VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes [0.03%]
去泛素化AMPKγ1并阻止心脏肌细胞中AMPKα-γ亚基组装的VCPIP1驱动糖尿病心肌病
Xue Han,Zhuqi Huang,Guoxuan Liu et al.
Xue Han et al.
Protein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined. This study sought to delineate...
Targeting EHMT2 overcomes 5-fluorouracil resistance in colorectal cancer by modulating cell cycle and apoptosis [0.03%]
靶向EHMT2通过调节细胞周期和凋亡克服结直肠癌对氟尿嘧啶的耐药性
In Hwan Tae,Yunsang Kang,Jinkwon Lee et al.
In Hwan Tae et al.
5-Fluorouracil (5-FU) is a first-line chemotherapy commonly used to treat colorectal cancer (CRC). However, the development of acquired resistance to 5-FU remains a significant clinical challenge, and the underlying epigenetic mechanisms ar...
Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinoma [0.03%]
干扰SOX2自关联和凝聚物形成以克服肺鳞状细胞癌对化疗药物的耐药性
Juehan Wang,Yulin Wen,Sainan Huang et al.
Juehan Wang et al.
Chemotherapy remains a primary treatment for lung squamous cell carcinoma (LSCC), and its efficacy is limited due to drug resistance; however, the mechanisms involved in drug resistance are still unclear. In this study, we identify a signif...
A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections [0.03%]
一种基于纳米抗体的蛋白降解嵌合体可提供广谱保护以抵御各种流感病毒感染
Yichao Zhuang,Lei Chen,Chen Qin et al.
Yichao Zhuang et al.
Influenza A viruses continue to pose a major threat to global public health. In addition to H1N1 and H3N2 subtypes causing seasonal epidemics that result in an estimated 3-5 million severe cases and 290,000-650,000 deaths annually, other su...
Clinical translational research on stem cell products: prospects and challenges [0.03%]
干细胞产品的临床转化研究：前景与挑战
Shuang Chen,Lin Zhang,Yushuang Ren et al.
Shuang Chen et al.
Stem cell therapy has shown significant efficacy as a viable treatment for several resistant diseases. Despite the increasing number of stem cell products on the market worldwide, the clinical translational application of stem cell products...
HILL: the efficacy and safety of hepatic arterial infusion chemotherapy with the FOLFOX regimen combined with lenvatinib and the PD-L1 inhibitor durvalumab in unresectable hepatocellular carcinoma: a prospective, single-arm, phase 2 clinical trial [0.03%]
肝动脉灌注FOLFOX联合仑伐替尼和Durvalumab治疗不可切除的肝细胞癌：一项前瞻性单臂二期临床试验
Shao-Hua Li,Zhi-Jun Zuo,Liang-He Lu et al.
Shao-Hua Li et al.
Despite numerous available treatment options, the overall prognosis for patients with unresectable hepatocellular carcinoma (uHCC) remains poor. This study aimed to evaluate the efficacy and safety of combining hepatic arterial infusion che...
Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment [0.03%]
质子感应GPR65介导的肿瘤免疫抑制微环境的研究
Natalia Truong-Andrievici,Jean-Fred Fontaine,Sebastian Kunz et al.
Natalia Truong-Andrievici et al.
Hypoxia-driven microRNA-27b underlies pathologic cardiac endoreplication in heart disease [0.03%]
缺氧驱动的微小核糖核酸-27b在心脏病理性心肌内倍性中发挥关键作用
Peter Mirtschink,Ting Yuan,Corinne Bischof et al.
Peter Mirtschink et al.
Heart disease is characterized by stress-induced endoreplication preceding pathological cardiomyocyte overgrowth, yet the upstream regulatory mechanisms linking tissue hypoxia to aberrant cellular growth remain incompletely defined. Here, w...
Investigating the effects and underlying mechanisms of glycosylation sites on the immunogenicity of COVID-19 vaccines [0.03%]
糖基化位点对新冠肺炎疫苗免疫原性影响及其机制研究
Heru Wang,Xiang Li,Peng He et al.
Heru Wang et al.
Glycosylation plays a pivotal role in modulating the structure and immunogenicity of viral antigens. Three glycosylation sites on the receptor-binding domain (RBD) of SARS-CoV-2, including N331, N343 (N-linked), and T323 (O-linked), are hig...
A specific stem cell program and CD112 immunological axis dysfunctions underpinning monosomy 7-associated myeloid neoplasms [0.03%]
基于染色体7单体相关骨髓肿瘤的特定干细胞程序和CD112免疫轴功能障碍
Anair Graciela Lema Fernandez,Carlotta Nardelli,Martina Quintini et al.
Anair Graciela Lema Fernandez et al.
Monosomy 7 (-7) is occurring as isolated change or in complex karyotypes in 10-20% of myeloid neoplasms with poor prognosis. Although several genes mapping at chromosome 7 have been involved in pathogenetic mechanisms, the -7 molecular land...