Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells [0.03%]
STAT3特异性中性粒细胞靶向通过增加细胞毒性CD8+T细胞的增殖来抑制肿瘤进展
Irem Ozel,Guanyu Sha,Agnieszka Będzińska et al.
Irem Ozel et al.
Neutrophils have emerged as key players in tumor progression and are often associated with poor prognosis. Despite ongoing efforts to target neutrophil functions in cancer, therapeutic success has been limited. In this study, we addressed t...
Neuronal immunoproteasome and PFKFB3-forced glycolysis: key players in multiple sclerosis [0.03%]
神经免疫蛋白酶体和PFKFB3强制性糖酵解：多发性硬化的关键因素
Claudia Rodríguez-López,Juan P Bolaños,José J Lucas
Claudia Rodríguez-López
Single amino acid substitution in Hendra virus attachment glycoprotein induces cross-neutralizing antibodies against Nipah virus [0.03%]
亨德拉病毒糖蛋白单氨基酸替代诱导尼帕病毒交叉中和抗体产生
Yaohui Li,Xiaoyan Huang,Ruihua Li et al.
Yaohui Li et al.
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses within the Paramyxoviridae family, causing severe respiratory and neurological diseases in humans and animals with fatality rates up to 75%, and no licensed human ...
The deacetylases HDAC1/HDAC2 control JAK2V617F-STAT signaling through the ubiquitin ligase SIAH2 [0.03%]
去乙酰化酶HDAC1/HDAC2通过泛素连接酶SIAH2调控JAK2V617F-STAT信号转导
Al-Hassan M Mustafa,Giuseppe Petrosino,Marten A Fischer et al.
Al-Hassan M Mustafa et al.
Epigenetic modulators of the histone deacetylase (HDAC) family control key biological processes and are frequently dysregulated in cancer. There is superior activity of HDAC inhibitors (HDACi) in patients with myeloproliferative neoplasms (...
Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinoma [0.03%]
酸性卷曲螺旋结构域含跨膜区蛋白3介导的脂质代谢重组抑制肝细胞癌CD8⁺T细胞的胞毒性作用
Ying Li,Zule Chen,Dongdong Wang et al.
Ying Li et al.
Recent evidence has highlighted immune checkpoint inhibitors as among the most promising immunotherapies for various malignancies. However, a significant proportion of HCC patients exhibit poor responses. Lipid metabolic heterogeneity is co...
Disarming a molecular brake: cAMP-responsive element modulator deletion supercharges CAR-NK cells [0.03%]
解除分子制动:cAMP反应元件调节物的缺失可增强CAR-NK细胞功能
Sudheendra Hebbar Subramanyam,Klaus Tenbrock
Sudheendra Hebbar Subramanyam
Adjuvant icotinib for resected EGFR-mutated stage II-IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study [0.03%]
术后EGFR突变II至IIIA期非小细胞肺癌患者辅助艾坦治疗研究（ICTAN，GASTO1002）：一项随机对照研究
Ning Li,Wei Ou,Chao Cheng et al.
Ning Li et al.
The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with resected EGFR-mutated non-small-cell lung cancer (NSCLC) were not known until 2014, whe...
Enrichment of Streptococcus oralis in respiratory microbiome enhance innate immunity and protects against influenza infection [0.03%]
口腔链球菌增强呼吸道微生物组可增强先天免疫并预防流感感染
Xiaohui Zou,Hongyun Cao,Lizhe Hong et al.
Xiaohui Zou et al.
Respiratory microbial dysbiosis has been implicated in the occurrence and progression of community-acquired pneumonia (CAP). However, the dynamic variation in the respiratory microbiota and its interaction with the host response remain poor...
Pain management beyond opioids: a β-arrestin2-biased allosteric GPCR modulator opens new avenues for drug development [0.03%]
阿片类止痛药之外的新途径：一种偏向性激活受体的调节剂开创药物研发新方向
Eline Pottie,Sophie A M Steinmüller,Michael Decker
Eline Pottie
Bone marrow microenvironment in autoimmune hemolytic anemia: from trephine biopsy to single cell RNA sequencing [0.03%]
自身免疫性溶血性贫血的骨髓微环境：从活检到单细胞RNA测序
Bruno Fattizzo,Matteo Claudio Da Vià,Francesca Lazzaroni et al.
Bruno Fattizzo et al.
The role of bone marrow (BM) compensatory response in autoimmune hemolytic anemias (AIHAs) is emerging and inadequate reticulocytosis has been associated with more severe disease and adverse outcomes. However, few is known about the BM immu...