Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases [0.03%]
血红蛋白的假过氧化物酶活性及其作为氧化应激相关疾病药物靶点的作用
Woojin Won,Elijah Hwejin Lee,Lizaveta Gotina et al.
Woojin Won et al.
Hemoglobin (Hb) is well known for transporting oxygen in the blood, but its role in the brain remains poorly understood. Here, we identified Hb in the cytosol, mitochondria, and nuclei of hippocampal and substantia nigra astrocytes and dopa...
A multicenter single-arm clinical study of Chinese children's cancer group-acute promyelocytic leukemia-2017 (CCCG-APL-2017) protocol [0.03%]
中国儿童急性早幼粒细胞白血病诊疗方案（2017版）多中心单臂临床研究（CCCG-APL-2017）
Lixian Chang,Ju Gao,Xiaoying Lei et al.
Lixian Chang et al.
The Realgar-Indigo Naturalis formula (RIF) is a proprietary Chinese medicine, which is one of the important drugs in the treatment of pediatric acute promyelocytic leukemia (APL). However, the dose of RIF in clinical application is not unif...
Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies [0.03%]
间充质干细胞在治疗人类疾病中的作用：分子机制和临床研究
Xia Han,Rongdong Liao,Xiang Li et al.
Xia Han et al.
Mesenchymal stem cells (MSCs) have emerged as a highly promising strategy in regenerative medicine due to their self-renewal, pluripotency and immunomodulatory properties. MSCs are nonhematopoietic, multipotent stem cells that can different...
Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells [0.03%]
Piezo1介导的机械转导调节组2固有淋巴样细胞的翻译活性、功能和肺部致病性
MinYeong Lim,Seonjun Park,Yoon Ha Joo et al.
MinYeong Lim et al.
Group 2 innate lymphoid cells (ILC2s) are central effectors of type 2 immune responses in the lung; however, how mechanical cues regulate their function remains unclear. Here, we identified the mechanosensitive ion channel Piezo1 as a key r...
Fencing the genome: ubiquitin signaling restricts heterochromatin spread [0.03%]
用泛素信号划界基因组：限制异染色质扩散
Collin Bakker,Joanna Paulson,Nitika Taneja
Collin Bakker
First-line tislelizumab and ociperlimab combined with gemcitabine and cisplatin in advanced biliary tract cancer (ZSAB-TOP): a multicenter, single-arm, phase 2 study [0.03%]
替雷利珠单抗和奥希珀利单抗联合吉西他滨和顺铂作为一线治疗药物用于晚期胆道癌的多中心、开放性、单组Ⅱ期研究(ZSAB-TOP)
Guoming Shi,Xiaoyong Huang,Liang Ma et al.
Guoming Shi et al.
Adding a PD-1/PD-L1 inhibitor to gemcitabine plus cisplatin (GemCis) has shown survival benefits in advanced biliary tract cancer (BTC). Dual inhibition of PD-1/PD-L1 and TIGIT may act synergistically, and further enhance antitumor effects....
F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair [0.03%]
F-box/LRR重复蛋白12通过重新调控小胶质细胞抑制瘢痕形成并实现成人脊髓损伤修复
Xu Xu,Feng Gao,Qixin Chen et al.
Xu Xu et al.
Scarring is an insurmountable obstacle for axonal regeneration in recovery from spinal cord injury (SCI). It impedes the repair effects of therapeutic targets in cortical neurons, such as PTEN-/- and hyper-IL-6, which cannot break through d...
NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts [0.03%]
NADPH氧化酶1/4双抑制作用可削弱转化生长因子-β在胆管癌相关成纤维细胞中的促肿瘤生成效应
Josep Amengual,Ester Gonzalez-Sanchez,Mariana Yáñez-Bartolome et al.
Josep Amengual et al.
Transforming growth factor beta (TGF-β) signalling has become an attractive therapeutic target due to its pro-tumorigenic actions on epithelial cells and its immunosuppressive effects in the tumour microenvironment. In intrahepatic cholang...
DNA/RNA-binding protein KIN17 supports esophageal cancer progression via resolving noncanonical STING activation induced by R-loop [0.03%]
DNA/RNA结合蛋白KIN17通过解析R-loop诱导的非经典STING激活支持食管癌进展
Zichao Wei,Ning Zhao,Lu Kuang et al.
Zichao Wei et al.
Targeting the DNA damage response (DDR) exhibits potent efficacy in inducing immune activation and enhancing patient prognosis. However, the benefits of DDR regulation are not universally observed across all patients, owing to the intricate...
Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis [0.03%]
单细胞RNA测序鉴定出腺肌症治疗新靶点 prolactin receptor
Runze Wang,Shuai Xu,Qionghua Cui et al.
Runze Wang et al.
Adenomyosis is a complex gynecological disease characterized by endometrial tissue invasion into the myometrium. Current interventions, such as hormonal therapy or hysterectomy, are associated with significant side effects and compromise fe...