Extracellular RNA dimension in alternative medicine: processing-dependent integrity and bioactivity of honeysuckle miRNA MIR2911 [0.03%]
外泌rna视角下的替代医学：忍冬miRNA MIR2911的处理依赖性完整性及生物活性
Jieqiong Lei,Yangchao Dong,Yiting Wu et al.
Jieqiong Lei et al.
What's past is prologue: epigenetic memory links transient inflammation to future disease [0.03%]
往事不忘──表观遗传记忆链接短暂的炎症和未来的疾病
Samuel T Keating,Assam El-Osta
Samuel T Keating
Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells [0.03%]
肿瘤细胞治疗进展与前景——从T细胞到干细胞探索
Guisha Zi,Lei Zhang,Ling Zhou et al.
Guisha Zi et al.
The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolving rapidly from the successful application of chimeric antigen receptor T (CAR-T) cells i...
Tetrahedral DNA nano-PROTACs enable enhanced ocular penetration and efficient nucleolin degradation for choroidal neovascularization therapy [0.03%]
四面体DNA纳米分子胶降解核糖核酸结合蛋白核糖核酸酶，治疗脉络膜新生血管病
Jiayi Song,Xu Wei,Kai He et al.
Jiayi Song et al.
Despite the paradigm shift brought about by anti-VEGF therapy against neovascular age-related macular degeneration, significant challenges persist, including the risk of intraocular infection and retinal structural damage caused by frequent...
Xiaochi Sun,Xinmeng Wang,Ruikun Jia et al.
Xiaochi Sun et al.
The rise of biologics, including recombinant proteins, gene therapies, and cell therapies, is reshaping the landscape of modern therapeutics, offering new strategies to address previously "undruggable" targets. Cardiovascular diseases (CVDs...
Correction: Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir [0.03%]
关于新型溴西多福韦和(S)-9-[3-羟基-2-(膦酸甲氧基)丙基]鸟苷衍生物的更正：这些化合物比溴西多福韦更高效地抑制正痘病毒和人类腺病毒
Yifan Zhang,Yanmin Wan,Cuiyuan Guo et al.
Yifan Zhang et al.
Heli Wang,Zhuang Miao,Chang Zhao et al.
Heli Wang et al.
Opioid analgesics provide potent pain relief but are limited by severe adverse effects, tolerance, and interindividual genetic variability in response. Poly-pharmacology and allosteric modulation of opioid receptors offer promising strategi...
Potent anti-tumor activity of CD98hc-targeted antibody-drug conjugates in ovarian cancer [0.03%]
以CD98hc为靶点的抗体药物偶联物在卵巢癌中的抗肿瘤活性
Juan Carlos Montero,Verónica Fraile Rivero,María José Doyague et al.
Juan Carlos Montero et al.
Ovarian cancer remains a challenging malignancy with high recurrence rates and limited long-term therapeutic success. Antibody-drug conjugates (ADCs) represent a promising therapeutic class capable of delivering potent cytotoxic agents sele...
TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity [0.03%]
TWIK-1在控制机械敏感性和神经病理性超敏反应的脊髓和外周感觉电路中发挥不同的作用
Seo Young Yang,Tery Yun,Yunjeong Lee et al.
Seo Young Yang et al.
Ion channels are essential for sensing somatic stimuli, and their dysregulation can cause chronic conditions such as neuropathic pain. Although the potassium channel Twik-1 has been linked to sensory processing, its specific roles in the so...
Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses [0.03%]
利巴韦林喷鼻清除鼻部共生病毒治疗过敏性鼻炎
Ye Zhou,Tianyu Wang,Yiwen Fan et al.
Ye Zhou et al.
Much attention has focused on commensal bacteria in health and disease, but the role of commensal viruses is largely unexplored. Although commensal viruses are suggested in some organs such as intestine to maintain tissue homeostasis, it is...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Jun 26;11(1):249. DOI:10.1038/s41392-026-02744-y 2026