Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis [0.03%]
内皮GABA通过抑制内皮和线粒体功能障碍维持血管稳态来预防主动脉夹层
Lianbo Shao,You Yu,Haoyue Huang et al.
Lianbo Shao et al.
Thoracic aortic dissection (TAD) is a highly lethal vascular condition closely associated with endothelial cell (EC) dysfunction. γ-Aminobutyric acid (GABA) can be synthesized in ECs and modulate cell functions; however, its underlying rol...
Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance [0.03%]
肿瘤来源的DNA通过促进网织红细胞清除来驱动癌症相关性贫血
Ting Yuan,Xuebing Liu,Yucui Wu et al.
Ting Yuan et al.
Anemia is one of the most prevalent systemic complications in patients with cancer, substantially impairing quality of life and limiting the safe administration of cytoreductive therapies. Despite its clinical significance, the mechanisms b...
Michelle C C Lim,Gunter Maubach,Michael Naumann
Michelle C C Lim
Macrophage metabolic reprogramming by vanadium released from glucose-responsive bio-gel accelerates diabetic wound repair [0.03%]
释放钒的葡萄糖响应生物凝胶重塑巨噬细胞代谢以加速糖尿病伤口愈合
Jiangfeng Li,Zheng Li,Lili Han et al.
Jiangfeng Li et al.
Dysregulated glucose metabolism in diabetic wound macrophages impairs polarization toward the reparative M2 phenotype, leading to compromised innate immunity, chronic inflammation, and delayed wound healing. However, effective strategies to...
Sexual dimorphism of COVID-19 inspires drug repositioning and host-targeting immunotherapy for viral pneumonia [0.03%]
新冠肺炎性别二态性启发老药新用和靶宿主免疫治疗肺炎病毒感染
Lunzhi Yuan,Haiqing Xiao,Xuan Liu et al.
Lunzhi Yuan et al.
Sexual hormones play an important role in modulating disease outcome of COVID-19. The interplay between viral replication, host immune responses, pathology process and sexual hormone levels are complicated, and the underlying mechanisms rem...
Temporal assessment of behavior in Parkinson's visual hallucinations via a multidimensional analysis strategy [0.03%]
帕金森病视觉幻视多维度分析策略下的纵向行为评估研究
Quan-Xin Zhang,Yi-Xuan Zhang,Chen-Chen Jiang et al.
Quan-Xin Zhang et al.
Visual hallucination (VH) is a common nonmotor symptom of Parkinson's disease (PD). However, the lack of reliable animal models and quantitative assessment tools poses significant challenges for mechanism and intervention research in this a...
Preventing trogocytosis by cathepsin B inhibition augments CAR T-cell function [0.03%]
通过猫氨酸B抑制防止细胞内吞作用可增强CAR-T细胞的功能
Kenneth A Dietze,Kiet Nguyen,Aashli Pathni et al.
Kenneth A Dietze et al.
Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in cancer treatment. Nevertheless, most patients receiving CAR T cells relapse within 5 years of treatment. CAR-mediated trogocytosis (CMT) is a potential tumor es...
Surface CD81 supports leukemia stem cell function and reveals a therapeutic vulnerability in acute myeloid leukemia [0.03%]
表面CD81支持白血病干细胞功能并揭示了急性髓系白血病的治疗弱点
Fanny Gonzales,Pauline Peyrouze,Djohana Laurent et al.
Fanny Gonzales et al.
Relapse remains the leading cause of mortality in acute myeloid leukemia (AML), largely due to the persistence of therapy-resistant leukemia stem cells (LSCs). However, surface determinants that sustain LSC function and disease aggressivene...
Sirolimus plus roxadustat synergistically enhances immunosuppression and erythropoiesis in pure red cell aplasia: a multicenter trial [0.03%]
西罗莫司联合罗沙克苏马刺激纯红细胞再生免疫抑制和促红细胞生成的协同作用：多中心试验
Hong Wang,Qingyuan Wang,Shan Liu et al.
Hong Wang et al.
Acquired pure red cell aplasia (aPRCA) is rare and challenging to treat. We investigated the efficacy and safety of sirolimus plus roxadustat in patients with aPRCA (Chinese Clinical Trial Register number, ChiCTR2200065107). We enrolled 82 ...
Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets [0.03%]
心血管衰老：标志物、信号通路、疾病及治疗靶点
Pingjing Zheng,Wendi Yan,Yangnan Ding et al.
Pingjing Zheng et al.
Cardiovascular disease (CVD) predominantly affects elderly individuals and is the leading cause of morbidity, disability, and mortality worldwide. Systemic ageing, especially cardiovascular ageing, contributes to the development of CVD phen...