Engineered butyrate-producing yeasts mitigate Alzheimer-associated phenotypes [0.03%]
工程化丁酸盐产生酵母菌可缓解与阿尔茨海默病相关的表型
Biao Zhang,Zhiyu Sun,Weihong Song et al.
Biao Zhang et al.
Benjamin H Mullish,Lauren A Roberts,Horace R T Williams
Benjamin H Mullish
Catheter-based endovascular celiac and hepatic denervation for type 2 diabetes: a multicenter, open-label, single-arm study [0.03%]
经导管内脏神经消融治疗2型糖尿病：一项多中心、开放标签研究
Zhi Wang,Tao Pan,Weifu Lv et al.
Zhi Wang et al.
Sympathetic hyperactivity is crucial driving factor for hyperglycemia in type 2 diabetes (T2D). We conducted a multicenter, open-label, single-arm trial to evaluate the safety and efficacy of endovascular denervation (EDN) targeting the cel...
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors [0.03%]
寡聚半胱氨酸肽酶抑制剂C通过与抑制性受体相互作用支持髓系细胞的免疫抑制活性
Chengcheng Zhang,Yubo He,Xiaoye Liu et al.
Chengcheng Zhang et al.
Amyloid proteins are linked to various diseases; however, their functional roles in immunity and cancer remain unclear. Here, we establish a direct link between oligomeric cystatin C-a cysteine cathepsin inhibitor and a well-characterized a...
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessment [0.03%]
针对SARS-CoV-2 XBB的免疫印记效应及其对疫苗策略和变异风险评估的影响
Xiaoyun Yang,Guichang Li,Yuan Wang et al.
Xiaoyun Yang et al.
The immune imprinting against SARS-CoV-2 subvariants that dynamically evolves through sequential vaccination and infection has been rarely studied. Using antigenic cartography and neutralizing antibody (NAb) profiling, we demonstrate that p...
Reframing cancer cachexia: the vagal brain-liver axis as a novel neuro-metabolic target [0.03%]
从迷走神经脑-肝轴的角度重新认识癌症恶病质：一种新的神经代谢靶点
Daoyan Wei,Xinwen Lin,Robert S Bresalier
Daoyan Wei
Maternal cholesterol deficiency predisposes congenital heart defects risk [0.03%]
母体胆固醇缺乏易诱发先天性心脏病风险
Yayun Gu,Jimiao Gao,Hong Lv et al.
Yayun Gu et al.
The relationship between maternal cholesterol deficiency and the risk of congenital heart defects (CHDs) in offspring is not fully understood. In a birth cohort study of 5041 family trios, we found that low maternal cholesterol levels were ...
Ablation plus immunotherapy versus immunotherapy alone in patients of advanced NSCLC who develop oligo-residual disease after anti-PD-1/L1 therapy (BOOSTER): a randomized phase 2 trial [0.03%]
抗PD-1/L1治疗后发展为寡残留病灶的晚期NSCLC患者中放疗联合免疫治疗对比单用免疫治疗：一项随机II期临床试验（BOOSTER研究）
Shuo Yang,Xinyu Liu,Jia Yu et al.
Shuo Yang et al.
Local consolidative therapy (LCT) has been demonstrated to enhance the survival benefits of immunotherapy in non-small cell lung cancer (NSCLC) patients with oligometastatic or oligoprogressive disease. This randomized, phase 2 trial invest...
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma [0.03%]
KAT2A驱动的SRSF11琥珀酰化通过促进RAD52剪接和同源重组介导肝癌放疗抵抗
Jun Wu,Jingsheng Yuan,Zijian Liu et al.
Jun Wu et al.
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized....