Diabetes and its complications: molecular mechanisms, prevention and treatment [0.03%]
糖尿病及其并发症的分子机制、预防和治疗措施
Lijun Zhao,Jiamin Yuan,Qing Yang et al.
Lijun Zhao et al.
Diabetic complications represent a formidable clinical challenge characterized by hyperglycemia-induced multiorgan dysfunction and dysregulated intercellular signaling networks. Advances in spatial multiomics and single-cell transcriptomic ...
Astrocytic noncanonical WNT5B signaling modulates extracellular matrix remodeling and neuropathology in Huntington's disease [0.03%]
astrocyte非经典WNT5B信号通路调节亨廷顿病中的细胞外基质重塑及神经病理学变化
Phuong Thi Thanh Nguyen,Ali Yousefian-Jazi,Seung Jae Hyeon et al.
Phuong Thi Thanh Nguyen et al.
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by a triad of behavioral symptoms: involuntary movement, emotional change, and cognitive dysfunction. Although alterations in WNT signaling have been reported in ...
A microbiota-dependent bile acid reprograms alveolar macrophages to control lung inflammation [0.03%]
一种依赖微生物群的胆汁酸重新编程肺泡巨噬细胞以控制肺部炎症
Magdalena Wolska,Pilar Rodríguez-Viso,Anna Świątkowska et al.
Magdalena Wolska et al.
Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis [0.03%]
代谢功能紊乱相关脂肪性肝病通过巨噬细胞迁移抑制因子-CD44轴加速胰腺癌的进展和转移
Qian Yu,Hui Song,Xiao-Ya Shi et al.
Qian Yu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis, particularly in the presence of liver metastases. The mechanisms by which metabolic dysfunction-associated steatotic liver disease (MASLD), for...
Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations [0.03%]
胰腺癌中的垂直RAS通路抑制驱动了可药物利用的线粒体改变
Philipp Hafner,Steffen J Keller,Xun Chen et al.
Philipp Hafner et al.
Oncogenic KRAS mutations drive metabolic reprogramming in pancreatic ductal adenocarcinoma (PDAC). Src-homology 2 domain-containing phosphatase 2 (SHP2) is essential for full KRAS activity, and promising dual SHP2/mitogen-activated protein ...
Extracellular vesicle-derived miRNA-182-5p educates macrophages towards an immunosuppressive phenotype in pancreatic cancer [0.03%]
胰腺癌中细胞外小泡衍生的miRNA-182-5p使巨噬细胞向免疫抑制表型分化
Baldev Singh,Pankaj Gaur,Pritha Bose et al.
Baldev Singh et al.
Reprogramming the immunosuppressive milieu in pancreatic cancer (PaCa) remains an important yet unmet therapeutic goal. Although tumor-associated macrophages (TAMs) are known to promote tumor growth and metastasis, little is known about the...
Perioperative penpulimab-based combination therapy in patients with resectable non-small cell lung cancer (ALTER-L043): an open-label, multicenter, randomized, phase II trial [0.03%]
可切除非小细胞肺癌患者围手术期派安普利单抗联合治疗：一项开放性、多中心、随机II期试验（ALTER-L043）
Meng Wang,Weiran Liu,Hongbo Guo et al.
Meng Wang et al.
Although perioperative immunotherapy combined with neoadjuvant chemotherapy has improved the clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC), the optimal combination strategy remains unknown. This multicente...
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology [0.03%]
芳烃受体：结构、信号转导及其生理和病理作用
Xavier Coumoul,Robert Barouki,Charlotte Esser et al.
Xavier Coumoul et al.
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family. In this review, we explore the multifaceted roles of AHR in both health and disease, tracing its recognition as a xenobiotic sens...
The dysadherin/carbonic anhydrase 9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression [0.03%]
粘附不良蛋白/碳酸酐酶9轴塑造酸性肿瘤微环境以促进结直肠癌进展
Choong-Jae Lee,Hyeon-Ji Yun,Tae-Young Jang et al.
Choong-Jae Lee et al.
The tumor microenvironment (TME) plays a central role in cancer progression and metastasis. A key feature of the TME is extracellular acidity, which promotes disease progression, immune evasion, and drug resistance. Tumor acidity is increas...
Qian Hu,Yue Hu,Chunlu Tan et al.
Qian Hu et al.
Acute pancreatitis is a complex inflammatory condition characterized by sudden onset and rapid progression, with severe cases often associated with high mortality. In recent years, the global incidence of acute pancreatitis has been increas...