Hayley M Sabol,Lorenzo Galluzzi,Lucia Borriello
Hayley M Sabol
mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics [0.03%]
mTOR信号网络：疾病治疗中的机制见解和转化前沿
Hanxiao Zhang,Xia Xiao,Zhenrui Pan et al.
Hanxiao Zhang et al.
The mammalian target of rapamycin (mTOR) pathway is a central regulator of cellular growth, metabolism, and homeostasis, integrating a wide array of intracellular and extracellular cues, including nutrient availability, growth factors, and ...
When vaccines reset tumors: SARS-CoV-2 mRNA shots create a transient checkpoint-sensitive state [0.03%]
当疫苗重置肿瘤时：SARS-CoV-2 mRNA疫苗产生一种短暂的检查点敏感状态
Hao Chi,Michele Carbone,Youping Deng
Hao Chi
Low density lipoprotein receptor-related protein 8: a critical receptor for tick-borne encephalitis virus entry [0.03%]
低密度脂蛋白受体相关蛋白8：一种重要的发热性伴血小板减少综合征病毒宿主细胞受体
Pengtao Jiao,Lin Du,Yan Zeng
Pengtao Jiao
A novel antituberculosis agent exhibits potent clinical efficacy and good safety profile: an open-label, randomized-controlled, multicenter, phase 2a trial [0.03%]
一种新型抗结核药物临床疗效佳且安全性好：一项开放标签、随机对照、多中心二期试验
Naihui Chu,Wenjuan Nie,Juan Du et al.
Naihui Chu et al.
Tuberculosis (TB) is a contagious disease that threatens human health worldwide. Combination chemotherapy is usually recommended for this disease. Recently, 2 nitroimidazole-based agents, namely, delamanid and pretomanid, have been approved...
Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer [0.03%]
肝癌中Dysadherin/YAP轴促进干细胞的可塑性和免疫逃逸
Tae-Young Jang,So-El Jeon,Hyeon-Ji Yun et al.
Tae-Young Jang et al.
Hepatocellular carcinoma (HCC) is an aggressive malignancy that is often refractory to chemotherapy and immune checkpoint inhibitors. This therapeutic resistance is driven in part by the persistence of cancer stem-like cells (CSCs) and the ...
Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression [0.03%]
抑制素βA通过巨噬细胞M2极化和线粒体依赖性铁死亡抑制驱动结直肠癌进展
Wentao Li,Lin Liang,Siyi Liu et al.
Wentao Li et al.
Colorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis has not yet been fully elucidated. The tumor microenvironment (TME) and ferroptosis in cancer cells are key drivers of tumor progression and metastasis. This resea...
Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer [0.03%]
RNA结合蛋白的抑制可增强卵巢癌免疫治疗效果
Nadine Bley,Alexander Rausch,Simon Müller et al.
Nadine Bley et al.
High-grade serous ovarian cancer (HGSC) accounts for more than 70% of ovarian cancer-related deaths, yet therapeutic progress remains stagnant. Among the four molecular subtypes reported for HGSC, the C5 subtype is distinguished by high pro...
Correction: Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders [0.03%]
关于自身免疫机制认识的进展和自身免疫性疾病新治法的研究纠正通知
Yi Song,Jian Li,Yuzhang Wu
Yi Song
Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease [0.03%]
工程化的细胞外囊泡通过靶向PD-1和PHB1信号重编程炎症性肠病中的T细胞
Mi-Kyung Oh,Hyun Sung Park,Dong-Hoon Chae et al.
Mi-Kyung Oh et al.
Current therapies for inflammatory bowel disease (IBD) often fail to achieve complete remission and are associated with systemic toxicity owing to their broad immunosuppressive effects. To overcome these limitations, we developed a bioengin...