TCR-mimic bispecific nanobody-based T cell engager targeting intracellular tumor antigens for cancer immunotherapy [0.03%]
一种双特异性纳米抗体靶向胞内肿瘤抗原的T细胞连接剂用于癌症免疫治疗
Ziqiang Ding,Shuyang Sun,Xiaomei Yang et al.
Ziqiang Ding et al.
T cell engager (TCE) immunotherapies have revolutionized the landscape of cancer treatment; however, their efficacy remains limited by the inaccessibility of intracellular tumor antigens. Conventional bispecific T cell engagers, typically c...
Engineering T cells with a novel PD-L1-specific TCR targeting immune and cancer cells [0.03%]
工程化T细胞：新型PD-L1特异性TCR靶向免疫和肿瘤细胞
Thomas Landkildehus Lisle,Emilie Bülow Jacobsen,Shamaila Munir Ahmad et al.
Thomas Landkildehus Lisle et al.
Novel post-transcriptional dimension of glucocorticoid action through mRNA translation and P-body remodeling [0.03%]
通过mRNA翻译和P体重塑的糖皮质激素作用的新转录后维度
Victoria J Nicolini;FRENCH GR-P-BODY NETWORK;Patrick Brest
Victoria J Nicolini;FRENCH GR-P-BODY NETWORK;Patrick Brest
Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting [0.03%]
基于大规模高分辨率质谱的蛋白质组学定义鼻咽癌治疗靶点分子亚型
Yi-Ping Wu,Yao-Hui He,Guo-Sheng Hu et al.
Yi-Ping Wu et al.
Challenges in the precise diagnosis and treatment of nasopharyngeal carcinoma (NPC) remain, mainly due to the absence of a multi-omics-based molecular classification and effective targeted therapies. In this study, we performed proteomic an...
Nab-paclitaxel plus S-1 induction chemotherapy for patients with locally advanced pancreatic cancer: a multicenter, open-label phase 2 study [0.03%]
纳米紫杉醇联合S-1新辅助化疗治疗局部晚期胰腺癌患者：一项多中心开放性Ⅱ期临床试验
Zhe Cao,Jiangdong Qiu,Wenhao Luo et al.
Zhe Cao et al.
Locally advanced pancreatic cancer (LAPC) is associated with a poor prognosis and limited therapeutic options. This study aimed to evaluate the efficacy and safety of nab-paclitaxel plus S-1 (SnP) as a first-line treatment in patients with ...
Activity-dependent antioxidant gene therapy protects against epileptogenesis [0.03%]
活性依赖型抗氧化基因疗法对癫痫发病的保护作用
Prince Kumar Singh,Gabriele Lignani,Matthew C Walker et al.
Prince Kumar Singh et al.
Spatially interpretable artificial intelligence framework to tailored neoadjuvant dual HER2 blockade in HER2-positive breast cancer [0.03%]
空间可解释的人工智能框架在HER2阳性乳腺癌新辅助治疗中靶向双重HER2阻断疗法的应用研究
Xiang-Rong Wu,Hong Lv,Shen Zhao et al.
Xiang-Rong Wu et al.
Neoadjuvant dual HER2 blockade with trastuzumab and pertuzumab plus chemotherapy represents the current standard-of-care for HER2-positive breast cancer. However, treatment responses remain heterogeneous, underscoring the lack of clinically...
Targeting N1-methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis [0.03%]
靶向成骨细胞中tRNA甲基转移酶10C的N1-甲基腺苷修饰逆转线粒体功能障碍并改善骨质疏松症
Haijian Sun,Wei Wang,Chi Zhang et al.
Haijian Sun et al.
Osteoporosis is among the most common degenerative systemic bone diseases and is accompanied by abnormally downregulated oxidative phosphorylation (OXPHOS) in osteoblasts. While mutations in the tRNA methyltransferase (TRMT10C) gene in huma...
Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy [0.03%]
靶向细胞内胆固醇不平衡可修复扩张型心肌病中的肌丝-内质网接点信号及内质网重塑问题
Nadezda Ignatyeva,Cleophas Cheruiyot,Hafiza Nosheen Saleem et al.
Nadezda Ignatyeva et al.
Dysregulated intracellular lipid metabolism emerged as a driver of heart failure (HF), a leading cause of death worldwide that is frequently caused by dilated cardiomyopathy (DCM). Yet, how defective lipid signaling destabilizes failing car...
Targeting oncogenic TβRI signaling inhibits androgen-independent prostate cancer growth and metastasis [0.03%]
靶向致癌TβRI信号抑制雄激素非依赖性前列腺癌生长和转移
Per Flodbring Larsson,Alexej Schmidt,Yabing Mu et al.
Per Flodbring Larsson et al.
Metastatic castration-resistant prostate cancer (mCRPC) remains the primary cause of prostate cancer-related mortality. Despite the availability of treatments, the molecular mechanisms underlying tumor invasion and metastasis are not fully ...