Multidimensional tumor-blood profiling uncovers systemic lymphocyte-monocyte imbalance in pituitary neuroendocrine tumors [0.03%]
多维度肿瘤-血液检测发现垂体神经内分泌瘤存在系统性淋巴细胞-单核细胞失衡现象
Yuting Dai,Shaojian Lin,Junchen Wu et al.
Yuting Dai et al.
Pituitary neuroendocrine tumors (PitNETs) are pathologically characterized by dysregulation of neuroendocrine function and systemic disruption of hormonal homeostasis, yet their regulatory effects on peripheral immune networks remain poorly...
Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome [0.03%]
丙酮酸激酶M2介导的组蛋白乳酸化可改变多囊卵巢综合征中的三维基因组结构
Chuanjin Yu,Tingting Liu,Yishu Wang et al.
Chuanjin Yu et al.
Polycystic ovary syndrome (PCOS) is a frequent endocrine and metabolic imbalance that typically occurs in women of reproductive age. Its molecular pathophysiology is yet unknown, especially the ovarian cellular metabolic inefficiency that c...
Therapeutic targeting of endothelial calcium signaling accelerates the resolution of lung injury [0.03%]
针对内皮细胞钙信号通路的治疗可加速肺损伤的恢复
Wan Ching Chan,Man Long Kwok,Xinyan Qu et al.
Wan Ching Chan et al.
Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease characterized by acute, noncardiogenic pulmonary edema and hypoxemia leading to respiratory failure. It is induced by a diverse array of etiologies, including recent S...
Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer [0.03%]
含有与家族114成员A1相似序列的蛋白在三阴性乳腺癌中参与免疫逃逸调控
Wenhao Zhang,Yanzhi Gai,Mengxue Qiao et al.
Wenhao Zhang et al.
Immune checkpoint blockade (ICB) therapy, which has revolutionized cancer treatment, has been approved for the treatment of triple-negative breast cancer (TNBC). Unfortunately, most patients with TNBC are either not eligible for treatment o...
Engineered butyrate-producing yeasts mitigate Alzheimer-associated phenotypes [0.03%]
工程化丁酸盐产生酵母菌可缓解与阿尔茨海默病相关的表型
Biao Zhang,Zhiyu Sun,Weihong Song et al.
Biao Zhang et al.
Benjamin H Mullish,Lauren A Roberts,Horace R T Williams
Benjamin H Mullish
Catheter-based endovascular celiac and hepatic denervation for type 2 diabetes: a multicenter, open-label, single-arm study [0.03%]
经导管内脏神经消融治疗2型糖尿病：一项多中心、开放标签研究
Zhi Wang,Tao Pan,Weifu Lv et al.
Zhi Wang et al.
Sympathetic hyperactivity is crucial driving factor for hyperglycemia in type 2 diabetes (T2D). We conducted a multicenter, open-label, single-arm trial to evaluate the safety and efficacy of endovascular denervation (EDN) targeting the cel...
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors [0.03%]
寡聚半胱氨酸肽酶抑制剂C通过与抑制性受体相互作用支持髓系细胞的免疫抑制活性
Chengcheng Zhang,Yubo He,Xiaoye Liu et al.
Chengcheng Zhang et al.
Amyloid proteins are linked to various diseases; however, their functional roles in immunity and cancer remain unclear. Here, we establish a direct link between oligomeric cystatin C-a cysteine cathepsin inhibitor and a well-characterized a...
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessment [0.03%]
针对SARS-CoV-2 XBB的免疫印记效应及其对疫苗策略和变异风险评估的影响
Xiaoyun Yang,Guichang Li,Yuan Wang et al.
Xiaoyun Yang et al.
The immune imprinting against SARS-CoV-2 subvariants that dynamically evolves through sequential vaccination and infection has been rarely studied. Using antigenic cartography and neutralizing antibody (NAb) profiling, we demonstrate that p...
Reframing cancer cachexia: the vagal brain-liver axis as a novel neuro-metabolic target [0.03%]
从迷走神经脑-肝轴的角度重新认识癌症恶病质：一种新的神经代谢靶点
Daoyan Wei,Xinwen Lin,Robert S Bresalier
Daoyan Wei