Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation [0.03%]
一项II期试验：在具有KRAS G12C突变的晚期实体瘤中，GARSORASIB（一种KRAS G12C抑制剂）联合或不联合西妥昔单抗（EGFR抗体）用于结直肠癌患者的临床研究
Dan-Yun Ruan,Hao-Xiang Wu,Ye Xu et al.
Dan-Yun Ruan et al.
Mutations in the KRAS gene have long been implicated in the pathogenesis of colorectal cancer (CRC). KRAS G12C inhibitors overcome the "undruggable" challenge, enabling precision therapy. Garsorasib (D-1553), a highly potent and selective K...
Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage [0.03%]
嘌呤核苷磷酸酶通过嘌呤补救途径主导流感病毒的复制和宿主过度炎症反应
Yang Yue,Qingyu Li,Changguo Chen et al.
Yang Yue et al.
Influenza A virus (IAV) poses a significant threat to human health. The outcome of IAV results from the viral-host interaction, with the underlying molecular mechanisms largely unknown. By integrating the plasma proteomics data of the IAV-i...
Qing Huang,Yuanxiang Li,Yingdan Huang et al.
Qing Huang et al.
Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitabl...
Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting [0.03%]
茎环结合蛋白通过-1程序化核糖体框移促进SARS-CoV-2复制
Tanxiu Chen,Ruimin Zhu,Tingfu Du et al.
Tanxiu Chen et al.
The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins. To date, the host factors influencing this process re...
Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer [0.03%]
利用双效ENPP1/ATM敲低削弱DNA修复能力提高放免疗疗效以治疗三阴性乳腺癌的研究
Borja Ruiz-Fernández de Córdoba,Karmele Valencia,Connor Welch et al.
Borja Ruiz-Fernández de Córdoba et al.
The ATP-hydrolytic ectoenzyme ENPP1 has been implicated in the metastasis and recurrence in triple-negative breast cancer (TNBC), primarily by contributing to tumor cell survival and treatment resistance. However, the precise mechanisms rem...
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances [0.03%]
氧化应激、炎症和衰老情况下的线粒体：从机制到治疗进展
Xieyang Xu,Yan Pang,Xianqun Fan
Xieyang Xu
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces...
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation [0.03%]
Mitsugumin 53通过促进干细胞分化来缓解肠损伤和炎症
Yumeng Pei,Meng Fang,Hong-Kun Wu et al.
Yumeng Pei et al.
Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased linea...
Limited but powerful toolbox: myeloid cells as critical immunomodulators in glioma progression [0.03%]
有限但强大的工具箱：髓系细胞在胶质瘤进展中的关键免疫调节作用
Yun Liu,Jincheng Fang,Roman Sankowski
Yun Liu
Single-cell transcriptional dissection illuminates an evolution of immunosuppressive microenvironment during pancreatic ductal adenocarcinoma metastasis [0.03%]
单细胞转录组解析揭示了胰腺导管腺癌转移过程中免疫抑制微环境的演变规律
Xiaowei Liu,Jinen Song,Meiling Yuan et al.
Xiaowei Liu et al.
How the host immune system loses its surveillance function during the evolution from normal cell to malignancy is still largely unknown. Here, we investigate the dynamics changes of the pancreatic ductal adenocarcinoma (PDAC) tumor microenv...
Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production [0.03%]
微生物代谢物丁酸通过抑制Tfh13介导的IgE产生来缓解哮喘
Baichao Yu,Chong Pei,Wenjun Peng et al.
Baichao Yu et al.
Gut microbiota-derived short-chain fatty acids (SCFAs) impact asthma outcomes, highlighting the importance of understanding the disease mechanisms through the gut-lung axis. In this study, we identified that among SCFAs, butyrate uniquely a...