Double-strand break-free epigenetic programming: a safer path for T-cell therapies [0.03%]
无DNA双链断裂的表观遗传重编程：T细胞治疗的安全路径
Lanxin Deng,Yujia Yang,Assam El-Osta
Lanxin Deng
LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1 [0.03%]
长链非编码RNA Wee1-AS通过激活线粒体CDK1/CYCLIN B1来协调氧化型脂肪酸代谢
Hyeon-Ji Kim,Cheolhee Jeong,Sang-Heon Lee et al.
Hyeon-Ji Kim et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is steadily increasing with life-threatening complications, underscoring the need for new therapeutic targets. In this study, we identified a novel long noncoding RNA, Wee1-AS...
Cilium-by-cilium: unveiling hidden proteomic diversity and the molecular basis of ciliopathies [0.03%]
从纤毛到纤毛：揭示隐藏的蛋白质组多样性及纤毛疾病的分子基础
Mario Chiong,Hongliang Li,Sergio Lavandero
Mario Chiong
Correction: Signaling pathways and targeted therapy for pulmonary hypertension [0.03%]
关于肺动脉高压的信号通路与靶向治疗的更正论文
Joseph Adu-Amankwaah,Yue Shi,Hequn Song et al.
Joseph Adu-Amankwaah et al.
Universal scaling law: transcription factors homeostatically control promoter activity [0.03%]
普遍的标度定律：转录因子稳态地控制启动子活性
Minhao Gao,Aimin Wu,Min Wu
Minhao Gao
Jin Yang,Shimeng Wang,Xin Li et al.
Jin Yang et al.
Precancers, defined as normal-appearing or morphologically altered tissues with a risk of oncogenesis, exhibit various detectable manifestations across anatomical sites, including epithelial dysplasia, metaplasia, hyperplasia, and stromal f...
Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases [0.03%]
器官对话：疾病相关的分子机制、生物学功能及治疗干预措施
Huiting Che,Yidan Gao,Yonghu Xu et al.
Huiting Che et al.
Organ cross-talk, also known as the organ axis or organ interaction network, plays a vital role in maintaining physiological homeostasis and responding to environmental stimuli. This review comprehensively integrates cutting-edge observatio...
The role of ER-associated degradation and ER-phagy in health and disease [0.03%]
内质网相关降解和内质网自噬在健康与疾病中的作用
Young Joo Jeon,Ze&#x;ev A Ronai
Young Joo Jeon
The endoplasmic reticulum (ER) is a major cellular organelle for the synthesis and folding of secretory and transmembrane proteins, whose proper function underpins organellar homeostasis, proper tissue function, and organismal physiology. P...
Immunoglobulin heavy-chain status and stromal interactions shape ferroptosis sensitivity in chronic lymphocytic leukemia [0.03%]
免疫球蛋白恒定链状态和基质相互作用塑造慢性淋巴细胞白血病的铁死亡敏感性
Martin Böttcher,Lea Reemts,Paul J Hengeveld et al.
Martin Böttcher et al.
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B cells. Although targeted therapies have improved outcomes, resistance remains a challenge, particularly in high-risk patients with TP53 mutations or unmutat...
Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion [0.03%]
T细胞的复苏：克服T细胞耗竭的突破与挑战
Yiran Wu,Yuchen Wu,Zhengyu Gao et al.
Yiran Wu et al.
T cell exhaustion is a prevalent phenomenon in chronic infections and tumor microenvironments, severely compromising the effectiveness of antitumor and antiviral immunity. In recent years, there has been significant progress in understandin...