Yi Zhang,Yanqi Han,Ying Sun et al.
Yi Zhang et al.
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate i...
CRISPR gene editing of angiopoietin-like 3: toward one-time precision therapy for dyslipidaemia [0.03%]
针对血管生成素样蛋白3的CRISPR基因编辑技术：一次治疗血脂异常的新途径
Amandeep Mondal,Ashish Misra
Amandeep Mondal
Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer [0.03%]
利用脂质驱动的免疫代谢途径增强卵巢癌患者腹膜转移灶的免疫治疗
Meggy Suarez-Carmona,Mareike Hampel,Xin-Wen Zhang et al.
Meggy Suarez-Carmona et al.
Immunotherapy with immune checkpoint blockade (ICB) in epithelial ovarian carcinoma (EOC) shows limited clinical benefit only for a small subset of patients. Overall response rates are low, so that overcoming immunotherapy resistance and im...
Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR [0.03%]
通过无酶活性dCas9VPR增强心肌细胞中KLF15的活性：防止病理重编程和纤维化的新型方法
Eric Schoger,Rosa Kim,Federico Bleckwedel et al.
Eric Schoger et al.
Transcriptional activity perturbation holds promise for selectively modulating harmful transcriptional networks, but its therapeutic potential remains largely unexplored. We employed a network-based analysis of single-cell heart transcripto...
Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment [0.03%]
血小板衍生四聚体 thromboxane 激动剂通过抑制树突状细胞募集中性粒细胞减轻脓毒症
Ronglu Du,Ting Pan,Yuhan Wang et al.
Ronglu Du et al.
Dendritic cells (DCs) regulate both innate and adaptive immunity during sepsis. Prostaglandins (PGs), small lipid molecules derived from arachidonic acid via COX enzymes, are crucial regulators of immune homeostasis and inflammation. Howeve...
GPR54 regulates non-small cell lung cancer development via dopa decarboxylase [0.03%]
GPR54通过多巴脱羧酶调节非小细胞肺癌的发生发展
Hyun-Ha Hwang,Seo Yeon Lee,Chanhee Lee et al.
Hyun-Ha Hwang et al.
Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is a leading cause of cancer death. G protein-coupled receptor 54 (GPR54) plays a role in cancer development by interacting with its endogenous ligand kisspeptin encod...
Efficacy and safety of bofanglutide, a GLP-1 receptor agonist, in Chinese adults with overweight or obesity: a randomized, double-blind, placebo-controlled phase 2b trial [0.03%]
勃法利肽治疗中国超重或肥胖成人受试者的有效性和安全性：一项随机、双盲、安慰剂对照II期临床试验
Linong Ji,Leili Gao,Junhang Tian et al.
Linong Ji et al.
Bofanglutide is a novel biweekly (once every two weeks; Q2W) glucagon-like peptide-1 receptor agonist. We evaluated the efficacy and safety of bofanglutide in Chinese adults with overweight or obesity in a randomized, double-blind, placebo-...
Targeting fused in sarcoma (FUS): a novel antisense strategy for treating idiopathic pulmonary fibrosis [0.03%]
针对融合在恶性 schwann瘤中的FUS蛋白：特发性肺间质纤维化的新型反义寡核苷酸治疗策略
Bhavika B Katariya,Shashipavan Chillappagari,Lisa Arnold et al.
Bhavika B Katariya et al.
Fused in sarcoma (FUS) is a highly conserved RNA-binding protein with essential roles in RNA processing and genomic stability. While extensively studied in the context of neurodegeneration, its involvement in fibrotic diseases, particularly...
Coronary atherosclerotic plaque intervention with Tongxinluo capsule (TXL-CAP): a multicenter, randomized, double-blind and placebo-controlled study [0.03%]
通心络胶囊干预冠脉动脉粥样硬化斑块随机、双盲、安慰剂平行对照的多中心试验
Mei Ni,Yun Ti,Huai Yu et al.
Mei Ni et al.
Clinical evidence of traditional Chinese medicine Tongxinluo capsule therapy on coronary plaque vulnerability is lacking. To investigate whether Tongxinluo may increase coronary plaque stability in patients admitted with acute coronary synd...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2026 Feb 24;11(1):72. DOI:10.1038/s41392-026-02581-z 2026
Antiviral drug discovery and development: challenges and future directions [0.03%]
抗病毒药物发现与开发：挑战与未来方向
Shaoqing Du,Xueping Hu,Ping Li et al.
Shaoqing Du et al.
The coronavirus disease 2019 (COVID-19) pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins for viral infe...