NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome
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The ubiquitin-like modifier FAT10 targets hundreds of proteins in the mammalian immune system to the 26S proteasome for degradation. This degradation pathway requires the cofactor NUB1, yet the underlying mechanisms remain unknown. Here, we reconstituted a min... ...
