A novel antituberculosis agent exhibits potent clinical efficacy and good safety profile: an open-label, randomized-controlled, multicenter, phase 2a trial [0.03%]
一种新型抗结核药物临床疗效佳且安全性好：一项开放标签、随机对照、多中心二期试验
Naihui Chu,Wenjuan Nie,Juan Du et al.
Naihui Chu et al.
Tuberculosis (TB) is a contagious disease that threatens human health worldwide. Combination chemotherapy is usually recommended for this disease. Recently, 2 nitroimidazole-based agents, namely, delamanid and pretomanid, have been approved...
Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer [0.03%]
肝癌中Dysadherin/YAP轴促进干细胞的可塑性和免疫逃逸
Tae-Young Jang,So-El Jeon,Hyeon-Ji Yun et al.
Tae-Young Jang et al.
Hepatocellular carcinoma (HCC) is an aggressive malignancy that is often refractory to chemotherapy and immune checkpoint inhibitors. This therapeutic resistance is driven in part by the persistence of cancer stem-like cells (CSCs) and the ...
Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression [0.03%]
抑制素βA通过巨噬细胞M2极化和线粒体依赖性铁死亡抑制驱动结直肠癌进展
Wentao Li,Lin Liang,Siyi Liu et al.
Wentao Li et al.
Colorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis has not yet been fully elucidated. The tumor microenvironment (TME) and ferroptosis in cancer cells are key drivers of tumor progression and metastasis. This resea...
Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer [0.03%]
RNA结合蛋白的抑制可增强卵巢癌免疫治疗效果
Nadine Bley,Alexander Rausch,Simon Müller et al.
Nadine Bley et al.
High-grade serous ovarian cancer (HGSC) accounts for more than 70% of ovarian cancer-related deaths, yet therapeutic progress remains stagnant. Among the four molecular subtypes reported for HGSC, the C5 subtype is distinguished by high pro...
Correction: Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders [0.03%]
关于自身免疫机制认识的进展和自身免疫性疾病新治法的研究纠正通知
Yi Song,Jian Li,Yuzhang Wu
Yi Song
Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease [0.03%]
工程化的细胞外囊泡通过靶向PD-1和PHB1信号重编程炎症性肠病中的T细胞
Mi-Kyung Oh,Hyun Sung Park,Dong-Hoon Chae et al.
Mi-Kyung Oh et al.
Current therapies for inflammatory bowel disease (IBD) often fail to achieve complete remission and are associated with systemic toxicity owing to their broad immunosuppressive effects. To overcome these limitations, we developed a bioengin...
Lipocalin-2 drives brain metastatic progression through reciprocal tumor-microenvironment interactions in lung cancer [0.03%]
脂川蛋白-2通过肺癌脑转移瘤-微环境的相互作用驱动脑转移进展
Yixiang Zhu,Jian Zhang,Danming He et al.
Yixiang Zhu et al.
Brain metastasis is a major contributor to mortality in patients with lung cancer. The unique microenvironment of the brain plays a critical role in the initiation and progression of brain metastases (BM), yet the molecular mechanisms under...
Anti-MSLN chimeric antigen receptor-like NK cell therapy with tumor-penetrating capacity (uCAR-like NK) for solid tumors [0.03%]
具有肿瘤渗透能力的抗MSLN嵌合抗原受体样NK细胞疗法(uCAR-like NK)治疗实体瘤
Mengchao An,Ying Wang,Jie Shao et al.
Mengchao An et al.
Although natural killer (NK) cells are endowed with intrinsic cytotoxicity, their therapeutic application often faces limitations because of their lack of tumor-specific targeting ability and limited ability to infiltrate solid tumors. To o...
Xiaojuan Yang,Tian Lan,Buzhe Zhang et al.
Xiaojuan Yang et al.
Ubiquitination, a critical posttranslational modification (PTM), involves the enzymatic covalent attachment of ubiquitin to target proteins. This process is fundamental for maintaining cellular homeostasis and regulating key biological func...
Targeting SKAP2 restores sperm motility and morphology through modulating mitochondrial organization and cytoskeletal remodeling [0.03%]
靶向SKAP2通过调节线粒体排列和细胞骨架重塑恢复精子活力和形态
Shiming Gan,Lin Yin,Jiaming Zhou et al.
Shiming Gan et al.
Sperm motility and morphology are indispensable for sperm-egg interaction and successful fertilization. However, the RNA splicing mechanisms in an m6A-dependent manner regulating spermiogenesis-related genes remain poorly defined, and targe...