Serpina3c protects against metabolic dysfunction-associated steatotic liver disease in offspring induced by prenatal prednisone exposure [0.03%]
孕期皮质醇暴露诱导子代肝脏糖脂代谢异常及SERPINA3C的保护作用机制研究
Yongguo Dai,Zhengjie Lu,Yu Peng et al.
Yongguo Dai et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major global public health problem, and its occurrence is associated with adverse environmental exposures during development. In this study, we investigated the i...
Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy [0.03%]
外源性EBNA1诱导ADAR1介导的肿瘤免疫治疗抵抗作用
Changlin Liu,Zhiqiang Sun,Chao Li et al.
Changlin Liu et al.
Immune checkpoint blockade (ICB) therapy continues to face limitations due to tumor resistance linked to suppressed interferon (IFN) signaling. This suppression can be attributed to multiple mechanisms, among which viral pathogens represent...
A novel necroptosis pathway: orchestrated by non-canonical STING-ZBP1 signaling [0.03%]
一种新的坏死性凋亡通路：由非经典STING-ZBP1信号传导介导
Xiangyu Zhu,Sijia Liu,Long Zhang
Xiangyu Zhu
Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes [0.03%]
环指蛋白213通过调节B细胞受体信号传导、代谢和发育在B淋巴细胞中发挥作用
Ziyin Zhang,Nanshu Xiang,Qian Liu et al.
Ziyin Zhang et al.
The development and function of B lymphocytes require the precise integration of signaling, transcriptional networks, and metabolic programs. While interferon (IFN)-inducible proteins can bridge innate and adaptive immunity, their roles in ...
PKC-eta promotes breast cancer metastasis by regulating the Hippo-YAP signaling pathway [0.03%]
PKC-η通过调节Hippo-YAP信号通路促进乳腺癌转移
Vijayasteltar B Liju,Kamran Waidha,Amitha Muraleedharan et al.
Vijayasteltar B Liju et al.
Triple-negative breast cancer (TNBC) is an aggressive disease characterized by high metastatic potential and limited treatment options. Protein kinase C-eta (PKCη), an antiapoptotic kinase of the novel PKC subfamily, is associated with poo...
Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry [0.03%]
SARS-CoV-2入侵过程中胆固醇依赖性膜融合的分子机制
Wei Li,Mengdan Wu,Shirong Feng et al.
Wei Li et al.
Enveloped virus invasion relies on spike glycoprotein-mediated membrane fusion. Cholesterol that serves crucial roles in modulating protein conformations and membrane properties, plays an essential role in the severe acute respiratory syndr...
Zhenghao Li,Wende Deng,Lanxuan Yang et al.
Zhenghao Li et al.
Lipid metabolism is essential for maintaining cellular homeostasis, and its dysregulation is linked to various diseases, including cancer, cardiovascular disease, and diabetes. Immune cells, such as macrophages, T cells, B cells, and neutro...
Long-term follow-up demonstrates the curative potential of dual CD19/CD22 CAR-T-cell therapy alone or combined with autologous stem cell transplantation in TP53-altered relapsed/refractory B-cell non-Hodgkin lymphoma [0.03%]
长期随访证明，双特异性CD19/CD22 CAR-T细胞疗法或联合自体干细胞移植可作为TP53突变复发难治B细胞非霍奇金淋巴瘤的潜在根治手段
Zekai Mao,Juan Peng,Yang Cao et al.
Zekai Mao et al.
The prognostic implications of TP53 alterations in patients with relapsed or refractory (r/r) aggressive B-cell non-Hodgkin lymphoma (B-NHL) treated with chimeric antigen receptor (CAR) T-cell therapy remain inadequately characterized, part...
Targeting coronaviral inflammation: aptamer-based strategies for emerging threats [0.03%]
靶向冠状病毒炎性：应对新发威胁的适配体策略
Yongyun Zhao,Gang Yang,Zhaoyong Zhang et al.
Yongyun Zhao et al.
Coronaviruses have repeatedly emerged in recent years, causing significant and ongoing threats to global public health. The development of therapeutic agents and strategies capable of responding to future outbreaks caused by emerging corona...
Ruihan Luo,Haixia Xu,Qingbo Zhou et al.
Ruihan Luo et al.
RNA modifications represent a dynamic layer of gene expression regulation, RNA stability, and translation with profound implications for cellular function and disease. However, the critical regulation and functions of RNA-modifying proteins...