Yuan et al.
Anemia is one of the most prevalent systemic complications in patients with cancer, substantially impairing quality of life and limiting the safe administration of cytoreductive therapies. Despite its clinical significance, the mechanisms b...
Michelle C C Lim,Gunter Maubach,Michael Naumann
Michelle C C Lim
Macrophage metabolic reprogramming by vanadium released from glucose-responsive bio-gel accelerates diabetic wound repair [0.03%]
释放钒的葡萄糖响应生物凝胶重塑巨噬细胞代谢以加速糖尿病伤口愈合
Jiangfeng Li,Zheng Li,Lili Han et al.
Jiangfeng Li et al.
Dysregulated glucose metabolism in diabetic wound macrophages impairs polarization toward the reparative M2 phenotype, leading to compromised innate immunity, chronic inflammation, and delayed wound healing. However, effective strategies to...
Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia [0.03%]
新冠肺炎性别二态性启发老药新用和靶宿主免疫治疗肺炎病毒感染
Lunzhi Yuan,Haiqing Xiao,Xuan Liu et al.
Lunzhi Yuan et al.
Sexual hormones play an important role in modulating disease outcome of COVID-19. The interplay between viral replication, host immune responses, pathology process and sexual hormone levels are complicated, and the underlying mechanisms rem...
Temporal assessment of behavior in Parkinson's visual hallucinations via a multidimensional analysis strategy [0.03%]
帕金森病视觉幻视多维度分析策略下的纵向行为评估研究
Quan-Xin Zhang,Yi-Xuan Zhang,Chen-Chen Jiang et al.
Quan-Xin Zhang et al.
Visual hallucination (VH) is a common nonmotor symptom of Parkinson's disease (PD). However, the lack of reliable animal models and quantitative assessment tools poses significant challenges for mechanism and intervention research in this a...