Synergistic immunotherapeutic effects of irreversible electroporation and CAR-NK cell therapy against hepatocellular carcinoma [0.03%]
不可逆电穿孔联合CAR-NK细胞治疗对肝癌的协同免疫效应
Joo Dong Park,Ha Eun Shin,Hye Jung Jang et al.
Joo Dong Park et al.
Chimeric antigen receptor natural killer (CAR-NK) cell therapy has emerged as a promising immunotherapeutic modality with potent cytotoxicity and a favorable safety profile. However, its therapeutic efficacy is often limited by poor infiltr...
Exocyst complex regulates fungal-mediated IL-33 release from cancer cells [0.03%]
异源七聚体外泌体复合物调节癌细胞来源的IL-33释放
Aftab Alam,Shyamananda Singh Mayengbam,Scott I Abrams et al.
Aftab Alam et al.
Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies [0.03%]
器官纤维化的机制见解和新兴治疗策略
Xiangqi Chen,Jinhang Zhang,Ling Guo et al.
Xiangqi Chen et al.
Fibrosis is a maladaptive pathophysiological process characterized by excessive deposition of extracellular matrix resulting from dysregulated tissue repair responses. Fibrosis can affect nearly all organ systems, such as the lung, heart, l...
Personalized pharmacokinetic-pharmacodynamic guided therapy via an induced pluripotent stem cell-derived multi-organoid platform in NF1-mutant breast cancer [0.03%]
通过诱导多能干细胞衍生的多器官芯片平台进行NF1突变型乳腺癌的药代动力学-药效学个性化治疗指导疗法
Jung Hwa Lim,Seon Ju Mun,Hyun Mi Kang et al.
Jung Hwa Lim et al.
Effective precision oncology demands integration of pharmacokinetics/pharmacodynamics (PK/PD) profiling with tumor-specific genomic features. Here, we present a personalized treatment model using a patient-derived Networking Organoid Cultur...
Unleashing the potential of bimetallic nanobomb-mediated STING pathway to enhance bispecific T-cell engager against colorectal cancer photo-immunotherapy [0.03%]
利用双金属纳米炸弹介导的STING途径增强双特异性T细胞衔接剂用于结直肠癌光免疫疗法
Min Mu,Hui Li,Bo Chen et al.
Min Mu et al.
The broader clinical application of Bispecific T-cell engagers (BiTEs) is hindered by their short half-life, on-target off-tumor toxicity, and limited therapeutic effect for solid tumors. Herein, we constructed a bimetallic-enriched triple-...
Yi Zhang,Yanqi Han,Ying Sun et al.
Yi Zhang et al.
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate i...
CRISPR gene editing of angiopoietin-like 3: toward one-time precision therapy for dyslipidaemia [0.03%]
针对血管生成素样蛋白3的CRISPR基因编辑技术：一次治疗血脂异常的新途径
Amandeep Mondal,Ashish Misra
Amandeep Mondal
Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer [0.03%]
利用脂质驱动的免疫代谢途径增强卵巢癌患者腹膜转移灶的免疫治疗
Meggy Suarez-Carmona,Mareike Hampel,Xin-Wen Zhang et al.
Meggy Suarez-Carmona et al.
Immunotherapy with immune checkpoint blockade (ICB) in epithelial ovarian carcinoma (EOC) shows limited clinical benefit only for a small subset of patients. Overall response rates are low, so that overcoming immunotherapy resistance and im...
Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR [0.03%]
通过无酶活性dCas9VPR增强心肌细胞中KLF15的活性：防止病理重编程和纤维化的新型方法
Eric Schoger,Rosa Kim,Federico Bleckwedel et al.
Eric Schoger et al.
Transcriptional activity perturbation holds promise for selectively modulating harmful transcriptional networks, but its therapeutic potential remains largely unexplored. We employed a network-based analysis of single-cell heart transcripto...
Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment [0.03%]
血小板衍生四聚体 thromboxane 激动剂通过抑制树突状细胞募集中性粒细胞减轻脓毒症
Ronglu Du,Ting Pan,Yuhan Wang et al.
Ronglu Du et al.
Dendritic cells (DCs) regulate both innate and adaptive immunity during sepsis. Prostaglandins (PGs), small lipid molecules derived from arachidonic acid via COX enzymes, are crucial regulators of immune homeostasis and inflammation. Howeve...