In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance [0.03%]
用于降解AR和HSP90以克服去势抵抗性前列腺癌的体内自组装纳米型PROTAC
Fei-Ya Yang,Ni-Yuan Zhang,Yang Yang et al.
Fei-Ya Yang et al.
Castration-resistant prostate cancer demonstrates intrinsic or acquired resistance to second-generation androgen-targeted therapies, posing a challenge in clinical treatment. In this study, on the basis of in vivo self-assembly nanotechnolo...
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential [0.03%]
稳态与疾病下的调节性T细胞：分子机制和治疗潜力
Lingling Wang,Ying Liang,Chunxia Zhao et al.
Lingling Wang et al.
Regulatory T cells (Treg cells or Tregs), a subset of CD4⁺ T cells with immunosuppressive properties, are essential for immune homeostasis and self-tolerance. Characterized by their immunosuppressive capabilities and reliance on the transc...
Towards biomarker-driven cancer immunotherapy: the rising of a protein phosphatase regulator [0.03%]
面向生物标志物的癌症免疫疗法：一种蛋白磷酸酶调节因子的崛起
Xiaoyu Liu,Weiqin Yang,Alfred Sze-Lok Cheng
Xiaoyu Liu
Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia [0.03%]
多组学揭示磷脂酰胆碱和鞘磷脂在抗精神病药物治疗精神分裂症中的关键作用
Junyuan Sun,Zhe Lu,Zhewei Kang et al.
Junyuan Sun et al.
Nearly 30% of patients with schizophrenia respond inadequately to current antipsychotics, with unclear markers and mechanisms of antipsychotic efficacy. A total of 208 patients with schizophrenia treated for 6 weeks with oral paliperidone w...
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus [0.03%]
间充质基质细胞通过诱导中性粒细胞聚集和胞外囊泡风暴促进系统性红斑狼疮发病
Qianmin Ou,Luhan Niu,Dandan Wang et al.
Qianmin Ou et al.
Mesenchymal stromal cell (MSC) transplantation has achieved significant clinical benefits for many diseases, such as systemic lupus erythematosus (SLE) and inflammatory diseases. However, the detailed therapeutic mechanism of MSCs is not fu...
The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer [0.03%]
肝脏型磷酸果糖激酶的非-canonical功能增强HDAC抑制剂在癌症中的疗效
Taiyu Shang,Tianyi Jiang,Jiangqi Tan et al.
Taiyu Shang et al.
Zinc-dependent histone deacetylases (HDACs) are pivotal enzymes governing the epigenetic modulation of gene expression through chromatin remodeling. The dysregulated expression of HDACs is intricately linked to various pathological conditio...
First-line treatment with chemotherapy, surufatinib (an angio-immuno kinase inhibitor), and camrelizumab (an anti-PD-1 antibody) for locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II randomized study [0.03%]
化疗、苏泰替尼（一种抗血管生成免疫激酶抑制剂）和卡瑞利珠单抗（一种抗PD-1抗体）一线治疗局部晚期或转移性胰腺导管腺癌：Ib/II期随机研究
Ru Jia,Hai-Yan Si,Meng-Jiao Fan et al.
Ru Jia et al.
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and limited first-line treatments. This phase Ib/II randomized trial (NCT05218889) investigated the efficacy and safety of surufatinib plus camrelizumab and nab-paclitaxel/S-1 (NA...
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma [0.03%]
单细胞RNA测序揭示青光眼的分子和遗传特征
Huaping Tian,Yuhong Chen,Tujing Zhao et al.
Huaping Tian et al.
Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness, involves complex neurodegeneration in which the contribution of systemic immunity remains enigmatic. Here, we dissect the circulating immune landscape in POAG pa...
Decoding lysophosphatidic acid signaling in physiology and disease: mapping the multimodal and multinodal signaling networks [0.03%]
生理和疾病中的溶血磷脂酸信号通路解析：多模态及多节点信号网络构建
Revathy Nadhan,Karthik Nath,Sneha Basu et al.
Revathy Nadhan et al.
Lysophosphatidic acid (LPA) signaling has emerged as a central regulatory axis in both normal physiology and disease, orchestrating diverse cellular processes such as proliferation, survival, migration, immune modulation, and tissue remodel...
CD8+ TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients [0.03%]
新辅助免疫化疗后肿瘤坏死组织中浸润的CD8+t细胞预测非小细胞肺癌患者的预后
Haifeng Lin,Yi Han,Lei Guo et al.
Haifeng Lin et al.
Neoadjuvant immunochemotherapy has shown promising results, with major pathologic response (MPR, ≤10% residual viable tumors [RVT]) as the primary outcome. However, %RVT showed limited predictive power in stratifying outcomes within the MP...