Molecular glues that inhibit deubiquitylase activity and inflammatory signaling [0.03%]
抑制去泛素酶活性和炎症信号的分子粘合剂
Francesca Chandler,Poli Adi Narayana Reddy,Smita Bhutda et al.
Francesca Chandler et al.
Deubiquitylases (DUBs) are crucial in cell signaling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signaling by cleaving K63-linked polyubiquitin chains on t...
A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance [0.03%]
核孔锚定的凝聚物使生殖颗粒组织和跨代表观遗传继承成为可能
Pu Lu,Boyuan Deng,Xinru Li et al.
Pu Lu et al.
Biomolecular condensates, such as stress and germ granules, often contain subcompartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is composed of at least f...
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
PYROXD1介导的人tRNA连接酶复合物抵抗氧化失活的机制基础
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
Melina Casadio
Melina Casadio
Michelle Korda
Michelle Korda
Author Correction: Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants [0.03%]
《作者勘误：抗惊厥药物与突触小泡蛋白2A和2B的结合结构》
Anshumali Mittal,Matthew F Martin,Elena J Levin et al.
Anshumali Mittal et al.
Published Erratum
Nature structural & molecular biology. 2025 Mar 6. DOI:10.1038/s41594-025-01528-2 2025
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly [0.03%]
ZFP207和U1 snRNP的凝结促进剪接体的组装
Yuenan Zhou,Chong Tong,Zuokun Shi et al.
Yuenan Zhou et al.
The U1 small nuclear ribonucleoprotein (snRNP) has an essential role in initiating spliceosome assembly, yet the mechanism underlying its synergy with other splicing regulators for efficient spliceosome assembly remains elusive. Here we ide...
Publisher Correction: Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition [0.03%]
出版更正：转录因子调控人类细胞类型转变过程中靠近启动子的RNA聚合酶II终止
Kseniia Lysakovskaia,Arjun Devadas,Björn Schwalb et al.
Kseniia Lysakovskaia et al.
Published Erratum
Nature structural & molecular biology. 2025 Mar 5. DOI:10.1038/s41594-025-01521-9 2025
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W [0.03%]
具有阿尔茨海默病构象的人MAPT突变体V337M和R406W中的tau纤维
Chao Qi,Sofia Lövestam,Alexey G Murzin et al.
Chao Qi et al.
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the most common forms of early-onset dementia. Unlike AD, FTD begins with behavioral changes before the development of cognitive impairment. Dominantly inherited mutations in MA...