Phase 1 pilot study for hemophilia-A: AAV8 vector with prophylactic tacrolimus-glucocorticoid achieves therapeutic FVIII activity [0.03%]
AAV8载体联合预防性他克莫司-糖皮质激素方案治疗甲型血友病I期试点研究取得突破：血液八因子活性水平达到临床疗效阈值
Wei Liu,Xiaolei Pei,Tenghui Yu et al.
Wei Liu et al.
This prospective phase 1 pilot study evaluated the safety and efficacy of GS001, an adeno-associated virus serotype 8 (AAV8)-based vector encoding B-domain-deleted factor VIII with exploratory assessment of prophylactic immunosuppression. T...
Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapy [0.03%]
一种天然启发的限域级联酶纳米反应器用于动脉粥样硬化治疗
Yuehuang Wu,Hongping Xia,He Ding et al.
Yuehuang Wu et al.
Oxidative stress and excessive inflammatory responses are major drivers of atherosclerosis (AS) formation and progression. In this study, we report a nature-inspired nanoreactor (named USPB@SeDMSN@NM) with superoxide dismutase (SOD), catala...
Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: preclinical and clinical analysis [0.03%]
针对Claudin18.2的IL-7/XCL1武装CAR-T细胞在消化道肿瘤中的疗效和免疫调节作用：前期临床和临床分析
Xuan Zhao,Jinyan Liu,Zhen Zhang et al.
Xuan Zhao et al.
Chimeric antigen receptor (CAR)-T cell therapy exerts limited therapeutic efficacy in solid tumors including digestive tract cancer (DTC), which is largely attributable to the suppressive tumor microenvironment (TME) and the functional defi...
Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets [0.03%]
细胞毒性的CD4+T细胞：起源、生物学功能、疾病和治疗靶点
Longyong Lai,Shuan Ran,Yuan Li et al.
Longyong Lai et al.
Cytotoxic CD4+ T lymphocytes are a unique subset of CD4+ T cells characterized by their cytokine secretion and cytolytic activity. Unlike traditional CD4+ helper T cells, cytotoxic CD4+ T lymphocytes exhibit similar cytotoxicity to that of ...
Synergistic immunotherapeutic effects of irreversible electroporation and CAR-NK cell therapy against hepatocellular carcinoma [0.03%]
不可逆电穿孔联合CAR-NK细胞治疗对肝癌的协同免疫效应
Joo Dong Park,Ha Eun Shin,Hye Jung Jang et al.
Joo Dong Park et al.
Chimeric antigen receptor natural killer (CAR-NK) cell therapy has emerged as a promising immunotherapeutic modality with potent cytotoxicity and a favorable safety profile. However, its therapeutic efficacy is often limited by poor infiltr...
Exocyst complex regulates fungal-mediated IL-33 release from cancer cells [0.03%]
异源七聚体外泌体复合物调节癌细胞来源的IL-33释放
Aftab Alam,Shyamananda Singh Mayengbam,Scott I Abrams et al.
Aftab Alam et al.
Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies [0.03%]
器官纤维化的机制见解和新兴治疗策略
Xiangqi Chen,Jinhang Zhang,Ling Guo et al.
Xiangqi Chen et al.
Fibrosis is a maladaptive pathophysiological process characterized by excessive deposition of extracellular matrix resulting from dysregulated tissue repair responses. Fibrosis can affect nearly all organ systems, such as the lung, heart, l...
Personalized pharmacokinetic-pharmacodynamic guided therapy via an induced pluripotent stem cell-derived multi-organoid platform in NF1-mutant breast cancer [0.03%]
通过诱导多能干细胞衍生的多器官芯片平台进行NF1突变型乳腺癌的药代动力学-药效学个性化治疗指导疗法
Jung Hwa Lim,Seon Ju Mun,Hyun Mi Kang et al.
Jung Hwa Lim et al.
Effective precision oncology demands integration of pharmacokinetics/pharmacodynamics (PK/PD) profiling with tumor-specific genomic features. Here, we present a personalized treatment model using a patient-derived Networking Organoid Cultur...
Unleashing the potential of bimetallic nanobomb-mediated STING pathway to enhance bispecific T-cell engager against colorectal cancer photo-immunotherapy [0.03%]
利用双金属纳米炸弹介导的STING途径增强双特异性T细胞衔接剂用于结直肠癌光免疫疗法
Min Mu,Hui Li,Bo Chen et al.
Min Mu et al.
The broader clinical application of Bispecific T-cell engagers (BiTEs) is hindered by their short half-life, on-target off-tumor toxicity, and limited therapeutic effect for solid tumors. Herein, we constructed a bimetallic-enriched triple-...
Yi Zhang,Yanqi Han,Ying Sun et al.
Yi Zhang et al.
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate i...