Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies [0.03%]
利用巨噬细胞信号通路和工程化技术开发下一代免疫疗法
Daniela Paasch,Kathrin Haake,Chloe Kan et al.
Daniela Paasch et al.
Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional divers...
Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes [0.03%]
果糖通过直接重塑极性膜转运蛋白来损害足细胞的氧化磷酸化
Wenyuan Wu,Wenhe Wang,Jingzi Zhang et al.
Wenyuan Wu et al.
Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure ...
Alzheimer's disease: erasing the peptidyl-arginine deiminase 2 (PAD2) stamp to restore microglial defense [0.03%]
擦除肽精氨酸脱氨酶2(PAD2)印迹可恢复小胶质细胞防御以治疗阿尔茨海默病
Xiya Shen,Shengya Wang,Weihong Song
Xiya Shen
Temperature-sensitive liquid embolic agent transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for BCLC Stage B/C hepatocellular carcinoma: a multicenter real-world study and spatial transcriptomics profiling (CHANCE 2515) [0.03%]
温度敏感载药栓塞微球与药物洗脱珠经导管动脉化疗栓塞治疗巴塞罗那分期B/C期肝细胞癌的多中心真实世界研究和空间转录组学分析(CHANCE 2515)
Qingyun Xie,Ying Yang,Sinan Xie et al.
Qingyun Xie et al.
Transarterial chemoembolization (TACE) remains a cornerstone therapy for intermediate-to-advanced hepatocellular carcinoma (HCC); however, the optimal embolic platform remains uncertain. This multicenter, retrospective, real-world study (Cl...
Observational Study
Signal transduction and targeted therapy. 2026 Aug 11;11(1):329. DOI:10.1038/s41392-026-02953-5 2026
Temperature-sensitive liquid embolic agent transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for BCLC Stage B/C hepatocellular carcinoma: a multicenter real-world study and spatial transcriptomics profiling (CHANCE 2515) [0.03%]
温度敏感载药栓塞微球与药物洗脱 beads 经导管动脉化疗栓塞治疗 BCLC 中/晚期肝细胞癌的多中心真实世界研究及空间转录组学分析（CHANCE 2515）
Qingyun Xie,Ying Yang,Sinan Xie et al.
Qingyun Xie et al.
Transarterial chemoembolization (TACE) remains a cornerstone therapy for intermediate-to-advanced hepatocellular carcinoma (HCC); however, the optimal embolic platform remains uncertain. This multicenter, retrospective, real-world study (Cl...
Observational Study
Signal transduction and targeted therapy. 2026 Aug 11;11(1):329. DOI:10.1038/s41392-026-02953-5 2026
C-MET tyrosine kinase receptor: mechanisms, clinical applications and future perspectives in cancer therapy [0.03%]
C- MET酪氨酸激酶受体：机制、临床应用及癌症治疗中的未来展望
Chenjing Zhu,Yue Li,Hanzi Xu et al.
Chenjing Zhu et al.
The high incidence and mortality rates of tumors have resulted in significant social and economic burdens, posing a major global threat to human life and societal development. In recent years, molecular targeted therapy for tumors has becom...
CAR T cell therapy beyond cancer: current status, challenges and future prospects [0.03%]
CAR-T细胞治疗在癌症之外的疾病中的应用：现状、挑战与未来前景
Saurabh Upadhyay,Sungwoo Cho,Kirti Upmanyu et al.
Saurabh Upadhyay et al.
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized oncology, and its foundational logic-precise antigen recognition coupled with durable effector activity-extends naturally to chronic non-malignant diseases sustained by long-...
Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression [0.03%]
缺氧通过HIF-2α刺激的E1A表达增强溶瘤腺病毒的活性
Egon J Jacobus,Véronique N Lafleur,Kerry D Fisher et al.
Egon J Jacobus et al.
Hypoxia, a hallmark of solid tumors, poses a significant challenge in cancer therapy due to its association with poor prognosis and resistance to conventional treatments. Oncolytic viruses represent a promising treatment strategy, as they s...
Cong Xie,Ying Wei,Chang Su et al.
Cong Xie et al.
Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), ...
Cong Xie,Ying Wei,Chang Su et al.
Cong Xie et al.
Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), ...