Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma [0.03%]
前列腺素E2驱动的施万细胞去分化导致胰腺导管腺癌的癌周神经侵犯
Ling Wang,Qicai Liu,Zhibo Zhang et al.
Ling Wang et al.
Perineural invasion (PNI), a prominent pathological feature of pancreatic ductal adenocarcinoma (PDAC), is closely associated with poor prognosis. Clarifying its mechanism is therefore critical for developing new therapies. Recent research ...
Suppression of mitochondrial energy production by a photosynthetic bacterial cupredoxin peptide inhibits tumor growth [0.03%]
光合细菌铜蓝蛋白肽通过抑制线粒体能量生成抑制肿瘤生长
Samer A Naffouje,Duy Binh Tran,David J Rademacher et al.
Samer A Naffouje et al.
Accumulating evidence shows that bacteria influence cancer homeostasis, yet the effects of tumor‑associated microbes and their products remain largely unexplored. We previously reported that P. aeruginosa-cancer crosstalk suppresses tumors...
p53: from understanding its structure to advances in therapeutic targeting [0.03%]
从认识p53结构到精准药物研发的进展
Wenhua Wang,Xia Liu,Hengqi Liu et al.
Wenhua Wang et al.
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers and has been a popular area of research in the field of oncology. The p53 protein, encoded by the TP53 gene, not only binds to many targeted genes but also ...
Aditya Shreenivas,Adam Wahida,Razelle Kurzrock
Aditya Shreenivas
Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation [0.03%]
酰基辅酶a结合蛋白（ACBP）：脓毒症中的不良预后生物标志物及疾病缓解靶点
Flavia Lambertucci,Omar Motiño,Uxía Nogueira-Recalde et al.
Flavia Lambertucci et al.
Sepsis remains a major clinical challenge, with high mortality and long-term disability despite current interventions. Here, we identify the tissue hormone acyl-CoA-binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), as ...
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation [0.03%]
糖皮质激素通过抑制H4K12乳酸化提高透明细胞肾细胞癌对HIF-2α抑制剂的敏感性
Kenan Zhang,Lin He,Yizhou Wang et al.
Kenan Zhang et al.
Approximately 70% of clear cell renal cell carcinoma (ccRCC) patients harbor von Hippel‒Lindau (VHL) deficiency, which drives pseudohypoxia and metabolic reprogramming. Here, we report a histone H4 lysine 12 lactylation (H4K12la)-fueled ph...
Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder [0.03%]
伴有快动眼睡眠行为障碍的帕金森病患者特有的代谢组和蛋白质组特征
Yaping Shao,Jing Wang,Yaping Liu et al.
Yaping Shao et al.
Rapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinson's disease (PD), affecting 40-50% of PD patients. PD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more sever...
PRIME-HFrEF Trial: a randomized, double-blind, multi-dose umbilical cord-derived mesenchymal stem cell regimen for heart failure [0.03%]
关于脐带间充质干细胞治疗心力衰竭的随机、双盲、多剂量PRIME-HFREF试验
Wei Han,Yuheng Jiao,Wei Chen et al.
Wei Han et al.
The safety of multi-dose mesenchymal stem cell (MSC) regimens has seldom been systematically investigated. The PRIME-HFrEF (Prospective Randomized Controlled Study of Multiple Intravenous Infusions of Umbilical Cord-derived MSCs in Patients...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Mar 26;11(1):112. DOI:10.1038/s41392-026-02678-5 2026
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer [0.03%]
结直肠癌中短链酰基辅酶a脱氢酶触发线粒体DNA去甲基化和释放以促进抗肿瘤免疫反应
Fang Yang,Meng Wang,Shaofan Hu et al.
Fang Yang et al.
Reprogramming of lipid metabolism and cyclic GMP‒AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is associated with cancer development. However, whether and how fatty acid metabolism regulates the cGAS‒STING pathway i...