DUSP6 ablation restores CAR T-cell fitness impaired by tumor CD58 loss through invigoration of AP-1 signaling [0.03%]
DUSP6缺失通过活化AP-1信号转导恢复肿瘤CD58丢失引起的CAR-T细胞活性损伤
Xinran Ma,Yang Zhang,Yao Wang et al.
Xinran Ma et al.
Primary resistance to chimeric antigen receptor (CAR) T-cell therapies has limited their widespread application. Our prior genome-wide CRISPR/Cas9 screening revealed that the loss of CD58, a crucial intrinsic resistance factor in tumors, re...
A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms [0.03%]
一种生物安全的鼠类模型可更逼真地模拟SARS-CoV-2感染和COVID-19症状
Xiaoya Huang,Yingjian Li,Jikai Deng et al.
Xiaoya Huang et al.
COVID-19 resulting from SARS-CoV-2 infection has presented significant challenges to global health over the past several years. Animal models are essential for studying the pathogenic mechanisms of SARS-CoV-2 and facilitating the developmen...
Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination [0.03%]
导电配位纳米酶前药精准触发焦亡、铜依赖性细胞死亡和铁依赖性细胞死亡用于原位癌症疫苗治疗
Yuqiao Wang,Hao Zhao,Ke Sun et al.
Yuqiao Wang et al.
Pyroptosis, which rapidly releases cellular contents through pyroptotic pores, is an ideal method for inducing in situ cancer vaccines, evoking systemic antitumor immunity, and suppressing primary and metastatic tumors. However, the clinica...
Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications [0.03%]
基于纳米粒子的光疗系统：分子机制及临床应用
Deepak S Chauhan,Rajendra Prasad,Mukesh Dhanka et al.
Deepak S Chauhan et al.
Nanoparticle-based phototherapy represents a paradigm shift in precision medicine, harnessing light-activated mechanisms to modulate cellular pathways across a spectrum of diseases. By integrating nanoparticles, phototherapeutic modalities ...
Modulating fatty acid signaling to restore allopregnanolone balance: a novel strategy for anxiety disorders [0.03%]
调制脂肪酸信号恢复别孕烯醇酮平衡：焦虑症的一种新策略
Zhiqian Bi,Yawen Xie,Na Han et al.
Zhiqian Bi et al.
Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors [0.03%]
时空谱分析揭示了CAR-T和CAR-NKT细胞对抗实体瘤的不同动力学和检查点调节机制
Yan-Ruide Li,Miao Li,Yuning Chen et al.
Yan-Ruide Li et al.
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapies have demonstrated remarkable efficacy in hematologic malignancies; however, their clinical performance in solid tumors remains limited due to suboptimal tumor infiltration,...
Gut microbiota modulation via repeated donor fecal transplantation improves motor and gastrointestinal symptoms in drug-naïve Parkinson's disease: a randomized phase 2 trial [0.03%]
随机二期试验通过重复捐赠者粪便移植调节肠道菌群可改善帕金森病患者的运动和胃肠道症状
Rui Zhang,Renyi Feng,Jiuqi Wang et al.
Rui Zhang et al.
The gut-brain axis is increasingly recognized as a critical contributor to Parkinson's disease (PD) pathogenesis, yet the therapeutic impact of microbiota modulation remains unclear due to lack of clinical trials in drug-naïve patients. We...
Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy [0.03%]
环鸟苷酸-蛋白激酶G信号通过ULK1介导的自噬减轻主动脉瓣钙化
Yan Wang,Fei Xu,Chengxiang Song et al.
Yan Wang et al.
Calcific aortic valve disease (CAVD) is a prevalent age-related valvulopathy characterized by high morbidity and mortality. CAVD pathogenesis involves maladaptive differentiation of valvular interstitial cells (VICs) into profibrotic and os...
Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer [0.03%]
泛素介导的KDM5B蛋白稳定通过抑制双重特异性磷酸酶4诱导卵巢癌耐药性
Jung Yoo,Go Woon Kim,Yu Hyun Jeon et al.
Jung Yoo et al.
Despite advances in therapeutic regimens for managing cancer progression, ovarian cancer (OVC) still depends on platinum-based chemotherapy as its first-line treatment. Acquired resistance is accompanied by abnormal alterations in epigeneti...