Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets [0.03%]
肿瘤和炎症中免疫细胞的迁移：分子机制与治疗靶点
Yufeng Lu,Di Shao,Yi Xiao et al.
Yufeng Lu et al.
Cancer and inflammatory diseases are critically influenced by dynamic interactions between pathological tissues and the host immune system. The precise migration of immune cells into the local microenvironments of tumors or inflammation is ...
RAF1 extrachromosomal DNA amplification confers acquired erlotinib resistance in a non-small cell lung cancer cell model [0.03%]
RAF1染色体外DNA扩增通过非小细胞肺癌细胞模型获得了对厄洛替尼的继发性耐药性
Sujin Kim,Boyoon Kim,Ahjin Lim et al.
Sujin Kim et al.
A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases [0.03%]
一种分子胶能诱发异常的STING寡聚化并抑制自身炎症性疾病
Zi-Wen Feng,Ting Zeng,Qing Shu et al.
Zi-Wen Feng et al.
Dysregulated activation of the stimulator of interferon genes (STING) pathway underlies various inflammatory and autoimmune pathologies. Since STING oligomerization is fundamental to its biological function, targeted modulation of this poly...
β-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation [0.03%]
靶向β细胞的RNA激活血管内皮生长因子-A可改善胰岛移植效果
Dimitri Van Simaeys,Per-Olof Berggren
Dimitri Van Simaeys
Pancreatic islet transplantation can restore insulin production in patients with severe diabetes, but donor material is scarce, and early engraftment is constrained by inflammatory and mechanical stress and a prolonged avascular phase, duri...
Peptide-targeted cubosome and hexosome nanoassemblies mitigate mitochondrial dysfunction in a MitoPark model [0.03%]
肽靶向立方组装体和六方组装体纳米结构可缓解MitoPark模型中的线粒体功能障碍
Thelma Akanchise,Fucen Luo,Borislav Angelov et al.
Thelma Akanchise et al.
Mitochondrial dysfunction is a primary pathogenic mechanism underlying dopaminergic neuron loss in the nigrostriatal pathway in Parkinson's disease (PD). To investigate mitochondrion-targeted therapeutic strategies, we utilized the MitoPark...
Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress [0.03%]
两种应激响应蛋白激酶通过轻度氧化性压力下激活抗氧化程序来抑制铁死亡
Yumiko Fujikawa,Hirotatsu Imai,Tetsuo Onuki et al.
Yumiko Fujikawa et al.
Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce...
Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology [0.03%]
靶向免疫代谢轴可逆转正畸导致的全身病理变化
Yuning Zhang,Shengjie Jiang,Huimin Zheng et al.
Yuning Zhang et al.
Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently ex...
Cancer drug response and resistance: molecular mechanisms and combating strategies [0.03%]
抗癌药效和耐药性的分子机制及应对策略
Xiaoxia Cheng,Miaochun Xu,Juncheng Wei et al.
Xiaoxia Cheng et al.
Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resista...
BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage-fibroblast interactions to attenuate pulmonary fibrosis [0.03%]
BCL9抑制通过调节巨噬细胞-成纤维细胞相互作用促进成纤维细胞脂质生成以减轻肺纤维化
Wenjie Wang,Yuan Zhang,Fenglian He et al.
Wenjie Wang et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. T...
Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain [0.03%]
铁死亡调控增强新型化学鸡尾酒诱导的血肿脑星形胶质细胞重编程为神经元能力
Jingyi Wang,Shiling Chen,Jiarui Li et al.
Jingyi Wang et al.
Intracerebral hemorrhage (ICH) leads to significant neuronal loss and glial scar formation, but the regenerative capacity of the adult brain remains limited. Although small-molecule-induced astrocyte-to-neuron (AtN) conversion has shown pro...