Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry [0.03%]
SARS-CoV-2入侵过程中胆固醇依赖性膜融合的分子机制
Wei Li,Mengdan Wu,Shirong Feng et al.
Wei Li et al.
Enveloped virus invasion relies on spike glycoprotein-mediated membrane fusion. Cholesterol that serves crucial roles in modulating protein conformations and membrane properties, plays an essential role in the severe acute respiratory syndr...
Zhenghao Li,Wende Deng,Lanxuan Yang et al.
Zhenghao Li et al.
Lipid metabolism is essential for maintaining cellular homeostasis, and its dysregulation is linked to various diseases, including cancer, cardiovascular disease, and diabetes. Immune cells, such as macrophages, T cells, B cells, and neutro...
Long-term follow-up demonstrates the curative potential of dual CD19/CD22 CAR-T-cell therapy alone or combined with autologous stem cell transplantation in TP53-altered relapsed/refractory B-cell non-Hodgkin lymphoma [0.03%]
长期随访证明，双特异性CD19/CD22 CAR-T细胞疗法或联合自体干细胞移植可作为TP53突变复发难治B细胞非霍奇金淋巴瘤的潜在根治手段
Zekai Mao,Juan Peng,Yang Cao et al.
Zekai Mao et al.
The prognostic implications of TP53 alterations in patients with relapsed or refractory (r/r) aggressive B-cell non-Hodgkin lymphoma (B-NHL) treated with chimeric antigen receptor (CAR) T-cell therapy remain inadequately characterized, part...
Targeting coronaviral inflammation: aptamer-based strategies for emerging threats [0.03%]
靶向冠状病毒炎性：应对新发威胁的适配体策略
Yongyun Zhao,Gang Yang,Zhaoyong Zhang et al.
Yongyun Zhao et al.
Coronaviruses have repeatedly emerged in recent years, causing significant and ongoing threats to global public health. The development of therapeutic agents and strategies capable of responding to future outbreaks caused by emerging corona...
Ruihan Luo,Haixia Xu,Qingbo Zhou et al.
Ruihan Luo et al.
RNA modifications represent a dynamic layer of gene expression regulation, RNA stability, and translation with profound implications for cellular function and disease. However, the critical regulation and functions of RNA-modifying proteins...
Ulcerative colitis: signaling pathways, therapeutic targets and interventional strategies [0.03%]
溃疡性结肠炎：信号传导途径、治疗靶点及干预策略
Jinhao Jia,Ying Liu,Dan Wang et al.
Jinhao Jia et al.
Ulcerative colitis (UC) is the most common chronic inflammatory disease of the intestinal tract in clinical practice, and long-term chronic inflammation leads to repeated damage to and repair of the colonic mucosa, which may progress to mal...
Investigation of a clinical trial drug VV261 as a potent antiviral candidate against Chikungunya virus [0.03%]
VV261 抗 chikungunya 病毒临床试验研究探索性实验
Yumin Zhang,Sheng Tang,Lu Chen et al.
Yumin Zhang et al.
Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair [0.03%]
利用四面体DNA纳米结构递送生物可切换三miR-22实现眼内新生血管和神经退行病变的治疗
Qiong Wang,You Wang,Li Chen et al.
Qiong Wang et al.
Ocular neovascular and neurodegenerative diseases, such as diabetic retinopathy and age-related macular degeneration, are characterized by abnormal angiogenesis, vascular leakage, and progressive retinal neurodegeneration, ultimately leadin...
Immunogenic relationship mapping supports a minimal-set trivalent vaccine strategy for broad sarbecovirus protection [0.03%]
免疫相关性映射支持用于广谱sarbecovirus保护的三联疫苗最小组分策略
Yeqing Sun,Ziqi Cheng,Xi Wu et al.
Yeqing Sun et al.
Major outbreaks of severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19), together with the continuous risk of zoonotic spillover of animal sarbecoviruses, underscore the urgent need for vaccines that confer broad...
Spatial dynamics in health and disease: from neurodevelopment to therapeutic target identification for inflammatory diseases [0.03%]
从神经发育到炎症疾病的治疗靶点鉴定：健康和疾病的空间动态学研究
Matteo Barberis,Jinkun Xie
Matteo Barberis